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"Su-Hyun Lee"

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"Su-Hyun Lee"

Original Articles
A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue
Sang-Hoon Lee, Doo-Yeoun Cho, Seok-Hoon Lee, Kyung-Sun Han, Sung-Won Yang, Jin-Ho Kim, Su-Hyun Lee, Soo-Min Kim, Kyu-Nam Kim
Korean J Fam Med 2019;40(1):2-8.   Published online October 26, 2018
DOI: https://doi.org/10.4082/kjfm.17.0064
Background
This double-blind, randomized controlled design study aimed to assess the dose-dependent effects of synbiotics on gastrointestinal symptoms of and fatigue in irritable bowel syndrome (IBS).
Methods
Thirty subjects with IBS were randomly assigned into the following three groups and received 2 capsules a day for 8 weeks: (1) high-dose (2 capsules of synbiotics); (2) low-dose (1 capsule of synbiotics and 1 capsule of placebo); and (3) placebo (2 capsules of placebo). At baseline and 8 weeks, they completed the study questionnaires.
Results
Two subjects in the high-dose group were lost to follow-up, leaving a total of 28 patients for the analysis. After 8 weeks, abdominal discomfort, abdominal bloating, frequency of formed stool, fatigue Visual Analog Scale (VAS), and Multidimensional Fatigue Inventory were significantly different among the groups (P=0.002, 0.006, 0.007, 0.028, and 0.041, respectively, by Kruskal-Wallis test). However, only abdominal discomfort, abdominal bloating, frequency of formed stool, and fatigue VAS were significantly improved in the high-dose group compared with those in the placebo group (P=0.002, 0.003, 0.002, and 0.013, respectively) by Mann-Whitney test with Bonferroni correction. No adverse drug reactions were reported.
Conclusion
High-dose synbiotics were superior to placebo in improving bowel symptoms and fatigue of IBS patients, suggesting that synbiotic dosage plays an important role in the treatment of IBS.

Citations

Citations to this article as recorded by  
  • IBS and SIBO: Gut Microbiota, Pathophysiology, and Non-Pharmacological Interventions
    Jelena Šuran, Nikola Pavlović, Joško Božić, Marko Kumrić, Katarina Vukojević, Natalija Filipović, Božo Radić
    Antibiotics.2026; 15(3): 251.     CrossRef
  • Oligosaccharide prebiotics in functional foods and therapeutics: innovations and challenges
    K. S. Sandra, Megh Pravin Vithalkar, Vishnusai Beere, H. B. Bharath, B. Satyanarayana, Mohamed Rafiq, Yogendra Nayak
    3 Biotech.2026;[Epub]     CrossRef
  • Biotic therapies for irritable bowel syndrome: current interventions
    Gina Wodarczyk, Maria Winte, Diana Mastellone, Termen Singh, Joshua DeSipio, Sangita Phadtare
    Gastroenterology Report.2026;[Epub]     CrossRef
  • A randomized trial of inulin for bowel symptoms, depression and quality of life in constipation predominant IBS
    Çağlar Akçalı, Aslı Uçar, Kadri Atay
    Scientific Reports.2025;[Epub]     CrossRef
  • Effectiveness of a Balanced Nine-Strain Synbiotic in Primary-Care Irritable Bowel Syndrome Patients—A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial
    Henning Sommermeyer, Krzysztof Chmielowiec, Malgorzata Bernatek, Pawel Olszewski, Jaroslaw Kopczynski, Jacek Piątek
    Nutrients.2024; 16(10): 1503.     CrossRef
  • The Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis
    Youhe Wu, Yuetong Li, Qi Zheng, Lanjuan Li
    Nutrients.2024; 16(13): 2114.     CrossRef
  • Synbiotics as Treatment for Irritable Bowel Syndrome: A Review
    Henning Sommermeyer, Jacek Piątek
    Microorganisms.2024; 12(7): 1493.     CrossRef
  • The effects of synbiotic supplementation on oxidative stress markers, mental status, and quality of life in patients with Parkinson’s disease: A double-blind, placebo-controlled, randomized controlled trial
    Sanaz Mehrabani, Fariborz Khorvash, Zahra Heidari, Maryam Tajabadi-Ebrahimi, Reza Amani
    Journal of Functional Foods.2023; 100: 105397.     CrossRef
  • Irritable Bowel Syndrome: Treating the Gut and Brain/Mind at the Same Time
    Maleesha Jayasinghe, John A Damianos, Omesh Prathiraja, Melysze D Oorloff, Gairu M Nagalmulla K, Adithya Nadella, Dilushini Caldera, Ali Mohtashim
    Cureus.2023;[Epub]     CrossRef
  • The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancer: a randomized placebo-controlled double-blind clinical trial
    Yasaman Khazaei, Ali Basi, Maria Luz Fernandez, Hossein Foudazi, Rafat Bagherzadeh, Farzad Shidfar
    BMC Complementary Medicine and Therapies.2023;[Epub]     CrossRef
  • The role of gut microbiota in the treatment of irritable bowel syndrome
    Hamed Ebrahimzadeh Leylabadlo, Fatemah Sadeghpour Heravi, Elghar Soltani, Amin Abbasi, Hossein Samadi Kafil, Mahdi Parsaei, Sarvin Sanaie, Zainab Ahmadian, Reza Ghotaslou
    Reviews in Medical Microbiology.2022; 33(1): e89.     CrossRef
  • How to Improve Health with Biological Agents—Narrative Review
    Anna Zawistowska-Rojek, Stefan Tyski
    Nutrients.2022; 14(9): 1700.     CrossRef
  • Why Use Nutraceutical Strategies for the Irritable Bowel Syndrome?
    Flavia di Michele
    Current Medicinal Chemistry.2022; 29(12): 2075.     CrossRef
  • Efficacy of Bifidobacterium breve CECT7263 for infantile colic treatment: an open-label, parallel, randomised, controlled trial
    J.A. Maldonado-Lobón, R. Blanco-Rojo, J. Maldonado, M.A. Ali, M.V. Almazán, A. Suanes-Cabello, E. Callejón, R. Jaldo, M.R. Benavídes, A.M. Negrillo, A. Sañudo, C. Rodríguez, O. Bañuelos, J. Fonollá, M. Olivares, _ _
    Beneficial Microbes.2021; 12(1): 55.     CrossRef
  • Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome
    Elemer Simon, Lavinia Florina Călinoiu, Laura Mitrea, Dan Cristian Vodnar
    Nutrients.2021; 13(6): 2112.     CrossRef
  • Evaluation of the Effect of Limosilactobacillus fermentum CECT5716 on Gastrointestinal Infections in Infants: A Systematic Review and Meta-Analysis
    Belén Pastor-Villaescusa, Ruth Blanco-Rojo, Mónica Olivares
    Microorganisms.2021; 9(7): 1412.     CrossRef
  • Probiotics, Prebiotics, and Synbiotics in the Irritable Bowel Syndrome Treatment: A Review
    Agnieszka Chlebicz-Wójcik, Katarzyna Śliżewska
    Biomolecules.2021; 11(8): 1154.     CrossRef
  • The effects of synbiotic supplementation on thyroid function and inflammation in hypothyroid patients: A randomized, double‑blind, placebo‑controlled trial
    Sepide Talebi, Mozhgan Karimifar, Zahra Heidari, Hamed Mohammadi, Gholamreza Askari
    Complementary Therapies in Medicine.2020; 48: 102234.     CrossRef
  • Current and emerging pharmacological approaches for treating diarrhea-predominant irritable bowel syndrome
    Akhil Munjal, Bhavtosh Dedania, Brooks D. Cash
    Expert Opinion on Pharmacotherapy.2020; 21(1): 63.     CrossRef
  • Irritable Bowel Syndrome and Synbiotics
    Soo Young Kim
    Korean Journal of Family Medicine.2019; 40(1): 1.     CrossRef
  • Anti-Inflammatory Diets and Fatigue
    Ulrike Haß, Catrin Herpich, Kristina Norman
    Nutrients.2019; 11(10): 2315.     CrossRef
  • Research Progress in Fecal Microbiota Transplantation as Treatment for Irritable Bowel Syndrome
    Yao Wang, Fengling Zheng, Shan Liu, Huanhuan Luo
    Gastroenterology Research and Practice.2019; 2019: 1.     CrossRef
  • 17,474 View
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Socioeconomic Indicators Associated with Initiation and Cessation of Smoking among Women in Seoul
Yu-Na Kim, Young-Gyu Cho, Cheol-Hwan Kim, Jae-Heon Kang, Hyun-Ah Park, Kyoung-Woo Kim, Yang-Im Hur, Su-Hyun Lee, Yun-Min Na, No-Yai Park
Korean J Fam Med 2012;33(1):1-8.   Published online January 31, 2012
DOI: https://doi.org/10.4082/kjfm.2012.33.1.1
Background

While smoking prevalence in Korean men has been decreasing, it is increasing in Korean women. Little is known about women's smoking inequalities in Korea. This study was conducted to investigate the association of socioeconomic indicators with the initiation and cessation of smoking among Korean women.

Methods

This was a cross-sectional study on 9,089 women aged 25-64 years from the 2008 Seoul Community Health Survey. The data on smoking and socioeconomic status were obtained through face-to-face interviews. Smoking initiation rate was defined as the proportion of the individuals who had started smoking at least one cigarette among all subjects. Smoking cessation rate was calculated by dividing the number of individuals who had quit smoking by the number of ever smokers. Education level, total family income and occupation were investigated as socioeconomic indicators.

Results

Education level was significantly associated with both initiation and cessation of smoking. Lower educated women had a higher likelihood of smoking initiation (odds ratio [OR], 1.72; 95% confidence interval [CI], 1.17 to 2.51) but lower likelihood of smoking cessation (OR, 0.38; 95% CI, 0.22 to 0.66) than higher educated women. Smoking initiation rate was higher in manual workers (OR, 1.65; 95% CI, 1.20 to 2.27) than in non-manual workers. However, there were no significant differences of both initiation and cessation of smoking according to total household income.

Conclusion

This study shows that there are smoking inequalities among Korean women. It is thought that education level and occupation are important determinants of women's smoking status.

Citations

Citations to this article as recorded by  
  • The smoking spectrum: review of the existing evidence and future directions
    Garbis A. Meshefedjian
    Journal of Public Health.2020; 28(1): 105.     CrossRef
  • Cigarette Smoking in South Korea: A Narrative Review
    Rebekah Gunter, Edwin Szeto, Se-Hoon Jeong, Sooyeon Suh, Andrew J. Waters
    Korean Journal of Family Medicine.2020; 41(1): 3.     CrossRef
  • Women’s Smoking: Relationships Among Emotional Labor, Occupational Stress, and Health Promotion
    Sunjoo Boo, Hyunjin Oh
    Workplace Health & Safety.2019; 67(7): 361.     CrossRef
  • Factors associated with smoking cessation
    Samires Avelino de Souza França, Ana Ligian Feitosa das Neves, Tatiane Andressa Santos de Souza, Nandara Celana Negreiros Martins, Saul Rassy Carneiro, Edilene do Socorro Nascimento Falcão Sarges, Maria de Fátima Amine Houat de Souza
    Revista de Saúde Pública.2015;[Epub]     CrossRef
  • A History of Ashes: An 80 Year Comparative Portrait of Smoking Initiation in American Indians and Non-Hispanic Whites—the Strong Heart Study
    Raymond Orr, Darren Calhoun, Carolyn Noonan, Ron Whitener, Jeff Henderson, Jack Goldberg, Patrica Henderson
    International Journal of Environmental Research and Public Health.2013; 10(5): 1747.     CrossRef
  • Predictors of long-term smoking cessation: results from the global adult tobacco survey in Poland (2009–2010)
    Dorota Kaleta, Przemysław Korytkowski, Teresa Makowiec-Dąbrowska, Bukola Usidame, Leokadia Bąk-Romaniszyn, Adam Fronczak
    BMC Public Health.2012;[Epub]     CrossRef
  • 6,337 View
  • 29 Download
  • 6 Crossref
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