Korean Journal of Family Medicine

"Complications"

Original Articles

Usefulness of Glycated Albumin Levels in Predicting the Maternal or Neonatal Complications of Gestational Diabetes Mellitus during Late Pregnancy in South Korea: A Retrospective Study: Jihan Kim, Sami Lee, Jong Sung Kim; Received March 8, 2024 Accepted July 29, 2024 Published online November 12, 2024; DOI: https://doi.org/10.4082/kjfm.24.0048 [Epub ahead of print]

Abstract
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Background
Gestational diabetes can lead to complications in pregnant women and neonates. Maternal glycated albumin levels during late pregnancy may help predict complications in both mothers and neonates.
Methods
This study was conducted in 120 singleton pregnant women diagnosed with gestational diabetes who visited Trinium Woman’s Hostipal between July 1, 2020, and June 30, 2022. In this study, the patients’ medical records were retrospectively analyzed. Gestational diabetes was diagnosed using a two-step testing method, and glycated albumin tests were performed during the third trimester of pregnancy. The optimal cutoff value of glycated albumin for predicting maternal complications during pregnancy and neonatal complications was determined using the receiver operating characteristic curve.
Results
A total of 45 patients developed maternal complications, with cesarean section (39 patients) due to fetal cephalopelvic disproportion being the most common. As for the neonatal complications, eight neonates were macrosomic or overweight, while 15 neonates required neonatal intensive care unit admission. Additionally, 13 patients had concurrent complications affecting both the mother and neonate. The glycated albumin level in patients with complications was 12.87%, which was significantly higher than that in patients without complications (glycated albumin, 11.67%) (P<0.001). The optimal cutoff value of glycated albumin for predicting maternal and neonatal complications was 12.45%. The sensitivity, specificity, and Youden index were 66.7 %, 86.7%, and 0.534, respectively.
Conclusion
The third trimester glycated albumin test in mothers with gestational diabetes provides limited predictive value for maternal and neonatal complications.

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The Association between Serum Uric Acid and Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus: A Multicenter Nationwide CrossSectional Study: Wisit Kaewput, Charat Thongprayoon, Ram Rangsin, Sarawut Jindarat, Ploypun Narindrarangkura, Tarun Bathini, Michael A. Mao, Wisit Cheungpasitporn; Korean J Fam Med 2020;41(3):189-194. Published online May 20, 2020; DOI: https://doi.org/10.4082/kjfm.18.0205

Abstract
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Background
The role of uric acid in the development of diabetic peripheral neuropathy remains unclear. This study aimed to determine the association between uric acid and peripheral neuropathy among type 2 diabetes mellitus (T2DM) patients.
Methods
We conducted a nationwide cross-sectional study based on the diabetes and hypertension study of the Medical Research Network of the Consortium of Thai Medical Schools. Adult T2DM patients from 831 public hospitals in Thailand were evaluated. The serum uric acid level was categorized into five groups based on quintiles (<4.4, 4.4–5.3, 5.3–6.2, 6.2–7.3, and >7.3 mg/dL). A multivariate logistic regression model was used to assess the independent association between serum uric acid level and peripheral neuropathy.
Results
In total, 7,511 T2DM patients with available data about serum uric acid levels were included in the analysis. The mean age of the participants was 61.7±10.9 years, and approximately 35.6% were men. The prevalence rate of peripheral neuropathy was 3.0%. Moreover, the prevalence rates of peripheral neuropathy stratified according to uric acid levels <4.4, 4.4–5.3, 5.3–6.2, 6.2–7.3, and >7.3 mg/dL were 2.5%, 2.8%, 2.4%, 2.5%, and 4.7%, respectively. A serum uric acid level ≥7.3 mg/dL was found to be associated with an increase in odds ratio (1.54; 95% confidence interval, 1.02–2.32) for peripheral neuropathy compared with a serum uric acid level <4.4 mg/dL.
Conclusion
Serum uric acid level is independently associated with peripheral neuropathy in T2DM patients, and elevated serum uric acid levels should be considered a risk factor for diabetic peripheral neuropathy in clinical practice.

Citations

Citations to this article as recorded by

Uric acid in diabetic microvascular complications: Mechanisms and therapy
Xin Li, Bo Huang, Yue Liu, Meng Wang, Jing-Qiu Cui
Journal of Diabetes and its Complications.2025; 39(2): 108929. CrossRef
An overview of the role of serum uric acid to high-density lipoprotein cholesterol ratio in type 2 diabetes mellitus and in other inflammatory and metabolic conditions
Gulali AKTAS
Minerva Medica.2025;[Epub] CrossRef
Systemic inflammatory markers and epicardial fat volume as predictors of cardiometabolic risk in type 2 diabetes
Mehmet Cosgun, Zeliha Cosgun, Melike Elif Kalfaoglu, Gulali Aktas
Postgraduate Medical Journal.2025;[Epub] CrossRef
Causality between serum uric acid and diabetic microvascular complications - a mendelian randomization study
Hongli Wu, Xuefeng Li, Wenning Zhang, Huifang Peng, Hongwei Jiang
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Association between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes: a systematic review and meta-analysis
Xieyu Zhang, Xinwen Zhang, Xiaoxu Li, Xin Zhao, Guangcheng Wei, Jinjie Shi, Yue Yang, Su Fan, Jiahe Zhao, Ke Zhu, Jieyang Du, Junyi Guo, Wei Cao
Frontiers in Endocrinology.2024;[Epub] CrossRef
Comparison of Serum Uric Acid-to-HDL Ratio and Triglyceride Glucose Index in Relation to Glycemic Control Among Patients with Type 2 Diabetes Mellitus
Hafiza Farah Masood, Qurratul Ain, Hifza Noor Lodhi, Bilal Rafique Malik, Faheem Usman Sulehri, . Khushbakht, Mirza Zeeshan Sikandar, Sharoona Fatima
Pakistan Journal of Health Sciences.2024; : 130. CrossRef
Serum uric acid and diabetic peripheral neuropathy: a double-edged sword
Yong Zhuang, Huibin Huang, Xin Hu, Jinying Zhang, Qingyan Cai
Acta Neurologica Belgica.2023; 123(3): 857. CrossRef
The Ratio of Serum Uric Acid to Glycosylated Haemoglobin as a Predictor of All-Mortality in Elderly Patients with Diabetic Foot Ulcers: A Longitudinal Cohort Study
Xiuxian Huang, Licai Deng, Jianhao Huang, Jingxia Sun, Qiu Wang, Jiacheng Mo, Zhenwei Zhai, Yuechou Nong, Wensheng Lu
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 2779. CrossRef
Uric acid and diabetes mellitus: an update
Shailendra K Singh, Rina Singh, Santosh K Singh, Mir A Iquebal, Sarika Jaiswal, Pradeep K Rai
Postgraduate Medical Journal.2023; 99(1178): 1220. CrossRef
Serum uric acid and risk of diabetic neuropathy: a genetic correlation and mendelian randomization study
Youqian Zhang, Zitian Tang, Ling Tong, Yang Wang, Lin Li
Frontiers in Endocrinology.2023;[Epub] CrossRef
The relation between serum uric acid levels and diabetic peripheral neuropathy in type 2 diabetes in Guilan, north of Iran
Haniye Sadat Fayazi, Maryam Yaseri, Seyyede Sahere Mortazavi, Zahra Sharifhassan, Ali-Sina Assadinia
BMC Endocrine Disorders.2022;[Epub] CrossRef
Prevalence and Risk Factors for Peripheral Neuropathy in Chinese Patients With Gout
Kaifeng Guo, Nan Liang, Mian Wu, Lihui Chen, Haibing Chen
Frontiers in Neurology.2022;[Epub] CrossRef
Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
WeiZheng So, NatalieShi Qi Wong, HongChang Tan, MollyTzu Yu Lin, IsabelleXin Yu Lee, JodhbirS Mehta, Yu-Chi Liu
Neural Regeneration Research.2022; 17(10): 2172. CrossRef
Sodium Glucose Cotransporter-2 Inhibitor Protects Against Diabetic Neuropathy and Nephropathy in Modestly Controlled Type 2 Diabetes: Follow-Up Study
Fukashi Ishibashi, Aiko Kosaka, Mitra Tavakoli
Frontiers in Endocrinology.2022;[Epub] CrossRef
The association between serum uric acid and diabetic complications in patients with type 2 diabetes mellitus by gender: a cross-sectional study
Yimeng Hu, Qinge Li, Rui Min, Yingfeng Deng, Yancheng Xu, Ling Gao
PeerJ.2021; 9: e10691. CrossRef

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Case Report

A Diagnosis to Consider in an Adult Patient with Facial Features and Intellectual Disability: Williams Syndrome: Özlem Akgün Doğan, Pelin Özlem Şimşek Kiper, Gülen Eda Utine, Mehmet Alikaşifoğlu, Koray Boduroğlu; Korean J Fam Med 2017;38(2):102-105. Published online March 22, 2017; DOI: https://doi.org/10.4082/kjfm.2017.38.2.102

Abstract
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Williams syndrome (OMIM #194050) is a rare, well-recognized, multisystemic genetic condition affecting approximately 1/7,500 individuals. There are no marked regional differences in the incidence of Williams syndrome. The syndrome is caused by a hemizygous deletion of approximately 28 genes, including ELN on chromosome 7q11.2. Prenatal-onset growth retardation, distinct facial appearance, cardiovascular abnormalities, and unique hypersocial behavior are among the most common clinical features. Here, we report the case of a patient referred to us with distinct facial features and intellectual disability, who was diagnosed with Williams syndrome at the age of 37 years. Our aim is to increase awareness regarding the diagnostic features and complications of this recognizable syndrome among adult health care providers. Williams syndrome is usually diagnosed during infancy or childhood, but in the absence of classical findings, such as cardiovascular anomalies, hypercalcemia, and cognitive impairment, the diagnosis could be delayed. Due to the multisystemic and progressive nature of the syndrome, accurate diagnosis is critical for appropriate care and screening for the associated morbidities that may affect the patient's health and well-being.

Citations

Citations to this article as recorded by

Williams–Beuren syndrome: a complete guide for oral healthcare
Pavan Manohar Patil, Seema Pavan Patil
Journal of Oral Medicine and Oral Surgery.2021; 27(2): 21. CrossRef

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1 Crossref

Original Articles

Comparison of DEXA and CT for Truncal Obesity in Adult Women Related to Metabolic Complications.: Ji Soo Kim, Sun Mi Yoo, Kyu Nam Kim, Seon Yeong Lee; J Korean Acad Fam Med 2007;28(9):675-681. Published online September 10, 2007

Abstract
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Background
The metabolic risks associated with obesity are closely correlated with a central rather than a peripheral fat pattern. These complications of obesity have been attributed to increase in visceral adipose tissue. The aim of this study was to investigate whether the dual- energy X-ray absorptiometry (DEXA) method offers a good alternative to computed tomography (CT) for the prediction of visceral fat in the obese women in correlation of metabolic complication markers. Methods: The design is a cross-sectional analysis. Total body fat and truncal fat amounts were measured by using DEXA, while total abdominal fat area was measured by CT, and divided into visceral abdominal fat area and subcutaneous fat area. Partial correlation after controlling for age and multiple regression analyses after adjusting for age and total percent body fat were performed to relate the metabolic variables to the CT and DEXA body composition variables. Results: For serum uric acid, total abdominal fat area by CT had the largest R² values (R²=0.259). For AST, ALT, total cholesterol and log triglyceride, visceral fat area had the largest R² values (R²= 0.360, 0.407, 0.147, and 0.339), respectively, and for log insulin, truncal fat by DEXA had the largest R² values (R²=0.275). Conclusion: Truncal fat amount measured by DEXA had a strong correlation with visceral fat area measured by CT. Truncal fat amount measured by DEXA and correlated significantly with visceral abdominal fat area measured by CT reflected most of the metabolic complication markers. (J Korean Acad Fam Med 2007; 28:675-681)

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Factors Attributing to Increasing Attempts at Central Venous Catheterization.: Dong Hoon Suh, Dong Hee Oh, Hee Sun Seo, Kyung Hee Cho, Kyoung Kon Kim, Hee Cheol Kang, Bang Bu Youn; J Korean Acad Fam Med 2006;27(4):288-293. Published online April 10, 2006

Abstract
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Background
: Central venous catheterization allows the measurement of hemodynamic variables, the delivery of medications and nutritional support. It also has been used as a means to treat sepsis, cardiogenic and hemodynamic shocks. Arterial puncture, hematoma, and pneumo-hemothorax are the most common mechanical complications during the insertion of central venous catheters. This study was done to find out the factors attributing to the increase of puncture attempts in subclavian venous catheter insertion.

Methods : We have conducted surveys in residents who had previous experience with insertion of subclavian venous catheterization in Ilsan hospital from 01/09/2003 to 30/11/2003. A total of 40 cases were marked as two groups, those with less than three puncture attempts and those with more than or equal to three attempts.

Results : The incidence of three or less insertion attempts were 23, whereas in 17 cases three or more attempts were required. The results of the comparison between these two groups proved that the patient's hemoglobin level, skeletal deformity, the level of experience (more than 20), puncture site marking and insertion in the mid-clavicular line were significant factors (P＜0.05).

Conclusion : It seemed necessary to try three or less puncture attempts in order to decrease the incidence of mechanical complications. The operator factors such as previous experience with the procedure, puncture site marking prior to insertion, and insertion in the mid-clavicular line had affected the number of puncture attempts.