| Ah Reum Han | 5 Articles |
Background
Several studies showed the relationship between serum homocysteine and pulse wave velocity, but their subjects were confi ned to high risk group for cardiovascular diseases and recent study revealed no relationship in young healthy adults. We hypothesized that time interval would be needed for serum homocysteine to infl uence pulse wave velocity after exposure to vascular endothelium. The purpose of this study was to determine the relationship between serum homocysteine and pulse wave velocity in middle aged women on the basis of that hypothesis and necessity for further study in general population.Methods: The study subjects were 110 middle aged women who visited a health promotion center of a general hospital. We collected medical history by means of self-reported questionnaire and measured height, weight, blood pressure and brachial-ankle pulse wave velocity (baPWV). Blood sampling was performed after overnight fasting. We analyzed the relationship between several cardiovascular risk factors and baPWV and performed multiple regression analysis.Results: BaPWV velocity was correlated signifi cantly with age, mean blood pressure, serum homocysteine, total cholesterol and diabetes mellitus, but not with body mass index, high-density lipoprotein cholesterol, triglyceride, creatinine clearance, alcohol intake, hypertension and smoking. In multiple regression, there was a signifi cant association between age (P = 0.04), moderate hyperhomocysteinemia (P = 0.02), mean blood pressure (P < 0.001) and baPWV.Conclusion: In middle aged women, there was an independently positive association between serum homocysteine and baPWV. Citations Citations to this article as recorded by
Background
Metabolic syndrome (MetS) is characterized by a core set of disorders, including abdominal obesity, dyslipidemia, glucose intolerance and hypertension. Many studies have shown that MetS is associated with increased risk of developing cardiovascular diseases and related mortality. However, the relationship of MetS with early stage of cardiovascular diseases, which is even more important from a prevention prespective, has not been examined extensively. Brachial-ankle pulse wave velocity (baPWV) is known to predict future cardiovascular events. Thus, we examined the relationship of MetS, defined using the NCEP-ATP III criteria, with baPWV. Methods: We examined a total of 400 participants who did not have a past history of either coronary heart disease or peripheral vascular disease. All subjects underwent physical examination, blood chemistry, and baPWV. Results: Compared with subjects without MetS, subjects with MetS had increased age, body mass index (BMI), and ALT. Mean value of baPWV (adjusted for age, BMI, and blood pressure) was significantly higher in subjects with MetS (P=0.002). The baPWV was positively correlated with age, BMI, systolic and diastolic blood pressure in subjects with MetS. In group without MetS, the baPWV was associated with age, waist circumference, blood pressure, total cholesterol, LDL cholesterol, triglyceride, fasting blood sugar, AST, ALT, homocysteine, CRP, and ferritin. The mean values of baPWV with 0, 1, 2, 3, 4, 5 components of MetS were 1,362.3⁑182.2 cm/s, 1,531.3⁑267.0 cm/s, 1,694.1⁑315.8 cm/s, 1,777.0⁑334.0 cm/s, 2,087.7⁑192.3 cm/s, respectively. Conclusion: In this study, the MetS was associated with the risk for increased baPWV. (J Korean Acad Fam Med 2007;28:271-277)
Background
: Serum γ-GT is one of the biliary enzymes with the only enzymatic activity capable of cleaving extracellular glutathione, thus originating precursor amino acids for the intracellular resynthesis of glutathione. Several population-based studies have shown a strong cross-sectional association between serum γ-GT concentration and cardiovascular risk factors. And prospective studies showed that serum γ-GT concentration had a prognostic impact on cardiovascular mortality. But, the mechanism by which γ-GT is associated with cardiovascular disease is not elucidated. We hypothesized that there was an association between serum γ-GT and ferritin, a marker of oxidative stress. In this study, we investigated the relationship between serum γ-GT and serum ferritin. Methods : By reviewing the medical records of 288 healthy adults, we determined the serum levels of γ-GT and ferritin according to age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL-cholesterol, fasting blood sugar, hs-CRP, serum ferritin, AST, ALT, uric acid and smoking history. We studied the relationship between the variables by Pearson correlation coefficients and multiple stepwise regression analysis. Mean values of serum γ-GT according to the smoking history were compared using t-test. Results : Serum γ-GT correlated positively with serum ferritin (r=0.42; P＜0.001). BMI, triglycerides, total cholesterol, fasting blood sugar, AST and ALT also showed statistically significant correlation. Smokers showed significantly higher serum γ-GT. Serum γ-GT correlated with serum ferritin, ALT, current smoking and triglycerides by multiple stepwise regression analysis. Conclusion : Serum γ-GT correlated positively with serum ferritin.
Background
: Recently, thermal therapy such as sauna and sweating room is popular as a health behavior. In patients with heart failure, sauna treatment improves hemodynamic data and clinical symptoms by restoring endothelial function. The purpose of this study was to investigate that sauna bath could decrease pulse wave velocity reflecting vascular function of people in the community. Methods : A total of 43 volunteers (11 male, 32 female) older than 40 years old were kept in 60℃ dry sauna for 15 to 20 minutes. We measured the brachial-ankle pulse wave velocity (baPWV), blood pressure, heart rate, body weight and body temperature before and, 30 and 60 minutes after sauna bath and assessed the differences of the means of these measurements with repeated measures of ANOVA. Then, we performed multiple regression analysis to find out the factors independently associated with the amount of baPWV change. Results : The BaPWV and systolic and diastolic blood pressure decreased significantly 30 and 60 minutes after sauna bath comparing to those before (P＜0.001, P=0.003, P=0.011, respectively). Multiple regression analysis showed that baseline baPWV and history of hypercholesterolemia independently influenced on the amount of baPWV change (β=-0.47, P=0.002; β=-0.36, P=0.013, respectively). Conclusion : We studied the acute reduction of pulse wave velocity after sauna bath in adults over 40 years old. This change was striking in the subjects with faster baseline baPWV. This result suggests that sauna bath can improve vascular function in the high risk group of cardiovascular diseases.
Background
: Sullivan has suggested that higher incidence of coronary heart disease in men and postmenopausal women is due to higher levels of stored iron in these two groups. A few epidemiologic studies in humans have reported the association between iron stores and increased risk of cardiovascular diseases. But there is conflicting evidence regarding the relationship between iron and cardiovascular diseases. The present study evaluated the relationship between ferreting and well established cardiovascular risk factors. Methods : There were 288 healthy subjects who visited a health promotion center of a general hospital. We collected data by means of self-reported questionnaire and measured height, weight and blood pressure. Serum ferritin, fasting blood glucose, lipid profiles, and C-reactive protein were measured at a fasting state. Results : Mean serum ferritin values were 150.1±82.2 ng/mL in men and 61.7±38.2 ng/mL in women (P＜0.001). Serum ferritin level in current smoker was higher than in non-smoker (157.6±111.8 ng/mL versus 100.5±64.2 ng/mL, P=0.006). Serum ferritin was significantly and positively correlated with body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol and triglyceride. There was no statistical significance in age, C-reactive protein, high- density lipoprotein cholesterol and low-density lipoprotein cholesterol. In multiple regression analysis, there was association between ferritin and sex (β=-80.333, P＜0.001) and triglycerides (β=0.182, P=0.030). Conclusion : The serum ferritin level in men is higher than in women in healthy adults. Serum ferritin is positively associated with triglycerides.
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