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"Youhyun Song"

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"Youhyun Song"

Original Articles

Comparison of Metabolic Risk Factors Based on the Type of Physical Activity in Korean Adolescents: Results from a Nationwide Population-Based Survey
Min-Hyo Kim, Yaeji Lee, John Alderman Linton, Youhyun Song, Ji-Won Lee
Korean J Fam Med 2024;45(3):164-175.   Published online January 23, 2024
DOI: https://doi.org/10.4082/kjfm.23.0164
Background
Physical activity (PA) is associated with a favorable metabolic risk profile in adults. However, its role in adolescents remains unclear. In this study, using data (2019–2021) from the 8th Korea National Health and Nutrition Examination Survey, we investigated the optimal exercise type for preventing metabolic complications in adolescents.
Methods
A total of 1,222 eligible adolescent participants (12–18-year-old) were divided into four groups as follows: aerobic exercise (AE), resistance exercise (RE), combined aerobic and resistance exercise (CE), and no exercise (NE). Daily PA was assessed using the international PA questionnaire. Blood samples were collected to measure lipid, glucose, and insulin levels. Additionally, the homeostasis model assessment for insulin resistance (HOMA-IR) and triglyceride-glucose (TyG) indices were measured. Multivariate regression analysis was used to compare the metabolic risk factors across the PA groups before and after propensity score matching (PSM) adjustment for confounding variables.
Results
The CE group exhibited improved fasting glucose levels, lower TyG index, reduced white blood cell count, and higher high-density lipoprotein (HDL) cholesterol levels than the NE group. The RE group exhibited lower mean blood pressure, triglyceride, fasting insulin, HOMA-IR, TyG index and a reduced risk of metabolic syndrome than the NE group. The AE group had higher total and HDL cholesterol levels. In detailed comparison of the AE and RE groups, the RE group consistently exhibited favorable metabolic parameters, including lower blood pressure and total and low-density cholesterol levels, which persisted after PSM.
Conclusion
These findings highlight the positive effects of PA on cardiovascular risk factors in adolescents. Thus, RE may have a more favorable metabolic effect than AE. Further studies are needed to validate the benefits of exercise according to the exercise type.

Citations

Citations to this article as recorded by  
  • Reflecting on progress and challenges: the Korean Journal of Family Medicine in 2024
    Seung-Won Oh
    Korean Journal of Family Medicine.2025; 46(2): 55.     CrossRef
  • 3,138 View
  • 92 Download
  • 1 Web of Science
  • 1 Crossref
Defining Essential Topics and Procedures for Korean Family Medicine Residency Training
Youhyun Song, Jinyoung Shin, Yonghwan Kim, Jae-Yong Shim
Korean J Fam Med 2021;42(6):477-482.   Published online November 20, 2021
DOI: https://doi.org/10.4082/kjfm.20.0244
Background
This study aims to create a comprehensive list of essential topics and procedural skills for family medicine residency training in Korea.
Methods
Three e-mailed surveys were conducted. The first and second surveys were sent to all board-certified family physicians in the Korean Academy of Family Medicine (KAFM) database via e-mail. Participants were asked to rate each of the topics (117 in survey 1, 36 in survey 2) and procedures (65 in survey 1, 19 in survey 2) based on how necessary it was to teach it and personal experience of utilizing it in clinical practice. Agreement rates of the responses were calculated and then sent to the 32 KAFM board members in survey 3. Opinions on potential cut-off points to divide the items into three categories and the minimum achievement requirements needed to graduate for each category were solicited.
Results
Of 6,588 physicians, 256 responded to the first survey (3.89% response rate), 209 out of 6,669 to the second survey (3.13%), and 100% responded to the third survey. The final list included 153 topics and 81 procedures, which were organized into three categories: mandatory, recommended, and optional (112/38/3, 27/33/21). For each category of topics and procedures, the minimum requirement for 3-year residency training was set at 90%/60%/30% and 80%/60%/30%, respectively.
Conclusion
This national survey was the first investigation to define essential topics and procedures for residency training in Korean family medicine. The lists obtained represent the opinions of Korean family physicians and are expected to aid in the improvement of family medicine training programs in the new competency-based curriculum.

Citations

Citations to this article as recorded by  
  • Competency-Based Residency Training and the Development of Competencies and Entrustable Professional Activities for Family Medicine in South Korea
    Yon Chul Park, Danbi Lee, Seung Guk Park, Yonghwan Kim
    Korean Journal of Family Practice.2025; 15(2): 77.     CrossRef
  • Comparison of Domestic and Foreign Family Medicine Residency Education and Training Systems
    Seung Guk Park
    Korean Journal of Family Practice.2025; 15(2): 89.     CrossRef
  • Strengthening Evaluation-Based Resident Training through a Review of Overseas Family Medicine Residency Evaluation Systems
    Yonghwan Kim, Danbi Lee, Yon Chul Park
    Korean Journal of Family Practice.2025; 15(2): 84.     CrossRef
  • 16,793 View
  • 80 Download
  • 3 Crossref

Case Report

A Patient with Neutropenia and Splenomegaly: A Case Report from Department of Family Medicine in Tertiary Hospital Center
Jaehee Cho, Youhyun Song, Jiyeon Lee, Daeun Lee, Yunsun Go, Hee Cheol Kang
Korean J Fam Med 2021;42(3):250-254.   Published online May 22, 2020
DOI: https://doi.org/10.4082/kjfm.19.0130
Pancytopenia represents a unique challenge for primary care doctors and its etiological causes encompass various specialties, including hematology and rheumatology. Despite the existence of effective tests such as bone marrow biopsy and immunoassays to rule out the potential causes of pancytopenia, it is often difficult to pinpoint the exact diagnosis. In this case report, we have described such a ‘gray zone’ patient, who presented with pancytopenia, neutropenia, and splenomegaly, and was being treated for fungal pneumonia before being transferred to Severance Hospital (department of family medicine). As the patient had a 10-year history of multiple, long-term hospital admissions that were having a severely debilitating impact on the quality of life, we performed a partial splenic embolization as a potential cure for the symptoms. Although this induced acute blood count recovery, it failed to prevent eventual mortality from septic shock.
  • 6,118 View
  • 79 Download
Original Article
Association between C-Reactive Protein and Metabolic Syndrome in Korean Adults
Youhyun Song, Soo Kyung Yang, Jungeun Kim, Duk-Chul Lee
Korean J Fam Med 2019;40(2):116-123.   Published online October 30, 2018
DOI: https://doi.org/10.4082/kjfm.17.0075
Background
The prevalence of metabolic syndrome (MetS) is increasing, and obesity, insulin resistance, and inflammation are the known risk factors. However, results of previous studies regarding the relationship between MetS and inflammation have not been consistent. This study aimed to identify the associations between C-reactive protein (CRP) and MetS and its components in obese and non-obese men and women.
Methods
This was a cross-sectional study based on the 6th Korea National Health and Nutrition Examination Survey (2015), and a nationally representative sample of 3,013 Korean adults aged 40–78 years were included. Those with cardiovascular disease, cancer, CRP level >10 mg/L, white blood cell count >10,000/mm3 , chronic kidney disease, and lung/liver disease were excluded.
Results
Approximately 11.0%, 50.0%, 8.4%, and 48.8% of non-obese men, obese men, non-obese women, and obese women presented with MetS (P<0.001), respectively. In all four groups, those who presented with MetS or its components showed a higher high-sensitivity (hs-CRP) average than those without. Multivariate regression analysis showed the increased risk of developing MetS with higher quartiles of hs-CRP level in obese (3rd and 4th quartiles: odds ratios [ORs], 3.87 and 2.57, respectively) and non-obese women (4th quartile: OR, 2.63). The different components also showed increased ORs in the four groups. However, no statistically significant trend in the relationship was found in men.
Conclusion
Low-grade inflammation may increase the risk of MetS in Korean women independent of adiposity. However, due to the cross-sectional design of the present study, further studies must be conducted to identify the causal relationship between inflammation and metabolic disorders.

Citations

Citations to this article as recorded by  
  • Association of GGT and hs-CRP with hypertension across different glycemic states in Saudi adults: A cross-sectional study
    Basmah Eldakhakhny, Sumia Enani, Suhad Bahijri, Ghada Ajabnoor, Jawaher Al-Ahmadi, Rajaa Al-Raddadi, Hanan Jambi, Amani Matook Alhozali, Anwar Borai, Jaakko Tuomilehto
    Heliyon.2025; 11(4): e42880.     CrossRef
  • A machine learning-based framework for predicting metabolic syndrome using serum liver function tests and high-sensitivity C-reactive protein
    Bahareh Behkamal, Fatemeh Asgharian Rezae, Amin Mansoori, Rana Kolahi Ahari, Sobhan Mahmoudi Shamsabad, Mohammad Reza Esmaeilian, Gordon Ferns, Mohammad Reza Saberi, Habibollah Esmaily, Majid Ghayour-Mobarhan
    Scientific Reports.2025;[Epub]     CrossRef
  • Association between Korean Healthy Eating Index and abdominal obesity in Korean adults: the mediating effect of high-sensitivity C-reactive protein
    Jina Yoon, Dayeon Shin
    Journal of Nutrition and Health.2024; 57(1): 88.     CrossRef
  • Association of Three Novel Inflammatory Markers: Lymphocyte to HDL‐C Ratio, High‐Sensitivity C‐Reactive Protein to HDL‐C Ratio and High‐Sensitivity C‐Reactive Protein to Lymphocyte Ratio With Metabolic Syndrome
    Rana Kolahi Ahari, Nazanin Akbari, Negin Babaeepoor, Zahra Fallahi, Sara Saffar Soflaei, Gordon Ferns, Mahmoud Ebrahimi, Mohsen Moohebati, Habibollah Esmaily, Majid Ghayour‐Mobarhan
    Endocrinology, Diabetes & Metabolism.2024;[Epub]     CrossRef
  • C-reactive protein to albumin ratio and risk of incident metabolic syndrome in community-dwelling adults: longitudinal findings over a 12-year follow-up period
    Taekyeong Lim, Yong-Jae Lee
    Endocrine.2024; 86(1): 156.     CrossRef
  • Sex Differences in Biochemical Analyses, Cardiometabolic Risk Factors and Their Correlation with CRP in Healthy Mexican Individuals
    Aniel Jessica Leticia Brambila-Tapia, Alejandra Soledad González-Gómez, Laura Arely Carrillo-Delgadillo, Ana Míriam Saldaña-Cruz, Ingrid Patricia Dávalos-Rodríguez
    Journal of Personalized Medicine.2024; 14(9): 904.     CrossRef
  • Systemic Inflammation Across Metabolic Obesity Phenotypes: A Cross-Sectional Study of Korean Adults Using High-Sensitivity C-Reactive Protein as a Biomarker
    Seong-Uk Baek, Jin-Ha Yoon
    International Journal of Molecular Sciences.2024; 25(21): 11540.     CrossRef
  • The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson’s Disease
    Tal Ben Shaul, Dan Frenkel, Tanya Gurevich
    International Journal of Molecular Sciences.2024; 25(22): 12409.     CrossRef
  • Disturbed Ratios between Essential and Toxic Trace Elements as Potential Biomarkers of Acute Ischemic Stroke
    Anna Mirończuk, Katarzyna Kapica-Topczewska, Katarzyna Socha, Jolanta Soroczyńska, Jacek Jamiołkowski, Monika Chorąży, Agata Czarnowska, Agnieszka Mitrosz, Alina Kułakowska, Jan Kochanowicz
    Nutrients.2023; 15(6): 1434.     CrossRef
  • Serum uric acid to creatinine ratio and metabolic syndrome in middle-aged and elderly population: Based on the 2015 CHARLS
    Tengrui Cao, Chao Tong, Aheyeerke Halengbieke, Xuetong Ni, Jianmin Tang, Deqiang Zheng, Xiuhua Guo, Xinghua Yang
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(7): 1339.     CrossRef
  • A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation
    Seema Mehdi, Shahid Ud Din Wani, K.L. Krishna, Nabeel Kinattingal, Tamsheel Fatima Roohi
    Biochemistry and Biophysics Reports.2023; 36: 101571.     CrossRef
  • C-Reactive Protein as a Marker of Inflammation in Children and Adolescents with Metabolic Syndrome: A Systematic Review and Meta-Analysis
    Mihaela-Andreea Podeanu, Adina Turcu-Stiolica, Mihaela Simona Subțirelu, Mioara Desdemona Stepan, Claudiu-Marinel Ionele, Dan-Ionuț Gheonea, Bianca Ștefănița Vintilescu, Raluca Elena Sandu
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    Archives of Environmental & Occupational Health.2022; 77(9): 744.     CrossRef
  • Self-rated health may be a predictor for metabolic syndrome and high hs-CRP prevalences in healthy adults in South Korea: Based on the 2015 Korea National Health and Nutrition Examination Survey
    Mi Joung Kim, In Woo Kim
    Nutrition Research.2022; 102: 71.     CrossRef
  • Effect of weekend catch-up sleep on high-sensitivity C-reactive protein levels according to bedtime inconsistency: a population-based cross-sectional study
    Soyoung Park, Dong Yoon Kang, Hyungwoo Ahn, Namwoo Kim, Jeong-Hwa Yoon, Bo Ram Yang
    Scientific Reports.2022;[Epub]     CrossRef
  • Effect of night shift on development of metabolic syndrome among health care workers
    Jyotirmayee Bahinipati, Rajlaxmi Sarangi, Mona Pathak, Srikrushna Mohapatra
    Journal of Family Medicine and Primary Care.2022; 11(5): 1710.     CrossRef
  • Relationship between Low Vegetable Consumption, Increased High-Sensitive C-Reactive Protein Level, and Cardiometabolic Risk in Korean Adults with Tae-Eumin: A Cross-Sectional Study
    Jieun Kim, Kyoungsik Jeong, Siwoo Lee, Younghwa Baek, Swee Keong Yeap
    Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
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    Hai Nguyen Duc, Hojin Oh, Min-Sun Kim
    Antioxidants.2021; 10(5): 808.     CrossRef
  • High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors
    Małgorzata Koziarska-Rościszewska, Anna Gluba-Brzózka, Beata Franczyk, Jacek Rysz
    Life.2021; 11(8): 742.     CrossRef
  • Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population
    Hai Duc Nguyen, Hojin Oh, Ngoc Hong Minh Hoang, Min-Sun Kim
    Scientific Reports.2021;[Epub]     CrossRef
  • Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review
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    Obesity Reviews.2021;[Epub]     CrossRef
  • Combined Effects of Insulin Resistance and Inflammation on Comorbidities of Type 2 Diabetes
    Eun Jung Kim, Eun Young Lee, Yong-Ho Lee, Young Ju Choi, Seok Won Park, Eun Jig Lee, Hyun Chul Lee, Kap Bum Huh
    The Journal of Korean Diabetes.2021; 22(3): 207.     CrossRef
  • Significance of C-reactive protein determination in patients with metabolic syndrome
    Dušan Miljković, Slađana Todorović
    Medicinski casopis.2021; 55(2): 51.     CrossRef
  • Serum alkaline phosphatase level is positively associated with metabolic syndrome: A nationwide population-based study
    Ji-Hye Kim, Hye Sun Lee, Hye-Min Park, Yong-Jae Lee
    Clinica Chimica Acta.2020; 500: 189.     CrossRef
  • The association between C-reactive protein and common blood tests in apparently healthy individuals undergoing a routine health examination
    Tomer Ziv-Baran, Asaf Wasserman, Ilana Goldiner, Moshe Stark, Shani Shenhar-Tsarfaty, Itzhak Shapira, David Zeltser, Inna Mailis, Shlomo Berliner, Ori Rogowski
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  • High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population


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  • 221 Download
  • 25 Web of Science
  • 30 Crossref
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