Korean J Fam Med 2018; 39(1): 54-56  https://doi.org/10.4082/kjfm.2018.39.1.54
A Case of a Girl with Arnold-Chiari Type 1 Malformation with Precocious Puberty
Min Sun Kim, Pyoung Han Hwang, Dae-Yeol Lee*
Department of Pediatrics, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, Korea
Dae-Yeol Lee https://orcid.org/0000-0002-5733-2669
Tel: +82-63-250-1469, Fax: +82-63-250-1464, E-mail: leedy@jbnu.ac.kr
Received: August 1, 2016; Revised: August 31, 2016; Accepted: September 22, 2016; Published online: January 20, 2018.
© Korean Academy of Family Medicine. All rights reserved.

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A small percentage of individuals have the neurological anomaly of central precocious puberty (CPP). Common neurologic causes of CPP include a tumor or congenital lesions. Although Arnold-Chiari malformation can be caused by congenital or acquired causes, it is unusual in patients with CPP. We present the case of a girl aged 4.5 years who complained of breast budding. Her neurological examination and growth pattern were normal. She had no endocrinological abnormality, except for true precocious puberty. We performed brain magnetic resonance imaging, which showed an Arnold-Chiari type 1 malformation. Currently, this case represents the youngest girl who exhibited both Arnold-Chiari type 1 malformation and precocious puberty. Furthermore, it is likely that there is a meaningful association between the brain lesion and precocious puberty in this case.
Keywords: Precocious Puberty; Arnold-Chiari Malformation; Child

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