Citations

• An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis
  Weidong Weng, Hongming Li, Sheng Zhu
  Genes.2022; 13(5): 806.     CrossRef
• Risk Factors of Central Obesity in Indonesian Men: A Cross-Sectional Data Study of The Indonesia Family Life Survey 5 (IFLS 5)
  Dahlia, Gracia Satyawestri Pribadi, Santi Martini, Chung Yi-Li
  Folia Medica Indonesiana.2022; 58(3): 228.     CrossRef
• Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic
  Umberto Tarantino, Ida Cariati, Chiara Greggi, Elena Gasbarra, Alberto Belluati, Luigi Ciolli, Giulio Maccauro, Alberto Momoli, Simone Ripanti, Francesco Falez, Maria Luisa Brandi
  International Journal of Molecular Sciences.2021; 22(12): 6629.     CrossRef

The Korean Ministry of Food and Drug Safety has approved three anti-obesity drugs for long-term management in the past decade. In addition, since 2019, bariatric surgery has been financially supported by National Health Insurance Service in Korea. In this review, the mechanisms of action and the clinical implications of the recently approved anti-obesity drugs, lorcaserin, naltrexone/bupropion, and liraglutide are explained. Lorcaserin stimulates proopiomelanocortin (POMC)/cocaine- and amphetamine-regulated transcript (CART) neurons and inhibits neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons, which results in the activation of melanocortin 3/4 receptors. Naltrexone/bupropion stimulates POMC neurons through bupropion; this stimulation is augmented by blocking the autoinhibitory mechanism of POMC with naltrexone. The hypophagic effect of liraglutide is mediated through the direct activation of POMC/CART neurons and the indirect suppression of NPY/AgRP neurons through γ-aminobutyric acid-dependent signaling, with adjunctive suppression of the mesolimbic dopamine reward system. In addition to liraglutide, another glucagon-like peptide-1 receptor agonist, semaglutide, is expected to be added to the list of anti-obesity drugs in the near future. In patients with obesity and high cardiovascular risk, lorcaserin was considered neutral and liraglutide was considered favorable, whereas inconclusive results were obtained for naltrexone/bupropion.

Citations

• Phytoactives for Obesity Management: Integrating Nanomedicine for Its Effective Delivery
  Ashok Kumar Mandal, Ankit Sahoo, Waleed H Almalki, Salem Salman Almujri, Abdulrahman Alhamyani, Alhussain Aodah, Nabil K Alruwaili, Sharifah Zamiah Binti Syed Abdul Kadir, Rambha Kumari Mandal, Rami A Almalki, Jonathan A Lal, Mahfoozur Rahman
  Nutrition Reviews.2025; 83(6): 1152.     CrossRef
• Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice
  Ji-Eun Song, Hae-Jin Ko, A-Sol Kim
  Drug Design, Development and Therapy.2024; Volume 18: 845.     CrossRef
• Pharmacological Treatment of Obesity in Older Adults
  Ondřej Žižka, Martin Haluzík, Edward B. Jude
  Drugs & Aging.2024; 41(11): 881.     CrossRef
• 360-Degree Perspectives on Obesity
  Magdalena Cuciureanu, Cătălin-Cezar Caratașu, Levon Gabrielian, Otilia Elena Frăsinariu, Laura Elisabeta Checheriță, Laura Mihaela Trandafir, Gabriela Dumitrița Stanciu, Andrei Szilagyi, Ina Pogonea, Gabriela Bordeianu, Radu Petru Soroceanu, Călin Vasile
  Medicina.2023; 59(6): 1119.     CrossRef
• Visceral adipose tissue and residual cardiovascular risk: a pathological link and new therapeutic options
  Arturo Cesaro, Gianantonio De Michele, Fabio Fimiani, Vincenzo Acerbo, Gianmaria Scherillo, Giovanni Signore, Francesco Paolo Rotolo, Francesco Scialla, Giuseppe Raucci, Domenico Panico, Felice Gragnano, Elisabetta Moscarella, Olga Scudiero, Cristina Menn
  Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
• AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity
  Muhammad Sufyan Vohra, Khaled Benchoula, Christopher J. Serpell, Wong Eng Hwa
  European Journal of Pharmacology.2022; 915: 174611.     CrossRef
• Efficacy of subcutaneous semaglutide compared to placebo for weight loss in obese, non-diabetic adults: a systematic review & meta-analysis
  Naazneen Arastu, Olivia Cummins, Wanda Uribe, Eric C. Nemec
  International Journal of Clinical Pharmacy.2022; 44(4): 852.     CrossRef
• Pharmacotherapy in obesity: the current state and the near future
  Yoon Jeong Cho, Kyoung-Kon Kim
  Journal of the Korean Medical Association.2022; 65(8): 514.     CrossRef
• FDA-Approved Pharmacotherapy for Weight Loss Over the Last Decade
  Zarwa Idrees, Ivan Cancarevic, Li Huang
  Cureus.2022;[Epub]     CrossRef
• Pregnancy outcomes after inadvertent exposure of anti-obesity drugs during pregnancy
  Eun Jeong Choi, Jung Yeol Han
  Clinical and Experimental Obstetrics & Gynecology.2021;[Epub]     CrossRef
• Computational Drug Repurposing Approach to Identify Potential Fatty Acid-Binding Protein-4 Inhibitors to Develop Novel Antiobesity Therapy
  Somdutt Mujwar, Vivek Kumar
  ASSAY and Drug Development Technologies.2020; 18(7): 318.     CrossRef
• Managing obesity through natural polyphenols: A review
  Manisha Singh, Thilini Thrimawithana, Ravi Shukla, Benu Adhikari
  Future Foods.2020; 1-2: 100002.     CrossRef
• Reducing Effect of Farnesylquinone on Lipid Mass in C. elegans by Modulating Lipid Metabolism
  Xihua Jia, Manglin Xu, Aigang Yang, Yan Zhao, Dong Liu, Jian Huang, Peter Proksch, Wenhan Lin
  Marine Drugs.2019; 17(6): 336.     CrossRef
• Mechanisms of action and clinical applications of anti-obesity drugs currently available in Korea
  Kyoung Kon Kim
  Journal of the Korean Medical Association.2019; 62(11): 588.     CrossRef

Background
Family doctors are increasingly managing the diabetes care of Korean-Americans. Little is known about the prevalence of diabetes among non-obese Korean-Americans, or the extent to which they receive timely and appropriate diabetes care. The purpose of this investigation is to: (1) identify the prevalence of diabetes and to determine the adjusted odds of diabetes among non-obese Korean-Americans compared to non-Hispanic White (NHW) Americans, (2) examine the factors associated with having diabetes in a large sample of non-obese KoreanAmericans, and (3) determine the prevalence and adjusted odds of optimal frequency of eye care, foot care and A1C blood glucose level monitoring among non-obese Korean-Americans with diabetes in comparison to NHWs with diabetes.
Methods
Secondary analysis of population-based data from the combined 2007, 2009, and 2011 adult California Health Interview Survey. The sample included 74,361 respondents with body mass index (BMI) <30 kg/m2 (referred to as ‘non-obese BMI’), of whom 2,289 were Korean-Americans and 72,072 were NHWs, and 4,576 had diabetes.
Results
The prevalence and adjusted odds of diabetes among non-obese Korean-Americans are significantly higher than among their NHW peers. More than 90% of Korean-Americans with diabetes were non-obese. NHWs had substantially higher odds of having optimal frequency of eye care, foot care and A1C glucose level monitoring, even after adjusting for insulin dependence, sex, age, education, income, and BMI.
Conclusion
Non-obese Korean-Americans are at higher risk for diabetes and are much less likely to receive optimal diabetes care in comparison to NHWs. Targeted outreach is necessary.

Citations

• Adapting the NIMHD Research Framework for Type 2 Diabetes-Related Disparities
  Monica Diaz, Morgan E. Braxton, Eyitayo O. Owolabi, Timian M. Godfrey, Mantej Singh, Aliria M. Rascón, Gabriel Q. Shaibi
  Current Diabetes Reports.2025;[Epub]     CrossRef
• The interplay of social support and education on diabetes knowledge: a focus on Korean American women
  Young Ji Yoon, Soonok An, Y. Joon Choi, Hee Yun Lee
  Ethnicity & Health.2024; 29(7): 793.     CrossRef
• The prevalence and management of diabetes among Vietnamese Americans: A population-based survey of an understudied ethnic group
  Leanne R De Souza, Keith T Chan, Karen Kobayashi, Alexis Karasiuk, Esme Fuller-Thomson
  Chronic Illness.2022; 18(2): 306.     CrossRef
• Increasing Individual Target Glucose Levels to Prevent Hypoglycemia in Patients with Diabetes
  Juyoung Shin, Hyunah Kim, Hun-Sung Kim, Churlmin Kim, Whan-Seok Choi
  Korean Journal of Family Medicine.2021; 42(4): 269.     CrossRef

Background
Although the role of unintentional injuries as a cause of death in adults is known, there is limited knowledge about such adults’ behaviors. This study aims to investigate the frequency of and factors affecting unintentional injuries among the elderly living in rural areas and their related behaviors.
Methods
A cross-sectional study was carried out in the rural areas of Hamadan County, Iran, in 2016. The sample consists of randomly selected 445 adults aged 60–75 years. Data collection was conducted through face-to-face interviews, using questionnaires.
Results
One hundred and forty-three participants (34.7%) experienced 166 injury occurrences. The injuries occurred more in females than in males. There were more mild and severe injuries (48.2% and 31.3%, respectively) than moderate ones (20.5%). The most frequent mechanism of injuries was accidental falls (64.5%). There was a significant relationship between using aid devices and injuries (P=0.001). Among the most applied injury preventive measures as reported by the elderly, crossing streets safely and the use of proper lighting at night had the highest percentages (81.5% and 69.7%, respectively). However, the use of protective handles and plastic flooring in bathrooms in order to prevent slipping had the lowest percentages (less than 1.0%).
Conclusion
The injuries among the elderly in this study were important health concerns. Injury-related factors should be considered in the development of injury prevention programs.

Citations

• Prevalence and Risk Factors of Unintentional In-Home Injuries in Older Adults
  Ok-Hee Cho, Hyekyung Kim
  Medicina.2025; 61(7): 1235.     CrossRef
• Factors Affecting Home Injuries in Older Adults: An Analysis Using Binary Logistic Regression
  Mehdi Abbasian, Homayoun Sadeghi‐bazargani, Hossein Matlabi, Naser Havaei, Mina Hashemiparast, Hamid Allahverdipour
  Health Science Reports.2025;[Epub]     CrossRef

Background
The definition of sarcopenia focuses on muscle mass and function. Sarcopenic obesity is the relative excess of fat tissue with decreased muscle mass. We examined the association between cigarette smoking and sarcopenia according to obesity in middle-aged and elderly Koreans.
Methods
We conducted a cross-sectional study of 9,385 subjects (age ≥50 years) based on data from the fourth and fifth Korea National Health and Nutrition Examination Surveys (2008–2011). Smoking groups were categorized by smoking status and the number of cigarettes smoked daily. Sarcopenia was defined as weight-adjusted appendicular skeletal muscle mass of 2 standard deviations below the sex-specific mean for young adults. Obesity was defined as fat mass ≥30% for men and ≥40% for women. Subjects were categorized into three groups: sarcopenic obese (SO), sarcopenic non-obese (SNO), and normal. Multiple logistic regression analysis was performed to assess the association between smoking and SNO and SO.
Results
Among men, current smokers were more associated with SNO than never-smokers (adjusted odds ratio [OR], 3.34; 95% confidence interval [CI], 1.09–10.26). However, there was no significant association between smoking status and SNO in women or SO in either sex. Among current smokers, moderate smokers (11–20 cigarettes/d) were more likely to be SNO (adjusted OR, 5.81; 95% CI, 1.12–30.31) and heavy smokers (>20 cigarettes/d) were more likely to be SO (adjusted OR, 9.53; 95% CI, 1.65–55.01) than light smokers (<11 cigarettes/d).
Conclusion
In men, smoking was positively associated with SNO, and heavy smokers were more likely to be SO than light smokers.

Citations

• Prevalence of and risk factors for sarcopenia in patients with epilepsy
  Yu-Shiue Chen, Hung-Ling Huang, Huai-Hsien Huang, Tzu-Hsin Huang, Ming-Chi Lai, Chin-Wei Huang
  Seizure: European Journal of Epilepsy.2025; 125: 162.     CrossRef
• Reliability and Clinical Validity of the SARC-Global Questionnaire for Sarcopenia and Sarcopenic Obesity in Spanish Older Adults
  Juan Manuel Guardia-Baena, María del Carmen Carcelén-Fraile, Fidel Hita-Contreras, Agustín Aibar-Almazán, María de los Ángeles Arévalo-Ruíz, María Aurora Mesas-Aróstegui, Raquel Fábrega-Cuadros
  Nutrients.2025; 17(7): 1206.     CrossRef
• Association between triglyceride-glucose index and sarcopenic obesity in adults: a population-based study
  Zhengmei Zhao, Ruiting Cai, Lili Tao, Yuxiao Sun, Keping Sun
  Frontiers in Nutrition.2025;[Epub]     CrossRef
• Oxidative balance score is inversely associated with low muscle mass in young and middle-aged adults: a cross-sectional NHANES study
  Weiliang Kong, Jiayuan Ye, Shuaiqin Dai, Xiaowei Xia, Jingjing Hu, Weiping Ding, Hui Li, Yilian Xie, Chao Cao
  BMC Musculoskeletal Disorders.2025;[Epub]     CrossRef
• Multifactorial Determinants of Body Composition in the Korean Older Adults: Using Data from the 2022–2023 National Health and Nutrition Examination Survey
  Moonkyoung Park, ThiThu-Huyen Do, Jinsun Park
  Nutrients.2025; 17(9): 1477.     CrossRef
• The Theoretical and Practical Research of Traditional Chinese Medicine in the Prevention and Treatment of Sarcopenia
  Chunlin Hu, Xin Bao
  Journal of Contemporary Medical Practice.2024; 6(10): 42.     CrossRef
• Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease
  Amy H. Attaway, Annette Bellar, Nicole Welch, Jinendiran Sekar, Avinash Kumar, Saurabh Mishra, Umur Hatipoğlu, Merry‐Lynn McDonald, Elizabeth A. Regan, Jonathan D. Smith, George Washko, Raúl San José Estépar, Peter Bazeley, Joe Zein, Srinivasan Dasarathy
  Journal of Cachexia, Sarcopenia and Muscle.2023; 14(2): 1083.     CrossRef
• Higher dietary protein intake is associated with sarcopenia in older British twins
  Mary Ni Lochlainn, Ruth C E Bowyer, Ailsa A Welch, Kevin Whelan, Claire J Steves
  Age and Ageing.2023;[Epub]     CrossRef
• The Role of Smoking in the Mechanisms of Development of Chronic Obstructive Pulmonary Disease and Atherosclerosis
  Stanislav Kotlyarov
  International Journal of Molecular Sciences.2023; 24(10): 8725.     CrossRef
• Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study
  Lin Shi, Liang Zhang, Dan Zhang, Zhuo Chen
  BMC Public Health.2023;[Epub]     CrossRef
• Relationship between DNA methylation changes and skeletal muscle mass
  Jeong-An Gim, Sang-Yeob Lee, Seung Chan Kim, Kyung-Wan Baek, Sung Hyo Seo, Jun-Il Yoo
  BMC Genomic Data.2023;[Epub]     CrossRef
• Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation
  Stephen T. Decker, Alexs A. Matias, Adolfo E. Cuadra, Sean T. Bannon, Jack P. Madden, M. Enes Erol, Corinna Serviente, Karine Fenelon, Gwenael Layec
  American Journal of Physiology-Heart and Circulatory Physiology.2023; 325(5): H1088.     CrossRef
• Association between smoking status and handgrip strength in Korean male adults: based on Korea National Health and Nutrition Examination Survey 2016–2019
  Eunbyul Cho, Hi Sun Soh, Jae-Ryun Lee, Jieun Yun, Woo Kyung Bae, Hyejin Lee
  Frontiers in Medicine.2023;[Epub]     CrossRef
• Sleep duration and sarcopenia in adults aged ≥ 65 years from low and middle-income countries
  Lee Smith, Jae Il Shin, Nicola Veronese, Pinar Soysal, Guillermo F. López Sánchez, Damiano Pizzol, Jacopo Demurtas, Mark A. Tully, Yvonne Barnett, Laurie Butler, Ai Koyanagi
  Aging Clinical and Experimental Research.2022; 34(7): 1573.     CrossRef
• Relationship between sarcopenia and cardiovascular disease risk among Taiwanese older adults
  Yuan-Yuei Chen, Wei-Liang Chen, Tao-Chun Peng, Fang-Yih Liaw, Yuan-Ping Chao, Tung-Wei Kao
  Public Health Nutrition.2022; 25(7): 1745.     CrossRef
• Obesity, dynapenia, and their combination: Implications for bone mineral density in Brazilian adults—the Pró-Saúde study
  Amina Chain, Eduardo Faerstein, Vivian Wahrlich, Flavia F. Bezerra
  Nutrition.2021; 81: 110898.     CrossRef
• Relationship between smoking and the incidence of sarcopenia: The SarcoPhAge cohort
  M. Locquet, O. Bruyère, L. Lengelé, J.Y. Reginster, C. Beaudart
  Public Health.2021; 193: 101.     CrossRef
• Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic
  Umberto Tarantino, Ida Cariati, Chiara Greggi, Elena Gasbarra, Alberto Belluati, Luigi Ciolli, Giulio Maccauro, Alberto Momoli, Simone Ripanti, Francesco Falez, Maria Luisa Brandi
  International Journal of Molecular Sciences.2021; 22(12): 6629.     CrossRef
• Association of Cigarette Smoking with Muscle Mass Reduction and Low Muscle Strength in Community-Dwelling Elderly Men
  Eriko NOGAMI, Nobuyuki MIYAI, Yan ZHANG, Masato SAKAGUCHI, Hiroko HAYAKAWA, Sonomi HATTORI, Miyoko UTSUMI, Yuji UEMATSU, Mikio ARITA
  Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) .2021; 76: n/a.     CrossRef
• Sarcopenia in Liver Transplantation: an Update
  A. Dhaliwal, F. R. Williams, O. El-sherif, Matthew J. Armstrong
  Current Hepatology Reports.2020; 19(2): 128.     CrossRef
• Determinants of smoking behavior of older women (Ethnic Kaili) in Palu city
  Ratna Devi, Andi Zulkifli Abdullah, Rosmala Nur, Fauzan, Ni Wayan Sridani, Muhammad Ryman Napirah
  Enfermería Clínica.2020; 30: 52.     CrossRef
• Obesity, Sarcopenia, and Smoking: Landscape in the Mist
  Seung-Won Oh
  Korean Journal of Family Medicine.2019; 40(2): 61.     CrossRef
• Breastfeeding and Sarcopenia in Later Life
  Jungun Lee
  Korean Journal of Family Medicine.2019; 40(3): 133.     CrossRef

Background
Vitamin D deficiency is associated with an increased risk of pulmonary tuberculosis (PTB) infection and the treatment outcome. The aim of this study was to examine the relationship between the serum 25-hydroxyvitamin D (25[OH]D) level and lung function in Korean adults according to whether or not there is a history of PTB.
Methods
The data for subjects aged 19 years or older from the Korea National Health and Nutrition Examination Survey 2008–2012 who underwent spirometry, chest radiography, and serum 25(OH)D level measurement were analyzed.
Results
Evidence of past PTB infection was found in 1,482 (9.6%) of 15,516 subjects. The serum 25(OH)D level was lower in the group with past PTB than in the non-PTB group (P=0.013). Respiratory dysfunction was more common in the past PTB group than in the non-PTB group (restrictive pattern, 14.0% vs. 9.6%; obstructive pattern, 29.6% vs. 8.2%; both P<0.001). After adjusting for age, sex, height, and season, the mean difference in forced expiratory volume in 1 second (FEV1) between the highest and lowest quartiles of 25(OH)D was 100.2 mL (standard error=49.3 mL, P for trend=0.049) in the past PTB group and 34.7 mL (standard error=13.6 mL, P=0.009) in the nonPTB group.
Conclusion
FEV1 tended to increase as the vitamin D quartile increased in both study groups. This relationship was more pronounced in subjects with a history of PTB. A higher serum 25(OH)D level might be beneficial in preserving lung function after PTB infection.

Citations

• Post-pulmonary tuberculosis lung function: a systematic review and meta-analysis
  Sharina Ratnakumar, Sally E Hayward, Emma K Denneny, Lucy P Goldsmith, Rebecca Evans, William Checkley, Delia Goletti, Catherine W M Ong, Mateusz Gotowiec, Junkai Zhu, Jon S Friedland, Joanna C Porter
  The Lancet Global Health.2025; 13(6): e1020.     CrossRef
• Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people
  Olena Ivanova, Verena Sophia Hoffmann, Christoph Lange, Michael Hoelscher, Andrea Rachow
  European Respiratory Review.2023; 32(168): 220221.     CrossRef
• Associating the blood vitamin A, C, D and E status with tuberculosis: a systematic review and meta-analysis of observational studies
  Fei Xu, Baolan Ma, Dandan Wang, Jialin Lu, Ke Xiong, Jinyu Wang
  Food & Function.2022; 13(9): 4825.     CrossRef
• Effectiveness of Maternal Vitamin D Supplementation in Preventing Respiratory Tract Infections in Children
  Soo Young Kim
  Korean Journal of Family Medicine.2022; 43(3): 155.     CrossRef
• Decreased lung function is associated with vitamin D deficiency in apparently health, middle aged Koreans: the Kangbuk Samsung Health Study
  Jonghoo Lee, Hye Kyeong Park, Min-Jung Kwon, Soo-Youn Ham, Si-Young Lim, Jae-Uk Song
  European Journal of Clinical Nutrition.2021; 75(3): 501.     CrossRef

Background
Osteoporosis and osteopenia are characterized by reduced bone mineral density (BMD) and increased fracture risk. Although the risk of fractures is higher in underweight people than in overweight people, the accumulation of body fat (especially abdominal fat) can increase the risk of bone loss. This study aimed to evaluate the association between body fat percentage and BMD in normal-weight middle-aged Koreans.
Methods
This study included 1,992 adults (mean age, 48.7 years; 52.9% women). BMD and body fat were measured using dual-energy X-ray absorptiometry. Multiple linear regression analyses and analysis of covariance were used to assess the association between BMD and body fat. Body fat percentage was grouped by cut-off values. The cut-off values were 20.6% and 25.7% for men with a body mass index of 18.5–22.9 kg/m2 , while the cut-off values were 33.4% and 36% for women.
Results
Body fat percentage tended to be negatively associated with BMD. Increased body fat percentage was associated with reduced BMD in normal-weight middle-aged adults. The effects of body fat percentage on BMD in normal-weight individuals were more pronounced in men than in women.
Conclusion
There was a negative correlation between BMD and body fat percentage in middle-aged Korean men and women with normal body weight. This association was stronger in men than in women.

Citations

• Serum A20 level is associated with bone mineral density in male patients with type 2 diabetes mellitus
  Dongxu Han, Jingnan Liu, Yu Wang, Hongxia Wang, Lingdan Yuan, Wei Jin, Lige Song
  Frontiers in Endocrinology.2025;[Epub]     CrossRef
• Association between normal-weight obesity and bone mineral density in older Korean adults: A population-based cross-sectional study
  Jeonghyeon Kim, Seamon Kang, Hyunsik Kang
  Maturitas.2024; 180: 107891.     CrossRef
• Evaluation of the Relationship between Osteoporosis and Body Fat Mass of the Upper and Lower Extremities by Dual-Energy X-Ray Absorptiometry
  Numan Salman Dawood, Zainab Sami Abdel Aziz, Haneen Maan Alkhaales
  Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2024; 6(1): 34.     CrossRef
• Evaluation of the Relationships Between Bone Mineral Density and Anthropometric Measurements in Women with Postmenopausal Osteoporosis
  Ayşegül Yaman, Oya Özdemir, Şule Gök, Sevilay Karahan, Yeşim Gökçe Kutsal
  Turkish Journal of Osteoporosis.2024; 30(1): 16.     CrossRef
• Relationship between Body Composition and Gait Characteristics in Patients with Cerebral Small Vessel Disease
  Hongyang Xie, Zhenxi Xia, Cuiqiao Xia, Nan Zhang, Yu Ding, Hongyi Zhao, Yonghua Huang
  Current Neurovascular Research.2024; 21(2): 205.     CrossRef
• Increased fat mass negatively influences femoral neck bone mineral density in men but not women
  Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• A Prediction Model for Osteoporosis Risk Using a Machine-Learning Approach and Its Validation in a Large Cohort
  Xuangao Wu, Sunmin Park
  Journal of Korean Medical Science.2023;[Epub]     CrossRef
• The multiple regulatory effects of white adipose tissue on bone homeostasis
  Xiaohua Liu, Yuxiang Du, Zhonghan Zhao, Jun Zou, Xiaojing Zhang, Lingli Zhang
  Journal of Cellular Physiology.2023; 238(6): 1193.     CrossRef
• Associations of body mass index, body fat percentage and sarcopenia components with bone health estimated by second-generation high-resolution peripheral quantitative computed tomography in older adults with obesity
  Anoohya Gandham, Jakub Mesinovic, Mavil May Cervo, Costas Glavas, Paul Jansons, Carrie-Anne Ng, Juan Pena Rodriguez, Ayse Zengin, Maxine P. Bonham, Peter R. Ebeling, David Scott
  Experimental Gerontology.2023; 179: 112227.     CrossRef
• Gender-specific associations between abdominal adipose mass and bone mineral density in the middle-aged US population
  Xueqin Cao, Leilei He, Rong Sun, Siyu Chen
  BMC Musculoskeletal Disorders.2023;[Epub]     CrossRef
• Elevated circulating levels of IL-34 are strongly associated with osteoporosis
  Nader Tarabeih, Adel Shalata, Alexander Kalinkovich, Orabi Higla, Gregory Livshits
  Archives of Osteoporosis.2023;[Epub]     CrossRef
• Associations of Fat Mass and Fat Distribution With Bone Mineral Density in Non-Obese Postmenopausal Chinese Women Over 60 Years Old
  Jingzheng Fan, Yuyan Jiang, Junlian Qiang, Bin Han, Qiang Zhang
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Association between body mass index and fragility fracture in postmenopausal women: a cross-sectional study using Korean National Health and Nutrition Examination Survey 2008–2009 (KNHANES IV)
  Jihan Kim, Sami Lee, Sung Soo Kim, Jong-Pyo Lee, Jong Sung Kim, Jin Gyu Jung, Seok Jun Yoon, Kyu Pil Kim, Chan-Keol Park, Yong-Hwan Kim
  BMC Women's Health.2021;[Epub]     CrossRef
• Determinants of Bone Health Status in a Multi-Ethnic Population in Klang Valley, Malaysia
  Chin Yi Chan, Shaanthana Subramaniam, Norazlina Mohamed, Soelaiman Ima-Nirwana, Norliza Muhammad, Ahmad Fairus, Pei Yuen Ng, Nor Aini Jamil, Noorazah Abd Aziz, Kok-Yong Chin
  International Journal of Environmental Research and Public Health.2020; 17(2): 384.     CrossRef
• Anti-fracture Efficacy of Monthly Risedronate Compared with That of Weekly Risedronate in Postmenopausal Korean Women with Osteoporosis: A Nationwide Cohort Study
  Yong Ho Cho, Kyung Hyun Bae, Dong Ryul Lee, Jungun Lee
  Korean Journal of Family Medicine.2020; 41(5): 339.     CrossRef

Background
This study evaluated factors independently associated with electrocardiographic left ventricular hypertrophy (ECG-LVH) in subjects who were normotensive on clinical measurement and had no prior history of hypertension.
Methods
This cross-sectional study analyzed cases and controls in the Comprehensive Medical Examination Center of Hallym University Sacred Heart Hospital. Eligible case participants presented ECG-LVH according to the Sokolow-Lyon or Cornell criteria, were normotensive on clinical measurement, and had never received a diagnosis of hypertension. The control group comprised subjects with normal sinus rhythm who were normotensive on clinical measurement with no history of hypertension.
Results
A multiple logistic regression model showed male sex, age and systolic blood pressure to be positively related to the presence of ECG-LVH. A positive relation of smoking and regular exercise; an inverse relation of pulse rate to the presence of ECG-LVH were found only in men. An inverse relation of uric acid level was found only in women. Detailed analyses of relatively healthy and young men according to whether or not to exercise regularly showed that positive relations of age and systolic blood pressure; an inverse relation of obesity to the presence of ECG-LVH were apparent in the non-regular exercise group but not in the regular exercise group. In the regular exercise group, only pulse rate showed significant (inverse) association with the presence of ECG-LVH.
Conclusion
The varying risk factor profiles associated with ECG-LVH according to sex and the participation in regular exercise may help to elucidate the ECG-LVH in clinical normotensives with no prior history of hypertension.

Citations

• Prevalence, Performance and Predictors of Electrocardiographic Left Ventricular Hypertrophy in Male Black Athletes: A Retrospective Study
  Tochukwu F. Ilodibia, Clement O. Odigwe, Augustine N. Odili
  Indian Journal of Clinical Cardiology.2024; 5(1): 15.     CrossRef

Background
The prevalence of metabolic syndrome (MetS) is increasing, and obesity, insulin resistance, and inflammation are the known risk factors. However, results of previous studies regarding the relationship between MetS and inflammation have not been consistent. This study aimed to identify the associations between C-reactive protein (CRP) and MetS and its components in obese and non-obese men and women.
Methods
This was a cross-sectional study based on the 6th Korea National Health and Nutrition Examination Survey (2015), and a nationally representative sample of 3,013 Korean adults aged 40–78 years were included. Those with cardiovascular disease, cancer, CRP level >10 mg/L, white blood cell count >10,000/mm3 , chronic kidney disease, and lung/liver disease were excluded.
Results
Approximately 11.0%, 50.0%, 8.4%, and 48.8% of non-obese men, obese men, non-obese women, and obese women presented with MetS (P<0.001), respectively. In all four groups, those who presented with MetS or its components showed a higher high-sensitivity (hs-CRP) average than those without. Multivariate regression analysis showed the increased risk of developing MetS with higher quartiles of hs-CRP level in obese (3rd and 4th quartiles: odds ratios [ORs], 3.87 and 2.57, respectively) and non-obese women (4th quartile: OR, 2.63). The different components also showed increased ORs in the four groups. However, no statistically significant trend in the relationship was found in men.
Conclusion
Low-grade inflammation may increase the risk of MetS in Korean women independent of adiposity. However, due to the cross-sectional design of the present study, further studies must be conducted to identify the causal relationship between inflammation and metabolic disorders.

Citations

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Background
The blood level of alanine aminotransferase (ALT) is associated with increased coronary heart disease (CHD) risk. However, its use as an independent factor for CHD risk prediction remains unclear in Asian populations. The purpose of this study was to examine the association between serum ALT levels and CHD risk in Koreans.
Methods
This was a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011). The ALT levels of 3,215 individuals were analyzed. The Framingham Risk Score (FRS) modified by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) was used to compute the 10-year CHD risk prediction.
Results
Positive correlations were established between log-transformed ALT concentration and FRS (r=0.433, P<0.001). After adjusting for body mass index, low-density lipoprotein cholesterol, the amount of alcohol intake, and gamma-glutamyl transferase, the odds ratio (95% confidence interval) for intermediate or greater risk of 10- year CHD prediction (10-year risk ≥10%) for the lowest quartile of participants was 2.242 (1.405–3.577) for the second quartile, 2.879 (1.772–4.679) for the third quartile, and 3.041 (1.789–5.170) for the highest quartile.
Conclusion
In Koreans, a higher serum ALT concentration was significantly correlated with 10-year CHD risk prediction according to NCEP ATP III guidelines.

Citations

• Endothelin-converting Enzyme-1b Genetic Variants Increase the Risk of Coronary Artery Ectasia
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Acquired hemophilia is a rare, potentially life-threatening disease that usually remains under-recognized especially in a primary setting; thus, diagnosing this disease is very challenging. Given its prevalence in elderly patients, awareness and diagnosis of this condition in the aging population (particularly those with unexplained bleeding or prolonged activated partial thromboplastin time) should be improved and better managed by the clinicians. Early diagnosis and prompt treatment are usually effective in preventing the adverse outcomes of this disease. In this report, we discuss a case of an elderly patient with acquired hemophilia who initially presented with swelling of his lower left limb. The diagnosis of acquired hemophilia was made a month after the appearance of symptoms. Early diagnosis with proper treatment could have been provided to this patient, if the initial assessment had been thoroughly conducted.

Citations

• Assessment of Lebanese healthcare professionals’ awareness on acquired haemophilia: a cross-sectional study
  Ali Taher, Layal Al Mahmasani, Abdallah Aadra, Patricia Yazbeck, Georges Abi Saad, Fadi Nasr, Rita Habib, Amal Chalfoun, Fadi Haddad
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