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"Mortality"

Original Articles

One-year mortality disparities between infants of unmarried and married families in South Korea: a large scale retrospective cohort study
Seonyoung Jeong, Yeani Choi, Hajin Kim, Sang Min Park
Received September 2, 2024  Accepted December 5, 2024  Published online April 16, 2025  
DOI: https://doi.org/10.4082/kjfm.24.0226    [Epub ahead of print]
Background
This study examined disparities in 1-year mortality rates between infants born to married and unmarried single-parent families, emphasizing the need for targeted health policies.
Methods
Data from 3,298,263 cases, obtained from the South Korea National Statistical Office (2010–2017), were analyzed. T-tests and chi-square tests were used to assess the demographic characteristics of the study group. The number of deaths per 1,000 live births was calculated, and logistic and multivariable logistic regressions were employed to compare infant mortality rates between family types. Additional stratified analyses, based on gestational age and birth weight, further elucidated the relationship between parental marital status and infant mortality.
Results
Infants from unmarried families exhibited a 3.34-fold higher crude odds ratio (OR) for 1-year mortality (95% confidence interval [CI], 2.56–4.36; P<0.001) than that from married families. After adjusting for confounders, the adjusted OR was 1.40 (95% CI, 1.03–1.92). Stratification by gestational age and birth weight revealed crude ORs of 4.62 (95% CI, 3.34– 6.39) in non-preterm infants (≥37 weeks) and 4.76 (95% CI, 3.46–6.56) in non-low-birth-weight infants (≥2.5 kg), highlighting a more pronounced disparity in infants born at or above normal weight and full term. No significant difference (P>0.05) was found in the crude OR for 1-year mortality rates among low-birth-weight (<2.5 kg) or preterm (<37 weeks) infants between the two-family types.
Conclusion
This study highlights the significant disparity in infant mortality rates based on parental marital status, underscoring the need for enhanced social support and tailored policies for unmarried single-parent families.
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Age-Related Difference in Weight Change and All-Cause Mortality in Middle-Aged and Older Korean Populations: Korean Longitudinal Study of Aging
Jungki Suh, Yoon Jeong Cho, Hyun Ji Kim, Seong Soo Choi
Korean J Fam Med 2021;42(4):297-302.   Published online July 20, 2021
DOI: https://doi.org/10.4082/kjfm.20.0170
Background
Obesity is associated with increased mortality as a significant risk factor for chronic diseases, including cardiovascular diseases and cancer. Several people believe that weight gain is harmful, and weight loss helps maintain health. However, some studies have shown that weight loss, particularly among older adults, is more likely to increase the risk of mortality than weight gain.
Methods
We used data for the cohort of the Korean Longitudinal Study of Aging, which is a nationwide stratified multi-stage sample of adults aged 45 years. The all-cause mortality risk was assessed using the survival status and the number of months of survival calculated from 2006 (baseline year) to 2016. Cox proportional hazard regression were used to study the causal link between weight change and all-cause mortality risk.
Results
The results showed interactive associations between weight loss and mortality among middle-aged and older adults. The hazard ratio was 1.62 (95% confidence interval [CI], 1.10–2.40) for the participants aged 45–65 years with weight losses greater than 5 kg and 1.56 (95% CI, 1.29–1.89) for those older than 65 years with weight losses greater than 5 kg. The results for the group with weight gain above 5 kg were not significant. Middle-aged and older men showed an increase in all-cause mortality associated with weight loss of more than 5 kg, but only the older women showed significant results.
Conclusion
This large-scale cohort study in Korea showed a relationship between weight loss and all-cause mortality in middle-aged and older individuals.

Citations

Citations to this article as recorded by  
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  • Obesity in Caucasian Seniors on the Rise: Is It Truly Harmful? Results of the PolSenior2 Study
    Monika Puzianowska-Kuznicka, Alina Kurylowicz, Lukasz Wierucki, Aleksander Jerzy Owczarek, Kacper Jagiello, Malgorzata Mossakowska, Tomasz Zdrojewski, Jerzy Chudek
    Nutrients.2022; 14(21): 4621.     CrossRef
  • 4,159 View
  • 84 Download
  • 12 Web of Science
  • 12 Crossref

Review Article

Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks
Jung Ha Park, Ji Hyun Moon, Hyeon Ju Kim, Mi Hee Kong, Yun Hwan Oh
Korean J Fam Med 2020;41(6):365-373.   Published online November 19, 2020
DOI: https://doi.org/10.4082/kjfm.20.0165
One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known. The mean daily duration of sedentary behavior is 8.3 hours among the Korean population and 7.7 hours among the American adult population. Sedentary lifestyles are spreading worldwide because of a lack of available spaces for exercise, increased occupational sedentary behaviors such as office work, and the increased penetration of television and video devices. Consequently, the associated health problems are on the rise. A sedentary lifestyle affects the human body through various mechanisms. Sedentary behaviors reduce lipoprotein lipase activity, muscle glucose, protein transporter activities, impair lipid metabolism, and diminish carbohydrate metabolism. Furthermore, it decreases cardiac output and systemic blood flow while activating the sympathetic nervous system, ultimately reducing insulin sensitivity and vascular function. It also alters the insulin-like growth factor axis and the circulation levels of sex hormones, which elevates the incidence of hormone-related cancers. Increased sedentary time impairs the gravitostat, the body’s weight homeostat, and weight gain, adiposity, and elevated chronic inflammation caused by sedentary behavior are risk factors for cancer. Sedentary behaviors have wide-ranging adverse impacts on the human body including increased all-cause mortality, cardiovascular disease mortality, cancer risk, and risks of metabolic disorders such as diabetes mellitus, hypertension, and dyslipidemia; musculoskeletal disorders such as arthralgia and osteoporosis; depression; and, cognitive impairment. Therefore, reducing sedentary behaviors and increasing physical activity are both important to promote public health.

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Original Articles
Trajectories of Handgrip Strength and Their Associations with Mortality among Older Adults in Korea: Analysis of the Korean Longitudinal Study of Aging
Kyung Hyun Bae, Yong Ho Jo, Dong Ryul Lee, Jungun Lee
Korean J Fam Med 2021;42(1):38-46.   Published online May 27, 2020
DOI: https://doi.org/10.4082/kjfm.19.0140
Background
Handgrip strength (HGS) is a good predictor of adverse health outcomes in later life. This prospective study aimed to investigate whether HGS trajectory patterns were associated with all-cause mortality among older adults in Korea.
Methods
This study used the database of the 2006–2016 Korean Longitudinal Study of Aging. Study participants included 3,069 adults aged ≥65 years without a previous history of cancer. The trajectory model was developed to identify different homogeneous trajectory patterns of HGS according to study period. Cox proportional hazards models were then applied to investigate the association between HGS and all-cause mortality.
Results
The survival probability according to HGS during the follow-up period decreased as base HGS weakened. We identified four distinct trajectory groups of HGS among men and three among women. The risk of mortality increased as the HGS of both males and females decreased. Compared with the highest HGS group, the adjusted hazard ratios for all-cause mortality of the lowest, lower-mid, and upper-mid HGS groups among males were 3.46 (95% confidence interval [CI], 2.17–6.69), 2.26 (95% CI, 1.47–3.48), and 1.58 (95% CI, 1.07–2.32). Those of the low and mid HGS groups among females were 2.69 (95% CI, 1.39–5.21) and 1.97 (95% CI, 1.05–3.69).
Conclusion
The faster HGS declined over time, the greater the all-cause mortality risk increased compared with the slowly decreasing or maintained HGS groups among men and women. HGS measurement among older adults will be helpful in assessing their health statuses and pre-assessing disease-associated morbidity.

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  • Effects of a 16-week high-speed resistance training program on physical and cognitive function in community-dwelling independent older adults: a clinical trial
    Alexandre Duarte Martins, Nuno Batalha, Orlando Fernandes, Bruno Gonçalves, Rafael Oliveira, Joao Paulo Brito
    Sport Sciences for Health.2025;[Epub]     CrossRef
  • Longitudinal trajectories of handgrip strength and their association with motoric cognitive risk syndrome in older adults
    Hui Chang, Yu Zhao
    Archives of Gerontology and Geriatrics.2024; 120: 105334.     CrossRef
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    Wonjeong Jeong, Jong Youn Moon, Jae-Hyun Kim
    BMC Geriatrics.2023;[Epub]     CrossRef
  • Analysis of the association between osteoporosis and muscle strength in Korean adults: a national cross-sectional study
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    Journal of Health, Population and Nutrition.2023;[Epub]     CrossRef
  • Grip Strength Measurement in the Right Hand Better Predicts Mortality Regardless of Dominant Hand
    Yun-A Shin, Won-Ho Choi, Jae-Hyun Kim
    Exercise Science.2022; 31(1): 110.     CrossRef
  • Longitudinal association of handgrip strength with all-cause and cardiovascular mortality in older adults using a causal framework
    Rubén López-Bueno, Lars Louis Andersen, Joaquín Calatayud, José Casaña, Lee Smith, Louis Jacob, Ai Koyanagi, José Francisco López-Gil, Borja del Pozo Cruz
    Experimental Gerontology.2022; 168: 111951.     CrossRef
  • Importance of Handgrip Strength as a Health Indicator in the Elderly
    Soo Young Kim
    Korean Journal of Family Medicine.2021; 42(1): 1.     CrossRef
  • Grip Strength as a Cardiometabolic Marker
    Jungun Lee
    Korean Journal of Family Medicine.2020; 41(5): 271.     CrossRef
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  • 130 Download
  • 6 Web of Science
  • 8 Crossref
Fear of Falling and Mortality among Older Adults in Korea: Analysis of the Korean Longitudinal Study of Aging
Ari Lee, Jungun Lee, Gyumin Lee, Dong Ryul Lee
Korean J Fam Med 2020;41(4):243-249.   Published online May 12, 2020
DOI: https://doi.org/10.4082/kjfm.18.0128
Background
The fear of falling (FOF) has been reported in a high percentage of elderly people. An excessive FOF is a major concern among the elderly because it can lead to permanent disability. However, the impact of FOF on mortality has been insufficiently studied. The aim of this study was to investigate the impact of FOF on mortality among the elderly in Korea.
Methods
This was a prospective study carried out using the database of the Korean Longitudinal Study of Aging, a nationwide study of community-dwelling adults in Korea. Study participants included 3,421 adults, aged 65 years or older, without either severe cognitive impairment (Korean version of Mini-Mental Status Examination ≥10), or previous history of cancer. We used Cox proportional hazards models to investigate the association between FOF and all-cause mortality.
Results
This study included 1,474 men and 1,947 women. Cox regression showed that participants with FOF had an increased risk of mortality (mild: hazard ratio [HR], 1.25; 95% confidence interval [CI], 1.01−1.54; moderate: HR, 1.59; 95% CI, 1.23−2.05) after adjusting for confounding variables. In a subgroup analysis, FOF was still a significant risk factor of mortality for patients with no previous history of falling after adjusting for other risk factors, as in the full model, except for history of falling (HR, 1.65; 95% CI, 1.27−2.13).
Conclusion
We found that FOF was a significant risk factor for mortality in the elderly in Korea. Further studies on the effects and mechanism of FOF on mortality are needed.

Citations

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  • Association between fear of falling and mortality in middle-aged and older adults: A systematic review and meta-analysis
    Wenlian Ma, Xiaoli Liang, Hongyan Wang, Zhifei Wen, Linfeng Liu, Liangliang Fan, Xiangeng Zhang
    Geriatric Nursing.2024; 59: 113.     CrossRef
  • Factors Associated with Fear of Falling by Fall Experience in the Community-dwelling Elderly
    Yeong Mi Seo, Eun Sook Lee
    Research in Community and Public Health Nursing.2023; 34: 12.     CrossRef
  • Bidirectional relationship between fear of falling and frailty among community-dwelling older adults: A longitudinal study
    Cen Mo, Wenting Peng, Yuqian Luo, Siyuan Tang, Minhui Liu
    Geriatric Nursing.2023; 51: 286.     CrossRef
  • Fear of falling and all-cause mortality among young-old community-dwelling adults: a 6-year prospective study
    Giulia Belloni, Christophe Büla, Brigitte Santos-Eggimann, Yves Henchoz, Sarah Fustinoni, Laurence Seematter-Bagnoud
    European Journal of Ageing.2022; 19(2): 293.     CrossRef
  • A comparison of the prevalence of Fear of Falling between older patients with Lewy body dementia, Alzheimer's disease, and without dementia
    Pinar Soysal, Semen Gokce Tan, Lee Smith
    Experimental Gerontology.2021; 146: 111248.     CrossRef
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  • 102 Download
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Survival Analysis of Patients with Alzheimer’s Disease: A Study Based on Data from the Korean National Health Insurance Services’ Senior Cohort Database
Tae Ho Huh, Jong Lull Yoon, Jung Jin Cho, Mee Young Kim, Young Soo Ju
Korean J Fam Med 2020;41(4):214-221.   Published online April 23, 2020
DOI: https://doi.org/10.4082/kjfm.18.0114
Background
Korea’s rapidly aging population has experienced a sharp rise in the prevalence of dementia. Patients with Alzheimer’s disease (AD), which is estimated to be about three-quarters of all patients with dementia, tend to have higher mortality rates compared with patients without Alzheimer’s disease. In this study, a survival analysis of patients with AD was conducted in order to provide knowledge to those who provide medical care to these patients.
Methods
Data on individuals over 65 years old in 2004 were extracted from the Korean National Health Insurance Services’ Senior Cohort database (2002–2013). The subjects were 209,254 patients, including 2,695 who were first diagnosed with AD (the AD group) and 206,559 that had not been diagnosed with the disease (non-AD group). To investigate the independent effect of AD on survival, the Cox proportional-hazards model, hazard ratios (confidence interval of 95%), and the Kaplan-Meier method were used.
Results
Mean survival time in the AD group was 5.3±3.3 years, which was about 2.5 years shorter than that in the non-AD group (7.8±2.4 years). The mortality rate in the AD group (66.3%) was higher than that in the non-AD group (26.3%). The adjusted hazard ratio in the AD group was 2.5 and, therefore, it was found that the AD group had a 2.5-fold higher risk of death than the non-AD group.
Conclusion
Overall, AD has a large, independent impact on survival. Survival time was shorter, and the mortality rate and risk were generally higher in the AD group, compared with the non-AD group.

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  • Clinical profile and survival analysis of Alzheimer’s disease patients in a Brazilian cohort
    Elisa de Melo Queiroz, Christian Marques Couto, Cláudio Antônio da Cruz Mecone, Waneska Souza Lima Macedo, Paulo Caramelli
    Neurological Sciences.2024; 45(1): 129.     CrossRef
  • Survival After the Diagnosis of Mild‐to‐Moderate Alzheimer's Disease Dementia: A 15‐Year National Cohort Study in Taiwan
    Yu Sun, Chih‐Ching Liu, Chung‐Yi Li, Ming‐Jang Chiu
    International Journal of Geriatric Psychiatry.2024;[Epub]     CrossRef
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    Wanwan Xu, Selena Wang, Li Shen, Yize Zhao
    Statistics in Biosciences.2024;[Epub]     CrossRef
  • Effect of choline alfoscerate in older adult patients with dementia: an observational study from the claims data of national health insurance
    Khanh Linh Duong, Heeyoon Jung, Hyun-kyoung Lee, Young Jin Moon, Sang Ki Lee, Bo Ram Yang, Hwi-yeol Yun, Jung-woo Chae
    BMC Geriatrics.2024;[Epub]     CrossRef
  • Mortality Risks and Causes of Death by Dementia Types in a Japanese Cohort with Dementia: NCGG-STORIES
    Rei Ono, Takashi Sakurai, Taiki Sugimoto, Kazuaki Uchida, Takeshi Nakagawa, Taiji Noguchi, Ayane Komatsu, Hidenori Arai, Tami Saito
    Journal of Alzheimer's Disease.2023; 92(2): 487.     CrossRef
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    Yihan Hu, Kejia Hu, Huan Song, Yudi Pawitan, Fredrik Piehl, Fang Fang
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    Sung Hoon Kang, Sook‐young Woo, Seonwoo Kim, Jun Pyo Kim, Hyemin Jang, Seong‐Beom Koh, Duk L. Na, Hee Jin Kim, Sang Won Seo
    European Journal of Neurology.2022; 29(2): 413.     CrossRef
  • Deep learning algorithm reveals probabilities of stage‐specific time to conversion in individuals with neurodegenerative disease LATE
    Xinxing Wu, Chong Peng, Peter T. Nelson, Qiang Cheng
    Alzheimer's & Dementia: Translational Research & Clinical Interventions.2022;[Epub]     CrossRef
  • Time‐to‐event prediction using survival analysis methods for Alzheimer's disease progression
    Rahul Sharma, Harsh Anand, Youakim Badr, Robin G. Qiu
    Alzheimer's & Dementia: Translational Research & Clinical Interventions.2021;[Epub]     CrossRef
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The Influence of Negative Mental Health on the Health Behavior and the Mortality Risk: Analysis of Korean Longitudinal Study of Aging from 2006 to 2014
Eun Ryeong Jun, Sung Hi Kim, Yoon Jeong Cho, Yun-A Kim, Joo Young Lee
Korean J Fam Med 2019;40(5):297-306.   Published online September 11, 2019
DOI: https://doi.org/10.4082/kjfm.18.0068
Background
Several studies have shown that negative mental health increases risky health behavior and mortality risk. We investigated the relationship between mental health and health behavior, and the causal association between mental health and mortality risk.
Methods
We used data from the 8-year (2006–2014) Korean Longitudinal Study of Aging with a cohort of 10,247 individuals (whom we divided into a younger group aged <65 years and an older group aged ≥65 years). Mental health was assessed with the following factors: depression, social engagement, and satisfaction of life. Health behavior was assessed with smoking, alcohol use, and regular exercise. Mortality risk was calculated using survival status and survival months as of 2014. Multiple logistic regression and Cox proportional hazard analysis were performed.
Results
Negative mental health was associated with current smoking and sedentary life style, but not with alcohol consumption. In addition, it was associated with an increase in all-cause mortality risk. The increase in mortality risk in the highest quartile (vs. lowest) was 1.71 times (hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.12– 2.62) and 2.07 times (HR, 2.07; 95% CI, 1.60–2.67) for the younger and older group, respectively.
Conclusion
Our results show that mental health affects health behavior and mortality risk. A key inference from this study is that improving mental health can lead to positive changes in health behavior and reduce the risk of mortality.

Citations

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  • Effect of Lifestyle Counselling via a Mobile Application on Disease Activity Control in Inflammatory Arthritis: A Single-Blinded, Randomized Controlled Study
    Türker Kurt, Diana Vossen, Falk Schumacher, Johannes Strunk, Dmytro Fedkov, Christine Peine, Felix Lang, Abdullah Khalil, Ralph Brinks, Stefan Vordenbäumen
    Nutrients.2024; 16(10): 1488.     CrossRef
  • The Moderating Effect of Mental Health on the Relationship Between Cardiovascular Disease Awareness and Health Behaviors of Middle-Aged Korean Chinese Workers With Cardiovascular Risk Factors in Korea
    Yu Zhu Zhang, Seon Young Hwang
    Journal of Transcultural Nursing.2023; 34(2): 131.     CrossRef
  • Combined Effects of Depression and Chronic Disease on the Risk of Mortality: The Korean Longitudinal Study of Aging (2006-2016)
    Hyunji Kim, Sung Hi Kim, Yoon Jeong Cho
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • KLoSA—Korean Longitudinal Study of Aging
    Jungun Lee
    Korean Journal of Family Medicine.2020; 41(1): 1.     CrossRef
  • Mortality and cause of death in physical activity and insufficient physical activity participants: a longitudinal follow-up study using a national health screening cohort
    Chanyang Min, Dae Myoung Yoo, Jee Hye Wee, Hyo-Jeong Lee, Soo Hwan Byun, Hyo Geun Choi
    BMC Public Health.2020;[Epub]     CrossRef
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  • 6 Web of Science
  • 5 Crossref
Background
We evaluated the effects of socioeconomic factors and psychosocial factors, both individually and combined, on all-cause mortality risk (mortality risk).
Methods
We conducted an 8-year (2006–2014) longitudinal analysis of 10,247 individuals who took part in the Korean Longitudinal Study of Aging, a nationwide survey of people aged 45–79 years. Socioeconomic vulnerability (SEV) was assessed with factors such as education, household income, commercial health insurance, and residential area. Mental health (MH) was assessed with factors such as depression, social engagement, and life satisfaction. The covariates were age, gender, marital status, cohabiting, number of chronic diseases, and health behaviors such as regular exercise, smoking, and alcohol intake. We used a Cox proportional hazard analysis to investigate the effects of SEV and MH on mortality risk and also to analyze the superimposed effects of SEV-MH on mortality risk.
Results
After the controlling for the covariates, high SEV and negative MH were found to be strong predictors of all-cause mortality. The highest quartile of SEV (vs. lowest) had a 1.70 times greater mortality risk (hazard ratio [HR], 1.70; 95% confidence interval [CI], 1.24–2.33) and the highest quartile of MH (vs. lowest) had a 2.13 times greater mortality risk (HR, 2.13; 95% CI, 1.72–2.64). Being in the highest quartile for both SEV and MH (vs. lowest) increased mortality risk more than 3 times (HR, 3.11; 95% CI, 2.20–4.40).
Conclusion
High SEV and negative MH were independently associated with increased mortality risk, and their superimposed effects were associated with an increased risk of mortality.

Citations

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  • Sustained Low Income, Income Changes, and Risk of All-Cause Mortality in Individuals With Type 2 Diabetes: A Nationwide Population-Based Cohort Study
    Hong Seok Lee, Jimin Clara Park, Inkwan Chung, Junxiu Liu, Seong-Su Lee, Kyungdo Han
    Diabetes Care.2023; 46(1): 92.     CrossRef
  • The role of social factors in the successful ageing – Systematic review
    J. Takács, C. Nyakas
    Developments in Health Sciences.2022; 4(1): 11.     CrossRef
  • Combined Effects of Depression and Chronic Disease on the Risk of Mortality: The Korean Longitudinal Study of Aging (2006-2016)
    Hyunji Kim, Sung Hi Kim, Yoon Jeong Cho
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • KLoSA—Korean Longitudinal Study of Aging
    Jungun Lee
    Korean Journal of Family Medicine.2020; 41(1): 1.     CrossRef
  • 6,099 View
  • 64 Download
  • 3 Web of Science
  • 4 Crossref
Mild Anemia and Risk for All-Cause, Cardiovascular and Cancer Deaths in Apparently Healthy Elderly Koreans
Sil Vi Han, Minseon Park, Young-Min Kwon, Hyung-Jin Yoon, Yoosoo Chang, Ho Kim, Youn-Hee Lim, Su Gyeong Kim, Ahryoung Ko
Korean J Fam Med 2019;40(3):151-158.   Published online January 17, 2019
DOI: https://doi.org/10.4082/kjfm.17.0089
Background
Being common, mild anemia is sometimes considered a mere consequence of aging; however, aging alone is unlikely to lead to anemia. Therefore, this study aimed to investigate the association between mild anemia and total mortality and cause-specific mortality in apparently healthy elderly subjects.
Methods
A retrospective cohort study was conducted on 10,114 apparently healthy elderly individuals who underwent cancer screening and routine medical check-ups at one Health Promotion Center between May 1995 and December 2007. We defined mild anemia as a hemoglobin concentration between 10.0 g/dL and 11.9 g/dL in women and between 10.0 g/dL and 12.9 g/dL in men. We assessed the relationship between the overall, cardiovascular (CV), and cancer mortality and mild anemia using Cox proportional hazard models.
Results
Mild anemia was present in 143 men (3.1%) and 246 women (6.1%). During an average follow-up of 7.6 years, 495 deaths occurred, including 121 CV and 225 cancer deaths. After adjustments, mild anemia was associated with a 128% increase in the risk of all-cause mortality hazard ratio (HR, 2.28; 95% confidence interval [CI], 1.54– 3.37) in men and cancer-related mortality (HR, 2.25; 95% CI, 1.22–4.13), particularly lung cancer (HR, 2.70; 95% CI, 1.03–7.08) in men, but not in women. In the subgroup analyses based on smoking status, obesity, and age, the associations were more prominent in never or former smoker groups and the older group.
Conclusion
The present study shows that overall and cancer-related mortality was associated with mild anemia in elderly men. Future prospective studies are needed to consolidate our findings.

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    Ethan J. Cannon, Jeffrey R. Misialek, Leo F. Buckley, Iman A.F. Aboelsaad, Christie M. Ballantyne, John Leister, James S. Pankow, Pamela L. Lutsey
    Gerontology.2024; 70(10): 1023.     CrossRef
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    Ulfah Kartikasari, Suryanti Dwi Pratiwi, Tri Wahju Astuti, Nanik Setijowati
    Jurnal Respirasi.2024; 10(2): 120.     CrossRef
  • Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged ≥ 70 Years
    Sonali R. Gnanenthiran, Austin C.C. Ng, Robert G. Cumming, David B. Brieger, David G. le Couteur, Louise M. Waite, Markus Seibel, David J. Handelsman, Vasi Naganathan, Leonard Kritharides, Fiona M. Blyth
    Canadian Journal of Cardiology.2022; 38(6): 745.     CrossRef
  • Hematopoiesis, Inflammation and Aging—The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals
    Øystein Bruserud, Anh Khoi Vo, Håkon Rekvam
    Journal of Clinical Medicine.2022; 11(3): 706.     CrossRef
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    Fares M.S Muthanna, Mahmathi Karuppannan, Egbal Abdulrahman, Suriyon Uitrakul, Bassam Abdul Hassan Rasool, Ali Haider Mohammed, Abdelhakim Bouyahya
    Advances in Pharmacological and Pharmaceutical Sciences.2022; 2022: 1.     CrossRef
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    Reza Asadzadeh, Aliashraf Mozafari, Elham Shafiei, Mohammadreza Kaffashian, Iraj Ahmadi, Mohammadzaman Darvish, Saiyad Bastaminejad
    Iranian Biomedical Journal.2022; 26(5): 389.     CrossRef
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    Anna Lisa Kunz, Anton Schönstein, Philipp Bahrmann, Evangelos Giannitsis, Hans-Werner Wahl, Hugo A Katus, Norbert Frey, Anke Bahrmann
    BMJ Open.2022; 12(12): e056674.     CrossRef
  • ASSOCIATION OF ANEMIA WITH EXTRASYSTOLIA IN PATIENTS WITH SENIOR ASTHENIA
    Aksyutina N.V., Davydov E.L., Bolshakova T.Yu., Nadezhdina D.A., Voronin I.S., Suleymanov Yu.S., Matryonina A.V., Kusaev V.V.
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    N. O. Khovasova, A. V. Naumov
    Russian Journal of Geriatric Medicine.2020; (1): 81.     CrossRef
  • High anemia prevalence in Korean older adults, an advent healthcare problem: 2007–2016 KNHANES
    Hee Won Chueh, Hye Lim Jung, Ye Jee Shim, Hyoung Soo Choi, Jin Yeong Han
    BMC Geriatrics.2020;[Epub]     CrossRef
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Body Mass Index and Mortality according to Gender in a Community-Dwelling Elderly Population: The 3-Year Follow-up Findings from the Living Profiles of Older People Surveys in Korea
Seon Yeong Yu, Byung Sung Kim, Chang Won Won, Hyunrim Choi, Sunyoung Kim, Hyung Woo Kim, Min Joung Kim
Korean J Fam Med 2016;37(6):317-322.   Published online November 18, 2016
DOI: https://doi.org/10.4082/kjfm.2016.37.6.317
Background

Body mass index is widely regarded as an important predictor of mortality. The purpose of this study was to investigate the relationship between body mass index and mortality and to compare community-dwelling elderly people in South Korea according to sex.

Methods

Data were collected from the 2008 and 2011 Living Profiles of Older People Surveys, which comprised 10,613 community-living South Korean men and women aged 65 years or older. The participants were stratified into five groups according to body mass index as defined by the World Health Organization guidelines. The sociodemographic characteristics of participants and mortality rates were compared across the body mass index groups.

Results

The highest survival rates were observed in men with a body mass index of 25.0–29.9 kg/m2. A similar trend was observed in women, but it was not statistically significant. After adjusting for covariates, this association was also found in men across all BMI index groups, but not in women.

Conclusion

This study supports previous findings that overweight or mild obesity is associated with the lowest mortality and suggests that the current categories of obesity require revision. Furthermore, the absence of statistically significant findings in the female cohort suggests that body mass index is not a suitable predictor of mortality in women and that an alternative is required.

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    Mehnaz Munir, Sandi M Azab, Shrikant I Bangdiwala, Om Kurmi, Dany Doiron, Jeffrey Brook, Laura Banfield, Russell J de Souza
    BMJ Open.2024; 14(2): e080026.     CrossRef
  • Association of Underweight and Hand Grip Strength with the Risk of All-cause Mortality in Older Adults
    Min-jun Kim, Tae-woong Oh
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  • The Prognostic Value of Combined Status of Body Mass Index and Psychological Well-Being for the Estimation of All-Cause and CVD Mortality Risk: Results from a Long-Term Cohort Study in Lithuania
    Dalia Lukšienė, Abdonas Tamosiunas, Ricardas Radisauskas, Martin Bobak
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    Jae-Hyun Kim
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    Haksun Kim, Jong L Yoon, Aeyoung Lee, Yujin Jung, Mee Y Kim, Jung J Cho, Young S Ju
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Validation of the Prognosis in Palliative Care Study Predictor Models in Terminal Cancer Patients
Eun-Shin Kim, Jung-Kwon Lee, Mi-Hyun Kim, Hye-Mi Noh, Yeong-Hyeon Jin
Korean J Fam Med 2014;35(6):283-294.   Published online November 21, 2014
DOI: https://doi.org/10.4082/kjfm.2014.35.6.283
Background

Prognosis in Palliative Care Study (PiPS) predictor models were developed in 2011 to estimate the survival of terminal cancer patients in the United Kingdom. The aim of this study was to validate the PiPS model for terminal cancer patients in Korea, and evaluate its value in clinical practice.

Methods

This study included 202 advanced cancer patients who were admitted to the cancer hospital's palliative care ward from November 2011 to February 2013. On admission, physicians recorded the PiPS-A, PiPS-B, and doctor's survival estimates in inpatients.

Results

The median survival across PiPS-A categories was 9, 28, and 33 days, and the median survival across PiPS-B was 9.5, 27, and 43 days. The median actual survival was 25 days; overall accuracy between the PiPS-A, PiPS-B, doctor's estimates of survival, and actual survival was 52.0%, 49.5%, and 46.5%, respectively. The PiPS-A and PiPS-B groups for survival in 'days' showed a sensitivity of 48.4% and 64.1%, and specificity of 87.7%, and 77.5%, respectively. The PiPS-A and PiPS-B groups for survival in 'weeks' showed a sensitivity of 59.2%, and 44.7%, and specificity of 61.6%, and 64.7%, respectively. The PiPS-A and PiPS-B 'months' group showed a sensitivity of 37.1% and 37.1%, and specificity of 74.9% and 78.4%, respectively. The 'weeks' and 'months' groups showed significantly prolonged survival rates than 'days' group did in both PiPS-A and PiPS-B, by the Kaplan-Meier method.

Conclusion

The PiPS predictor models effectively predicted the survival ≥14 days in terminal cancer patients, and were superior to doctor's estimates.

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  • Validation of the prognostic model for palliative radiotherapy in older patients with cancer
    Hyojung Park
    World Journal of Clinical Oncology.2025;[Epub]     CrossRef
  • Prognosis palliative care study, palliative prognostic index, palliative prognostic score and objective prognostic score in advanced cancer: a prospective comparison
    Seung Hun Lee, Jeong Gyu Lee, Young Jin Choi, Young Mi Seol, Hyojeong Kim, Yun Jin Kim, Yu Hyeon Yi, Young Jin Tak, Gyu Lee Kim, Young Jin Ra, Sang Yeoup Lee, Young Hye Cho, Eun Ju Park, Youngin Lee, Jungin Choi, Sae Rom Lee, Ryuk Jun Kwon, Soo Min Son
    BMJ Supportive & Palliative Care.2024; 14(e1): e1016.     CrossRef
  • Malignancy-related ascites in palliative care units: prognostic factor analysis
    Toru Kadono, Hiroto Ishiki, Naosuke Yokomichi, Tetsuya Ito, Isseki Maeda, Yutaka Hatano, Tomofumi Miura, Jun Hamano, Takashi Yamaguchi, Ayaka Ishikawa, Yuka Suzuki, Sayaka Arakawa, Koji Amano, Eriko Satomi, Masanori Mori
    BMJ Supportive & Palliative Care.2023; 13(e3): e1292.     CrossRef
  • Das LUEBECKER-Modell in der Palliativmedizin
    Andreas S. Lübbe, Frank Gieseler
    Im Fokus Onkologie.2022; 25(3): 21.     CrossRef
  • Imminent death: clinician certainty and accuracy of prognostic predictions
    Nicola White, Fiona Reid, Victoria Vickerstaff, Priscilla Harries, Christopher Tomlinson, Patrick Stone
    BMJ Supportive & Palliative Care.2022; 12(e6): e785.     CrossRef
  • Onkologische Systemtherapie bei Palliativpatienten: Beendigung oder Fortführung?
    Jorge Riera Knorrenschild
    TumorDiagnostik & Therapie.2021; 42(02): 105.     CrossRef
  • The Prognosis in Palliative care Study II (PiPS2): A prospective observational validation study of a prognostic tool with an embedded qualitative evaluation
    P. C. Stone, A. Kalpakidou, C. Todd, J. Griffiths, V. Keeley, K. Spencer, P. Buckle, D. Finlay, V. Vickerstaff, R. Z. Omar, Tim Luckett
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  • Prognostic models of survival in patients with advanced incurable cancer: the PiPS2 observational study
    Patrick Stone, Anastasia Kalpakidou, Chris Todd, Jane Griffiths, Vaughan Keeley, Karen Spencer, Peter Buckle, Dori-Anne Finlay, Victoria Vickerstaff, Rumana Z Omar
    Health Technology Assessment.2021; 25(28): 1.     CrossRef
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    Frontiers in Public Health.2021;[Epub]     CrossRef
  • Validation of the Palliative Prognostic Index, Performance Status–Based Palliative Prognostic Index and Chinese Prognostic Scale in a home palliative care setting for patients with advanced cancer in China
    Jun Zhou, Sitao Xu, Ziye Cao, Jing Tang, Xiang Fang, Ling Qin, Fangping Zhou, Yuzhen He, Xueren Zhong, Mingcai Hu, Yan Wang, Fengjuan Lu, Yongzheng Bao, Xiangheng Dai, Qiang Wu
    BMC Palliative Care.2020;[Epub]     CrossRef
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    Muqing Wang, Xubin Jing, Weihua Cao, Yicheng Zeng, Chaofen Wu, Weilong Zeng, Wenxia Chen, Xi Hu, Yanna Zhou, Xianbin Cai
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    Yann Molin, Caroline Gallay, Julien Gautier, Audrey Lardy‐Cleaud, Romaine Mayet, Marie‐Christine Grach, Gérard Guesdon, Géraldine Capodano, Olivier Dubroeucq, Carole Bouleuc, Nathalie Bremaud, Anne Fogliarini, Aline Henry, Nathalie Caunes‐Hilary, Stéphani
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    PLOS ONE.2017; 12(4): e0175123.     CrossRef
  • Survival prediction for advanced cancer patients in the real world: A comparison of the Palliative Prognostic Score, Delirium-Palliative Prognostic Score, Palliative Prognostic Index and modified Prognosis in Palliative Care Study predictor model
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    European Journal of Cancer.2015; 51(12): 1618.     CrossRef
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Trends in Cervical Cancer Mortality by Socioeconomic Status in Korean Women between 1998 and 2009
Mi-Hyun Kim, Yun-Mi Song, Bo-Kyoung Kim, Sung-Min Park, Gwang Pyo Ko
Korean J Fam Med 2013;34(4):258-264.   Published online July 24, 2013
DOI: https://doi.org/10.4082/kjfm.2013.34.4.258
Background

Death from uterine cervical cancer could be preventable by an active participation of women at risk in a screening program such as the Papanicolaou test. In order to examine the presence of socioeconomic disparity in preventable deaths, we evaluated the time trends of cervical cancer mortality by socioeconomic status in Korean women.

Methods

We selected level of educational attainment and marital status as surrogate indices of socioeconomic status. Using death certificate data and Korean Population and Housing Census data from Korea National Statistical office, we calculated age-standardized yearly mortality rates from cervical cancer between 1998 and 2009 according to the level of education as well as marital status.

Results

Cervical cancer mortality peaked in 2003 and then decreased gradually over time. Cervical cancer mortality was the highest in the group with the lowest level of educational attainment in all age groups and the gap between the lowest and the highest educational level has increased over time. Cervical cancer mortality was lower in married women than unmarried women in all age groups, and the degree of difference did not change over time.

Conclusion

In the Korean population, socioeconomic differential in cervical cancer mortality has persisted over time.

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    Gabrielle Lisembard, Michaël Rochoy, François Quersin, Valérie Deken, Alain Duhamel, Axel Descamps, Christophe Berkhout, Fanny Serman
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Effect of Smoking Cessation on Mortality after Percutaneous Coronary Intervention.
Hanna Sung, Hong Jun Cho, Jin Hyun Kim, Seung Jung Park
J Korean Acad Fam Med 2007;28(9):698-704.   Published online September 10, 2007
Background
Smoking is one of the known major risk factors of coronary artery disease and previous studies have shown that the risk of mortality declines after cessation of smoking. The goal of this study was to determine the influence of smoking on mortality after percutaneous coronary intervention, which has still not been established in Korea. Methods: Patients who had undergone successful percutaneous coronary intervention at Asan Medical Center between January 1996 and June 1997 were classified into nonsmokers (n=306), ex-smokers (n=178), and current smokers (n=360). According to subsequent smoking status, current smokers were divided into quitters (n=152), persistent smokers (n=173), and unknown status (n=35). The data of the death Roll was from the National Statistical Office. Results: The maximum follow-up was 119 months (mean±SD=100±26.5). The total smoking rate was 42.7%. The mortality rates of nonsmokers, ex-smokers and current smokers were 17.6%, 20.8%, and 17.2%, respectively. In analyses adjusted for base line characteristics, the relative risk of death among current smokers was 1.57 (95% confidence interval [CI], 0.98 to 2.53) and among ex-smokers was 1.37 (95% CI, 0.80 to 2.35) compared with nonsmokers. The persistent smokers had a greater relative risk of death from all causes (relative risk, 2.20 [95% CI, 1.08 to 4.48]) as compared with the quitters. Conclusion: The persistent smokers were at greater risk for death than the quitters. Therefore, patients undergoing percutaneous intervention should be encouraged to stop smoking. (J Korean Acad Fam Med 2007;28: 698-704)
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Factors Related to Mortality of Elderly Patients Admitted with Community-acquired Pneumonia.
Ju Ri Lee, Sung Eun Jo, Mi Na Choi, Hye Ree Lee
J Korean Acad Fam Med 2006;27(2):97-103.   Published online February 10, 2006
Background
: Community-acquired pneumonia is one of the main causes of hospitalization and death, especially in elderly patients. There have been many studies on prognosis for community-acquired pneumonia, but few in Korea. We sought to identify characteristics on admission predicting mortality in elderly patients hospitalized with community-acquired pneumonia and to compare mortality rates by PORT score with PORT study's ones.

Methods : We performed a retrospective study of 267 patients aged 65 years and over admitted with community- acquired pneumonia from January 2000 to December 2002. We reviewed demographic, clinical, laboratory, microbiological and radiologic data and identified independent factors associated with the mortality using logistic regression analysis. We classified patients into risk classes by PORT score and calculated the mortality rate.

Results : Among of 267 patients, 48 (18.0%) died. We identified six independent predictors of mortality; male (OR, 2,496; 95% CI, 1,012∼6,153), lung cancer (OR, 3,409; 95% CI, 1,302∼8,920), general weakness (OR, 5.218; 95% CI, 2,140∼12,718), unable to walk (OR, 9,232; 95% CI, 2,228∼38,257), BUN ≥30 mg/dL (OR, 3,327; 95% CI, 1.072∼10.327), albumin <3 g/dL (OR, 3,219; 95% CI, 1,351∼7,670) and pleural effusion (OR, 3.135; 95% CI, 1,052∼9,342). Mortality rates of risk class II-V by PORT score were 6.7%, 9.5%, 30.4% and 34.4%, respectively.

Conclusion : There were factors that were associated with mortality in elderly patients hospitalized with community-acquired pneumonia.
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Relation of Lifestyle Variables to Total Mortality in a Cohort of Old Residents Aged 60-64 in a Rural Community.
Chan Hyang Park, Choong Won Lee, Bog Sang Ko
J Korean Acad Fam Med 2002;23(10):1219-1228.   Published online October 10, 2002
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Risk factors influencing to mortality and recurrence after first cerebral infarction.
Jai Young Kim, Ji Hwan Hwang, Jin Young Choi, Dong Young Cho, Byung Yeon Yu
J Korean Acad Fam Med 2001;22(6):840-858.   Published online June 1, 2001
Background
: Cerebral infarction is one of the common cause of death in Korea. There are many studies about risk factors of cerebral infarction in the world and Korea. and there are some studies about risk factors of mortality and recurrence after first cerebral infarction in the world. but there are no reliable epidemiologic studies about risk factors of mortality and recurrence after first cerebral infarction in Korea. So this study was designed to investigate the risk factors of mortality and recurrence after first cerebral infarction in Korea.

Methods : A cohort of 257 patients with diagnosing first cerebral infarction at our hospital were selected and followed for at least 5 years. 30 days, 1 year, 5 year cumulative mortality and recurrence was calculated. Risk Factors classified at the time of first cerebral infarction. and then entered into a Cox proportional harzards model for mortality and for recurrence.

Results : The cumulative risk of mortality after first cerebral infarction was 13%, at 30days, 21%, at 1year, 49% at 5years. The cumulative risk of recurrence after first cerebral infarction was 4% at 30days, 11% at 1year, 24% 5years. The significant risk factors of mortality after first cerebral infarction were age(≥65), heavy alcohol drinking history, heart, failure, untreated diabetes mellitus history, untreated hypertension history, high admission Hct(≥50%), high admission glucose(≥200), atrial fibrillation at admission, under drowsy mental state at admission, embolic infarction type, high admission systolic bolld pressure(≥160), high admission diastolic blood pressure(≥100). The significant risk factors of recurrence were age(<65), men, heavy alcohol drink-ing history, ischemic heart disease, untreated DM history, high admission glucose(≥200).

Conclusion : Diabetes mellitus, hypertension, heavy alcohol drinking, cardiovascular disease were important factor of cerebral infarction prognosis on our study. So primary care physicians focus on these factors when treating cerebral infarction patient.
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