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"Sang Yeoup Lee"

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"Sang Yeoup Lee"

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Association between E-Cigarette Smoking and Insulin Resistance Using the Triglyceride-Glucose Index in Korean Adults: Korea National Health and Nutrition Examination Survey
Dahae Lim, Jung In Choi, Ryuk Jun Kwon, Sang Yeoup Lee, Young Hye Cho, Eun Ju Park, Youngin Lee, Sae Rom Lee, Soo Min Son, Yun Jin Kim, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Gyu Lee Kim, Young Jin Ra
Received August 21, 2023  Accepted April 22, 2024  Published online August 20, 2024  
DOI: https://doi.org/10.4082/kjfm.23.0141    [Epub ahead of print]
Background
Insulin resistance contributes to the development of cardiovascular disease and type 2 diabetes mellitus. Smoking leads to an increase in triglyceride levels, which, in turn, increases insulin resistance. Although the number of e-cigarette users has increased in recent years, few studies have investigated the association between ecigarette use and insulin resistance. Therefore, this study aimed to determine the association between e-cigarette use and insulin resistance using the triglyceride-glucose (TyG) index in Korean adults.
Methods
This study included 4,404 healthy adults aged ≥20 years who participated in the Korea National Health and Nutrition Examination Survey between 2019 and 2020. Participants were categorized as never-smokers or ecigarette users, and the TyG index was categorized into low- and high-TyG index groups according to the median value (9.22). A logistic regression analysis was performed to determine the association between e-cigarette smoking and insulin resistance.
Results
E-cigarette users had a higher TyG index than never smokers (e-cigarette: mean=3.95; never: mean=9.18; P<0.001). The e-cigarette users had a higher risk of being in the high TyG index group than never-smokers (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.03–1.84). In the subgroup analysis stratified by sex, age, and body mass index, a higher OR for a high TyG index was observed in men (OR, 1.46; 95% CI, 1.03–2.08) and individuals aged 60 years or older (OR, 3.74; 95% CI, 1.14–12.30).
Conclusion
Our findings suggest that e-cigarette use is significantly associated with insulin resistance.
  • 1,565 View
  • 55 Download
Association between breakfast consumption frequency and chronic inflammation in Korean adult males: Korea National Health and Nutrition Examination Survey 2016–2018
Eun Ji Han, Eun Ju Park, Sae Rom Lee, Sang Yeoup Lee, Young Hye Cho, Young In Lee, Jung In Choi, Ryuk Jun Kwon, Soo Min Son, Yun Jin Kim, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Gyu Lee Kim, Young Jin Ra
Korean J Fam Med 2025;46(2):92-97.   Published online July 5, 2024
DOI: https://doi.org/10.4082/kjfm.23.0151
Background
Skipping breakfast is associated with an increased risk of chronic inflammatory diseases. This study aimed to examine the association between breakfast-eating habits and inflammation, using high-sensitivity C-reactive protein (hs-CRP) as a marker.
Methods
A total of 4,000 Korean adult males with no history of myocardial infarction, angina, stroke, diabetes, rheumatoid arthritis, cancer, or current smoking were included. Data from the 2016–2018 Korea National Health and Nutrition Examination Survey were used for analysis. The frequency of breakfast consumption was assessed through a questionnaire item in the dietary survey section asking participants about their weekly breakfast consumption routines over the past year. Participants were categorized into two groups, namely “0–2 breakfasts per week” and “3–7 breakfasts per week”; hs-CRP concentrations were measured through blood tests.
Results
Comparing between the “infrequent breakfast consumption (0–2 breakfasts per week)” and “frequent breakfast consumption (3–7 breakfasts per week)” groups, the mean hs-CRP was found to be significantly higher in the “infrequent breakfast consumption” group, even after adjusting for age, body mass index, physical activity, alcohol consumption, systolic blood pressure, blood pressure medication, fasting blood glucose, and triglycerides (mean hs-CRP: frequent breakfast consumption, 1.36±0.09 mg/L; infrequent breakfast consumption, 1.17±0.05 mg/L; P-value=0.036).
Conclusion
Less frequent breakfast consumption was associated with elevated hs-CRP levels. Further large-scale studies incorporating adjusted measures of daily eating patterns as well as food quality and quantity are required for a deeper understanding of the role of breakfast in the primary prevention of chronic inflammatory diseases.
  • 1,599 View
  • 63 Download
Association between Sleep Duration and Presbycusis in Korean Adults: Korea National Health and Nutrition Examination Survey
Min Ju Kang, Youngin Lee, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Yu Hyeon Yi, Young Hye Cho, Young Jin Tak, Eun Ju Park, Seung Hun Lee, Gyu Lee Kim, Jung In Choi, Young Jin Ra, Sae Rom Lee, Ryuk Jun Kwon, Soo Min Son, Yea Ji Lee, Young Eun Choi
Korean J Fam Med 2023;44(2):117-123.   Published online March 20, 2023
DOI: https://doi.org/10.4082/kjfm.22.0137
Background
Sleep duration is associated with hearing loss, especially presbycusis, which is the most common type of hearing loss; however, there is limited evidence regarding this association among the Korean population. We aimed to determine the relationship between sleep duration and high-frequency hearing loss in Korean adults aged ≥40 years.
Methods
We examined 5,547 Korean adults aged ≥40 years who completed audiometric tests and questionnaires regarding sleep duration during the 2010–2012 cycle of the Korea National Health and Nutrition Examination Survey. Mild presbycusis was defined as >25 decibels (dB) and <40 dB, whereas moderate-to-severe presbycusis was defined as >40 dB pure tone averages at high frequencies (3,000, 4,000, and 6,000 Hz) for both ears. Additionally, the sleep duration was divided into quartiles. Odds ratios and 95% confidence intervals were estimated using multivariable logistic regression after adjusting for covariates.
Results
The prevalence of presbycusis in South Korean adults was 62.1%, of which 61.4% showed moderate to severe presbycusis. The incidence of moderate-to-severe, but not mild, presbycusis showed a significant positive correlation with sleep duration.
Conclusion
Our findings suggest that sleep duration is associated with the prevalence of presbycusis.

Citations

Citations to this article as recorded by  
  • Joint association of sleep duration and depression with new-onset hearing loss: a national cohort study
    Fang Wang, Yu-Jun Xiong, Da-Ming Shao, Tian Lv, Shiqin Chen, Qian-Yuan Zhu
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • Sleep characteristics and hearing loss in middle-aged and older adults: The National Health and Nutrition Examination Survey 2015–2018
    Kening Jiang, Adam P. Spira, Nicholas S. Reed, Frank R. Lin, Jennifer A. Deal
    Sleep Epidemiology.2024; 4: 100082.     CrossRef
  • Age-related hearing loss and its potential drug candidates: a systematic review
    Shiyu Hu, Qingru Sun, Fei Xu, Ninghua Jiang, Jianli Gao
    Chinese Medicine.2023;[Epub]     CrossRef
  • 3,273 View
  • 124 Download
  • 2 Web of Science
  • 3 Crossref
Association between Serum Folic Acid Levels and Asthma in the Korean Population: A Study Based on the 2016–2018 Korea National Health and Nutrition Examination Survey
So Ra Kim, Eun Ju Park, Young Hye Cho, Sang Yeoup Lee, Jung-In Choi, Young-In Lee, Sae Rom Lee, Yun Jin Kim, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Gyu Lee Kim, Young Jin Ra
Korean J Fam Med 2022;43(4):241-245.   Published online July 19, 2022
DOI: https://doi.org/10.4082/kjfm.21.0143
Background
Folic acid is involved in inflammatory reactions; however, the association between folic acid and allergic diseases, particularly asthma, remains unclear. Thus, this study aimed to evaluate the association between serum folic acid levels and asthma in Koreans.
Methods
This study analyzed the serum folic acid levels of 6,615 individuals included in the 2016–2018 Korea National Health and Nutrition Examination Survey. The prevalence of asthma was determined using a questionnaire that identified cases of physician-diagnosed asthma. The relationship between serum folic acid levels and asthma was analyzed using logistic regression analysis.
Results
Multiple logistic regression analysis showed that a 1 ng/mL increase in serum folic acid level significantly reduced the risk of asthma after adjusting for confounding factors including sex, age, household income, current smoking, current alcohol use, and body mass index (odds ratio [OR], 0.930; 95% confidence interval [CI], 0.876– 0.987; P=0.017). The relationship between the adjusted odds of asthma and serum folic acid levels were consistently inverse (OR, 2.266; 95% CI, 1.126–4.420; P for trend=0.038).
Conclusion
Serum folic acid levels are inversely associated with physician-diagnosed asthma in the Korean population.

Citations

Citations to this article as recorded by  
  • Association between serum folate levels and blood eosinophil counts in American adults with asthma: Results from NHANES 2011–2018
    Jun Wen, Changfen Wang, Mohan Giri, Shuliang Guo
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • 4,005 View
  • 96 Download
  • 1 Web of Science
  • 1 Crossref
Association between Time to First Cigarette and Health-Related Quality of Life of Middle-Aged Male Current Smokers: A Nationwide Representative Study in Korea
Sung Eun Jo, Hye Rim Hwang, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Yu Hyeon Yi, Young Hye Cho, Young Jin Tak, Seung Hun Lee, Eun Ju Park, Youngin Lee
Korean J Fam Med 2021;42(3):225-231.   Published online August 4, 2020
DOI: https://doi.org/10.4082/kjfm.19.0103
Background
Although many studies have demonstrated that the first cigarette in the morning increases the prevalence of smoking-related morbidity, limited studies have examined the impact of time to first cigarette (TTFC) on the health-related quality of life (HRQoL). Thus, we assessed this relationship using nationally-representative data from the Korea National Health and Nutrition Examination Survey VII-1 (2016).
Methods
We conducted a cross-sectional study using data from 577 current male smokers aged 30–59 years, after excluding those with a certain disease. Participants were divided into four categories according to TTFC (≤5 min, 6–30 min, 31–60 min, >60 min). HRQoL was measured using self-reported EuroQol-5 (EQ-5D). The relationship between TTFC and EQ-5D index was analyzed using a multivariate-adjusted generalized linear model to assess how HRQoL varies according to TTFC. After adjusting for confounders, a multivariate-adjusted logistic regression analysis was performed to identify which of the five dimensions of the EQ-5D affected the HRQoL according to TTFC.
Results
The generalized linear analysis indicated that as TTFC decreased (6–30 min, 31–60 min vs. >60 min), the EQ-5D index score decreased significantly (P=0.037). Shorter TTFC (≤5 min vs. >60 min) was associated with higher pain/discomfort (odds ratio [OR], 3.82; 95% confidence interval [CI], 1.39–10.48) and anxiety/depression (OR, 7.58; 95% CI, 1.75–32.88).
Conclusion
Higher nicotine dependence was associated with impaired HRQoL. These results may be used to improve smoking cessation treatment outcomes.

Citations

Citations to this article as recorded by  
  • Current status of tobacco use, cessation and control policy in Korea
    Cheol Min Lee
    Journal of the Korean Medical Association.2022; 65(12): 789.     CrossRef
  • 4,234 View
  • 110 Download
  • 1 Web of Science
  • 1 Crossref
Association between Relative Handgrip Strength and Dyslipidemia in Korean Adults: Findings of the 2014–2015 Korea National Health and Nutrition Examination Survey
Bo Mi Kim, Yu Hyeon Yi, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Young Hye Cho, Young Jin Tak, Hye Rim Hwang, Seung Hun Lee, Eun Ju Park, Youngin Lee
Korean J Fam Med 2020;41(6):404-411.   Published online February 12, 2020
DOI: https://doi.org/10.4082/kjfm.19.0073
Background
Grip strength is a convenient method to measure muscle strength. Recently, relative handgrip strength (HGS) was recommended as a clinical predictor of metabolic health and disease, such as dyslipidemia, which is considered a risk factor for cardiovascular disease. The purpose of this study was to characterize the association between relative HGS and dyslipidemia.
Methods
We included 6,027 adults (2,934 men, 3,093 women) aged 30–69 years who participated in the Korea National Health and Nutrition Examination Survey in 2014 and 2015. Relative HGS was obtained by dividing the HGS by body mass index. Complex sampling analysis was conducted to compare the general characteristics of participants according to the quartiles of relative HGS. Logistic regression analysis was used to examine the association between quartiles of relative HGS and dyslipidemia.
Results
After adjustment for age, prevalence of diabetes mellitus, prevalence of hypertension, alcohol consumption, smoking status, exercise, income, and education level, relative HGS was inversely associated with dyslipidemia in both men and women. In multivariable logistic regression analysis, the odds ratios (95% confidence intervals) for dyslipidemia in quartiles 1, 2, and 3 relative to quartile 4 were 1.36 (1.00–1.83), 1.29 (0.98–1.70), 1.23 (0.95– 1.60) in men and 1.81 (1.30–2.50), 1.81 (1.32–2.47), 1.39 (1.07–1.81) in women, respectively.
Conclusion
Relative HGS was inversely associated with dyslipidemia risk in Korean adults. Muscle-strengthening exercise is recommended to enhance health outcomes.

Citations

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  • Association between handgrip strength and metabolic syndrome in relation to gender and adiposity among middle aged and older Saudi populations
    Shaea A. Alkahtani, Ghedeir M. Alshammari, Aishah Alzuwaydi, Abdulaziz Alfuhaid, Abeer A. Al-Masri, Rizwan Qaisar, Syed Shahid Habib
    The Aging Male.2024;[Epub]     CrossRef
  • Association Between Typologies of Sedentary Behavior and Muscle Strength, Gait Speed, and Balance in Community-Dwelling Older Adults
    Letícia Martins Cândido, Núbia Carelli Pereira de Avelar, Eleonora D’Orsi, Ana Cristina Rodrigues Lacerda, Vanessa Amaral Mendonça, Gabriella Tringali, Alessandro Sartorio, Ana Lúcia Danielewicz
    Journal of Aging and Physical Activity.2024; 32(2): 225.     CrossRef
  • Predictors of the onset of low handgrip strength in Europe: a longitudinal study of 42,183 older adults from 15 countries
    Rizwan Qaisar, M. Azhar Hussain, Fabio Franzese, Asima Karim, Firdos Ahmad, Atif Awad, Abeer A. Al-Masri, Shaea A. Alkahtani
    Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
  • Increasing muscular strength to improve cardiometabolic risk factors
    Patricio Lopez-Jaramillo, Jose P. Lopez-Lopez, Maria Camila Tole, Daniel D. Cohen
    Clínica e Investigación en Arteriosclerosis.2023; 35(3): 144.     CrossRef
  • Association of absolute and relative hand grip strength with all-cause mortality among middle-aged and old-aged people
    Wonjeong Jeong, Jong Youn Moon, Jae-Hyun Kim
    BMC Geriatrics.2023;[Epub]     CrossRef
  • Identification of subgroups with poor lipid control among patients with dyslipidemia using decision tree analysis: the Korean National Health and Nutrition Examination Survey from 2019 to 2021
    Hee Sun Kim, Seok Hee Jeong
    Journal of Korean Biological Nursing Science.2023; 25(2): 131.     CrossRef
  • Increasing muscular strength to improve cardiometabolic risk factors
    Patricio Lopez-Jaramillo, Jose P. Lopez-Lopez, Maria Camila Tole, Daniel D. Cohen
    Clínica e Investigación en Arteriosclerosis (English Edition).2023; 35(3): 144.     CrossRef
  • Association between Relative Handgrip Strength and Insulin Resistance in Korean Elderly Men without Diabetes: Findings of the 2015 Korea National Health Nutrition Examination Survey
    Kwang-Chae Joo, Da-Hye Son, Jae-Min Park
    Korean Journal of Family Medicine.2022; 43(3): 199.     CrossRef
  • Association Between C-Reactive Protein and Relative Handgrip Strength in Postmenopausal Korean Women Aged 45–80 Years: A Cross-Sectional Study
    Da-Hye Son, Seung-Ah Song, Yong-Jae Lee
    Clinical Interventions in Aging.2022; Volume 17: 971.     CrossRef
  • Relationship Between Relative Grip Strength and Serum Total Cholesterol, High-Density Lipoprotein Cholesterol, Low-Density Lipoprotein Cholesterol, and Triglyceride Levels in Korean Middle-Aged or Older Adults: A Panel Regression Model
    DooYong Park, Duck-Chul Lee, YeonSoo Kim
    Metabolic Syndrome and Related Disorders.2022; 20(9): 517.     CrossRef
  • Stroke-Related Sarcopenia among Two Different Developing Countries with Diverse Ethnic Backgrounds (Cross-National Study in Egypt and China)
    Marwa Mohammed, Jianan Li
    Healthcare.2022; 10(11): 2336.     CrossRef
  • Importance of Handgrip Strength as a Health Indicator in the Elderly
    Soo Young Kim
    Korean Journal of Family Medicine.2021; 42(1): 1.     CrossRef
  • Handgrip Strength: An Irreplaceable Indicator of Muscle Function
    Sang Yoon Lee
    Annals of Rehabilitation Medicine.2021; 45(3): 167.     CrossRef
  • Association between relative handgrip strength and abdominal obesity, type-2 diabetes and hypertension in a Mexican population
    Iris Paola Guzmán-Guzmán, Pedro Delgado-Floody, Ilse Adriana Gutiérrez-Pérez, Felipe Caamaño-Navarrete, Daniel Jerez-Mayorga, Óscar Zaragoza-García, Isela Parra-Rojas
    Nutrición Hospitalaria.2021;[Epub]     CrossRef
  • Grip Strength as a Cardiometabolic Marker
    Jungun Lee
    Korean Journal of Family Medicine.2020; 41(5): 271.     CrossRef
  • 7,272 View
  • 201 Download
  • 14 Web of Science
  • 15 Crossref
The Association between Obesity Phenotypes and Early Renal Function Decline in Adults without Hypertension, Dyslipidemia, and Diabetes
Jung In Choi, Young Hye Cho, Sang Yeoup Lee, Dong Wook Jeong, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, Hye Rim Hwang, Eun Ju Park
Korean J Fam Med 2019;40(3):176-181.   Published online May 10, 2019
DOI: https://doi.org/10.4082/kjfm.18.0139
Background
The prevalence of chronic kidney disease is increasing worldwide. Several studies have suggested that obesity is associated with early renal dysfunction. However, little is known about the relationship between obesity phenotypes and early renal function decline. Therefore, this study aimed to identify the relationship between obesity phenotypes and early renal function decline in adults without hypertension, dyslipidemia, and diabetes.
Methods
We conducted a cross-sectional analysis of clinical and anthropometric data from 1,219 patients who underwent a routine health checkup in 2014. We excluded adults with cardiovascular disease, renal disease, diabetes, hypertension, dyslipidemia, or low glomerular filtration rate (<60 mL/min/1.73 m2). Renal function was determined according to the estimated glomerular filtration rate calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation.
Results
Age, sex, body mass index, waist circumference, triglyceride, low-density lipoprotein, and fasting glucose had an association with the estimated glomerular filtration rate. After adjusting for age, sex, smoking status, and alcohol intake, the odds ratios of the metabolically abnormal normal weight and metabolically abnormal obese phenotypes for the presence of low estimated glomerular filtration rates were 1.807 (95% confidence interval, 1.009– 3.236) and 1.834 (95% confidence interval, 1.162–2.895), compared with the metabolically healthy normal weight phenotype. However, the metabolically healthy obese phenotype did not show a significant association with early renal function decline.
Conclusion
In this cross-sectional study, we confirmed the association between the metabolically abnormal normal weight and metabolically abnormal obese phenotypes and early kidney function decline in adults without hypertension, dyslipidemia, and diabetes.

Citations

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  • Obesity as a Risk Factor for Hyperglycemia, Electrolyte Disturbances, and Acute Kidney Injury in the Emergency Department
    Iulia Najette Crintea, Alexandru Cristian Cindrea, Ovidiu Alexandru Mederle, Teodor Florin Fulga, Adina Maria Marza, Alina Petrica, Cosmin Iosif Trebuian, Romulus Timar
    Biomedicines.2025; 13(2): 349.     CrossRef
  • Obesity Class and Severity of Metabolic Emergencies: A Single-Center Retrospective Five-Year Study
    Iulia Najette Crintea, Alexandru Cristian Cindrea, Teodor Florin Fulga, Cosmin Iosif Trebuian, Adina Maria Marza, Alina Petrica, Ovidiu Alexandru Mederle, Romulus Timar
    Healthcare.2025; 13(6): 617.     CrossRef
  • Metabolically healthy obesity and chronic kidney disease risk: exploring the dynamics
    Mustafa GULDAN, Lasin OZBEK, Ahmet U. TOPCU, Adrian COVIC, Mehmet KANBAY
    Panminerva Medica.2024;[Epub]     CrossRef
  • Visceral Adiposity Index and Lipid Accumulation Product as Effective Markers of Different Obesity Phenotypes in Korean Adults: A Cross-Sectional Analysis
    Sung Ryul Yu, Kyung-A Shin
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 495.     CrossRef
  • Metabolically healthy obesity is associated with higher risk of both hyperfiltration and mildly reduced estimated glomerular filtration rate: the role of serum uric acid in a cross-sectional study
    Hong Zhang, Rui Chen, Xiaohong Xu, Minxing Yang, Wenrong Xu, Shoukui Xiang, Long Wang, Xiaohong Jiang, Fei Hua, Xiaolin Huang
    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • Prevalence and associations of metabolic syndrome in patients with alcohol use disorder
    Anna Hernández-Rubio, Arantza Sanvisens, Ferran Bolao, Isabel Cachón-Suárez, Carme Garcia-Martín, Antoni Short, Ramón Bataller, Roberto Muga
    Scientific Reports.2022;[Epub]     CrossRef
  • Effects of bariatric surgery on renal function and associated factors with bivariate analysis: a cohort study
    Juliana Amaro Borborema Bezerra, Eduardo Pachu Raia dos Santos, Carlos Teixeira Brandt
    F1000Research.2022; 11: 409.     CrossRef
  • Metabolic obesity phenotypes and chronic kidney disease: a cross-sectional study from the RaNCD cohort study
    Samira Arbabi Jam, Behrooz Moloudpour, Farid Najafi, Mitra Darbandi, Yahya Pasdar
    BMC Nephrology.2022;[Epub]     CrossRef
  • Abdominal obesity phenotypes and risk of kidney function decline: Tehran Lipid and Glucose Study
    Asharf Shahali, Erfan Tasdighi, Maryam Barzin, Maryam Mahdavi, Majid Valizadeh, Mahtab Niroomand, Fereidoun Azizi, Farhad Hosseinpanah
    Obesity Research & Clinical Practice.2020; 14(2): 168.     CrossRef
  • Obese First degree relatives of hemodialysis patients are at Higher Risk for Developing Kidney Diseases: In a Cross-sectional Study
    Abozaid Mohammed Elemam
    Sudan Journal of Medical Sciences.2019;[Epub]     CrossRef
  • 7,409 View
  • 125 Download
  • 9 Web of Science
  • 10 Crossref
Factors Affecting Adherence to Antihypertensive Medication
Hyo Yoon Choi, Im Jung Oh, Jung Ah Lee, Jisun Lim, Young Sik Kim, Tae-Hee Jeon, Yoo-Seock Cheong, Dae-Hyun Kim, Moon-Chan Kim, Sang Yeoup Lee
Korean J Fam Med 2018;39(6):325-332.   Published online November 2, 2018
DOI: https://doi.org/10.4082/kjfm.17.0041
Background
Hypertension is a major contributor to the global disease burden of cardiovascular and cerebrovascular disease. The aim of this study was to determine demographic and clinical factors associated with adherence to antihypertensive medication.
Methods
From August 2012 to February 2015, we recruited 1,523 Korean patients with hypertension who visited family physicians. The study was conducted in 24 facilities located in urban and metropolitan areas. Of these facilities, two were primary care clinics and 22 were level 2 or 3 hospitals. Adherence was assessed using the pill count method; a cut-off value of 80% was used as the criterion for good adherence. Sociodemographic and lifestyle factors were compared between the adherent and nonadherent groups using the chi-square test for categorical variables and t-test for continuous variables. Binary logistic regression analysis was performed with medication adherence as the outcome variable.
Results
Of the 1,523 patients, 1,245 (81.7%) showed good adherence to antihypertensive medication. In the multivariate logistic analysis, age ≥65 years, exercise, treatment in a metropolitan-located hospital, being on ≥2 classes of antihypertensive medication and concomitant medication for diabetes, and a family history of hypertension or cardiovascular diseases were associated with good adherence. Patients who had a habit of high salt intake were less adherent to medication.
Conclusion
Multiple classes of antihypertensive medications, concomitant medication, and exercise were associated with good adherence to antihypertensive medication, and high salt intake was associated with poor adherence to antihypertensive medication. These factors should be considered to improve hypertension control.

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    Medicine.2024; 103(15): e37711.     CrossRef
  • Non-adherence to appointment follow-up and its associated factors among hypertensive patients in follow-up clinics in South Gondar hospitals
    Gebrie kassaw Yirga, Getu Sisay Mekonen, Endalk Getasew Hiruy, Kirubel Shiferaw, Berihun Bantie
    Scientific Reports.2024;[Epub]     CrossRef
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    Sangyong Jo, Taegyu Um, Jihye Shin, Dongchan Lee, Kyungil Park, Minkook Son
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    B. Pal, A. Dutta, V. Chaudhary, S. Kumari, S. Meenakshi, K. Murti
    Hipertensión y Riesgo Vascular.2024;[Epub]     CrossRef
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    Здобутки клінічної і експериментальної медицини.2024; (4): 39.     CrossRef
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    Chinonyerem O. Iheanacho, Agbaje Akeem Babatunde, Uchenna I. H. Eze
    Ageing International.2023; 48(3): 729.     CrossRef
  • Opportunities of Amlodipine as a Potential Candidate in the Evaluation of Drug Compliance during Antihypertensive Therapy
    Dmitrijs Kustovs, Inga Urtāne, Eduards Sevostjanovs, Eva Moreino, Kārlis Trušinskis
    Medicina.2023; 59(2): 340.     CrossRef
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    Aizhen Guo, Hua Jin, Jianbo Mao, Weihong Zhu, Ye Zhou, Xuhua Ge, Dehua Yu
    BMC Cardiovascular Disorders.2023;[Epub]     CrossRef
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    Humberto Badillo-Alonso, Marisol Martínez-Alanis, Ramiro Sánchez-Huesca, Abel Lerma, Claudia Lerma
    Journal of Cardiovascular Development and Disease.2023; 10(6): 243.     CrossRef
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    Qiuyu Pan, Cheng Zhang, Lansicheng Yao, Chenyao Mai, Jinpeng Zhang, Zhitong Zhang, Jun Hu
    Patient Preference and Adherence.2023; Volume 17: 1679.     CrossRef
  • The Development and Validation of the “Hippocratic Hypertension Self-Care Scale”
    Hero Brokalaki, Anastasia A. Chatziefstratiou, Nikolaos V. Fotos, Konstantinos Giakoumidakis, Evaggelos Chatzistamatiou
    Healthcare.2023; 11(18): 2579.     CrossRef
  • Adherence Behaviors and Related Factors Among Elderly Hypertensive Patients in China: Evidence from the China Health and Retirement Longitudinal Study
    Fengyu Liu, Huajing Chang, Xiaojun Liu
    Patient Preference and Adherence.2023; Volume 17: 3539.     CrossRef
  • Predictors of non-adherence to antihypertensive medications: A cross-sectional study from a regional hospital in Afghanistan
    Muhammad Haroon Stanikzai, Mohammad Hashim Wafa, Essa Tawfiq, Massoma Jafari, Cua Ngoc Le, Abdul Wahed Wasiq, Bilal Ahmad Rahimi, Ahmad Haroon Baray, Temesgen Anjulo Ageru, Charuai Suwanbamrung, Kahsu Gebrekidan
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  • Burden of hypertension in Ghana – Analysis of awareness and screening campaign in the Ashanti Region of Ghana
    Elliot Koranteng Tannor, Obed Ofori Nyarko, Yaw Adu-Boakye, Saabea Owusu Konadu, Gilda Opoku, Frank Ankobea-Kokroe, Mercy Opare Addo, Evans Xorse Amuzu, Gilgal Justice Ansah, Kate Appiah-Boateng, Daniel Ansong
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The Association of Body Fat and Arterial Stiffness Using the Brachial-Ankle Pulse Wave Velocity
Gyu Lee Kim, Hye Rim Hwang, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Dong Wook Jeong, Yu Hyeon Yi, Young Jin Tak, Seung Hun Lee, A Rum Park
Korean J Fam Med 2018;39(6):347-354.   Published online October 31, 2018
DOI: https://doi.org/10.4082/kjfm.17.0045
Background
BMI alone may not serve as an index of obesity because it does not reflect body composition. The present study aimed to compare arterial stiffness as assessed by the brachial-ankle pulse wave velocity (ba-PWV) among groups defined by body fat percentage (pBF) and BMI.
Methods
This cross-sectional study was based on 1,700 participants (1,044 men and 656 women) who completed a health screening examination at a national hospital between January 2011 and February 2016. Participants were divided into four groups according to BMI and pBF: normal fat and normal weight (NFNW); excessive fat and normal weight (EFNW); normal fat and obese (NFO); and excessive fat and obese (EFO). The ba-PWV and other cardiometabolic factors were compared among the four groups in men and women separately.
Results
For both sexes, the NFNW group had a lower metabolic risk compared to that in the other groups (EFNW, NFO, and EFO). After adjusting for multiple variables, the NFO males had a significantly lower ba-PWV compared to those in the other groups, including NFNW males. The NFO group had significantly more skeletal muscle mass and muscle mass compared the other groups (P<0.05). Among women, the NFNW group had a significantly lower ba-PWV compared the other groups, even after adjusting for multiple variables.
Conclusion
Lower pBF in obese men may be associated with improved cardiovascular risk.

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Erratum

Correction: The Effect of Lifestyle Changes on Blood Pressure Control among Hypertensive Patients
Myung Hwa Yang, Seo Young Kang, Jung Ah Lee, Young Sik Kim, Eun Ju Sung, Ka-Young Lee, Jun-Su Kim, Han Jin Oh, Hee Chul Kang, Sang Yeoup Lee
Korean J Fam Med 2017;38(5):311-312.   Published online September 22, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.5.311

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Original Articles

The Effect of Lifestyle Changes on Blood Pressure Control among Hypertensive Patients
Myung Hwa Yang, Seo Young Kang, Jung Ah Lee, Young Sik Kim, Eun Ju Sung, Ka-Young Lee, Jun-Su Kim, Han Jin Oh, Hee Chul Kang, Sang Yeoup Lee
Korean J Fam Med 2017;38(4):173-180.   Published online July 20, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.4.173
Background

Hypertension is highly prevalent among patients who visit primary care clinics. Various factors and lifestyle behaviors are associated with effective blood pressure control. We aimed to identify factors and lifestyle modifications associated with blood pressure control among patients prescribed antihypertensive agents.

Methods

This survey was conducted at 15 hospital-based family practices in Korea from July 2008 to June 2010. We prospectively recruited and retrospectively assessed 1,453 patients prescribed candesartan. An initial evaluation of patients' lifestyles was performed using individual questions. Follow-up questionnaires were administered at 4, 8, and 12 weeks. We defined successful blood pressure control as blood pressure <140 mm Hg systolic and <90 mm Hg diastolic.

Results

Of the 1,453 patients, 1,139 patients with available data for initial and final blood pressures were included. In the univariate analysis of the change in performance index, weight gain (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.52 to 3.11; P<0.001), physical inactivity (OR, 1.195; 95% CI, 1.175 to 3.387; P=0.011), and increased salt intake (OR, 1.461; 95% CI, 1.029 to 2.075; P=0.034) were related to inadequate blood pressure control. Salt intake also showed a significant association. Multivariate ORs were calculated for age, sex, body mass index, education, income, alcohol consumption, smoking status, salt intake, comorbidity, and family history of hypertension. In the multivariate analysis, sex (OR, 3.55; 95% CI, 2.02 to 6.26; P<0.001), salt intake (OR, 0.64; 95% CI 0.43 to 0.97; P=0.034), and comorbidity (OR, 1.82; 95% CI, 1.23 to 2.69; P=0.003) were associated with successful blood pressure control.

Conclusion

Weight gain, physical inactivity, and high salt intake were associated with inadequate blood pressure control.

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  • Correction: The Effect of Lifestyle Changes on Blood Pressure Control among Hypertensive Patients
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Shift Work Is Associated with Metabolic Syndrome in Young Female Korean Workers
Kyoung Hwa Yu, Yu Hyeon Yi, Yun Jin Kim, Byung Mann Cho, Sang Yeoup Lee, Jeong Gyu Lee, Dong Wook Jeong, So Yeon Ji
Korean J Fam Med 2017;38(2):51-56.   Published online March 22, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.2.51
Background

Shift work is associated with health problems, including metabolic syndrome. This study investigated the association between shift work and metabolic syndrome in young workers.

Methods

A total of 3,317 subjects aged 20–40 years enrolled in the 2011–2012 Korean National Health and Nutrition Examination Survey were divided into shift and day workers. We conducted a cross-sectional study and calculated odds ratios using multivariate logistic regression analysis in order to examine the association between shift work and metabolic syndrome.

Results

The prevalence of metabolic syndrome was 14.3% and 7.1% among male and female shift workers, respectively. After adjusting for confounding factors, shift work was associated with metabolic syndrome in female workers (odds ratio, 2.53; 95% confidence interval, 1.12 to 5.70).

Conclusion

Shift work was associated with metabolic syndrome in young women. Timely efforts are necessary to manage metabolic syndrome in the workplace.

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    Work.2022; 71(4): 1175.     CrossRef
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    Chaohui Dong, Honglian Zeng, Bo Yang, Yi Zhang, Zhitao Li
    BMC Cardiovascular Disorders.2022;[Epub]     CrossRef
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    Sleep Medicine Reviews.2021; 57: 101427.     CrossRef
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    Yihui Wang, Li Yu, Yinyan Gao, Lili Jiang, Lin Yuan, Pengju Wang, Yanwen Cao, Xuping Song, Long Ge, Guowu Ding
    Chronobiology International.2021; 38(3): 318.     CrossRef
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    Xingjin Yang, Wencheng Di, Yunhong Zeng, Dechen Liu, Minghui Han, Ranran Qie, Shengbing Huang, Yang Zhao, Yifei Feng, Dongsheng Hu, Liang Sun
    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(10): 2792.     CrossRef
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    Seong-Ryol Chai, Soon-Chan Kwon, Yong-Jin Lee, Eun-Chul Jang, Young-Sun Min, Su-yeon Lee
    Annals of Occupational and Environmental Medicine.2021;[Epub]     CrossRef
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    Arpita Shah, Arifa Turkistani, Kanita Luenam, Sayma Yaqub, Patricia Ananias, Arunima Mariya Jose, Joao Pedro Melo, Lubna Mohammed
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    Heeja Jung, Hyunju Dan, Yanghee Pang, Bohye Kim, Hyunseon Jeong, Jung Eun Lee, Oksoo Kim
    International Journal of Environmental Research and Public Health.2020; 17(20): 7697.     CrossRef
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    Maryam Nikpour, Aram Tirgar, Mahmod Hajiahmadi, Akram Hosseini, Behzad Heidari, Fatemeh Ghaffari, Abbas Ebadi, Fatemh Nasiri, Mojgan Firouzbakht
    Biomedical Reports.2019;[Epub]     CrossRef
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    Ramin Mehrdad, Gholamreza Pouryaghoub, Mahboubeh Moradi
    The International Journal of Occupational and Environmental Medicine.2018; 9(1): 45.     CrossRef
  • The Relationship between Workplace Environment and Metabolic Syndrome
    Hwee-Soo Jeong
    The International Journal of Occupational and Environmental Medicine.2018; 9(4): 176.     CrossRef
  • Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health
    Santiago A. Plano, Leandro P. Casiraghi, Paula García Moro, Natalia Paladino, Diego A. Golombek, Juan J. Chiesa
    Frontiers in Neurology.2017;[Epub]     CrossRef
  • Shift Work and Health Problems
    Jungun Lee
    Korean Journal of Family Medicine.2017; 38(2): 49.     CrossRef
  • 5,739 View
  • 69 Download
  • 20 Web of Science
  • 20 Crossref
Vitamin-Mineral Supplement Use Patterns in Elderly Koreans: Data from the 2007–2008 Korean National Health and Nutrition Examination Survey
So Young Park, Yun Jin Kim, Sang Yeoup Lee, Jeong Gyu Lee, Hye Rim Hwang, Dong Wook Jeong, Young Hye Cho, Eun Jung Choi, Yu Hyeon Yi, Young Jin Tak, A Ra Jo, Seung Hoon Lee, Jeong Suk Jeon, Bo Wha Lee
Korean J Fam Med 2016;37(2):123-129.   Published online March 25, 2016
DOI: https://doi.org/10.4082/kjfm.2016.37.2.123
Background

Vitamin-mineral supplements are the most popular dietary supplements in Korea. However, few studies have assessed the relationship between vitamin-mineral supplementation and associated factors among the Korean elderly. The purpose of this study was to assess the use of vitamin-mineral supplements among elderly in Korea as well as its association with sociodemographic factors, health-related behaviors, medical conditions, and nutrient intake.

Methods

This study was based on data from the Korean National Health and Nutrition Examination Survey, conducted by the Korean Ministry of Health and Welfare from 2008 to 2009. Data from 3,294 elderly men and women (65 years of age and older) were analyzed. Multivariable-weighted logistic regression model analysis was used to evaluate the association between vitamin-mineral supplement use and sociodemographic factors, health-related habits, and medical conditions.

Results

Vitamin-mineral supplementation was reported by 16.3% of the participants. The most common reason for using dietary supplements was recommendations from friends and acquaintances. Highly educated person, female participants had a greater likelihood of taking vitamin-mineral supplements. In addition, analysis of nutrient intake from food sources alone revealed a lower proportion of vitamin-mineral supplement users with nutrient intakes below the estimated average requirements for vitamin A, vitamin C, thiamine, riboflavin, niacin, calcium, iron, and phosphorus, compared to nonusers. However, vitamin-mineral supplementation was not associated with health-related behaviors or medical conditions.

Conclusion

Highly educated person, elderly Korean women had a greater likelihood of using vitamin-mineral supplements. In addition, nutrient intakes from food sources alone were significantly higher among vitamin-mineral supplement users. Finally, vitamin-mineral supplementation may be an indicator of healthier diet in elderly Koreans.

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  • Effect of a Single Multi-Vitamin and Mineral Supplement on Nutritional Intake in Korean Elderly: Korean National Health and Nutrition Examination Survey 2018–2020
    Hyoeun Kim, Seung Guk Park
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  • The Reason for Vitamin–Mineral Supplement Intake among Secondary School Adolescents in Malaysia and its Association with Nutritional Status and Dietary Practice
    Azli Baharudin, Fatimah Othman, Syafinaz Mohd Sallehuddin, Suhaila Abd Ghafar, Khairul Hasnan Amali, Norazizah Ibrahim Wong, Ahmad Ali Zainuddin
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    Wanyue Dong, Zhonghe Sun, Ruhai Bai
    Frontiers in Public Health.2022;[Epub]     CrossRef
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    Manuel Enrique Machado-Duque, Juan Daniel Ayala-Torres, Jorge Enrique Machado-Alba
    Revista Médicas UIS.2020;[Epub]     CrossRef
  • Impact of diet-derived signaling molecules on human cognition: exploring the food–brain axis
    Raymond L. Rodriguez, John G. Albeck, Ameer Y. Taha, Kassandra M. Ori-McKenney, Gregg H. Recanzone, Tyler W. Stradleigh, Bronte C. Hernandez, Feng-Yao Vincent Tang, En-Pei Isabel Chiang, Lillian Cruz-Orengo
    npj Science of Food.2017;[Epub]     CrossRef
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    Jeffrey Blumberg, Balz Frei, Victor Fulgoni, Connie Weaver, Steven Zeisel
    Nutrients.2017; 9(8): 849.     CrossRef
  • AVALIAÇÃO DA ROTULAGEM DE SUPLEMENTOS VITAMÍNICOS E/OU MINERAIS
    Andressa Barros Ibiapina, Monalisa de Alencar Lucena, Camila dos Reis Oliveira, Lucas Vaz de Castro Oliveira, Alessandra Braga Ribeiro
    Infarma - Ciências Farmacêuticas.2017; 29(1): 21.     CrossRef
  • 5,100 View
  • 38 Download
  • 4 Web of Science
  • 7 Crossref

Case Report

A Case of Scrub Typhus Complicated by Acute Calculous Cholecystitis
Su Jin Lee, Young Hye Cho, Sang Yeoup Lee, Dong Wook Jeong, Eun Jung Choi, Yun Jin Kim, Jeong Gyu Lee, Yu Hyun Lee
Korean J Fam Med 2012;33(4):243-246.   Published online July 25, 2012
DOI: https://doi.org/10.4082/kjfm.2012.33.4.243

We report a case of acute calculous cholecystitis through scrub typhus. A 69-year-old woman presented with a history of general myalgia, fever, and right abdominal pain. She referred to our hospital for surgical treatment of clinically suspected acute cholecystitis. Physicians concluded the cause of cholecystitis as gall bladder (GB) stone and proper antibiotics treatment of scrub typhus was started later. The patient developed acute respiratory distress syndrome and multi organ failure through scrub typhus. Five days after admission, the patient was treated with proper antibiotics and discharged on the 13th day after starting doxycycline treatment without any sequelae. In areas endemic for tsutsugamushi disease, even though a patient with GB stone presents with symptoms of acute cholecystitis, careful history and physical examination are required to reveal the existence of eschars or skin eruptions.

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  • Acalculous Cholecystitis in a Young Adult with Scrub Typhus: A Case Report and Epidemiology of Scrub Typhus in the Maldives
    Hisham Ahmed Imad, Aishath Azna Ali, Mariyam Nahuza, Rajan Gurung, Abdulla Ubaid, Aishath Maeesha, Sariu Ali Didi, Rajib Kumar Dey, Abdullah Isneen Hilmy, Aishath Hareera, Ibrahim Afzal, Wasin Matsee, Wang Nguitragool, Emi. E. Nakayama, Tatsuo Shioda
    Tropical Medicine and Infectious Disease.2021; 6(4): 208.     CrossRef
  • Acute Cholangitis Caused by Boryong Strain of Orientia tsutsugamushi
    Keun Hwa Lee, Sang Taek Heo, Seung Uk Jeong, Mi-yeon Kim, Woo Seong Jeong, Chang Lim Hyun, Young-Kyu Kim, Jeong Rae Yoo
    Infection & Chemotherapy.2020; 52(4): 621.     CrossRef
  • Acute Severe Calculous Cholecystitis with Multiorgan Failure Complicated by Scrub Typhus
    Suman Acharya, Jayant Kumar Yadav, Nischal Khanal, Raju Bhandari, Bikal Ghimire
    Case Reports in Surgery.2019; 2019: 1.     CrossRef
  • Clinical manifestations of scrub typhus
    Senaka Rajapakse, Praveen Weeratunga, Sriharan Sivayoganathan, Sumadhya Deepika Fernando
    Transactions of The Royal Society of Tropical Medicine and Hygiene.2017; 111(2): 43.     CrossRef
  • Acute Cholecystitis in Patients with Scrub Typhus
    Hyun Lee, Misuk Ji, Jeong-Hwan Hwang, Ja-Yeon Lee, Ju-Hyung Lee, Kyung Min Chung, Chang-Seop Lee
    Journal of Korean Medical Science.2015; 30(11): 1698.     CrossRef
  • Outcome of Intravenous Azithromycin Therapy in Patients with Complicated Scrub Typhus Compared with That of Doxycycline Therapy Using Propensity-Matched Analysis
    Mi-Ok Jang, Hee-Chang Jang, Uh Jin Kim, Joon Hwan Ahn, Seung-Ji Kang, Sook-In Jung, Hee-Young Shin, Kyung-Hwa Park
    Antimicrobial Agents and Chemotherapy.2014; 58(3): 1488.     CrossRef
  • 3,836 View
  • 24 Download
  • 6 Crossref

Brief Communication

Changes in Skin Color after Smoking Cessation
Young Hye Cho, Dong Wook Jeong, Sang Hee Seo, Sang Yeoup Lee, Eun Jung Choi, Yun Jin Kim, Jeong Gyu Lee, Yu-Hyun Lee, Mi Jin Bae, Hyun Woo Chin
Korean J Fam Med 2012;33(2):105-109.   Published online March 30, 2012
DOI: https://doi.org/10.4082/kjfm.2012.33.2.105

This study was performed to assess changes in skin color over 1 month after smoking cessation. The study population consisted of 49 men who participated in a smoking cessation program from March 2010 to June 2010 at a public health centre in Yangsan, South Korea. Thirty-four men who stop smoking completely were included in our study. Instrumental evaluations of skin color were performed using Mexameter (MX 18; Courage and Khazaka Electronic GmbH) at the beginning of the study and at 1-week and 4-week follow-up visits. Skin color was evaluated by measurement of 2 main color bases-melanin and haemoglobin-with the results expressed as melanin index (MI) and erythema index (EI). Both MI and EI were significantly reduced at the 4-week follow-up visit on all 7 sites measured. We anticipate that desirable effects on skin color after smoking cessation will play a positive role in maintaining smoking abstinence in routine clinical practice.

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  • Melanin levels in relation to vitamin D among first-generation immigrants from different ethnic groups and origins: A comparative national Canadian cross-sectional study
    Said Yousef, Manny Papadimitropoulos, MoezAlIslam Faris, Hayder Hasan, Alomgir Hossain, Ian Colman, Douglas Manuel, George A. Wells
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Promoting New Approach Methodologies (NAMs) for research on skin color changes in response to environmental stress factors: tobacco and air pollution
    Katherine Virginia Bouchard, Gertrude-Emilia Costin
    Frontiers in Toxicology.2023;[Epub]     CrossRef
  • Engaging with still-smokers

    Dental Nursing.2022; 18(3): 134.     CrossRef
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    Hyerim Han, Jimin Lee
    International Journal of Adolescence and Youth.2021; 26(1): 405.     CrossRef
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    Abigail K Langton, Evridiki Tsoureli‐Nikita, Holly Merrick, Xuegen Zhao, Christina Antoniou, Alexander Stratigos, Riaz Akhtar, Brian Derby, Michael J Sherratt, Rachel EB Watson, Christopher EM Griffiths
    The Journal of Pathology.2020; 251(4): 420.     CrossRef
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    Joshua J.X. Li, Joanna K.M. Ng, Amy B.W. Chan
    Pathology.2019; 51(6): 600.     CrossRef
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    Alex L. Jones
    Evolution and Human Behavior.2018; 39(1): 19.     CrossRef
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    M.J.W. Thompson, G. Jones, D.A. Aitken
    Osteoporosis International.2018; 29(8): 1887.     CrossRef
  • Linking Vitamin D Deficiency to Inflammatory Bowel Disease
    Matthew T. Palmer, Casey T. Weaver
    Inflammatory Bowel Diseases.2013; 19(10): 2245.     CrossRef
  • 8,397 View
  • 37 Download
  • 9 Crossref

Original Article

Usefulness of Sagittal Abdominal Diameter for Evaluation of Metabolic Syndrome and Insulin Resistance.
Yu Hyeon Yi, Dong Wook Jung, Jeong Gyu Lee, Yun Jin Kim, Sang Yeoup Lee, Yeong Joo Kim, Han Chul Son, Ha Lin Lee, Young Hye Cho
Korean J Fam Med 2011;32(1):46-55.   Published online January 20, 2011
DOI: https://doi.org/10.4082/kjfm.2011.32.1.46
Background
We studied the association of sagittal abdominal diameter (SAD) and metabolic syndrome and insulin resistance in Korean adults.Methods: This is a cross-sectional study by 190 patients who visited a Health Promotion Center of National University of Pusan from 11 November to 14 November, 2008. We analyzed the association of anthropometry (waist circumference, BMI, SAD), insulin resistance (homeostatic model assessment-insulin resistance, HOMA-IR), insulin sensitivity (quantitative insulin sensitivity check index, QUICKI), and plasma concentrations of glucose, insulin, total cholesterol, LDL, HDL, triglyceride. SAD was categorized into quartiles and assessed odds ratio of metabolic syndrome adjusted for age, sex, lifestyle factors.Results: SAD showed significance correlation to HOMA-IR than BMI. Quartiles of SAD showed a positive trend with metabolic risk factors including abdominal obesity, high blood pressure, HOMA-IR and obesity but hypertriglyceridemia, low HDL-cholesterolemia did not show signifi cant association. In men QUICKI was signifi cantly high. A multivariate model, adjusted for age, sex, smoking status, physical activity, heavy drinking, HOMA-IR and QUICKI, revealed a progressively increased odds ratio of metabolic syndrome, 3rd quartile (odds ratio [OR]; 9.467; 95% confi dence interval [CI], 3.225 to 27.789; P < 0.001) and 4th quartile (OR, 7.253; 95% CI, 2.437 to 21.586; P < 0.001), with increasing SAD.Conclusion: As shown above, SAD was a strong anthropometric marker of insulin resistance, risk of metabolic syndrome and decreased insulin sensitivity in Korean adults.

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  • Comparison of health-related habits and metabolic syndrome risk factors according to obesity type in Korean postmenopausal women
    Han-Gyo Choi, Hye-Jin Kim
    Menopause.2020; 27(9): 1022.     CrossRef
  • Biomarkers and their relative contributions to identifying coronary artery stenosis based on coronary computed tomography angiography in asymptomatic adults
    A. Ra Cho, Sang Yeoup Lee
    Clinica Chimica Acta.2019; 499: 128.     CrossRef
  • The Differences of Metabolic Syndrome Risk Factors according to Obesity and Abdominal Obesity in Elderly Korean Women
    Kyung-A Shin
    The Korean Journal of Clinical Laboratory Science.2016; 48(4): 304.     CrossRef
  • The Correlation between the Triglyceride to High Density Lipoprotein Cholesterol Ratio and Computed Tomography-Measured Visceral Fat and Cardiovascular Disease Risk Factors in Local Adult Male Subjects
    Hye-Rin Park, Sae-Ron Shin, A Lum Han, Yong Joon Jeong
    Korean Journal of Family Medicine.2015; 36(6): 335.     CrossRef
  • Association between Metabolic Components and Subclinical Atherosclerosis in Korean Adults
    In Cheol Hwang, Sang-Yeon Suh, Ah-Ram Seo, Hong Yup Ahn, Eunji Yim
    Korean Journal of Family Medicine.2012; 33(4): 229.     CrossRef
  • 3,321 View
  • 16 Download
  • 5 Crossref

Case Report

A Case of Co-infection of Salmonella typhi and Viral Hepatitis A after Traveling Abroad.
Young Hye Cho, Dong Wook Jeong, Sang Yeoup Lee, Son Ki Park, Ah Ra Cho, Su Jin Lee, Hee Kyoung Choi, Yun Jin Kim, Jeong Ku Lee, Yu Hyun Lee
Korean J Fam Med 2010;31(12):937-940.   Published online December 20, 2010
DOI: https://doi.org/10.4082/kjfm.2010.31.12.937
Infectious diseases imported from other countries have increased. Feco-oral route is the most common mode of transmission for both typhoid fever and hepatitis A, and thus infection by these agents have an association with poor sanitation. A 30-year-old male was visited to the hospital because of high fever after traveling in Thailand. The level of hepatic transaminases were mildly elevated and viral serological marker for hepatitis was negative. The blood culture was reported positive for Salmonella typhi. After a few days, the level of hepatic transaminases rapidly increased and viral serological marker for hepatitis became positive with anti-hepatitis A viral IgM at follow-up. Therefore we report a case of co-infection of S. typhi and viral hepatitis A after traveling abroad.
  • 1,975 View
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Review

Edema.
Dong Wook Jeong, Sang Yeoup Lee
Korean J Fam Med 2010;31(11):829-836.   Published online November 20, 2010
DOI: https://doi.org/10.4082/kjfm.2010.31.11.829
Generalized or localized edema is a very common symptom in primary care. Edema is developed from an imbalance in the filtration system between the vessel and interstitial spaces. A systematic approach is extremely important to determine the underlying diagnosis, because its management plan depends on the cause of edema. Treatment includes sodium restriction, diuretic use, appropriate management of the underlying disorder, et al. This review can be helpful in establishing the management of edema in clinical practice.

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  • Effect of Gyrokinesis Exercise on Lower Extremity Edema, Balance Ability, and Fatigue in office Women Workers
    Mi-Kyung Kim, Kyoung-Bin Min
    The Asian Journal of Kinesiology.2024; 26(3): 47.     CrossRef
  • A Case Study of Eyelid Edema Post Craniotomy
    Seo-young Kim, Jeong-woo Choi, Tae-bin Yim, Hye-jin Lee, Seung-yeon Cho, Seong-uk Park, Jung-mi Park, Chang-nam Ko
    The Journal of Internal Korean Medicine.2021; 42(5): 939.     CrossRef
  • Etiologies and Underlying Diseases of Leg Edema in Elderly Patients
    Seung Gyu Han, Youn Kyung Kee, Sung Woo Moon, Chang-Yun Yoon, Eunyoung Lee, Young Su Joo, In Mee Han, Eun Young Lee, Chang Oh Kim
    Journal of the Korean Geriatrics Society.2014; 18(2): 78.     CrossRef
  • 4,616 View
  • 362 Download
  • 3 Crossref

Original Article

Factors Related to Eating Behavior Assessed Using the Dutch Eating Behavior Questionnaire and Change of Eating Behavior after Receiving Weight Reduction Treatment.
Sukyeong Lee, Kayoung Lee, Sang Yeoup Lee, Tae Jin Park, Jun Su Kim
Korean J Fam Med 2010;31(5):361-368.   Published online May 20, 2010
DOI: https://doi.org/10.4082/kjfm.2010.31.5.361
Background
This study aimed to examine the factors related to eating behavior subscales and change of eating behavior subscales among obese patients received weight reduction management. Methods: Eating behavior subscales (restrained eating, emotional eating, and external eating) were assessed using the Korean version of Dutch Eating Behavior Questionnaire in 76 obese female patients at obesity clinic and 83 female visitors at health promotion center. Fifty nine patients received weight reduction management and completed followup survey after 2-3 months. Demographics, physical activity, health behaviors, diet experience, BMI, and weight change were assessed. Results: The score of restrained eating was significantly higher in obese patients compared to controls, while scores of other subscales were not different between the two groups. Diet experience, score of emotional eating, and BMI explained 15% of variance of restrained eating score after adjustment for covariates. Likewise, increase of restrained and external eating scores and younger age explained 27% of variance of emotional eating score. External eating score was associated with increase in emotional eating score, higher education, regular exercise, and frequent overeating (R2 = 30%). Among obese patients, the follow-up score of restrained eating was significantly higher compared to that score at baseline, while the scores of emotional and external eating were not significantly changed. After adjustment for covariates, only irregular eating habit was associated with the change of restrained eating score. Conclusion: Restrained eating score was associated with BMI regardless of subjects group, while, among obese patients, the change of restrained eating score was associated with frequent irregular eating habit.

Citations

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  • Relationship between convergence awareness for healthy weight management and eating behavior, creativity and convergence competency of adolescents
    Yunhwa Kim, Youngmi Lee, Yeon-Kyung Lee
    Journal of Nutrition and Health.2022; 55(3): 376.     CrossRef
  • Body Image Perception and Eating Behaviors among Male Middle and High School Students according to Weight Status in Seoul
    Bo-Mi Kim, Kyung-Hee Kim
    Journal of the East Asian Society of Dietary Life.2018; 28(2): 123.     CrossRef
  • Short-term Effects of a Lifestyle Intervention Program on Eating Behaviors, Physical Activity and Cardiovascular Risks in Korean Adults
    Jiyeon Park, Hyekyeong Kim
    Korean Journal of Health Education and Promotion.2014; 31(4): 37.     CrossRef
  • 2,186 View
  • 49 Download
  • 3 Crossref

Case Report

A Case of Tsutusgamushi Disease with Atypical Symptom.
Dae Woo Kim, Kook Huyng Lee, Sang Yeoup Lee, Hong Gi Min, Young Joo Kim, Yun Jin Kim
J Korean Acad Fam Med 2006;27(9):741-745.   Published online September 10, 2006
A 59 year old woman visited the hospital complaining of sore throat, chill, myalgia and whole body skin rash. There was abnormal finding of fever, sinus tachycardia, increased lactic dehydrogenase and elongation prothrombin time. We started treatment with acetaminophen and fluid because she had not specific history of visiting to the mountain or field, etc. After treatment increased aspartate aminotransferase/alanine aminotransferase and thrombocytopenia appeared without symptomatic improvement so that we investigated tsutsugamushi antibodies and diagnosed her condition as Tsutsugamushi disease with polyuria. But the clinical manifestation in our case showed atypical symptom which had polyuria. There is no report on that in Korea and over the world therefore the author et al. report of case of Tsutsugamushi disease with polyuria, atypical symptom.
  • 1,397 View
  • 15 Download

Original Articles

The Actual State of Handwashing in Nurses in Medical and Surgical Wards of a University Hospital.
Myung Hee Kim, Ju Sung Kim, Hyun Kyeong Jung, Sang Yeoup Lee, Jung Soon Kim, In Soon Kang
J Korean Acad Fam Med 2003;24(6):565-569.   Published online June 10, 2003
Background
: This study investigated the handwashing in clinical nurses for prevention and control of nosocomial infection.

Methods : The subjects were 192 nurses at a university hospital in Busan. The data were collected using questionnaires, which included items to measure the method, application time, and frequency of handwashing related to nursing intervention activities, and were analyzed using the mean score, frequency and percentage.

Results : Each day, the nurses had an average of 10.5 times of hand washing. 34.9% of nurses had evaluated "not enough" concerning their handwashing performance. Nurses indicated that the performance of handwashing had interrupted by overwork, lack of facilities, skin irritation with itching, etc. 19.4% of nurses had not received education program about handwashing. Some nurses did not strictly follow a handwashing protocol allowing potential chances of nosocomial infection to occur. The rate of handwashing performance increased after the activities of nursing intervention than before activities related to respiration, nutrition, elimination, hygiene, medication, etc.

Conclusion : These findings suggest that hospital administrators must develop education programs and policies for the prevention of nosocomial infection. We recommend that nurses participate in education to search for practical methods to improve the management of nosocomial infection such as handwashing performance.
  • 1,388 View
  • 22 Download
Influence of HMG-CoA Reductase Inhibitors on Bone Mass in Postmenopausal Women.
Sang Yeoup Lee, Yun Jin Kim
J Korean Acad Fam Med 2003;24(5):451-455.   Published online May 10, 2003
Background
: It is controversial whether the use of HMG CoA reductase inhibitors (statins) is associated with an increased bone mineral density (BMD) in humans. The purpose of this study was to assess the influence of statins on BMD in Korean postmenopausal women.

Methods : Forty-four postmenopausal women (aged 54.3±5.8 years) were included. The statin users (n=24) were administered either simvastain, atorvastatin, pravastatin, or lovastatin. The control group (n=20) did not take statins. BMD of the spine were measured by dual-energy X-ray absorptiometry. Alkaline phosphatase (ALP) was tested as a bone marker. The data were analysed with two-sample t test and paired t-test.

Results : The mean annual spinal BMD changes of the study groups were -1.5±5.6% for statin users and -0.2±4.2% for control group. There was no statistically significant difference in mean annual spinal BMD changes (P=0.696). The mean annual ALP changes of the study groups were -5.6±18.1% for the statin users and -0.4±13.9% for the control group. There was no statistically significant difference in mean annual ALP changes (P=0.246). In each group, the spinal BMD significantly was not changed after 1 year (P>0.05).

Conclusion : This study suggest that statins do not protect from bone loss in Korean postmenopausal women.
  • 1,250 View
  • 15 Download
The Association of Prostate Volume with Obesity Index.
Hong Gi Min, Sang Yeoup Lee, Sung Ryul Ahn, Yong Ju Kim, Sang Han Choi, Yun Jin Kim
J Korean Acad Fam Med 2002;23(12):1453-1461.   Published online December 10, 2002
  • 1,254 View
  • 14 Download

Case Report

A Case of Nonthyroidal Illness Syndrome in a Patient with Severe Liver Cirrhosis with Difficult Differential Diagnosis from Central Hypothyroidism.
Sang Yeoup Lee, Yun Jin Kim
J Korean Acad Fam Med 2002;23(9):1141-1147.   Published online September 10, 2002
  • 1,072 View
  • 14 Download

Original Article

The Association between Blood Pressure and Bone Mineral Loss in Perimenopausal Women; A Cross Sectional Study.
Nam Wook Yoo, Sang Yeoup Lee, Young Joo Kim, Sang Han Choi, Yun Jin Kim
J Korean Acad Fam Med 2002;23(6):787-793.   Published online June 30, 2002
  • 1,231 View
  • 12 Download

Note

Incidence of Influenza-like Illness after Influenza Vaccination in the Elderly.
Sang Yeoup Lee, Won Hee Choi, Sang Han Choi, Yun Jin Kim, Byeung Man Cho
J Korean Acad Fam Med 2002;23(5):652-656.   Published online May 31, 2002
  • 1,370 View
  • 29 Download
Original Articles
The association of obesity with erectile dysfunction.
Jung Ho Han, Seok Woo Ryu, Hyun Ho Kim, Sang Yeoup Lee, Yun Jin Kim
J Korean Acad Fam Med 2001;22(7):1112-1118.   Published online July 1, 2001
Background
: Many studies have shown that obesity is associated with sexual dysfunction and causes erectile dysfunction particularly, but these studies are mainly about chronic diseases caused by obesity. Therefore, we conducted a study to evaluate the association of obesity in itself with erectile dysfuntion.

Methods : The study sample consisted of men, aged over 20 who visited in a university hospital in Pusan from December 1999 to March 2000, who responded to the Korean version of the international index of erectile function(IIEF). The patients having obesity-related diseases were excluded from the subject group. The subjects were classified into 'obese', 'normal' group according to body mass index(BMI) and erectile function was classified into 'erectile dysfunction', 'normal' according to IIEF-5 score. Chi-square test and Fisher's exact test were performed for statistic analysis.

Results : The mean age was 42.1. In total 160 subjects. 109 men(68.1%)belonged to the normal group and 51(31.9%) to the obese group. and 100 men(62.5) had erectile dysfunction. In normal group, 43(39.4%) had normal erectile function and 66(60.6%) and erectile dysfunction. In obese group, 17(3.3%) were normal and 34(66.7%) had erectile dysfunction. No significant difference between two groups was noted in erectile function (P>0.05).

Conclusion : There was no significant association of obesity in itself with erectile dysfunction in this study after excluding effects of other obesity-related problems.
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A prospective study on the antihypertensive monotherapy in family practice.
Young Sik Kim, Byung Sung Kim, Kyung Soo Kim, Hoon Ki Park, Yoo Seock Cheong, Esther Yeo, Tae Hee Jun, Seung Pil Jung, Ji Ho Choi, Sang Yeoup Lee, Yun Jin Kim, Young Kyu Park
J Korean Acad Fam Med 2001;22(6):828-839.   Published online June 1, 2001
Background
: There are very few cohort studies on the hypertension in family practice. In order to investigate epidemiological characteristics of hypertensive patients and assess the safety and tolerabiliy of newly prescribed antihypertensive monotherapies in Korean patients, a prospective study was carried out.

Methods : A total of 1,181 patients were observed from July 1997 to August 1999. At 2,4,8 and 12 weeks after initiation of antihypertensive monotherapy, the patients were evaluated for whether treatment is continued and development of any adverse reactions.

Results : Calcium channel blockers(CCBs) were the most commonly prescribed initial drug class(44.2%) in family practice, followed by angiotensin converting enzyme inhibitors(ACEI) (21.0%), angiotensin II receptor antagonists(ARA) (11.8%), B-blockers(9.6%), a-blockers(3.9%), and diuretics(3.6%), During the first 12 weeks, the percentage of subjects continuing their initial ACEIs(40.7%) was substantially lower than the percentages that of subjects continuing ARAs(66.2%), a- blockers*(63.0%), CCBs(61.3%), B-blockers(55.8%), and diuretics(53.5%), respectively(P<0.001), The following adverse reactions were detected: cough(7.5%), headache(6.1%), dizziness(3.9%), flushing(3.7%), and impotence(2.4%). The incidence of cough associated with ACEI(27.9%), was higher than those of other classes(P<0.01)

Conclusion : CCBs were the most commonly prescribed initial drug class in family practice, followed by ACEIs, ARAs, B-blockers, a-blockers, and diuretics. The tolerability of antihypertensive medication was the highest in Korean patients treated with ARAs, followed by CCBs, B-blockers, diuretic, a-blocker, and ACEIs.
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Serum lipoprotein(a) and lipid concentrations in patients with subclinical hypothyroidism.
Kyoung Eun Kim, Ok Hee Lee, Ji Hyun Moon, Sang Yeoup Lee, Yun Jin Kim
J Korean Acad Fam Med 2001;22(3):345-353.   Published online March 1, 2001
Background
: There are no agreement for abnormalities in serum lipid concentrations and lipoprotein(a) (Lp(a)) in patients with subclinical hypothyroidism. But there are no reports for consideration of postmenopausal state and hormone replacement therapy(HRT). Therefore, we anayzed serum Lp(a) and lipid concentrations in patients with subclinical hypothyroidism considering menopause and HRT and the correlation between serum Lp(a) level and thyroid-stimulating hormone (TSH) concentration.

Methods : We undertook this study in 99 patients with subclinical hypothyroidism (TSH>5uIU/mL) and 297 age- and sex-matched normal control. They and no abnormalities in liver and renal function, fasting blood glucose and medical and drug histories. We excluded who were receiving HRT. Serum free thyroxine, triiodothyronine, TSH were measured by radioimmune assay using commercial kits, and Lp(a), total cholesterol, TG and HDL by Latex and enzyme method, respectively.

Results : There were no significant differences of serum Lp(a), total cholesterol, LDL, TG, HDL concentrations in patients with subclinical hypothyroidism and control subjects, analyzing after dividing into men, premenopausal and postmenopausal women. In patients with subclinical hypothyroidism, there was no correlation between serum Lp(a) and TSH concentraions(r=0.06, P>0.05).

Conclusion : Considering menopause and HRT, there were no increase in serum Lp(a) and lipid concentrations in subclinical hypothyroidism. There was no correlation between serum Lp(a) and TSH concentration in patients with subclinical hypothyroidism.
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Family physician's roles in health promotion, what patients want.
Jae Ho Choi, Jong Wha Lee, Seong Woong Jeong, Song Yee Han, Sang Yeoup Lee, Yun Jin Kim
J Korean Acad Fam Med 2001;22(2):230-240.   Published online February 1, 2001
Background
: Family physicians are interested in health promotion for maintaining one's sound health. But there is little information on what patients think about the practice of health promotion by family physicians. Therefore, we found out whether patiens think that it is appropriate for family physicians to be concerned about problems relating to four health risk factors, and the patients' perception both of their own health problems and of the concern actually shown by their family physicians.

Methods : Patients who had visited our two family medicine offices from March to August 1998 was asked to complete a self-administered questionnaire. Questions on attitudes towards and perceptions of family physicians' interest in weight, smoking, drinking, and fitness problems were included. 586 questionnaires with adequare response were analyzed using chi-square test and Mantel-Haenszel's linear trend test.

Results : A total of 586 respondents consisted of 230 men and 356 women. Of the respondents, the proportion of people who thought that family physicians should be concerned about the health risk factors ranged from 83.6% in the case of smoking to 86.5% of fitness, but 76.6% thought their family physicians had in fact been interested in smoking and 72.2% thought so about fitness. There was a significant age-group trend in the case of attitudes towards family physician concern for smoking with larger proportions of older patients (P<0.01). Significantly more women than men thought that their family physicians seemed interested in health risk factor with 62.2% to 70.0% in men and 78.6% to 80.9% in women (P<0.001). There were significant age-group differences in proportions who thought that their family physiciants seemed interested in weight(P<0.001), smoking(P<0.001), and drinking (P<0.05) problems except for fitness problem. 31.6% of the respondents thought that they had a weight problem, 20.5% smoking problem, 14.0% drinking problem, and 28.2% fitness problem.

Conclusion : These results suggest that many patients thought that most of their family physicians seemed interested in health promotion, but felt the need that should be come more interested.
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