Korean Journal of Family Medicine

"Jun Suk Kim"

Original Articles

Association between Helicobacter pylori Infection and Cerebral Small Vessel Disease: Soo Hyun Jang, Hyejin Lee, Jun Suk Kim, Hyun Jung Park, Su Min Jeong, Sang-Hyun Lee, Hyun Ho Kim, Jin Ho Park, Dong Wook Shin, Jae Moon Yun, BeLong Cho, Hyung-Min Kwon; Korean J Fam Med 2015;36(5):227-232. Published online September 18, 2015; DOI: https://doi.org/10.4082/kjfm.2015.36.5.227

Abstract
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Background

Small vessel disease is an important cause of cerebrovascular diseases and cognitive impairment in the elderly. There have been conflicting results regarding the relationship between Helicobacter pylori infection and ischemic stroke. This study aimed to examine the association between H. pylori infection and cerebral small vessel disease.

Methods

The study included 1,117 patients who underwent brain magnetic resonance imaging and H. pylori identification between 2005 and 2013 at Health Promotion Center, Seoul National University Hospital. Multivariable logistic regression analysis was used to assess the association between H. pylori infection and small vessel disease with adjustment for age, sex, hypertension, diabetes mellitus, dyslipidemia, body mass index, smoking status, problem drinking, and antiplatelet use.

Results

The adjusted odds ratios (aORs) for the association between H. pylori infection and silent brain infarction and cerebral microbleeds were 1.03 (95% confidence interval [CI], 0.66-1.61) and 0.70 (95% CI, 0.38-1.28), respectively. The aORs for silent brain infarction and cerebral microbleeds were 0.81 (95% CI, 0.44-1.44) and 0.59 (95% CI, 0.30-1.18) in patients aged <65 years and 1.59 (95% CI, 0.78-3.22) and 1.89 (95% CI, 0.38-9.33) in those aged >65 years, respectively. Moreover, the aORs for silent brain infarction and cerebral microbleeds were 0.96 (95% CI, 0.54-1.71) and 0.74 (95% CI, 0.33-1.69) in H. pylori-infected patients without atrophic gastritis and 0.89 (95% CI, 0.48-1.62) and 0.99 (95% CI, 0.43-2.27) in those with atrophic gastritis, respectively.

Conclusion

No association between H. pylori infection and small vessel disease was observed. H. pylori-induced inflammation may not be a risk factor for microcirculatory damage in the brain.

Citations

Citations to this article as recorded by

The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications
Robin B Brown, Stuart M Allan, Hugh S Markus
International Journal of Stroke.2026;[Epub] CrossRef
Helicobacter pylori Infection Acts as an Independent Risk Factor for Intracranial Atherosclerosis in Women Less Than 60 Years Old
Yinjie Guo, Canxia Xu, Linfang Zhang, Zhiheng Chen, Xiujuan Xia
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients
Mohamed Fahmy Doheim, Ahmad Amr Altaweel, Mohamed Gamal Elgendy, Alaa Ahmed Elshanbary, Mahmoud Dibas, Amira Abo Hegil Abo Ali, Toqa Mahmoud Dahy, Atef Khairy Sharaf, Ameer E. Hassan
Journal of Neurology.2021; 268(9): 3238. CrossRef
DAPT score: predictive model of dual-antiplatelet therapy for acute cerebral infarction
Yang Liu, Jia Yang, Panpan Jiang, Shan Wang, Mingming Wang, Mayan Wang, Tiankang Guo, Jianxiong Liu
Neurological Sciences.2021; 42(2): 681. CrossRef
Immune-Inflammation in Atherosclerosis: A New Twist in an Old Tale
Atefe Ghamar Talepoor, Hamed Fouladseresht, Shahdad Khosropanah, Mehrnoosh Doroudchi
Endocrine, Metabolic & Immune Disorders - Drug Targets.2020; 20(4): 525. CrossRef
Serum Level of Helicobacter pylori Antibody in Stroke Patients
Shahir Mazaheri, Mojtaba Khazaei, Abbas Moradi, Reza Raei
Avicenna Journal of Clinical Medicine.2020; 26(4): 206. CrossRef
Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community
Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
Neurology Clinical Practice.2018; 8(3): 223. CrossRef
Helicobacter pylori and extragastric diseases
Elisabetta Goni, Francesco Franceschi
Helicobacter.2016; 21(S1): 45. CrossRef
Update on prevention and treatment of Helicobacter pylori infection
Zhao-Chun Chi
World Chinese Journal of Digestology.2016; 24(16): 2454. CrossRef

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The Establishment of Hospice and Palliative Care System from the Cancer Patients and Families' Point of View.: Young Ho Yun, Young Sun Rhee, Jung Suk Lee, Chang Geol Lee, Si Young Kim, Eun Young Jung, Dae Seog Heo, Jun Suk Kim, Keun Seok Lee, Young Seon Hong; J Korean Acad Fam Med 2002;23(8):1042-1051. Published online August 10, 2002

Abstract
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Background
: Many terminal cancer patients and families are affected with physical, emotional, and social problems. Many people claim that a type of medical services is needed to manage them such as hospice·palliative care. There have not been many studies of cancer patients and families with respect to their opinions and attitudes on hospice·palliative care for terminal cancer patients, although their views on it is important.

Methods : We surveyed 687 in-patients, out-patients and their families with cancer in 8 hospitals. The self-administered questionnaires included the following; 1) socio-demographic and clinical variables; 2) opinions on hospice·palliative care; 3) attitudes on ethical issues associated with hospice·palliative care; 4) factors associated with withholding futile care at the end-of-life. The data were analyzed with x²-test, Mantel-Haenszel x²-test, and multiple logistic regression.

Results : Almost 90% of the subjects agreed to the need of obtaining hospice·palliative care with health care insurances and reaching a social consensus on the contents of its programs. Five hundred and seventy six (83.8%) subjects agreed to the need of using advanced directives. Two hundred and eighty five (72.2%) cancer patients and 200 (68.5%) families agreed to the need of withholding futile care at the end-of-life and of people accepting their cancer diagnosis with insight and living in the metropolis as they were more likely to do. In the multivariate analysis, the attitudes on withholding futile care at the end-of-life was significantly different only by insight of cancer diagnosis (OR; 1.09∼3.15).

Conclusion : This study showed that hospice·palliative care should be established through social consensus on the issues related to ethics and insurances, and that cancer patients and families must have a right to choose such services with informed decision-making.