Korean J Fam Med 2017; 38(6): 358-364  https://doi.org/10.4082/kjfm.2017.38.6.358
Osteoarthritis Affects Health-Related Quality of Life in Korean Adults with Chronic Diseases: The Korea National Health and Nutritional Examination Surveys 2009–2013
Ji Hye Yang1, Kiheon Lee2,*, Se Young Jung2, Woo Kyung Bae3, Hye Jin Ju1, In Young Cho1, Jae Kyeong Song1, Hwa Yeon Park2, Jong-Soo Han3, Ga-Hye Lee1, Ye Seul Bae1
1Department of Family Medicine, Seoul National University Hospital, Seoul, Korea
2Department of Family Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
3Department of Family Medicine, Health Promotion Center, Seoul National University Bundang Hospital, Seongnam, Korea
Kiheon Lee Tel: +82-31-787-7801, Fax: +82-31-787-4834, E-mail: keyhoney@gmail.com
Received: June 3, 2016; Revised: August 10, 2016; Accepted: August 29, 2016; Published online: November 20, 2017.
© Korean Academy of Family Medicine. All rights reserved.

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Background: Osteoarthritis (OA) is a chronic disease that commonly afflicts the elderly. This disease reduces the health-related quality of life (HRQoL) and causes a significant social burden. Whether the effect of coexisting chronic conditions on HRQoL varies according to the presence of OA remains unclear. Therefore, this study aimed to investigate this notion.
Methods: A total of 13,395 participants were identified from the 2009–2013 Korean National Health and Nutrition Examination Survey for analysis. HRQoL was assessed using the European quality of life-5 dimensions (EQ-5D) index. Patients with OA were defined as those diagnosed by a physician or those who displayed both, symptoms and radiological findings consistent with OA at the time of the survey. Associations between OA and 8 chronic conditions were tested using regression analysis.
Results: The EQ-5D index was lower in patients with OA than in those without (mean difference, -0.145; 95% confidence interval [CI], -0.138 to -0.151; P〈 0.001). Most patients with OA and chronic conditions showed a lower score than those without. EQ-5D was particularly lower in OA patients with hypertension, dyslipidemia, stroke, and renal failure. The estimated β coefficient for the interaction term was significant in renal failure (-0.034; 95% CI, -0.055 to -0.012), after adjusting for demographic and socio-economic variables.
Conclusion: OA significantly affects HRQoL of Korean elderly individuals alone or when combined with other conditions. OA combined with renal failure is particularly detrimental. These results indicate the importance of managing OA, which is an underestimated disease in public health surveys.
Keywords: Osteoarthritis; Chronic Disease; Quality of Life; Comorbidity

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