Korean Journal of Family Medicine

A Possible Case of Statin-Induced Ichthyosis in an Elderly Woman: Ki Dong Ko, Kyoung Kon Kim, Jin-Ok Baek, Heuy Sun Suh, In Cheol Hwang; Korean J Fam Med 2018;39(1):51-53. Published online January 23, 2018; DOI: https://doi.org/10.4082/kjfm.2018.39.1.51

Abstract
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Ichthyosis is a heterogeneous group of hereditary or acquired skin disorders, characterized by increased stratum corneum production. Several systemic diseases and many drugs can occasionally cause acquired ichthyosis. We report a case of statin-induced ichthyosis in which the causality between statin and ichthyosis was found possible by using the Naranjo scale. A 79-year-old woman presented with pruritic skin lesions on both legs that appeared erythematous, scaly, and cracked. A clinical diagnosis of acquired ichthyosis was made and the statin was suspected as the cause. The skin lesions improved after 6 weeks of dose reduction of the statin.

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Safety and efficacy of topical simvastatin plus cholesterol cream versus topical simvastatin cream alone for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled, investigator-initiated trial
Zhiming Chen, Yihe Liu, Hui Yu, Jing Li, Xin Huang, Ruiyu Xiang, Ran Mo, Hao Chen, Yong Yang
Journal of the American Academy of Dermatology.2025; 93(4): 980. CrossRef
Acquired ichthyosis, asteatotic dermatitis or xerosis? An update on pathoetiology and drug‐induced associations
Jason S. Park, Amir H. Saeidian, Leila Youssefian, Sylvia Hsu, Hassan Vahidnezhad, Jouni Uitto
Journal of the European Academy of Dermatology and Venereology.2023; 37(1): 47. CrossRef
Acquired ichthyosis: a clinical review
Roger Haber, Joelle Feghali, Umer Nadir, Michael D. Yi, Brian A. Cahn
Archives of Dermatological Research.2023; 315(9): 2529. CrossRef
Ichthyosis (concept, pathohistology, clinical picture, treatment)
Tatyana Gennadyevna Takhtarova, Zarema Rimovna Khismatullina, Lyudmila Dmitrievna Panova, Anastasia Nikolaevna Panova
Vestnik dermatologii i venerologii.2021; 97(3): 6. CrossRef

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Family Function and Children of Alcoholics Screening Test Score in High School Students .: In Wook Jung, Jong Sung Kim, Jin Gyu Jung, Keun Bae Kim, Chan Il Park, Won Ki Hong, Sung Soo Kim; J Korean Acad Fam Med 2007;28(6):436-441. Published online June 10, 2007

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Background
Parent's alcohol drinking not only influences their health but also their children. This research was designed to assess the family function of children who were affected by parent's alcohol drinking. Methods: Questionnaire survey was performed on 208 high school students (129 males and 79 females) in Daejeon from March to April, 2005. We defined the students whose CAST (Children of Alcoholics Screening Test) score was 6 or more as children of alcoholics (COA) group. Then, we evaluated the family function by family APGAR score between the COA group and the control group. Results: Among the total, 36 (27.9%) male and 27 (34.1%) female students were in COA group. There was a significant (P＜0.01) negative correlation between the CAST score and the family APGAR score in all students. In boys, there was no significant correlation between the CAST score and the family APGAR score, but in girls, there was significant negative correlation (P＜0.01). Mean family APGAR score of the COA group was significantly (P＜0.05) lower than that of the control group in all students. In boys, there was no significant difference, but in girls, the COA group's family APGAR score was significantly lower than the control group's score (P＜0.05). Conclusion: The high school students, especially girl students, who were affected by parent's alcohol drinking showed a lower family APGAR score. Therefore, family physicians need to evaluate the family function when encountering students similar to COA group.

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Influence of HMG-CoA Reductase Inhibitors on Bone Mass in Postmenopausal Women.: Sang Yeoup Lee, Yun Jin Kim; J Korean Acad Fam Med 2003;24(5):451-455. Published online May 10, 2003

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Background
: It is controversial whether the use of HMG CoA reductase inhibitors (statins) is associated with an increased bone mineral density (BMD) in humans. The purpose of this study was to assess the influence of statins on BMD in Korean postmenopausal women.

Methods : Forty-four postmenopausal women (aged 54.3±5.8 years) were included. The statin users (n=24) were administered either simvastain, atorvastatin, pravastatin, or lovastatin. The control group (n=20) did not take statins. BMD of the spine were measured by dual-energy X-ray absorptiometry. Alkaline phosphatase (ALP) was tested as a bone marker. The data were analysed with two-sample t test and paired t-test.

Results : The mean annual spinal BMD changes of the study groups were -1.5±5.6% for statin users and -0.2±4.2% for control group. There was no statistically significant difference in mean annual spinal BMD changes (P=0.696). The mean annual ALP changes of the study groups were -5.6±18.1% for the statin users and -0.4±13.9% for the control group. There was no statistically significant difference in mean annual ALP changes (P=0.246). In each group, the spinal BMD significantly was not changed after 1 year (P＞0.05).

Conclusion : This study suggest that statins do not protect from bone loss in Korean postmenopausal women.

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