Korean J Fam Med 2017; 38(5): 291-295  https://doi.org/10.4082/kjfm.2017.38.5.291
Carbohydrate-Deficient Transferrin as a Biomarker for Screening At-Risk Drinking in Elderly Men
Kwangmi Youn, Jong Sung Kim*, Sung-Soo Kim, Seok Joon Yoon, Dong-jin Woo
Department of Family Medicine, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, Korea
Jong Sung Kim Tel: +82-42-280-8172, Fax: +82-42-280-7879, E-mail: jskim@cnuh.co.kr
Received: July 12, 2016; Revised: August 11, 2016; Accepted: August 24, 2016; Published online: September 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

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Abstract
Background: Carbohydrate-deficient transferrin (CDT) is a useful biomarker to identify excessive alcohol consumption; however, few studies have validated the %CDT cut-off value in elderly men. This study estimated the optimal %CDT cut-off value that could identify excessive alcohol consumption in men aged ≥65 years.
Methods: This retrospective study included 120 men who visited the department of family medicine at Chungnam National University Hospital for health check-up between January 2010 and August 2013. At-risk drinking included heavy- and binge drinking. Heavy drinking was defined as more than seven standard drinks/wk, and binge drinking was defined as more than three standard drinks/d. The cut-off %CDT values for at-risk drinking were determined using receiver operating characteristic (ROC) curves.
Results: Based on the ROC curves, the optimal %CDT cut-off values in ≥65-year-old men were 1.95% for at-risk drinking, 1.81% for heavy drinking, and 2.07% for binge drinking. The sensitivity, specificity, and positive and negative predictive values were 58.7%, 83.6%, 69.2%, and 76.2% for at-risk drinking, respectively. The AUROC were >0.7 for all three evaluated cut-offs.
Conclusion: Our results suggest that the %CDT cut-off value for at-risk drinking in elderly Korean men (≥65 years) should be readjusted to a lower value of 1.95%.
Keywords: Transferrin; Biomarkers; Drinking; Screening


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