Background
This study evaluated the prevalence of Helicobacter pylori infection and the risk factors associated with H. pylori transmission among spouses.
Methods
We assessed the spousal concurrence of H. pylori infection using the Campylobacter-like organism (CLO) test under gastro-endoscopy in 132 couples. Based on the CLO test results, participants were categorized into H. pylori concurrent and independent groups. The chi-square test and Student t-test were performed for demographic comparisons between the concurrent and independent H. pylori groups. In addition, multivariate logistic regression analysis was performed to identify factors associated with concurrent H. pylori infection.
Results
The study revealed that the concurrence rate of H. pylori infection was 42.4% in married Korean couples. The odds ratio (OR) derived from the concurrence of H. pylori infection tended to decrease in older couples (OR, 0.975; 95% confidence interval [CI], 0.949–1.002; P=0.072). Gastric erosion was also associated with a decreased OR for concurrent infection (OR, 0.488; 95% CI, 0.295–0.808; P=0.005). Conversely, active duodenal ulcers were associated with an increased OR for concurrent infections (OR, 6.501; 95% CI, 1.267–33.346; P=0.025). Duodenal ulcer scars tended to increase the OR of concurrent infections (OR, 1.392; 95% CI, 0.815–2.380; P=0.226).
Conclusion
Spousal transmission and concurrence of H. pylori infection were negatively associated with gastric erosion; however, they were positively associated with active duodenal ulcers. Further studies are warranted to elucidate the mechanisms underlying these findings.

Citations

• Examining of Predictive Factors for Developing Gastroduodenal Ulcer among Patients Attending Gastrointestinal Teaching Hospitals in Baghdad
  Ali Hussein Alek Al-Ganmi, Haider Mohammed Majeed, Ahmed Fleih Hassan
  Journal of Nature and Science of Medicine.2025; 8(2): 146.     CrossRef
• Hookah Smoking and Risk of Helicobacter pylori Infection: Insights From a Case‐Control Study in Iran
  Hadi Eshaghi Sani Kakhaki, Nahid Shahabi, Nooshin Ebrahimi, Ehsan Ramezanian Nik, Farshid Soleimani, Shokrollah Mohseni, Moslem Gholamnezhad, Hanieh Sedeghi, Sara Dadipoor
  Health Science Reports.2025;[Epub]     CrossRef

Background
The reports that obesity could be associated with upper gastrointestinal disorders such as gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis have not been consistent. Therefore, we studied the association between esophagogastroduodenoscopic (EGD) fi ndings and the related risk factors of obesity. Methods: The study subjects include 2,210 adults who visited the Health Promotion Center of one university hospital from January 2006 to December 2006. All subjects had standard physical measurements as well as resting blood pressure, fasting blood glucose, HbA1c, serum lipids, and gastroendoscopic examination. BMI was classifi ed into two groups (BMI ≥ 23 kg/m2, normal; BMI < 23 kg/m2, overweight or obese). The study subjects were classifi ed into four groups according to the EGD fi ndings; normal, gastritis, gastric or duodenal ulcer, refl ux esophagitis. Results: Mean BMI of gastritis, gastric or duodenal ulcer, and refl ux esophagitis groups were higher than normal group after adjusting age, sex, alcohol and smoking (P < 0.001). Gastritis risk (OR, 2.098; 95% CI, 1.195 to 3.682; P = 0.01), gastric or duodenal ulcer risk (OR, 2.562; 95% CI, 1.282 to 5.117; P = 0.008), and refl ux esophagitis risk (OR, 2.856; 95% CI, 1.522 to 5.360; P = 0.001) were signifi cantly higher in overweight and obesity group compare with normal weight group after adjusting age, sex, alcohol and smoking. Conclusion: We suggest that overweight or obesity is the risk factor of gastritis, gastric or duodenal ulcer, and reflux esophagitis.

Candida was found in the oral cavity, jejunum, and ileum of the healthy population.
In case of alimentary tract, the factors of favorable to candida colonization include old age,
malnutrition, diabetes, burns, trauma, surgical operations, parenteral nutrition, intravascular or
bladder catheterization, H2-blocker therapy, steroid therapy, immunosuppresive treatment and
the use of wide spectrum antibiotics: however, gastrointestinal candida colonization is rarely
found in the healthy adult. No case of duodenal ulcer with candidiasis has been reported in
healthy people. Recently we experienced a case of asymptomatic duodenal ulcer with
candidiasis in a healthy male, who had taken H2-blocker and proton pump inhibitor for 3
months after primary closure of duodenal ulcer perforation. Therefore we report this case with
review of several literatures.

Background
: Helicobacter pylori infection is thought to be an important factor the pathogenesis of gastric and duodenal ulcer. But in Korea, there are new studies on the prevalence of Helicobacter pylori infection in peptic ulcer patients and their relationship between the location of ulcers and Helicobacter pylori infection. The aim of this study was to investigate the prevalence of Helicobacter pylori infection of gastric and duodenal ulcer patients in Korea and the relationship between the location of ulcers and Helicobacter pylori infection.

Methods : We studied 476 consecutive patients with duodenal ulcers or benign gastric ulcer which were diagnosed by gastrofiberscopy in Family Medicine of Hanil Hospital from January 1995 to December 1998l Helicobacter pylori infection was evaluated with rapid urease test(CLO test) in 72.7% patients.

Results : The test rate of CLO test was not significantly different by sex, age and site of gastric ulcer lesions, but test rate in the gastric ulcer was significantly lower than in the duodenal ulcer. The prevalence of Helicobacter pylori infection diagnosed with CLO test was 90.1%. The prevalence of Helicobacter pylori infection was not significantly different between males and females. Also it was also not significantly different according to age. 90.8% of those with gastric ulcer patients and 88.9% of the duodenal ulcer had Helicobacter pylori infection, but the difference was not significant. significantly. 94.6% of gastric ulcers located in only one area had Helicobacter pylori infection, compared to 83.6% of gastric ulcers which was located in multiple areas. The prevalence of Helicobacter pylori infection was significantly lower in patients who had lesions located in multiple areas.

Conclusion : We conclude that the majority of peptic ulcer patients in Korea have Helicobacter pylori infection. Gastric ulcer located in multiple areas had significantly lower prevalence of Helicobacter pylori infection, which may suggest that gastric ulcers in multiple areas have other etiologic factors.