Background
Despite increased clinical and research interest in sarcopenia, even in Asia, not much is known about the association between sarcopenia and depressive symptoms. Sarcopenia and depressive symptoms are associated with several health problems in older adults; therefore, we investigated the association between sarcopenia and depression in Korean older adults.
Methods
The study sample included 1,929 participants aged over 60 years (44.6% men; mean age, 69.7 years) from nationally representative data of the 2018 Korea National Health and Nutrition Examination survey. Possible sarcopenia was defined according to the diagnostic algorithm of the Asian Working Group for Sarcopenia 2019; however, we measured only hand-grip strength (kg) in this study. Patient Health Questionnaire-9 was used for screening for symptoms of depression. A cross-sectional analysis was used to examine the relationship between possible sarcopenia and depressive symptoms.
Results
Possible sarcopenia and depressive symptoms were identified in 538 (27.9%) and 97 (5.0%) participants, respectively. After adjusting for age, sex, and other potential covariates, possible sarcopenia was positively associated with higher odds of depressive symptoms (odds ratio, 2.06; 95% confidence interval, 1.36–3.11; P<0.001).
Conclusion
Possible sarcopenia was significantly associated with depressive symptoms in Korean older adults. Early interventions for possible sarcopenia and depressive symptoms in routine clinical practice could help Korean older adults to have healthy aging. Future studies are required to explore any causal relationship between possible sarcopenia and depressive symptoms in Korean older adults.

Citations

• Social media-based Health Education plus Exercise Program (SHEEP) to improve muscle function among young-old adults with possible sarcopenia in the community: A feasibility study protocol
  Ya Shi, Emma Stanmore, Lisa McGarrigle, Chris Todd, Marina De Rui
  PLOS ONE.2025; 20(1): e0303481.     CrossRef
• Association between sarcopenia components and depressed mood varies by sex among community-dwelling older adults from the Korean Frailty and Aging Cohort Study
  Yong Soon Park, Keunjoong Yoo, Hye Jin Kim, Miji Kim, Chang Won Won
  Scientific Reports.2025;[Epub]     CrossRef
• Bidirectional association between sarcopenia and depression: A systematic review and meta-analysis
  Xiangpeng Meng, Ze Wang, Linyu Lyu
  Archives of Gerontology and Geriatrics.2025; 132: 105787.     CrossRef
• Association between handgrip strength, handgrip strength asymmetry, and anxiety in Korean older adults: The Korean National Health and Nutrition Examination Survey 2022
  Sang-Youn Choi, Su-Min Park, Eun-Cheol Park, Marina De Rui
  PLOS ONE.2025; 20(4): e0315256.     CrossRef
• Relationship between dietary protein and amino acid intake and handgrip strength in Korean adults: data from the 2014–2019 Korea National Health and Nutrition Examination Survey
  Hyunji Ham, Sumin Kim, Kyungho Ha
  Nutrition Journal.2025;[Epub]     CrossRef
• Association of possible sarcopenia and its components with all-cause mortality in a middle-aged and older population: a 9-year cohort study
  Zhiping Duan, Guihua Jiang, Yingxia Zhu, Wei Huang, Yunda Huang, Hong Yang
  Scientific Reports.2025;[Epub]     CrossRef
• Association between Possible Sarcopenia and Fall Risk, Depression, and Quality of Life in Middle-Aged and Older Adults
  Jaisun Koo, Seung Kil Lim, Sunga Kong
  Canadian Journal on Aging / La Revue canadienne du vieillissement.2025; : 1.     CrossRef
• The bidirectional association between depression and sarcopenia: a systematic review and meta-analysis
  Yuan Zhu, Mengjia Pan, Yu Qiu, Zhenmei An, Shuangqing Li
  Frontiers in Public Health.2025;[Epub]     CrossRef
• Análisis de la relación entre sarcopenia y síntomas depresivos en adultos mayores: una revisión de alcance
  Miguel Ángel Hernández Real, Uriel Nahum Hernández Puebla
  RESPYN Revista Salud Pública y Nutrición.2024; 23(2): 23.     CrossRef