Korean J Fam Med 2017; 38(6): 352-357  https://doi.org/10.4082/kjfm.2017.38.6.352
The Relationship between the Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Metabolic Syndrome
Hyun-Gyu Shin, Young-Kwang Kim, Yong-Hwan Kim, Yo-Han Jung, Hee-Cheol Kang*
Department of Family Medicine, Yonsei University Hospital, Seoul, Korea
Hee-Cheol Kang Tel: +82-2-2228-2332, Fax: +82-2-362-2473, E-mail: kanghc@yuhs.ac
Received: March 30, 2016; Revised: August 28, 2016; Accepted: August 29, 2016; Published online: November 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

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Background: Metabolic syndrome is associated with cardiovascular diseases and is characterized by insulin resistance. Recent studies suggest that the triglyceride/high-density lipoprotein cholesterol (TG/HDLC) ratio predicts insulin resistance better than individual lipid levels, including TG, total cholesterol, low-density lipoprotein cholesterol (LDLC), or HDLC. We aimed to elucidate the relationship between the TG/HDLC ratio and metabolic syndrome in the general Korean population.
Methods: We evaluated the data of adults ≥20 years old who were enrolled in the Korean National Health and Nutrition Examination Survey in 2013 and 2014. Subjects with angina pectoris, myocardial infarction, stroke, or cancer were excluded. Metabolic syndrome was defined by the harmonized definition. We examined the odds ratios (ORs) of metabolic syndrome according to TG/HDLC ratio quartiles using logistic regression analysis (SAS ver. 9.4; SAS Institute Inc., Cary, NC, USA). Weighted complex sample analysis was also conducted.
Results: We found a significant association between the TG/HDLC ratio and metabolic syndrome. The cutoff value of the TG/HDLC ratio for the fourth quartile was ≥3.52. After adjustment, the OR for metabolic syndrome in the fourth quartile compared with that of the first quartile was 29.65 in men and 20.60 in women (P〈0.001).
Conclusion: The TG/HDLC ratio is significantly associated with metabolic syndrome.
Keywords: Metabolic Syndrome; Insulin Resistance; Low-Density Lipoprotein Cholesterol; Triglycerides; High-Density Lipoprotein Cholesterol

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