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"Mostafa Alikhani"

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"Mostafa Alikhani"

Original Articles
Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study
Rozita Naseri, Vahid Farnia, Katayoun Yazdchi, Mostafa Alikhani, Behrad Basanj, Safora Salemi
Korean J Fam Med 2019;40(6):362-367.   Published online May 9, 2019
DOI: https://doi.org/10.4082/kjfm.18.0067
Background
Menopausal symptoms have remarkable negative effects on women’s quality of life, justifying the need to assess various therapeutic options. This research aimed to determine the effectiveness of Vitex agnus-castus extracts in alleviating menopausal symptoms in comparison with that of placebo.
Methods
This study was a randomized controlled double-blind clinical trial with a study group of 52 women referred to a clinic in Kermanshah in 2017. The participants were randomly divided into two groups: Vitex group (26 subjects) and placebo group (26 subjects). Menopausal symptoms were assessed using the Greene Scale before and 8 weeks after the intervention.
Results
After the intervention, the mean scores for total menopausal disorder, anxiety, and vasomotor dysfunction were significantly lower in the Vitex group than in the placebo group (P<0.05). The mean scores of the variables of somatic complications, depression, and sexual dysfunction did not show significant differences between the Vitex and placebo groups (P>0.05).
Conclusion
Administration of Vitex agnus-castus extracts as a phytoestrogenic medicine can alleviate menopausal symptoms in women.

Citations

Citations to this article as recorded by  
  • The chemical composition and the effects of Vitex agnus-castus at the cellular and organismal levels
    Mentor Sopjani, Shpëtim Thaçi, Marina Russo, Nguyen Thi Xuan, Caterina Faggio
    Journal of Essential Oil Research.2026; 38(1): 88.     CrossRef
  • Vitex agnus‐castus in Menopause: Phytochemistry, Mechanistic Insights, Clinical Applications, and Safety Perspectives
    Mentor Sopjani, Vlerë Murati, Duresa Mataj‐Berisha, Nguyen Thi Xuan, Caterina Faggio, Arleta Rifati‐Nixha
    Phytotherapy Research.2026;[Epub]     CrossRef
  • Treatment of Menopausal Symptoms with Herbal Medicines: A Review
    Pranay Wal, Indu Singh, Deependra Singh, Manju Rawat Singh, Ankita Wal
    Current Women s Health Reviews.2025;[Epub]     CrossRef
  • Scabiosa artropurperea var.maritima aqueous extracts improve in vivo fertility parameters and in vitro granulosa cell steroidogenesis in Ewe
    Wijden Niama, Samia Ben Said, Christelle Rame, Kahena Bouzid, Ahlem Bartakiz, Pascal Froment, Mokhtar Mahouachi, Joëlle Dupont
    Theriogenology.2025; 235: 9.     CrossRef
  • Effectiveness of Multisymptom Support for Better Relief and Alleviation of Common Effects in Perimenopause (EMBRACE PERIMENOPAUSE)
    Reena Choudhury, Kiran Coelho, Sachin Suryawanshi, Anoop Hajare, Abhijeet Kumar
    Cureus.2025;[Epub]     CrossRef
  • Exploring the Efficacy and Safety of Black Cohosh (Cimicifuga racemosa) in Menopausal Symptom Management
    Kritiksha Hedaoo, Ankit K. Badge, Yugeshwari R. Tiwade, Nandkishor J. Bankar, Vaishnavi H. Mishra
    Journal of Mid-life Health.2024; 15(1): 5.     CrossRef
  • Vitex agnus-castus (VAC) plant commonly used in Aydın province, Turkey: women's menstrual and menopausal symptoms
    Serpil Abalı Çetin, Fatma Mutlu
    Journal of Herbal Medicine.2024; 46: 100900.     CrossRef
  • Unlocking nature’s secrets: Medicinal plants for enhanced female fertility
    Karishma Singh, Roger Coopoosamy, Alabi David, Kuben Naidoo
    Journal of Medicinal Plants for Economic Development.2024;[Epub]     CrossRef
  • Effects of nutritional interventions on the severity of depressive and anxiety symptoms of women in the menopausal transition and menopause: a systematic review, meta-analysis, and meta-regression
    Ruth B. Grigolon, Gilciane Ceolin, Yan Deng, Alexander Bambokian, Elena Koning, Jennifer Fabe, Maiara Lima, Fernando Gerchman, Claudio N. Soares, Elisa Brietzke, Fabiano A. Gomes
    Menopause.2023; 30(1): 95.     CrossRef
  • Sexual dysfunction: an interdisciplinary problem of classical gynecology
    Natalia M. Podzolkova, Liliana V. Sumyatina
    Gynecology.2023; 25(1): 95.     CrossRef
  • A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women
    Rosita Dangmann
    Medical Hypotheses.2023; 178: 111136.     CrossRef
  • Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety
    Fateme Sadat Najib, Tahereh Poordast, Monireh Sufi Mahmudi, Zahra Shiravani, Niloofar Namazi, Gholamhossein Ranjbar Omrani
    Journal of Pharmacopuncture.2022; 25(2): 106.     CrossRef
  • Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.
    Nurkhalida Kamal, Nurul Syahidah Mio Asni, Ivana Nur Allisya Rozlan, Muhammad Aniq Hamzah Mohd Azmi, Noor Wini Mazlan, Ahmed Mediani, Syarul Nataqain Baharum, Jalifah Latip, Suvik Assaw, Ru Angelie Edrada-Ebel
    Plants.2022; 11(15): 1944.     CrossRef
  • Menopause symptoms in women and its relation with using complementary and alternative medicines: A survey in southeast Iran
    Mahlagha Dehghan, Zahra Isari, Mohammad Hossein Abbaszadeh, Asma Ghonchehpour
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Perimenopause and Mental Health
    Nicole Leistikow, Milena H. Smith
    Advances in Psychiatry and Behavioral Health.2022; 2(1): 107.     CrossRef
  • Comparison of Cinnamon and Vitex on Improving Sexual Function in Postmenopausal Women: A Triple-blind Randomized Clinical Trial
    Tanya Koliji, Zohrah Keshavarz, Faraz Mojab, Malihe Nasiri, Elham Zare
    Jundishapur Journal of Natural Pharmaceutical Products.2022;[Epub]     CrossRef
  • Global survey of medicinal plants during lactation and postpartum recovery: Evolutionary perspectives and contemporary health implications
    Lindiwe Sibeko, Timothy Johns
    Journal of Ethnopharmacology.2021; 270: 113812.     CrossRef
  • The Effect of Jazar Supplement on Quality of Life and Sexual Function in Postmenopausal Women: A Double-Blind, Randomized, Placebo-Controlled Trial
    Sousan Hafizi, Alireza Abbassian, Malihe Tabarrai, Deborah A. Kennedy
    Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
  • Investigation of the role of herbal medicine, acupressure, and acupuncture in the menopausal symptoms: An evidence-based systematic review study
    Abed Ebrahimi, Naeimeh Tayebi, Ahmadinezhad Fatemeh, Marzieh Akbarzadeh
    Journal of Family Medicine and Primary Care.2020; 9(6): 2638.     CrossRef
  • Vitex agnus-castus L.: Main Features and Nutraceutical Perspectives
    Eliana B. Souto, Alessandra Durazzo, Amirhossein Nazhand, Massimo Lucarini, Massimo Zaccardelli, Selma B. Souto, Amelia M. Silva, Patricia Severino, Ettore Novellino, Antonello Santini
    Forests.2020; 11(7): 761.     CrossRef
  • 24,327 View
  • 391 Download
  • 17 Web of Science
  • 20 Crossref
Attachment Style and Resiliency in Patients with Obsessive-Compulsive Personality Disorder
Ali Zakiei, Mostafa Alikhani, Vahid Farnia, Zinab Khkian, Jalal Shakeri, Sanobar Golshani
Korean J Fam Med 2017;38(1):34-39.   Published online January 18, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.1.34
Background

The goal of the present study was to determine the relationships between attachment styles and resiliency in obsessive-compulsive personality disorder.

Methods

A random sample of 260 subjects was obtained from the population of undergraduate students of the Nour Branch of Islamic Azad University, which is located in Mazandaran, and these subjects were enrolled in this descriptive and correlational study. The collected data included the subjects' responses to an adult attachment style questionnaire, resilience scale, and obsessive-compulsive personality disorder questionnaire. The data were analyzed with Pearson correlation coefficient indices and multiple regressions.

Results

The results of the data analysis showed a positive correlation (relationship) between ambivalent/avoidant attachment styles and obsessive-compulsive personality disorder and a negative correlation between resilience and obsessive-compulsive personality disorder. Furthermore, these results demonstrated that attachment style and resiliency can predict obsessive-compulsive personality disorder. In addition, no significant relationships were found between the demographic variables (convertibles) and obsessive-compulsive personality disorder.

Conclusion

These results suggested that attachment style and resiliency contribute to the development of obsessive-compulsive personality disorder.

Citations

Citations to this article as recorded by  
  • Is This Partner and Relationship Really Right for Me?
    Mahsa Seddighi, Mansoureh Sadat Sadeghi, Jalil Fathabadi
    Marriage & Family Review.2026; : 1.     CrossRef
  • Attachment Differences Across Close Relationships Among Inpatients With Avoidant or Obsessive‐Compulsive Personality Pathology
    John T. Rucker, Katrina A. Rufino
    Clinical Psychology & Psychotherapy.2025;[Epub]     CrossRef
  • Adverse Childhood Experiences and Obsessive-Compulsive Personality Traits: Mediating Effects of Attachment and Metacognition
    Emily Gray, Simon Boag
    Studia Psychologica: Theoria et praxis.2024;[Epub]     CrossRef
  • Child Abuse and Neglect and Obsessive–Compulsive Personality Traits: Effects of Attachment, Intolerance of Uncertainty, and Metacognition
    Emily Gray, Naomi Sweller, Simon Boag
    Journal of Child & Adolescent Trauma.2024; 17(4): 1189.     CrossRef
  • The relationship between moral judgment ability, parenting style, and perfectionism in obsessive–compulsive disorder patients: A mediating analysis
    Jiacheng Cui, Kongmei Zhu, Jianglin Wen, Wanjie Nie, Dong Wang
    Frontiers in Psychology.2023;[Epub]     CrossRef
  • Obsessive-Compulsive Personality Disorder: A Review of Symptomatology, Impact on Functioning, and Treatment
    Anthony Pinto, Jonathan Teller, Michael G. Wheaton
    Focus.2022; 20(4): 389.     CrossRef
  • Does a Secure Attachment Style Predict High Psychological Resilience in Patients With Cancer Receiving Chemotherapy?
    Fatma Basal, Seda Onur, Deniz Yamac, Cengiz Karacin, Guliz Zengin, İrem Bilgetekin, Umut Demirci, Berna Oksuzoglu
    Cureus.2020;[Epub]     CrossRef
  • Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study
    André Kracker Imthon, César Antônio Caldart, Maria Conceição do Rosário, Leonardo F. Fontenelle, Euripedes Constantino Miguel, Ygor Arzeno Ferrão
    Journal of Clinical Medicine.2020; 9(10): 3371.     CrossRef
  • Obsessive compulsive disorder and attachment
    František Hodný, Ján Praško, Marie Ocisková, Michaela Holubová, Jakub Vaněk, Dana Končelíková, Petra Kasalová, Vlastimil Nesnidal, Jana Zmeková
    Psychiatrie pro praxi.2020; 21(3): 142.     CrossRef
  • 8,093 View
  • 116 Download
  • 7 Web of Science
  • 9 Crossref
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