Patients with angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema (ACEIIA) may visit family physicians. The aim of this article was to describe a case of delayed-onset ACEIIA and to present a concise scoping review. Using a case report and a scoping review study design, we report a case of ACEIIA, with clinically confirmed diagnosis. The symptoms resolved after replacing the offending ACEI with another antihypertensive agent. After excluding other causes of perioral swelling and discontinuation of ACEI, the patient was symptom-free within a few days thereafter. Based on this case presentation, we performed a meta-narrative scoping review including up-todate diagnosis and management of ACEIIA, based on published data in English, French, and German from inception to April 1, 2021. Patients with angioedema of unknown origin should be cautiously examined to rule out oral diseases, including allergy to dental materials and drug-induced angioedema. Clinicopathological aspects and current treatment guidelines for ACEI-associated angioedema are also presented.

Citations

• Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema Following Long-Term Lisinopril Use: Response to C1 Esterase Inhibitor Treatment
  Zaid Mula Hussein, Mohammed Emran Khan, Ashfaque Sorathia, Kithsri Karunatilake
  Cureus.2025;[Epub]     CrossRef
• A stepwise approach to chainsaw kickback injury of the nasoorbital complex: a case-based meta-narrative review
  Poramate Pitak-Arnnop, Ornvenus Nimitwongsakul, Nattapong Sirintawat, Keskanya Subbalekha, Christian Stoll, Jean-Paul Meningaud
  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2024; 138(1): e1.     CrossRef