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"Da-Hye Son"

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"Da-Hye Son"

Original Articles

Background
Evidence regarding the association between handgrip strength (HGS) and insulin resistance in a non-diabetic population is scarce. This study aimed to investigate the association between relative HGS and insulin resistance in older men without diabetes, using a representative sample of the Korean male population.
Methods
The study population comprised 206 participants aged 65–80 years, selected from the 2015 Korea National Health and Nutrition Examination Survey. Insulin resistance was defined as the upper tertile of the homeostatic model assessment of insulin resistance (HOMA-IR). Odds ratios and 95% confidence intervals for insulin resistance were assessed using multiple logistic regression analyses after adjusting for confounding variables.
Results
The prevalence of insulin resistance decreased with increasing relative HGS. The prevalence in the T1, T2, and T3 groups was 46.0%, 32.2%, and 26.4%, respectively. Compared with the individuals in the highest tertile of relative HGS, the odds ratio (95% confidence interval) for insulin resistance in individuals in the lowest quartile was 2.82 (1.10–7.21) after adjusting for age, smoking, alcohol consumption, aerobic exercise, resistance exercise, systolic blood pressure, total cholesterol, residential area, household income, and education level.
Conclusion
Lower relative HGS was inversely associated with an increased risk of insulin resistance in older Korean men without diabetes. In clinical practice, relative HGS, which is a simple and inexpensive tool, could be a useful measure for identifying older men with insulin resistance. Moreover, these findings suggest that muscle strengthening exercises should be considered to reduce insulin resistance and increase insulin sensitivity.

Citations

Citations to this article as recorded by  
  • Analysis of Handgrip Strength with Insulin Resistance in Male and Female Indonesian Adults
    Liong Boy Kurniawan, Sabilla Sheridan, Andi Wali Syafaat, Andi Ainun Zulkiah Surur, Naurah Nadhifah, Ichlas Nanang Afandi, Andi Ariyandy, Muhammad Iqbal Basri, Aminuddin Aminuddin
    INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY.2025; 31(2): 145.     CrossRef
  • Guidelines for physical activity counseling in primary healthcare clinics
    Yun Jun Yang
    Journal of the Korean Medical Association.2024; 67(4): 265.     CrossRef
  • Dietary patterns and the risk of diabetes in Korean adults: A cross-sectional and prospective cohort study
    Jiyoung Hwang, Hyesook Kim, Oran Kwon
    Nutrition.2024; 125: 112491.     CrossRef
  • Correlation between low handgrip strength and metabolic syndrome in older adults: a systematic review
    Joana da Costa d'Avila, Talel Georges Moreira El Nabbout, Hayfa Georges Moreira El Nabbout, Aline dos Santos Silva, Antonio Carlos Barbosa Ramos, Eliana Rosa da Fonseca, Aluana Santana Carlos, Rodrigo de Azeredo Siqueira
    Archives of Endocrinology and Metabolism.2024;[Epub]     CrossRef
  • Handgrip strength in type 2 diabetics and nondiabetics: A comparative cross-sectional study among adults in rural Mysore
    Deepak ANIL, M. RAKESH, Shabeena AKBAR, Vijaylakshmi Rao VADAGA, D. Sunil KUMAR
    Journal of Integrative Nursing.2024; 6(3): 150.     CrossRef
  • Association of relative handgrip strength on the development of diabetes mellitus in elderly Koreans
    Yeo Ju Sohn, Hong Soo Lee, Hasuk Bae, Hee Cheol Kang, Hyejin Chun, Insun Ryou, Eun Jee Chang, Sungchan Kang, Sang Wha Lee, Kyung Won Shim, Mario Ulises Pérez-Zepeda
    PLOS ONE.2024; 19(10): e0309558.     CrossRef
  • Association between handgrip strength and mortality risk among cardiovascular disease patients: A cohort study from the NHANES 2011–2014
    Zhengjie Qin, Youhua Guo, Weilin Yang, Zhuoran Kuang, Guoming Li
    Journal of the Formosan Medical Association.2024;[Epub]     CrossRef
  • Sarcopenia and osteosarcopenia among patients undergoing hemodialysis
    Ting Xiang, Ping Fu, Li Zhou
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Relationships of neck circumference and abdominal obesity with insulin resistance considering relative handgrip strength in middle-aged and older individuals
    Kayoung Lee
    Archives of Gerontology and Geriatrics.2023; 114: 105097.     CrossRef
  • 5,509 View
  • 118 Download
  • 6 Web of Science
  • 9 Crossref
Background
This study aimed to examine the association between sitting time and handgrip strength in healthy Korean women.
Methods
A total of 5,437 participants were included from the Korea National Health and Nutrition Examination Survey 2014–2016. The overall daily sitting time was estimated using health interview surveys, and handgrip strength was assessed using a digital hand dynamometer. The relationship between sitting time and handgrip strength was calculated with a weighted analysis of covariance after adjusting for confounding variables.
Results
Participants in each age group (19–39, 40–64, ≥65 years) were divided into three categories according to sitting time: ≤5, 6–9, and ≥10 h/d. The handgrip strength tended to decrease as sitting time increased after adjusting for age, body mass index, alcohol intake, cigarette smoking, resistance exercise, aerobic physical activity, household income, education level, hypertension, diabetes mellitus, dyslipidemia, and depression in all age groups (all P<0.001).
Conclusion
We observed the inverse relationship between sitting time and handgrip strength in healthy Korean women.

Citations

Citations to this article as recorded by  
  • The Relationship Between Longest-Held Occupation and Hand Function in Older Adults
    Jaden E. Levinson, Rachel N. Logue Cook, Susan H. Brown
    Journal of Occupational & Environmental Medicine.2025; 67(4): e203.     CrossRef
  • Examining factors contributing to the socioeconomic inequalities in handgrip strength among older adults in India: a decomposition analysis
    Manacy Pai, T. Muhammad
    Scientific Reports.2024;[Epub]     CrossRef
  • Association between sedentary behavior and dynapenic abdominal obesity among older adults from low- and middle-income countries
    Lee Smith, Guillermo F. López Sánchez, Masoud Rahmati, Mark A. Tully, Damiano Pizzol, Nicola Veronese, Pinar Soysal, Karel Kostev, Dong Keon Yon, Laurie Butler, Jae Il Shin, Ai Koyanagi
    Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
  • Joint associations of sedentary behavior and domain-specific physical activity on C-reactive protein in Korea
    Sungjin Park, Heeseung Son
    Preventive Medicine.2024; 182: 107944.     CrossRef
  • Joint association of sedentary behavior and physical activity domains with depression in Korean adults: Cross-sectional study combining four biennial surveys (2016–2022)
    Sungjin Park, June-Hee Lee, Rashid Menhas
    PLOS ONE.2024; 19(10): e0312029.     CrossRef
  • Factors Influencing Grip Strength of Depressed Patients: Using Data from the National Health and Nutrition Examination Survey (2018~2019)
    Moonhee Gang, Sukhee Han
    Journal of Korean Academy of psychiatric and Mental Health Nursing.2023; 32(1): 92.     CrossRef
  • Associations of occupational and leisure-time physical activity with self-rated health in Korea
    Sungjin Park, June-Hee Lee
    Preventive Medicine.2022; 158: 107022.     CrossRef
  • Association of Physical Activity and Sedentary Behavior With the Risk of Colorectal Cancer
    Sanghyun An, Sungjin Park
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Current status of health promotion in Korea
    Soo Young Kim
    Journal of the Korean Medical Association.2022; 65(12): 776.     CrossRef
  • Importance of Handgrip Strength as a Health Indicator in the Elderly
    Soo Young Kim
    Korean Journal of Family Medicine.2021; 42(1): 1.     CrossRef
  • Effects of 12 Weeks of Strength Training and Gluten-Free Diet on Quality of Life, Body Composition and Strength in Women with Celiac Disease: A Randomized Controlled Trial
    Alejandro Martínez-Rodríguez, Daniela Alejandra Loaiza-Martínez, Javier Sánchez-Sánchez, Jacobo A. Rubio-Arias, Fernando Alacid, Soledad Prats-Moya, María Martínez-Olcina, Rodrigo Yáñez-Sepúlveda, Nuria Asencio-Mas, Pablo J. Marcos-Pardo
    Applied Sciences.2021; 11(22): 10960.     CrossRef
  • Grip Strength as a Cardiometabolic Marker
    Jungun Lee
    Korean Journal of Family Medicine.2020; 41(5): 271.     CrossRef
  • 5,417 View
  • 130 Download
  • 11 Web of Science
  • 12 Crossref
Review Article
Recent Advances in Anti-Aging Medicine
Da-Hye Son, Woo-Jin Park, Yong-Jae Lee
Korean J Fam Med 2019;40(5):289-296.   Published online September 20, 2019
DOI: https://doi.org/10.4082/kjfm.19.0087
A rapidly aging population in Korea has led to increased attention in the field of anti-aging medicine. The purpose of anti-aging medicine is to slow, stop, or reverse the aging process and its associated effects, such as disability and frailty. Anti-aging medicine is emerging as a growing industry, but many supplements or protocols are available that do not have scientific evidence to support their claims. In this review, the mechanisms of action and the clinical implications of anti-aging interventions were examined and explained. Calorie restriction mimetics define compounds that imitate the outcome of calorie restriction, including an activator of AMP protein kinase (metformin), inhibitor of growth hormone/insulin-like growth factor-1 axis (pegvisomant), inhibitor of mammalian target of rapamycin (rapamycin), and activator of the sirtuin pathway (resveratrol). Hormonal replacement has also been widely used in the elderly population to improve their quality of life. Manipulating healthy gut microbiota through prebiotic/probiotics or fecal microbiota transplantation has significant potential in anti-aging medicine. Vitamin D is expected to be a primary anti-aging medicine in the near future due to its numerous positive effects in the elderly population.

Citations

Citations to this article as recorded by  
  • Involvement of TGF-β, mTOR, and inflammatory mediators in aging alterations during myxomatous mitral valve disease in a canine model
    Arkadiusz Grzeczka, Szymon Graczyk, Pawel Kordowitzki
    GeroScience.2025;[Epub]     CrossRef
  • The significance of caloric restriction mimetics as anti-aging drugs
    Khloud Nassar, Doaa El-mekawey, Ahmed E. Elmasry, Mohamed S. Refaey, Mai El-Sayed Ghoneim, Yaseen A.M.M. Elshaier
    Biochemical and Biophysical Research Communications.2024; 692: 149354.     CrossRef
  • Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise
    Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Qiongqiong Angela Zhou
    ACS Chemical Neuroscience.2024; 15(3): 408.     CrossRef
  • Pharmacotherapeutic Considerations on Telomere Biology: The Positive Effect of Pharmacologically Active Substances on Telomere Length
    Miruna-Maria Apetroaei, Persefoni Fragkiadaki, Bruno Ștefan Velescu, Stella Baliou, Elisavet Renieri, Cristina Elena Dinu-Pirvu, Doina Drăgănescu, Ana Maria Vlăsceanu, Marina Ionela (Ilie) Nedea, Denisa Ioana Udeanu, Anca Oana Docea, Artistidis Tsatsakis,
    International Journal of Molecular Sciences.2024; 25(14): 7694.     CrossRef
  • Preparation and characterization of novel antioxidant peptides from protein hydrolysate of Ophiocordyceps gracilis
    Yidan Zhang, Hui Lian, Linhui Yang, Lingling Tong, Yang Wu, Suxing Jin, Dongsheng Guo
    Process Biochemistry.2024; 146: 571.     CrossRef
  • Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates
    Hui Yang, Qiting Zhang, Bin Zhang, Yufen Zhao, Ning Wang
    Marine Drugs.2023; 21(3): 144.     CrossRef
  • Introducing aesthetic regenerative scaffolds: An immunological perspective
    Niamh Corduff
    Journal of Cosmetic Dermatology.2023; 22(S1): 8.     CrossRef
  • Sensory Characteristic, Nutritional Content, and Glycemic Analysis of Instant Porridge Made of Red Rice, Pumpkin, and Tuna Formulated for the Elderly
    Toto Sudargo, Adisti Qamahadlina Larasati, Bianda Aulia, Atika Anif Prameswari, Tira Aristasari, Sheila Rosmala Putri
    Current Nutrition & Food Science.2023; 19(3): 300.     CrossRef
  • Enzymatic Deglycation of Damaged Skin by Means of Combined Treatment of Fructosamine-3-Kinase and Fructosyl-Amino Acid Oxidase
    Ignace De Decker, Margo Notebaert, Marijn M. Speeckaert, Karel E. Y. Claes, Phillip Blondeel, Elisabeth Van Aken, Jo Van Dorpe, Filip De Somer, Margaux Heintz, Stan Monstrey, Joris R. Delanghe
    International Journal of Molecular Sciences.2023; 24(10): 8981.     CrossRef
  • A green-based approach for noninvasive skin rejuvenation: Potential application of hyaluronic acid
    Amirabas Tanha, Mohammad Rabiee, Azin Rostami, Sepideh Ahmadi
    Environmental Research.2023; 234: 116467.     CrossRef
  • Antioxidant and anticancer activities of Adenophora triphylla leaf and root extracts
    Seon Young Yoon, Ki Hyun Kim, Tae Kyung Hyun
    Journal of Plant Biotechnology.2023;[Epub]     CrossRef
  • The Ethanolic Extract of Lycium ruthenicum Ameliorates Age-Related Physiological Damage in Mice
    Boya Cui, Lanying Liu, Tao Shi, Min Yin, Xu Feng, Yu Shan
    Molecules.2023; 28(22): 7615.     CrossRef
  • Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice
    Leigh Goedeke, Kelsey N. Murt, Andrea Di Francesco, João Paulo Camporez, Ali R. Nasiri, Yongliang Wang, Xian‐Man Zhang, Gary W. Cline, Rafael de Cabo, Gerald I. Shulman
    Aging Cell.2022;[Epub]     CrossRef
  • Growth Hormone Stimulates Murine Macrophage Migration during Aging
    Karen Steponavicius Cruz Borbely, Aldilane Lays Xavier Marques, Felipe Lima Porto, Beatriz Santana Mendonça, Salete Smaniotto, Maria Danielma dos Santos Reis
    Current Aging Science.2022; 15(3): 266.     CrossRef
  • Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms
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    Frontiers in Aging.2022;[Epub]     CrossRef
  • Antiobesity Effects of Adipose‐Derived Stromal/Stem Cells in a Naturally Aged Mouse Model
    Qiong Wu, Shuangli He, Yu Zhu, Shiming Pu, Zuping Zhou
    Obesity.2021; 29(1): 133.     CrossRef
  • Current trends on resveratrol bioactivities to treat periodontitis
    Javad Sharifi-Rad, Cristina Quispe, Mary Angelia Alfred, Nanjangud Venaktesh Anil Kumar, Niccolò Lombardi, Lucrezia Cinquanta, Marcello Iriti, Elena M. Varoni, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua, Susana M. Cardoso, Gregorio Peron, Abhijit De
    Food Bioscience.2021; 42: 101205.     CrossRef
  • Antiaging Potential of Peptides from Underused Marine Bioresources
    Enqin Xia, Xuan Zhu, Xuebin Gao, Jindong Ni, Honghui Guo
    Marine Drugs.2021; 19(9): 513.     CrossRef
  • Immunology of Aging: the Birth of Inflammaging
    T. Fulop, A. Larbi, G. Pawelec, A. Khalil, A. A. Cohen, K. Hirokawa, J. M. Witkowski, C. Franceschi
    Clinical Reviews in Allergy & Immunology.2021; 64(2): 109.     CrossRef
  • Postmenopozal Kadınların Probiyotikler Hakkındaki Bilgi Düzeylerinin ve Tüketim Durumlarının Belirlenmesi
    Sefa Can KÜÇÜK, Artun YIBAR
    Journal of Research in Veterinary Medicine.2021; 40(2): 125.     CrossRef
  • Diagnosis and Management of Frailty in Primary Health Care
    Chang Won Won
    Korean Journal of Family Medicine.2020; 41(4): 207.     CrossRef
  • Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study
    Sol Mochón-Benguigui, Almudena Carneiro-Barrera, Manuel J. Castillo, Francisco J. Amaro-Gahete
    Antioxidants.2020; 9(8): 738.     CrossRef
  • The efficacy and safety of health qigong for anti-aging
    Peng Yu, Weihong Li, Han Li, Shuang Ouyang, Haiyang Cai, Jing Wu, Chaohui Tang, Qingsong Huang
    Medicine.2020; 99(49): e22877.     CrossRef
  • 18,639 View
  • 506 Download
  • 20 Web of Science
  • 23 Crossref
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