Adrenocortical carcinoma (ACC) in pediatric and adolescent patients is rare, and it is associated with various clinical symptoms. We introduce the case of an 8-year-old boy with ACC who presented with peripheral precocious puberty at his first visit. He displayed penis enlargement with pubic hair and facial acne. His serum adrenal androgen levels were elevated, and abdominal computed tomography revealed a right suprarenal mass. After complete surgical resection, the histological diagnosis was ACC. Two months after surgical removal of the mass, he subsequently developed central precocious puberty. He was treated with a gonadotropin-releasing hormone agonist to delay further pubertal progression. In patients with functioning ACC and surgical removal, clinical follow-up and hormonal marker examination for the secondary effects of excessive hormone secretion may be a useful option at least every 2 or 3 months after surgery.
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Pubertal, Auxological, and Adult Height Outcomes in Children Treated for Adrenocortical Tumors: Half a Century Experience Fernanda Bora Moletta, Maria Cláudia Schmitt Lobe, Suzana Nesi França, Luiz de Lacerda, Rosana Marques Pereira Hormone Research in Paediatrics.2024; : 1. CrossRef
Peripheral precocious puberty in Li–Fraumeni syndrome: a case report and literature review of pure androgen-secreting adrenocortical tumors Sofie Ryckx, Jean De Schepper, Philippe Giron, Ken Maes, Freya Vaeyens, Kaat Wilgenhof, Pierre Lefesvre, Caroline Ernst, Kim Vanderlinden, Daniel Klink, Frederik Hes, Jesse Vanbesien, Inge Gies, Willem Staels Journal of Medical Case Reports.2023;[Epub] CrossRef
Central precocious puberty secondary to peripheral precocious puberty due to a pineal germ cell tumor: a case and review of literature Han Chen, Cai-Yan Mo, Li-yong Zhong BMC Endocrine Disorders.2023;[Epub] CrossRef
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Central precocious puberty after resection of a virilising adrenocortical oncocytic tumour Lee Rima Madi, Naama Fisch Shvalb, Chen Sade Zaltz, Yael Levy-Shraga BMJ Case Reports.2021; 14(5): e239562. CrossRef
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