Background Physical activity (PA) is associated with a favorable metabolic risk profile in adults. However, its role in adolescents remains unclear. In this study, using data (2019–2021) from the 8th Korea National Health and Nutrition Examination Survey, we investigated the optimal exercise type for preventing metabolic complications in adolescents.
Methods A total of 1,222 eligible adolescent participants (12–18-year-old) were divided into four groups as follows: aerobic exercise (AE), resistance exercise (RE), combined aerobic and resistance exercise (CE), and no exercise (NE). Daily PA was assessed using the international PA questionnaire. Blood samples were collected to measure lipid, glucose, and insulin levels. Additionally, the homeostasis model assessment for insulin resistance (HOMA-IR) and triglyceride-glucose (TyG) indices were measured. Multivariate regression analysis was used to compare the metabolic risk factors across the PA groups before and after propensity score matching (PSM) adjustment for confounding variables.
Results The CE group exhibited improved fasting glucose levels, lower TyG index, reduced white blood cell count, and higher high-density lipoprotein (HDL) cholesterol levels than the NE group. The RE group exhibited lower mean blood pressure, triglyceride, fasting insulin, HOMA-IR, TyG index and a reduced risk of metabolic syndrome than the NE group. The AE group had higher total and HDL cholesterol levels. In detailed comparison of the AE and RE groups, the RE group consistently exhibited favorable metabolic parameters, including lower blood pressure and total and low-density cholesterol levels, which persisted after PSM.
Conclusion These findings highlight the positive effects of PA on cardiovascular risk factors in adolescents. Thus, RE may have a more favorable metabolic effect than AE. Further studies are needed to validate the benefits of exercise according to the exercise type.
Citations
Citations to this article as recorded by
Reflecting on progress and challenges: the Korean Journal of Family Medicine in 2024 Seung-Won Oh Korean Journal of Family Medicine.2025; 46(2): 55. CrossRef
Background This study aims to create a comprehensive list of essential topics and procedural skills for family medicine residency training in Korea.
Methods Three e-mailed surveys were conducted. The first and second surveys were sent to all board-certified family physicians in the Korean Academy of Family Medicine (KAFM) database via e-mail. Participants were asked to rate each of the topics (117 in survey 1, 36 in survey 2) and procedures (65 in survey 1, 19 in survey 2) based on how necessary it was to teach it and personal experience of utilizing it in clinical practice. Agreement rates of the responses were calculated and then sent to the 32 KAFM board members in survey 3. Opinions on potential cut-off points to divide the items into three categories and the minimum achievement requirements needed to graduate for each category were solicited.
Results Of 6,588 physicians, 256 responded to the first survey (3.89% response rate), 209 out of 6,669 to the second survey (3.13%), and 100% responded to the third survey. The final list included 153 topics and 81 procedures, which were organized into three categories: mandatory, recommended, and optional (112/38/3, 27/33/21). For each category of topics and procedures, the minimum requirement for 3-year residency training was set at 90%/60%/30% and 80%/60%/30%, respectively.
Conclusion This national survey was the first investigation to define essential topics and procedures for residency training in Korean family medicine. The lists obtained represent the opinions of Korean family physicians and are expected to aid in the improvement of family medicine training programs in the new competency-based curriculum.
Citations
Citations to this article as recorded by
Competency-Based Residency Training and the Development of Competencies and Entrustable Professional Activities for Family Medicine in South Korea Yon Chul Park, Danbi Lee, Seung Guk Park, Yonghwan Kim Korean Journal of Family Practice.2025; 15(2): 77. CrossRef
Comparison of Domestic and Foreign Family Medicine Residency Education and Training Systems Seung Guk Park Korean Journal of Family Practice.2025; 15(2): 89. CrossRef
Strengthening Evaluation-Based Resident Training through a Review of Overseas Family Medicine Residency Evaluation Systems Yonghwan Kim, Danbi Lee, Yon Chul Park Korean Journal of Family Practice.2025; 15(2): 84. CrossRef
Pancytopenia represents a unique challenge for primary care doctors and its etiological causes encompass various specialties, including hematology and rheumatology. Despite the existence of effective tests such as bone marrow biopsy and immunoassays to rule out the potential causes of pancytopenia, it is often difficult to pinpoint the exact diagnosis. In this case report, we have described such a ‘gray zone’ patient, who presented with pancytopenia, neutropenia, and splenomegaly, and was being treated for fungal pneumonia before being transferred to Severance Hospital (department of family medicine). As the patient had a 10-year history of multiple, long-term hospital admissions that were having a severely debilitating impact on the quality of life, we performed a partial splenic embolization as a potential cure for the symptoms. Although this induced acute blood count recovery, it failed to prevent eventual mortality from septic shock.
Background The prevalence of metabolic syndrome (MetS) is increasing, and obesity, insulin resistance, and inflammation are the known risk factors. However, results of previous studies regarding the relationship between MetS and inflammation have not been consistent. This study aimed to identify the associations between C-reactive protein (CRP) and MetS and its components in obese and non-obese men and women.
Methods This was a cross-sectional study based on the 6th Korea National Health and Nutrition Examination Survey (2015), and a nationally representative sample of 3,013 Korean adults aged 40–78 years were included. Those with cardiovascular disease, cancer, CRP level >10 mg/L, white blood cell count >10,000/mm3 , chronic kidney disease, and lung/liver disease were excluded.
Results Approximately 11.0%, 50.0%, 8.4%, and 48.8% of non-obese men, obese men, non-obese women, and obese women presented with MetS (P<0.001), respectively. In all four groups, those who presented with MetS or its components showed a higher high-sensitivity (hs-CRP) average than those without. Multivariate regression analysis showed the increased risk of developing MetS with higher quartiles of hs-CRP level in obese (3rd and 4th quartiles: odds ratios [ORs], 3.87 and 2.57, respectively) and non-obese women (4th quartile: OR, 2.63). The different components also showed increased ORs in the four groups. However, no statistically significant trend in the relationship was found in men.
Conclusion Low-grade inflammation may increase the risk of MetS in Korean women independent of adiposity. However, due to the cross-sectional design of the present study, further studies must be conducted to identify the causal relationship between inflammation and metabolic disorders.
Citations
Citations to this article as recorded by
Association of GGT and hs-CRP with hypertension across different glycemic states in Saudi adults: A cross-sectional study Basmah Eldakhakhny, Sumia Enani, Suhad Bahijri, Ghada Ajabnoor, Jawaher Al-Ahmadi, Rajaa Al-Raddadi, Hanan Jambi, Amani Matook Alhozali, Anwar Borai, Jaakko Tuomilehto Heliyon.2025; 11(4): e42880. CrossRef
A machine learning-based framework for predicting metabolic syndrome using serum liver function tests and high-sensitivity C-reactive protein Bahareh Behkamal, Fatemeh Asgharian Rezae, Amin Mansoori, Rana Kolahi Ahari, Sobhan Mahmoudi Shamsabad, Mohammad Reza Esmaeilian, Gordon Ferns, Mohammad Reza Saberi, Habibollah Esmaily, Majid Ghayour-Mobarhan Scientific Reports.2025;[Epub] CrossRef
Association between Korean Healthy Eating Index and abdominal obesity in Korean adults: the mediating effect of high-sensitivity C-reactive protein Jina Yoon, Dayeon Shin Journal of Nutrition and Health.2024; 57(1): 88. CrossRef
Association of Three Novel Inflammatory Markers: Lymphocyte to HDL‐C Ratio, High‐Sensitivity C‐Reactive Protein to HDL‐C Ratio and High‐Sensitivity C‐Reactive Protein to Lymphocyte Ratio With Metabolic Syndrome Rana Kolahi Ahari, Nazanin Akbari, Negin Babaeepoor, Zahra Fallahi, Sara Saffar Soflaei, Gordon Ferns, Mahmoud Ebrahimi, Mohsen Moohebati, Habibollah Esmaily, Majid Ghayour‐Mobarhan Endocrinology, Diabetes & Metabolism.2024;[Epub] CrossRef
C-reactive protein to albumin ratio and risk of incident metabolic syndrome in community-dwelling adults: longitudinal findings over a 12-year follow-up period Taekyeong Lim, Yong-Jae Lee Endocrine.2024; 86(1): 156. CrossRef
Sex Differences in Biochemical Analyses, Cardiometabolic Risk Factors and Their Correlation with CRP in Healthy Mexican Individuals Aniel Jessica Leticia Brambila-Tapia, Alejandra Soledad González-Gómez, Laura Arely Carrillo-Delgadillo, Ana Míriam Saldaña-Cruz, Ingrid Patricia Dávalos-Rodríguez Journal of Personalized Medicine.2024; 14(9): 904. CrossRef
Systemic Inflammation Across Metabolic Obesity Phenotypes: A Cross-Sectional Study of Korean Adults Using High-Sensitivity C-Reactive Protein as a Biomarker Seong-Uk Baek, Jin-Ha Yoon International Journal of Molecular Sciences.2024; 25(21): 11540. CrossRef
The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson’s Disease Tal Ben Shaul, Dan Frenkel, Tanya Gurevich International Journal of Molecular Sciences.2024; 25(22): 12409. CrossRef
Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke Anna Mirończuk, Katarzyna Kapica-Topczewska, Katarzyna Socha, Jolanta Soroczyńska, Jacek Jamiołkowski, Monika Chorąży, Agata Czarnowska, Agnieszka Mitrosz, Alina Kułakowska, Jan Kochanowicz Nutrients.2023; 15(6): 1434. CrossRef
Serum uric acid to creatinine ratio and metabolic syndrome in middle-aged and elderly population: Based on the 2015 CHARLS Tengrui Cao, Chao Tong, Aheyeerke Halengbieke, Xuetong Ni, Jianmin Tang, Deqiang Zheng, Xiuhua Guo, Xinghua Yang Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(7): 1339. CrossRef
A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation Seema Mehdi, Shahid Ud Din Wani, K.L. Krishna, Nabeel Kinattingal, Tamsheel Fatima Roohi Biochemistry and Biophysics Reports.2023; 36: 101571. CrossRef
C-Reactive Protein as a Marker of Inflammation in Children and Adolescents with Metabolic Syndrome: A Systematic Review and Meta-Analysis Mihaela-Andreea Podeanu, Adina Turcu-Stiolica, Mihaela Simona Subțirelu, Mioara Desdemona Stepan, Claudiu-Marinel Ionele, Dan-Ionuț Gheonea, Bianca Ștefănița Vintilescu, Raluca Elena Sandu Biomedicines.2023; 11(11): 2961. CrossRef
Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome Bogdan M. Tarcău, Laura G. Vicaș, Lorena Filip, Florin Maghiar, Mircea Șandor, Annamaria Pallag, Tunde Jurca, Mariana Eugenia Mureșan, Eleonora Marian Journal of Personalized Medicine.2023; 14(1): 32. CrossRef
Comparison of metabolic syndrome and related factors in married pre-menopausal white- and blue-collar woman Seungmi Park, Chul-Gyu Kim, Youngji Kim Archives of Environmental & Occupational Health.2022; 77(9): 744. CrossRef
Self-rated health may be a predictor for metabolic syndrome and high hs-CRP prevalences in healthy adults in South Korea: Based on the 2015 Korea National Health and Nutrition Examination Survey Mi Joung Kim, In Woo Kim Nutrition Research.2022; 102: 71. CrossRef
Effect of weekend catch-up sleep on high-sensitivity C-reactive protein levels according to bedtime inconsistency: a population-based cross-sectional study Soyoung Park, Dong Yoon Kang, Hyungwoo Ahn, Namwoo Kim, Jeong-Hwa Yoon, Bo Ram Yang Scientific Reports.2022;[Epub] CrossRef
Effect of night shift on development of metabolic syndrome among health care workers Jyotirmayee Bahinipati, Rajlaxmi Sarangi, Mona Pathak, Srikrushna Mohapatra Journal of Family Medicine and Primary Care.2022; 11(5): 1710. CrossRef
Relationship between Low Vegetable Consumption, Increased High-Sensitive C-Reactive Protein Level, and Cardiometabolic Risk in Korean Adults with Tae-Eumin: A Cross-Sectional Study Jieun Kim, Kyoungsik Jeong, Siwoo Lee, Younghwa Baek, Swee Keong Yeap Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1. CrossRef
Effects of Antioxidant Vitamins, Curry Consumption, and Heavy Metal Levels on Metabolic Syndrome with Comorbidities: A Korean Community-Based Cross-Sectional Study Hai Nguyen Duc, Hojin Oh, Min-Sun Kim Antioxidants.2021; 10(5): 808. CrossRef
High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors Małgorzata Koziarska-Rościszewska, Anna Gluba-Brzózka, Beata Franczyk, Jacek Rysz Life.2021; 11(8): 742. CrossRef
Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population Hai Duc Nguyen, Hojin Oh, Ngoc Hong Minh Hoang, Min-Sun Kim Scientific Reports.2021;[Epub] CrossRef
Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review Vincent G. Pluimakers, Selveta S. van Santen, Marta Fiocco, Marie‐Christine E. Bakker, Aart J. van der Lelij, Marry M. van den Heuvel‐Eibrink, Sebastian J. C. M. M. Neggers Obesity Reviews.2021;[Epub] CrossRef
Combined Effects of Insulin Resistance and Inflammation on Comorbidities of Type 2 Diabetes Eun Jung Kim, Eun Young Lee, Yong-Ho Lee, Young Ju Choi, Seok Won Park, Eun Jig Lee, Hyun Chul Lee, Kap Bum Huh The Journal of Korean Diabetes.2021; 22(3): 207. CrossRef
Significance of C-reactive protein determination in patients with metabolic syndrome Dušan Miljković, Slađana Todorović Medicinski casopis.2021; 55(2): 51. CrossRef
Serum alkaline phosphatase level is positively associated with metabolic syndrome: A nationwide population-based study Ji-Hye Kim, Hye Sun Lee, Hye-Min Park, Yong-Jae Lee Clinica Chimica Acta.2020; 500: 189. CrossRef
The association between C-reactive protein and common blood tests in apparently healthy individuals undergoing a routine health examination Tomer Ziv-Baran, Asaf Wasserman, Ilana Goldiner, Moshe Stark, Shani Shenhar-Tsarfaty, Itzhak Shapira, David Zeltser, Inna Mailis, Shlomo Berliner, Ori Rogowski Clinica Chimica Acta.2020; 501: 33. CrossRef
High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population
Clinical and Pathogenic Characteristics of Lower Respiratory Tract Infection Treated at the Vietnam National Children’s Hospital Hien T. Pham, Phuc T. T. Nguyen, Sinh T. Tran, Thuy T. B. Phung Canadian Journal of Infectious Diseases and Medical Microbiology.2020; 2020: 1. CrossRef
Association of high sensitivity C-reactive protein and metabolic syndrome components in middle-aged subjects without overt cardiovascular disease in LitHiR primary prevention programme Ieva Marija Saulė, Jurgita Mikolaitytė, Jolita Badarienė, Jūratė Zupkauskienė, Roma Puronaitė, Alma Čypienė, Aleksandras Laucevičius Seminars in Cardiovascular Medicine.2020; 26(1): 14. CrossRef
Associations of Cardiovascular and All-Cause Mortality with Metabolic Syndrome in Hemodialysis Patients: A Prospective Single-Center Study Zorica Dimitrijevic, Andriana Jovanovic, Mina Cvetkovic, Tamara Vrecic, Emina Kostic, Branka Mitic Medicina.2019; 55(10): 694. CrossRef