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"Prediabetic State"

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"Prediabetic State"

Original Articles
The Correlation between Carotid Intima-Media Thickness and Neutrophil to Lymphocyte Ratio in Prediabetes Patients
Dayoung Lee, Mi-Jeong Park, Mee Young Kim, Jung Jin Cho, Jong Lull Yoon
Korean J Fam Med 2021;42(6):464-470.   Published online November 20, 2021
DOI: https://doi.org/10.4082/kjfm.21.0070
Background
Prediabetes is a metabolic state between normoglycemia and diabetes and is known to carry a higher risk of developing overt diabetes and cardiovascular disease (CVD). The relative and absolute risks of all-cause mortality, CVD, coronary heart disease, and stroke in prediabetes patients, as well as in diabetic patients, is higher than that in patients with normoglycemia. Carotid intima-media thickness (cIMT) is a method used to stratify CVD risk. In this study, we aimed to determine whether the neutrophil-to-lymphocyte ratio (NLR) correlates with cIMT in prediabetes patients.
Methods
From January 1, 2016, to February 20, 2021, 581 adults their 30s–70s who underwent carotid ultrasonography as part of a comprehensive medical examination at the Dongtan Sacred Heart Hospital were enrolled. Statistical analysis using SPSS presented t-test and chi-square test significance levels into a group with normal cIMT (nIMT; cIMT <1 mm) and a group with thick cIMT (tIMT; cIMT ≥1 mm). Binary logistic regression analysis was performed to confirm the correlation between NLR and cIMT.
Results
In prediabetic adults, age, hemoglobin A1c (HbA1c), systolic blood pressure, and NLR were significantly higher in the tIMT group than in the nIMT group. In the regression analysis, NLR, age, and HbA1c were significantly correlated with cIMT.
Conclusion
NLR was significantly higher in the tIMT group than in the nIMT group; therefore, NLR may be used to assess CVD risk in prediabetes patients.

Citations

Citations to this article as recorded by  
  • The relationship between oxLDL, sLOX-1, PCSK9 and carotid intima-media thickness in patients with prediabetes and type 2 diabetes
    Zeki Dogan, Abdulhalim Senyigit, Sinem Durmus, Canan Duvarcı, Remise Gelişgen, Hafize Uzun, Omur Tabak
    Scientific Reports.2025;[Epub]     CrossRef
  • Triglyceride–glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride–glucose strata
    Xueguang Lin, Shishuai Xie, Bingbing Pu, Zheyu Wang, Hui Zhang, Yunxia Li, Jingdong Tang, Bo Yu, Shuai Jiang
    BMC Cardiovascular Disorders.2025;[Epub]     CrossRef
  • Exploring the Correlation between Systemic Inflammatory Markers and Carotid Atherosclerosis Indices in Middle-Aged Adults: A Cross-Sectional Study
    Ji-Eun Song, Ji-In Hwang, Hae-Jin Ko, Ji-Yeon Park, Hee-Eun Hong, A-Sol Kim
    Journal of Cardiovascular Development and Disease.2024; 11(3): 73.     CrossRef
  • Could Systemic Inflammation in Healthy Individuals With Obesity Indicate Subclinical Atherosclerosis?
    Nail B. Ozbeyaz, Gokhan Gokalp, Engin Algul, Pinar Kilic, Orkun Saricam, Faruk Aydinyilmaz, Ilkin Guliyev
    Angiology.2023; 74(1): 62.     CrossRef
  • A Relação entre a Relação Ácido Úrico/Albumina e a Espessura Média-Intimal da Carótida em Pacientes com Hipertensão
    Faysal Şaylık, Tufan Çınar, Murat Selçuk, İbrahim Halil Tanboğa
    Arquivos Brasileiros de Cardiologia.2023;[Epub]     CrossRef
  • A Study to Assess and Correlate Metabolic Parameters with Carotid Intima-Media Thickness after Combined Approach of Yoga Therapy Among Prediabetics
    Neha Saboo, Sudhanshu Kacker
    Advanced Biomedical Research.2023;[Epub]     CrossRef
  • 4,859 View
  • 86 Download
  • 6 Web of Science
  • 6 Crossref
Effect of Coffee Consumption on the Progression of Type 2 Diabetes Mellitus among Prediabetic Individuals
Ji-Ho Lee, Mi-Kyeong Oh, Jun-Tae Lim, Haa-Gyoung Kim, Won-Joon Lee
Korean J Fam Med 2016;37(1):7-13.   Published online January 27, 2016
DOI: https://doi.org/10.4082/kjfm.2016.37.1.7
Background

A previous large-scale cohort study investigated the relationship between coffee intake and the progression of diabetes mellitus in the United States. However, studies on the effects of coffee on diabetes are rare in South Korea. Therefore, this study assessed the amount and method of coffee intake in Koreans in order to determine if coffee intake has a prophylactic effect on diabetes progression.

Methods

This study included 3,497 prediabetic patients from a single medical institution, with glycated hemoglobin levels ranging from 5.7% to 6.4%. Cross-tabulation and Kaplan-Meier survival analyses were performed to compare patients with and without diabetes progression based on the frequency and method of coffee intake. Cox proportional hazard analysis was performed to correct for confounding variables.

Results

The observation period (mean±standard deviation) was 3.7±2.3 years. Kaplan-Meier survival analysis revealed that the risk of diabetes progression was lowest in patients who drank black coffee three or more times per day (P=0.036). However, correction for confounding variables in Cox proportional hazard analysis revealed that, while the risk was lower for the patients who typically consumed black coffee than for those who mixed creamer and sugar into their coffees, the difference was not significant.

Conclusion

The results of this study suggest that drinking coffee without sugar and creamer at least three times daily has the greatest preventive effect on diabetes onset.

Citations

Citations to this article as recorded by  
  • Effect of Sidikalang Coffee on Flow Rate, pH, Total Protein, and the Concentration of Salivary Glucose Levels in Smokers
    Ameta Primasari, Minasari ., Atika Resti Fitri, Yoga Pratama
    The Open Dentistry Journal.2025;[Epub]     CrossRef
  • The magical smell and taste: Can coffee be good to patients with cardiometabolic disease?
    Marcia Ribeiro, Livia Alvarenga, Ludmila F. M. F. Cardozo, Julie A. Kemp, Ligia S. Lima, Jonatas S. de Almeida, Viviane de O. Leal, Peter Stenvinkel, Paul G. Shiels, Denise Mafra
    Critical Reviews in Food Science and Nutrition.2024; 64(2): 562.     CrossRef
  • Habitual coffee drinking and the chance of prediabetes remission: findings from a population with low coffee consumption
    Shabnam Hosseini, Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi
    Journal of Diabetes & Metabolic Disorders.2024; 23(1): 817.     CrossRef
  • Differences in Cholesterol Levels in Coffee Drinkers Without Sugar and Coffee Drinkers With Sugar in The Work Area
    Nadira Salsabila, Ari Khusuma, Yunan Jiwintarum
    THRIVE Health Science Journal.2024; 1(1): 19.     CrossRef
  • Impact of coffee and its bioactive compounds on the risks of type 2 diabetes and its complications: A comprehensive review
    Almahi I. Mohamed, Ochuko L. Erukainure, Veronica F. Salau, Md Shahidul Islam
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(7): 103075.     CrossRef
  • Coffee constituents with antiadipogenic and antidiabetic potentials: A narrative review
    Jennifer Kusumah, Elvira Gonzalez de Mejia
    Food and Chemical Toxicology.2022; 161: 112821.     CrossRef
  • Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study
    Maria Lazo-Porras, Antonio Bernabe-Ortiz, Andrea Ruiz-Alejos, Liam Smeeth, Robert H. Gilman, William Checkley, German Málaga, J. Jaime Miranda
    Diabetes Research and Clinical Practice.2020; 163: 107829.     CrossRef
  • Comparison of 24-hour Recalls with a Food Frequency Questionnaire in Assessing Coffee Consumption: The Health Examinees (HEXA) Study
    An Na Kim, Jiyoung Youn, Hyun Jeong Cho, Taiyue Jin, Sangah Shin, Jung Eun Lee
    Korean Journal of Community Nutrition.2020; 25(1): 48.     CrossRef
  • Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation
    Ricardo Raúl Robles-Rivera, José Alberto Castellanos-González, Cecilia Olvera-Montaño, Raúl Alonso Flores-Martin, Ana Karen López-Contreras, Diana Esperanza Arevalo-Simental, Ernesto Germán Cardona-Muñoz, Luis Miguel Roman-Pintos, Adolfo Daniel Rodríguez-
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • Phytochemical properties of black tea (Camellia sinensis) and rooibos tea (Aspalathus linearis); and their modulatory effects on key hyperglycaemic processes and oxidative stress
    Xin Xiao, Ochuko L. Erukainure, Olakunle Sanni, Neil A. Koorbanally, Md. Shahidul Islam
    Journal of Food Science and Technology.2020; 57(12): 4345.     CrossRef
  • Lack of Association of Coffee Consumption with the Prevalence of Self-Reported Type 2 Diabetes Mellitus in a Mexican Population: A Cross-Sectional Study
    Ana Karen Gil-Madrigal, Thelma Beatriz González-Castro, Carlos Alfonso Tovilla-Zárate, Daniela Georgina Aguilar-Velázquez, Tania Guadalupe Gómez-Peralta, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Elizabeth Carmona-Díaz, Ana Fresan, Jorge Luis
    International Journal of Environmental Research and Public Health.2018; 15(10): 2100.     CrossRef
  • Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia
    Bernd Richter, Bianca Hemmingsen, Maria-Inti Metzendorf, Yemisi Takwoingi
    Cochrane Database of Systematic Reviews.2018;[Epub]     CrossRef
  • Differential associations between diet and prediabetes or diabetes in the KORA FF4 study
    Taylor A. Breuninger, Anna Riedl, Nina Wawro, Wolfgang Rathmann, Konstantin Strauch, Anne Quante, Annette Peters, Barbara Thorand, Christa Meisinger, Jakob Linseisen
    Journal of Nutritional Science.2018;[Epub]     CrossRef
  • Association between the Prevalence of Metabolic Syndrome and the Level of Coffee Consumption among Korean Women
    Keyhoon Kim, Kyuwoong Kim, Sang Min Park, Pratibha V. Nerurkar
    PLOS ONE.2016; 11(12): e0167007.     CrossRef
  • Association between Consumption of Coffee and the Prevalence of Periodontitis: The 2008–2010 Korea National Health and Nutrition Examination Survey
    Kyungdo Han, Eunkyung Hwang, Jun-Beom Park, Alberto G Passi
    PLOS ONE.2016; 11(7): e0158845.     CrossRef
  • 6,282 View
  • 64 Download
  • 17 Web of Science
  • 15 Crossref
Background

Impaired fasting glucose (IFG) is an established risk factor for type 2 diabetes and cardiovascular disease. This study evaluated the relationship between sleep duration and IFG.

Methods

This cross-sectional study included 14,925 Korean adults (5,868 men and 9,057 women) ≥19 years of age who participated in the Korean National Health and Nutrition Examination Survey between 2011 and 2012. Blood glucose levels were measured after at least eight hours of fasting. Study subjects were categorized into three groups based on self-reported sleep duration (<7, 7–8, or >8 h/d). IFG was diagnosed according to recommendations American Diabetes Association guidelines. Multiple logistic regression analysis was performed with adjustment for covariates.

Results

In men, short sleep duration (<7 hours) was associated with increased risk of IFG (odds ratio [OR], 1.46; 95% confidence interval [CI], 1.08 to 1.96) compared to adequate sleep duration (7–8 hours), whereas long sleep duration (>8 hours) was not associated with risk of IFG (OR, 0.90; 95% CI, 0.37 to 2.18). In women, sleep duration was not associated with risk of IFG.

Conclusion

The association between sleep duration and IFG differed by sex; sleep deprivation, was associated with increased risk of IFG, especially in men.

Citations

Citations to this article as recorded by  
  • Associations of prediabetes and sleep duration, and inflammation as a mediator in the China Health and Retirement Longitudinal Study
    Yanran Duan, Hang Fu, Jinghong Gao, Sufan Wang, Changying Chen, Yaojun Zhao, Shuai Jiang, Chengzeng Wang
    Sleep Health.2024; 10(4): 470.     CrossRef
  • Associations between night-time sleep duration and fasting glucose and ratio of triglyceride to high-density lipoprotein cholesterol among adults free of type 2 diabetes or without diagnosed type 2 diabetes: a multicentre, cross-sectional study in China
    Jiangshan He, Chenglin Hong, Li Zhang, chunjun Li, Yuxue Wang, Yaqi Fan, Pei Guo, Binbin Zhang, Xin Qi, Shuo Chen, Yu-jie Niu, Feng Liu, Rong Zhang, Qiang Li, Shitao Ma, Mianzhi Zhang, Minying Zhang
    BMJ Open.2022; 12(7): e062239.     CrossRef
  • Sleep deprivation and its association with diseases- a review
    Siaw Cheok Liew, Thidar Aung
    Sleep Medicine.2021; 77: 192.     CrossRef
  • A Meta-Analysis of a Cohort Study on the Association between Sleep Duration and Type 2 Diabetes Mellitus
    Huapeng Lu, Qinling Yang, Fang Tian, Yi Lyu, Hairong He, Xia Xin, Xuemei Zheng, Takayuki Masaki
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
  • Effect of omega‐3 and vitamin D co‐supplementation on psychological distress in reproductive‐aged women with pre‐diabetes and hypovitaminosis D: A randomized controlled trial
    Masoumeh Rajabi‐Naeeni, Mahrokh Dolatian, Mostafa Qorbani, Amir Abbas Vaezi
    Brain and Behavior.2021;[Epub]     CrossRef
  • Digital health device measured sleep duration and ideal cardiovascular health: an observational study
    Jane A. Leopold, Elliott M. Antman
    BMC Cardiovascular Disorders.2021;[Epub]     CrossRef
  • Association between sleep and severe periodontitis in a nationally representative adult US population
    Hend Alqaderi, J. Max Goodson, Israel Agaku
    Journal of Periodontology.2020; 91(6): 767.     CrossRef
  • Association between sleep duration and impaired fasting glucose according to work type in non-regular workers: data from the first and second year (2016, 2017) of the 7th Korean National Health and Nutrition Examination (KNHANE) (a cross-sectional study)
    JaeHan Joo, Jae-Gwang Lee, SangWoo Kim, JaeHan Lee, June-Hee Lee, Kyung-Jae Lee
    Annals of Occupational and Environmental Medicine.2020;[Epub]     CrossRef
  • Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes
    Babak Mokhlesi, Karla A. Temple, Ashley H. Tjaden, Sharon L. Edelstein, Kristina M. Utzschneider, Kristen J. Nadeau, Tamara S. Hannon, Susan Sam, Elena Barengolts, Shalini Manchanda, David A. Ehrmann, Eve Van Cauter, David A. Ehrmann, Karla A. Temple, Abb
    Diabetes Care.2019; 42(7): 1326.     CrossRef
  • Sleep Quality and Its Association with the Dietary Behavior and Lifestyle of University Students in Cheongju
    Sewhan Jin, Munkyong Pae
    Korean Journal of Community Nutrition.2019; 24(5): 395.     CrossRef
  • Associations of sleep duration and prediabetes prevalence in a middle‐aged and elderly Chinese population with regard to age and hypertension: The China Health and Retirement Longitudinal Study baseline survey
    Mingming Yan, Zhen Fu, Tingting Qin, Nanjin Wu, Yalan Lv, Qinyun Wei, Hongwei Jiang, Ping Yin
    Journal of Diabetes.2018; 10(11): 847.     CrossRef
  • Differential Impact of Sleep Duration on Fasting Plasma Glucose Level According to Work Timing
    Chan-hee Jung, Sang Hee Jung, Bora Lee, Dukhyun Choi, Bo-yeon Kim, Chul-hee Kim, Sung-koo Kang, Ji-oh Mok
    Archives of Medical Research.2018; 49(1): 51.     CrossRef
  • Prevalence and Risk Factors of Impaired Fasting Glucose Among Adults in Northeast China: A Cross-Sectional Study
    Qian Zhao, Q.i.n.g. Zhen, Yong Li, Ruogu Lv, Kaixin Zhang, Yichun Qiao, Changgui Kou, Bo Li, Yuchun Tao, Yaqin Yu, Yunkai Liu, Yi Cheng, Yawen Liu
    Endocrine Practice.2018; 24(7): 677.     CrossRef
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    Kei Nakajima, Kaname Suwa, Kenji Toyama
    World Journal of Diabetes.2017; 8(8): 397.     CrossRef
  • Prevalence, Awareness, Treatment and Control of Diabetes Mellitus in a Chinese Population
    Jiqiang Yue, Xuhua Mao, Kun Xu, Lingshuang Lü, Sijun Liu, Feng Chen, Jianming Wang, Aristidis Veves
    PLOS ONE.2016; 11(4): e0153791.     CrossRef
  • Effects of chronic sleep deprivation on glucose homeostasis in rats
    Xiaowen Xu, Liang Wang, Yan Zhang, Tianjiao Su, Liying Chen, Yan Zhang, Weifeng Ma, Yuanyuan Xie, Tiantian Wang, Fan Yang, Li He, Wenjiao Wang, Xuemei Fu, Hongxia Hao, Yuanzheng Ma
    Sleep and Biological Rhythms.2016; 14(4): 321.     CrossRef
  • Effect of Sleep and Salivary Glucose on Gingivitis in Children
    H. Alqaderi, M. Tavares, M. Hartman, J.M. Goodson
    Journal of Dental Research.2016; 95(12): 1387.     CrossRef
  • 6,242 View
  • 64 Download
  • 19 Web of Science
  • 17 Crossref
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