Korean Journal of Family Medicine

"Jin Ho Park"

Original Articles

Association between Helicobacter pylori Infection and Cerebral Small Vessel Disease: Soo Hyun Jang, Hyejin Lee, Jun Suk Kim, Hyun Jung Park, Su Min Jeong, Sang-Hyun Lee, Hyun Ho Kim, Jin Ho Park, Dong Wook Shin, Jae Moon Yun, BeLong Cho, Hyung-Min Kwon; Korean J Fam Med 2015;36(5):227-232. Published online September 18, 2015; DOI: https://doi.org/10.4082/kjfm.2015.36.5.227

Abstract
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Background

Small vessel disease is an important cause of cerebrovascular diseases and cognitive impairment in the elderly. There have been conflicting results regarding the relationship between Helicobacter pylori infection and ischemic stroke. This study aimed to examine the association between H. pylori infection and cerebral small vessel disease.

Methods

The study included 1,117 patients who underwent brain magnetic resonance imaging and H. pylori identification between 2005 and 2013 at Health Promotion Center, Seoul National University Hospital. Multivariable logistic regression analysis was used to assess the association between H. pylori infection and small vessel disease with adjustment for age, sex, hypertension, diabetes mellitus, dyslipidemia, body mass index, smoking status, problem drinking, and antiplatelet use.

Results

The adjusted odds ratios (aORs) for the association between H. pylori infection and silent brain infarction and cerebral microbleeds were 1.03 (95% confidence interval [CI], 0.66-1.61) and 0.70 (95% CI, 0.38-1.28), respectively. The aORs for silent brain infarction and cerebral microbleeds were 0.81 (95% CI, 0.44-1.44) and 0.59 (95% CI, 0.30-1.18) in patients aged <65 years and 1.59 (95% CI, 0.78-3.22) and 1.89 (95% CI, 0.38-9.33) in those aged >65 years, respectively. Moreover, the aORs for silent brain infarction and cerebral microbleeds were 0.96 (95% CI, 0.54-1.71) and 0.74 (95% CI, 0.33-1.69) in H. pylori-infected patients without atrophic gastritis and 0.89 (95% CI, 0.48-1.62) and 0.99 (95% CI, 0.43-2.27) in those with atrophic gastritis, respectively.

Conclusion

No association between H. pylori infection and small vessel disease was observed. H. pylori-induced inflammation may not be a risk factor for microcirculatory damage in the brain.

Citations

Citations to this article as recorded by

The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications
Robin B Brown, Stuart M Allan, Hugh S Markus
International Journal of Stroke.2026;[Epub] CrossRef
Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old
Yinjie Guo, Canxia Xu, Linfang Zhang, Zhiheng Chen, Xiujuan Xia
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients
Mohamed Fahmy Doheim, Ahmad Amr Altaweel, Mohamed Gamal Elgendy, Alaa Ahmed Elshanbary, Mahmoud Dibas, Amira Abo Hegil Abo Ali, Toqa Mahmoud Dahy, Atef Khairy Sharaf, Ameer E. Hassan
Journal of Neurology.2021; 268(9): 3238. CrossRef
DAPT score: predictive model of dual-antiplatelet therapy for acute cerebral infarction
Yang Liu, Jia Yang, Panpan Jiang, Shan Wang, Mingming Wang, Mayan Wang, Tiankang Guo, Jianxiong Liu
Neurological Sciences.2021; 42(2): 681. CrossRef
Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525. CrossRef
Serum Level of Helicobacter pylori Antibody in Stroke Patients
Shahir Mazaheri, Mojtaba Khazaei, Abbas Moradi, Reza Raei
Avicenna Journal of Clinical Medicine.2020; 26(4): 206. CrossRef
Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community
Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
Neurology Clinical Practice.2018; 8(3): 223. CrossRef
Helicobacter pylori and extragastric diseases
Elisabetta Goni, Francesco Franceschi
Helicobacter.2016; 21(S1): 45. CrossRef
Update on prevention and treatment of Helicobacter pylori infection
Zhao-Chun Chi
World Chinese Journal of Digestology.2016; 24(16): 2454. CrossRef

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Fasting Plasma Glucose Levels and Metabolic Syndrome in Normoglycemic Adults.: Jae Kyung Choi, Youl Lee Lym, Seung Won Oh, Jin Ho Park, Cheol Min Lee, Sang Ho Yoo, Yeol Kim; J Korean Acad Fam Med 2008;29(9):651-657. Published online September 10, 2008

Abstract
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Background: Metabolic syndrome has been introduced to increase the incidence of cardiovascular diseases and type 2 diabetes mellitus. Our aim of this study was to investigate the association of fasting plasma glucose levels and metabolic syndrome in normoglycemic adults. Methods: We examined lifestyle factors, anthropometric and laboratory measurement of adults with no personal history of diabetes and normal fasting glucose from the Korean National Health and Nutrition Examination Survey 2001. We categorized the fasting plasma glucose levels below 100 mg/dl into the quintiles and assessed the association of metabolic syndrome with increasing glycemia in normoglycemic adults. Results: Quintiles of normal fasting plasma glucose levels showed a positive trend with metabolic risk factors including abdominal obesity, high blood pressure, and obesity in normoglycemic adults (P＜0.001). Hypertriglyceridemia, low HDL-cholesterolemia, smoking, heavy drinking, and physical activity were of no significance. A multivariate model, adjusted for age, sex, smoking status, physical activity, and heavy drinking, revealed a progressively increased odds ratio of metabolic syndrome, 1.05 (95% CI, 0.76∼1.44), 1.15 (95% CI, 0.84∼1.58), 1.33 (95% CI, 0.99∼1.80), 1.55 (95% CI, 1.14∼2.10), with increasing fasting plasma glucose levels, as compared with fasting plasma glucose level of 81 mg/dl or less (P＜0.001). Conclusion: Higher fasting plasma glucose levels within the normoglycemic range may constitute a risk of metabolic syndrome in normoglycemic adults. (J Korean Acad Fam Med 2008;29:651-657)

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The Current Educational Measurement of Family Practice Residents.: Min Jeong Kim, Ho Cheol Shin, Cheol Hawn Kim, Youn Seon Choi, Hang Lee, Ae Kyung Choi, Yu Jin Paek, Eon Sook Lee, Jin Ho Park, Yoon Jung Chang; J Korean Acad Fam Med 2007;28(8):616-625. Published online August 10, 2007

Abstract
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Background
The educational assessment of residents is very important in order to check their knowledge and to improve their ability. In case of family practice, the residents spend most of their training time in outside rotations with other specialities. Therefore, they are requested to be evaluated by each specialist after each rotation. To give more accurate assessment, we surveyed directly our family practice residents and family practice faculties. Methods: A questionnaire was sent to family practice residents and family practice faculties in 116 hospitals from May to June 2006. The response rate was 29% and 78%, respectively. Results: Among the total, 70.2% of family practice residents thought an assessment is necessary, but only 51.7% were evaluated. Overall, 90.4% of family practice faculties knew about the assessment of residents made by other specialists, and only 56.7% of faculties requested other specialists to assess their family practice residents. Conclusion: Most of the family practice residents and their faculties knew the need for assessment, but they complained there were no objectivity and the assessment tool was lacking. In order to solve this problem, it is urgent to develop a unified form and guidelines of assesment. (J Korean Acad Fam Med 2007;28:616-625)

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Curriculum and Training Difficulties of Family Medicine Residency Programs in Korea.: Yu Jin Paek, Ho Cheol Shin, Cheol Hawn Kim, Youn Seon Choi, Hang Lee, Ae Kyung Cho, Eon Sook Lee, Jin Ho Park, Yoon Jung Chang, Min Jung Kim; J Korean Acad Fam Med 2007;28(5):367-374. Published online May 10, 2007

Abstract
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Background
This study was conducted to survey the current status of family medicine residency programs and to evaluate the difficulties in training of the curriculums. Methods: Questionnaires on residency programs were sent to all the centers of residency programs by mail in April 2006. The questionnaire included detailed characteristics of residency programs, curriculum schedule, reasons for failed specific curriculum, and review and measures by the program center and the Korean Academy of Family Medicine to resolve problematic curriculums. Results: A total of 113 residency programs responded. Among the 93 residency programs except for the 20 subsidiary hospitals, inadeguate subjects were mainly dermatology (12 programs, 12.3%), psychiatry (6 programs, 7.5%), ophthalmology (5 programs, 7.1%), and otolaryngology (5 programs, 7.1%). Training rejection rate was higher in dermatology (13 programs, 14.4%), radiology (11 programs, 13.1%), gastrofibroscopy (8 programs, 9.5%), and psychiatry (5 programs, 6.2%). Emergency me-dicine in 4 programs and general surgery in 3 programs had a longer duration of training than initially planned. Difficulties in training some subjects were due to failed establishment of specific curriculums in non-university hospital. Commonly established clinics were health promotion center, obesity clinic, smoking cessation clinic, geriatric clinic, stress clinic, and clinical nutrition clinic. Family medicine center programs included gastrofibroscopy, obesity, smoking cessation, geriatrics, hospice care, and evidence-based medicine. Conclusion: There is repeated demand for taking measures to promote better curriculum in the nation-wide view of family medicine. Dermatology, radiology, psychiatry, and otolaryngology were the subjects difficult to receive training. Measures to strengthen the weak subjects are urgently needed. (J Korean Acad Fam Med 2007;28: 367-374)

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Comparison of Physical Activity Recall with Triaxial Accelerometer.: Dong Ju Lee, Seung Min Oh, Jin Ho Park, Ju Young Kim, Tai Woo Yoo; J Korean Acad Fam Med 2005;26(2):74-80. Published online February 10, 2005

Abstract
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Background
: The purpose of this study was to compare the Physical Activity Recall (Stanford 7-days physical activity recall) with the Triaxial accelerometer (RT3) to assess physical activity in young adults.

Methods : Thirty-seven subjects wore the RT3 for 24 hours and then completed the physical activity recall. The Stanford 7-Day Recall records hours of sleep, light-, moderate-, hard- and very hard levels of physical activity.

Results : The total energy expenditure per day for the Stanford 7-day recall and RT3 was 2381.29±594.93 kcal/day and 2232.97±398.32 kcal/day, respectively, and showed high correlation (r=0.821). The activity energy expenditure per day for the Stanford 7-day recall and RT3 was 836.21±290.5 9 kcal/day and 509.83±181.57 kcal/day, respectively, and showed less high but significant correlation (r=0.327). When compared by sex, the total energy expenditure was significantly correlated in men (r=0.572) and the activity energy expenditure in women (r=0.484).

Conclusion : The Stanford 7-day recall and the RT3 was highly correlated in the total energy expenditure and significantly correlated in the activity energy expenditure. Therefore, it may be used reciprocally to assess physical activity.

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Recognition of Osteoporosis and Analysis of Influencing Factors.: Jin Ho Park, Hee Gyung Joe, Ju Young Kim, Tae Yoon Kim, Jung Sun Kim, Jung Ah Lee; J Korean Acad Fam Med 2004;25(7):542-549. Published online July 10, 2004

Abstract

Background
: As the average lifespan of human increases, osteoporosis and osteoporosis-related fractures have become major health care problems. Despite recent advances in medical treatment, few studies have assessed the recognition of osteoporosis in general adults. This study examined the recognition of osteoporosis and analysed the relating factors.

Methods : We made a survey in a rural area called Chunjunlee in Chunchon city. The questionnaire contained general characteristics of people, sociocultural factors, questions constructed to know the recognition of osteoporosis and factors that were presumed to influence people's recognition of osteoporosis. DEXA was performed on those who visited our medical office free of charge.

Results : The total number of people who responded to the questionnaire was 204. They were composed of 81 men and 123 women. Among the total, 83% of women and 72.8% of men said that they had heard about osteoporosis. There was no significant recognition score difference between men and women. In the items of recognition, wrong answer rate concerning the association between osteoporosis and musculoskeletal disorders such as osteoarthritis and low back pain was above 90%. The significant factors that influenced its recognition were age, education level, menopause state and newspaper/ magazine subscription. All men who were diagnosed with osteoporosis on DEXA initially said that they did not have osteoporosis.

Conclusion : Many people had a conceptual confusion between osteoporosis and other muscular skeletal disorders such as osteoarthritis and low back pain. Physicians played no significant role in improvement of people's recognition of osteoporosis. Generally, men thought that osteoporosis was a problem in women only.

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Factors of Patient Satisfaction with Pain Management in Cancer Patients.: Yoon Jung Chang, Young Ho Yun, In Goo Lee, Min Seon Park, Jin Ho Park, Dae Seok Heo, Bong Yul Huh, Eun Ju Sung; J Korean Acad Fam Med 2003;24(9):812-818. Published online September 10, 2003

Abstract
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Background
: For cancer patients, pain is the most common symptom and the most important factor that seriously affects their treatment and quality of life. The purpose of the research was to determine the controllable factors for pain management in order to increase patients' satisfaction for pain management.

Method: This study was based on the survey answers and medical records of 464 cancer patients, in 8 hospitals in Korea from March until September 2000.

Results : As shown by Chi-square test, according to the degree of satisfaction for cancer pain management, those patients who were "satisfied" with pain treatment showed better activity rate (P=0.007) than the "unsatisfied" group. Additionally, the frequency of using painkillers according to WHO step-ladder, Pain Management Index (PMI), or patients own knowledge and attitude toward cancer pain control was not found to be relevant to patients satisfaction (P=0.106, P=0.382, P＞0.05). But, in the "satisfaction" group, more patients were informed of the importance of pain management (P=0.004) and reported less pain (P＜0.05). A close relationship between higher satisfaction and lower pain interference rate was discovered, but no correlation was found for activity, mood, or gate. The average of interference rate was lower in the "satisfaction" group (P＜0.05).

Conclusion : For higher satisfaction rate for pain management among cancer patients, high activity rate, patient education of importance of pain management, less severity of pain, and low interference rate in life are found to be the determinants.

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Changes of VO2max According to Sex, Age and Related Factors in Korean Adults.: Jin Ho Park, Yoon Jung Chang, Seung Wook Hwang, Jong Seung Kim, Kyu Nam Kim, Be Long Cho; J Korean Acad Fam Med 2003;24(6):556-564. Published online June 10, 2003

Abstract
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Background
: There is a lack of data on Korean average VO₂max values. This study attempted to yield average values of VO₂max corresponding to each age group of Koreans. This study was also designed to investigate the factors associated with VO₂max.

Methods : From May 1st 1996 to January 30th 2000, we recruited 21,458 subjects who visited the health promotion center at one university hospital. We obtained the data related to age, exercise by self-administered questionnaire and weight, height and blood pressure by instrumental measurements and hemoglobin, cholesterol by overnight fasting blood sampling. VO₂max was estimated by submaximal bicycle ergometer test.

Results : The number of research subjects was 21,458: males 12,646 (58.9%) and females 8,812 (41.1%) and the average age was 48.6 (SD: ±10.05) years with age span from 20 to 79 years. The average VO₂max was 26.4 (SD; ±6.77) (ml/kg/min) for men and was 19.8 (SD; ±5.94) (ml/kg/min) for women. Relating to factors such as age, VO₂max, SBP, DBP, cholesterole, Hb, and body mass index, there were significant statistical differences between sex (p＜0.05). For both sexes, VO₂max decreased as age, cholesterol, BP and BMI increased. Regular exercise group showed significantly a higher VO₂max than non-exercise group for both sexes.

Conclusion : The average VO₂max values for Koreans, according to sex and age group are reported in this study. The decreasing VO₂max may be attributed to increasing age, BP, cholesterol, BMI and non-exercise.