| Jun Hyun Yoo | 15 Articles |
Background
Circadian misalignment is associated with metabolic syndrome. This study aimed to examine the association between circadian rhythm-disturbing factors and metabolic syndrome. Methods We used data from the 7th and 8th Korea National Health and Nutrition Examination Survey conducted between 2016 and 2020, which surveyed 16,253 individuals. Circadian rhythm-disturbing factors were defined as follows: sleep duration outside the reference group (6–8 hours), irregular breakfast, shift work, and physical inactivity. The adjusted odds ratio (aOR) for metabolic syndrome was calculated based on the number of circadian rhythm-disturbing factors present in adults over the age of 19 years. Results Among a total of 16,253 participants (mean age 48.2±15 years), metabolic syndrome was found in 5,237 participants (29.3 %). The participants were classified into three categories based on the number of circadian rhythm-disturbing factors as follows: 2,627 (15.6%) did not have any factors, 6,406 (38.13%) had one factor, and 7,220 (46.3%) had two or more factors. Participants with a single circadian rhythm-disturbing factor were 21% more likely to have metabolic syndrome (aOR, 1.21; 95% confidence interval [CI], 1.08–1.36), and participants with two or more factors were 27% more likely to have metabolic syndrome (aOR, 1.27; 95% CI, 1.12–1.43). Conclusion Circadian rhythm-disturbing factors were significantly associated with the prevalence of metabolic syndrome in Korean adults. This finding has potential clinical implications for maintaining circadian rhythms by avoiding certain factors to prevent metabolic syndrome. Further studies are required to confirm these findings.
Background
Previous studies have shown a close relationship between skipping breakfast and nutritional deficiency. However, the impact of regular eating, including lunch and dinner, has not been studied well. We explored the correlation between regularity and frequency of daily meals and nutritional status. Methods We analyzed Korea National Health and Nutrition Examination Surveys between 2016 and 2018. A total of 7,725 adults aged 19–49 years were classified into four groups according to the regularity of meal intake: three-meal regular diet (3MRD), two-meal regular diet, one-meal regular diet, and irregular diet (IRD). Food and nutrient intake was assessed using the 24-hour recall method and estimated by a generalized linear model in complex sample weight variables. Results In IRD, there were relatively more females who were not married, lived alone, or reported low levels of education. As subjects ate more meals, more people felt thinner and healthier by themselves. Dietary intake of cereal, vegetables, seaweed, and fiber was directly proportional to the number of regular meals as well as essential components such as water, carbohydrates, protein, fat, and micronutrients. Contrarily, alcohol and beverage consumption was inversely proportional to the number of regular meals. Intake level of legumes, fish, fruits, seasonings, milk, oils, sugars, and cholesterol was consistent regardless of meal frequency. Conclusion Our findings suggest that 3MRD showed nutrient adequacy and a healthier profile on body weight, body mass index, waist circumference, blood pressure, serum fasting glucose, total cholesterol, and triglyceride. Citations Citations to this article as recorded by
Background
Few studies have evaluated risk factors for behavioral and psychological symptoms of dementia at the initial assessment for Alzheimer disease in large patient samples. In this study, the factors influencing Alzheimer disease were examined using the Clinical Research of Dementia of South Korea data. Methods This cross-sectional study was conducted using data of 1,128 patients with Alzheimer disease. The behavioral and psychological symptoms of dementia were examined using the Korean version of the Neuropsychiatric Inventory. Demographic characteristics, health-related behavior, neuropsychological tests, comorbidities, blood test results, and caregiver characteristics were assessed. Median logistic regression analysis with adjustment for covariates was conducted. Results The behavioral and psychological symptoms of dementia were negatively associated with memory (P=0.022) and frontal/executive (P<0.001) function in the Seoul Neuropsychological Screening Battery-dementia, Barthel Index for Activities of Daily Living (P<0.001), Korean version of the Mini-Mental State Examination score (P=0.003), and caregiver age (P=0.005) after adjustment for confounding factors, and positively associated with the Seoul-Instrumental Activities of Daily Living score (P<0.001), Clinical Dementia Rating Sum of Box (P<0.001), Global Deterioration Scale score (P<0.001), abnormality of free T4 level (P<0.001), anemia (P<0.001), and family history of stroke (P=0.001). Patients with female caregivers exhibited more severe behavioral and psychological symptoms of dementia than those with male caregivers. Conclusion Behavioral and psychological symptoms of dementia in Alzheimer disease patients were associated with various risk factors including the inability to live independently and Alzheimer disease severity. These findings suggest that prevention and treatment strategies for the behavioral and psychological symptoms of dementia should be comprehensive. Citations Citations to this article as recorded by
Background
Many epidemiological studies suggest the pathogenic role of serum uric acid level in development of hypertension. Several cross-sectional studies have shown the relationship between uric acid and development of hypertension in Korea. We investigated whether uric acid associates with the development of hypertension in a retrospective cohort study. Methods: We included 2,353 people who did not have hypertension initially and underwent general medical examination between 1997 and 1998 and were re-examined after 10 years later. Study people divided into three groups according to serum uric acid level tertiles. Results: The incidences of hypertension in tertile groups were 14.1% (108/764), 22.0% (175/769), and 24.3% (193/793) and they showed statistically significant difference. We performed multivariable logistic regression with serum uric acid and other risk factors of hypertension. The incidence of hypertension in second and third tertile group were significantly higher than first tertile group (odds ratio [OR], 1.53; 95% confidence interval [CI], 1.11 to 2.10; P = 0.009 in second tertile group and OR, 1.66; 95% CI, 1.17 to 2.37; P = 0.005 in third tertile group). Conclusion: Serum uric acid level is associated with the development of hypertension. Citations Citations to this article as recorded by
Background
Several studies have suggested that smoking may cause insulin resistance. However, the association between smoking and insulin resistance is still controversial. The purpose of this study was to investigate the association between smoking status and insulin resistance in Korean nondiabetic male population.Methods: A total of 5,969 men, aged > 20 years were recruited from those who visited the Health Promotion Center, Samsung Medical Center between 2005 and 2006. All subjects were divided into three categories: on-smokers (n = 2,594), ex-smokers (n = 1,580), and current-smokers (n = 1,795). Fasting values for glucose and insulin were used to estimate insulin resistance by HOMA (homeostasis model assessment). An independent association between smoking status and HOMA-IR (homeostasis model assessment of insulin resistance) was assessed after adjustment for factors infl uencing insulin sensitivity such as age, exercise, alcohol, body mass index, abdominal circumference, and blood pressure.Results: HOMA-IR was signifi cantly higher in ex-smokers and current-smokers than in non-smokers (2.09 ± 0.94 vs. 2.04 ± 0.90, 1.96 ± 0.86, P < 0.01, respectively). After adjustment for factors potentially affecting insulin sensitivity (age, alcohol intake, exercise, BMI, body fat, abdominal circumference, and blood pressure), the association persisted for ex-smokers (P = 0.008). And HOMA-IR was signifi cantly higher in ≥ 40 pack-years smokers than in non-smokersConclusion: Based on HOMA-IR, previous-smoking and chronic smoking were significantly associated with insulin resistance in apparently healthy Korean nondiabetic men.
Background
Menstruation is often regarded as a privilege for women allowing reproductive activity. However, abrupt hormonal fluctuations in menstrual cycle may cause distressing physical and psychological symptoms such as premenstrual syndrome (PMS). PMS is known to have a great impact on daily life activities and social functions, and might result in significantly decreased quality of life (QOL). In this study, we aimed to evaluate a relation between PMS and QOL in young adult Korean women. Methods: Self-administered questionnaires were distributed to a total of 514 women who were aged 16∼35 years and who were employed in an industrial complex located in Gyeonggi-do, Korea. PMS was assessed using diagnostic criteria recommended by the American Psychiatric Association. QOL was assessed using Korean health related Quality of Life Scale. The association between PMS and QOL was examined in 440 women using the two-sample t-test after excluding 74 women who were missing for variables essential for the assessment of PMS and QOL. Results: The prevalence of PMS was 7.3% (32 out of 440 women). Women with PMS had the worse QOL score in almost all domains of QOL except for spiritual health (physical function, psychological health, social function, pain, vitality, role limitation, health status perception, and health status change). Conclusion: There was a significant relation between PMS and QOL. The finding of significantly lower QOL in women with PMS suggests that PMS should be evaluated and treated actively in primary care. (J Korean Acad Fam Med 2008;29:108-113)
Background
There are few studies about association between the metabolic syndrome and smoking status (onset of smoking, duration, number of cigarettes per day, pack-years) in long-term smokers. And CRP level, a risk factor of the metabolic syndrome, is known to be higher in smokers than in non-smokers. This study was done to assess the association of smoking status and CRP level with the metabolic syndrome in long-term smokers. Methods: Healthy men aged 40 years old or more who visited the Samsung Medical Health Promotion Center were selected. We examined the participants' clinical characteristics by using self-reporting questionnaires, laboratory data, and Bruce treadmill test. We estimated the prevalence of the metabolic syndrome and identified the association between smoking status, CRP, and the metabolic syndrome by multiple logistic regression method. Results: The prevalence of the metabolic syndrome was higher in the long-term smokers (21.4%) than in the non-smokers (17.5%). The odds ratios of developing the metabolic syndrome were 2.46 (95% CI 1.31∼4.62) and 2.57 (95% CI 1.20∼5.50) in men who smoked 20∼29 and 30 or more cigarettes, respectively, compared with those who smoked 1∼9 cigarettes. And the odd ratio was 1.41 (95% CI 1.01∼1.97) in men who had high CRP level (≥0.3 mg/dl) compared with the normal CRP group. The number of cigarettes had statistically positive association with the CRP level (coefficient Ղ=0.059; P＜0.05). Conclusion: The prevalence of the metabolic syndrome was higher in the long-term smokers than in the non-smokers, and proportional to the number of cigarettes in the long-term smokers. The number of cigarettes smoked per day was correlated positively to the CRP level in the middle-aged Korean men. (J Korean Acad Fam Med 2008;29:94-101)
Background
PAP smear has been highly appraised for screening cervical cancer. Generally regarded is that women physicians regularly screen for PAP would promote patients' early detection and treatment rate by their strong recommendation. Hereby we investigated PAP-screening in primary care women physicians, recommending proportion and associated factors. Methods: Questionnaires were sent to 981 members of the Korean Academy of Family Medicine, Korean Association of Family Practitioners, Korean Medical Women's Association, and Songpa-gu and Kangdong-gu family practitioners. a total of 193 respondents was analyzed. Results: Among the total 55.4% of the respondents screened for PAP smear regularly, either annually (23.9%), or from their treating gynecologists (61.6%) or through routine check-up (81.1%). Common reasons for not screening were lack of time (40.7%) and forgetfulness (38.4%). Recommending proportion for PAP to patients was 49.2%. Reasons for not recommending were lack of equipment, forgetfulness (18.8% each). Confidence of PAP as a screening test was very high (71.5%); significantly related to PAP-screening and to recommending proportion (P=0.033, P=0.005, respectively). Many of the respondents thought physician's own PAP-screening affected its recommendation (45.3%), whereas significant relation to their actual PAP-screening was not found (P=0.845). PAP-screening in physicians showed no significant relationship with recommending proportion (P=0.053). Internal disease history had meaningful relation only with recommending proportion (P=0.001). Conclusion: Though physicians show strong confidence in PAP and undergo more than the general public, most do not screen for it regularly and the recommending proportion was low. To improve physician's PAP-screening and recommending proportion, re-education of physicians and provision of proper clinical equipment are required. (J Korean Acad Fam Med 2007;28:589-598)
Background
: Although caffeine is commonly consumed substance and not seriously harmful as compared to alcohol and nicotine, Korea is planning to mark on the products which contain caffeine above a definite level with "containing large amounts caffeine". At this point in time, the study concerning caffeine related symptoms is in need. Methods : After surveying university students by using self-administered questionnaires based on DSM-IV substance related disorder, healthy 810 subjects were assessed for socio-demographic characteristics and features of caffeine intake and its dependence, withdrawal, and intoxication. Results : The mean amount of caffeine consumption in 810 subjects was 120.49 mg (median=93.0) per day. The major features of caffeine dependence were as follows: tolerance (61.1%), withdrawal (46.3%), using more or longer than intended (46.0%), and unsuccessful attempt to cut down or control use (12.6%). The prevalence was increased by daily caffeine consumption. Among 711 subjects who had experienced no caffeine consumption over 24 hours {amount of daily caffeine consumption was 116.0 mg (median=86.5)}, 6.19% showed significant distress in usual activity, and 22.1% used caffeine contents to avoid withdrawal symptoms. The prevalence of caffeine withdrawal based on DSM-IV research criteria was 2.67% and the frequency for symptoms were as follows: fatigue (37.7%), drowsiness (17.6%), headache (14.5%), an anxiety (8.3%). In addition, the prevalence of caffeine intoxication was 2.1% and the frequency for symptoms were as follows: insomnia (41.9%), diuresis (35.8%), tachycardia (26.7%), and gastrointestinal disturbance (23.3%). Conclusion : The unwanted symptoms related to caffeine withdrawal or intoxication were common in students using caffeine. Therefore, major features of caffeine-related symptoms should be considered in primary care practice.
Background
: The primary physician may be the first or the only professional who may come in contact with victims of spouse abuse. But little is known about family physician's knowledge of and attitude towards spouse abuse in Korea. Therefore, this study was conducted. Methods : We selected 191 doctors from the participants of the 2003 annual meeting of the Korean Academy of Family Medicine (KAFM). We distributed a 5 paged questionnaire them to fill out and analyzed 125 cases among them. The questionnaire included social demographic characteristics, individual knowledge of and attitudes toward spouse abuse, individual practice experience, education and training experience, and others. Results : We found a significant relationship between doctor's knowledge of spouse abuse and intervention after coming in contact with the victim. Also, this study showed that 31.8% of doctors intervened and traced the spouse abuse cases actively after physical treatment of victims, but none of the cases were reported to the police. Among the total 64.7% of the doctors explained that they did not want to intervene because they were afraid of getting involved in a legal situation. Some of the doctors who had prior educational experience concerning spouse abuse showed very significant high rate of actual intervention (P=0.0112). Conclusion : The more educational experience on spouse violence the doctors had, the more active intervention they showed. Therefore, we need to intensify the practical educational program along with the training medical program targeting medical practitioners. Of course we need to request sacrifice from doctors based on moral principles, but we also need systemic aid and reform to legal system to minimize burden to doctors.
Background
: A prospective study about the association between serum ferritin concentration and diabetes mellitus showed that higher risk of diabetes was found in men in higher concentration of serum ferritin. The aims of this study is to examine the association between serum ferritin concentration and the risk of diabetes mellitus in healthy Korean in hospital-based samples. Methods : In a volunteered healthy population(n=14.782), who underwent health examination in Samsung Medical Center, from January to December 1997, serum ferritin and glucose were determined. Results : After adjusting for age, BMI, serum triglyceride concentration, and multiple logistic regression analysis showed that those in the highest quartile had increased risk of diabetes mellitus (OR: men 2.26(95% CI 2.41-2.95, p=0.0001), women 3.03(95% CI 2.51-3.67, p=0.0001), compared with those in the lowest quartile. Conclusion : In studied population, elevated serum ferritin concentration was associated with an increased risk of diabetes.
Background
: As a primary care physician, Family physician should have concern in early detection of cancer. Early detectionof malignancy is very important because usually, the disease more untreatable when cancer is discovered among the tumor markers. There is opinion that urinary hydroxyphenyl derivative is useful for detection of various kinds of cancer, recently. We study whether GIFTEC test is clinically available in respect to early detection or not. Methods : Data gathered for in 1954 patients for general health examination during the period from May 1992 to october 1993 in Kang Dong Sacred Hospital. Results : among 1954 ptients, 1795 patients were GIFTEC negative patients, 159 patients were GIFTEC negative patients and 4 cancer patients in GIFTEC positive patients. Therefore cancer prevalence of this study was 8/1,954(0.4%). sensitivity was 4/8(50%), specipicity was 1,791/1,946(92%) false positive rate was 155/1,946(8%), false negative rate was 4/8(50%), positive predictive value rate was 4/159(2.5%), negative predictive value rate was 1,791/1,795(99.8%). Conclusion : In this study, although GIFTEC test is clinically available for cancer screening test for excluding cancer, but because of low sensitivity and very low rate of positive predictive value, We knew that the clinical availability of GIFTEC test for early detection of cancers was not available.
|
|
