Background
Obesity, sarcopenia, and sarcopenic obesity are increasingly prevalent in older adults and negatively affect health-related quality of life (HRQOL). While EuroQol-5 Dimension and Short Form-36 Health Survey are widely used HRQOL measures, they have limitations in sensitivity and cultural relevance. In contrast, the Health-related Quality of Life Instrument with 8 Items (HINT-8) is a preference-based instrument developed specifically for the Korean population, offering finer discrimination of physical, emotional, and social health domains.
Methods
This study analyzed data from 1,387 older adults (≥65 years) from the 2023 Korea National Health and Nutrition Examination Survey. Obesity was defined as body mass index ≥25 kg/m 2 , sarcopenia by Asian Working Group for Sarcopenia 2019 criteria, and sarcopenic obesity as having both conditions. Multiple linear regression was used to examine their independent effects on HRQOL, adjusting for potential confounders.
Results
Of the participants, 54.2% were classified as normal, 34.9% as obese, 9.8% with sarcopenia, and 1.1% with sarcopenic obesity. All three conditions were significantly associated with greater difficulty in stair climbing: obesity (B=0.223, P<0.001), sarcopenia (B=0.242, P<0.001), and sarcopenic obesity (B=0.338, P=0.048). Sarcopenia was also linked to impaired working ability and higher total HINT-8 scores. Sarcopenic obesity was associated with greater pain. And obesity was linked to slightly lower depression scores.
Conclusion
Obesity, sarcopenia, and sarcopenic obesity negatively impact HRQOL in older adults. Early detection and intervention are essential to improve quality of life and extend health-adjusted life expectancy.

Background
Although the association between smoking and health-related quality of life (HRQoL) has been established, the effects of tobacco products, including combustible cigarettes (CCs) and non-combustible nicotine or tobacco products (NNTPs), on HRQoL remain unclear. This study examined the association between tobacco use and HRQoL in Korean men.
Methods
Data from the Korea National Health and Nutrition Examination Survey conducted between 2013 and 2020 were analyzed. A total of 16,429 male participants aged ≥19 years completed the European Quality of Life-5 Dimensions (EQ-5D). Impaired HRQoL was defined as scoring in the lowest 20% of the EQ-5D index and having some or extreme problems in the following five domains of the EQ-5D: mobility, self-care, usual activities, pain/ discomfort, and anxiety/depression. Multiple logistic regression was conducted to evaluate the risk of impaired HRQoL in current tobacco users.
Results
Current tobacco users exhibited a significantly higher risk of impaired HRQoL compared with never users (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.05–1.92). Compared to never users, current tobacco users reported more problems with mobility and pain/discomfort (all P<0.05). Moreover, compared with former tobacco users, current tobacco users had a higher risk of impaired HRQoL (OR, 1.60; 95% CI, 1.18–2.17). Compared to former tobacco users, current tobacco users reported more problems with mobility and pain/discomfort (all P<0.05).
Conclusion
Use of CCs and NNTPs is associated with impaired HRQoL in Korean men. Therefore, further interventions for lifestyle modification and smoking cessation treatments are required to reduce the risk of impaired HRQoL among current tobacco users.

Background
The relationship between weight change and quality of life remains controversial. This study aimed to investigate whether changes in body weight among participants in different baseline body mass index categories are associated with physical and mental health functioning.
Methods
We conducted an analysis involving 5,106 adults who participated in the Korean Genome and Epidemiology Study, a cohort comprising Korean adults aged 40 to 69 years. We categorized participants into three groups based on body weight change, and physical and mental health were assessed using the 12-Item Short-Form Health Survey in year 4. We employed logistic regression analysis to assess the association between body weight change and poor functioning at year 4. We also utilized a generalized estimating equation to determine the relationship between weight changes and mental component summary (MCS) scores over the study period for each weight group.
Results
Weight gain in both the normal weight (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.13–3.11; P=0.01) and overweight groups (OR, 1.75; 95% CI, 1.05–2.91; P=0.03) was associated with poor MCS. Normal weight weight-losers were associated with a greater increase (2.69 points; 95% CI, 0.50–4.88) in MCS compared to weightmaintainers. Significant differences in mean MCS were observed for overweight weight-losers, obese weight-gainers, and underweight weight-gainers when compared to weight maintainers in each respective weight group.
Conclusion
Different patterns of relationships between weight change and mental health-related quality of life were observed. Hence, it is crucial to focus on the mental health of middle-aged and older adults when assessing body weight changes.

Background
Establishing cost-effective informal care services for lonely older adults living at home in developing countries can be an innovative approach for improving their well-being. This study investigated the effectiveness of an informal home care support intervention program (HoSIP) reducing the loneliness and improving quality of life of lonely community-dwelling older adults.
Methods
This quasi-experimental pre-post study employed a non-randomized control group design with a 12-week intervention period and three follow-up points at the end of the HoSIP. Questionnaires were used to measure feelings of loneliness (20-item UCLA Loneliness Scale), quality of life (Control, Autonomy, Self‐Realization and Pleasure Scale), general health (12-item General Health Questionnaire), social network (six-item Lubben Social Network Scale), social support (12-item Multidimensional Scale of Perceived Social Support), and self-care ability (17-item Self-care Ability Scale for the Elderly). Repeated-measures analysis of variance was used to gauge the effect of the intervention program over time and in comparison to the control group. Data analyses were performed using the IBM SPSS Statistics software (IBM Corp.).
Results
We found a significant relationship between the outcome variables, including feelings of loneliness (P<0.001) and quality of life (P<0.001), at different stages of measurement. Despite the positive feasibility results, the implementation of the HoSIP faced challenges due to a lack of facilities (e.g., place restriction for holding educational classes, educational facilities like computers, video projector, and whiteboard at daycare center) and the absence of supporting organizations.
Conclusion
Utilizing the existing capabilities of older adults to provide online and face-to-face care services can be a cost-effective way to improve their quality of life and reduce loneliness. The process of facilitating such informal care services for lonely older adults should be managed by either governmental or non-governmental organizations to reduce the rate of social isolation among this vulnerable population.

Background
The factors associated with sleep disorder are controversial. This study aimed to evaluate the prevalence of sleep disorder and the factors associated with sleep disorder among Korean adult cancer survivors.
Methods
In this cross-sectional study, we collected data on sleep problems as outcome variables, and sociodemographic and clinical information as predictor variables from cancer survivors at two university-affiliated hospitals. Sleep disorder was defined as “a difficulty in sleep initiation or sleep maintenance at least 3 times a week that started after a cancer diagnosis.” Multiple logistic regression analysis was performed with odds ratios (OR) and 95% confidence intervals (95% CI) to evaluate the factors associated with sleep disorder.
Results
The participants were 1,893 Korean cancer survivors (mean age, 58.1 years; females 68.0%). The prevalence of sleep disorder among male and female cancer survivors were 16.5% and 20.3%, respectively. An increase of age by 1-year was associated with a 1.04 (95% CI, 1.01–1.07; P=0.011) times higher risk of sleep disorder in males, while an inverse association was found in females. In female survivors, high fear of cancer recurrence (FCR), high anxiety, menopause, and high EuroQol Visual Analog Scale were associated with 1.45 (95% CI, 1.06–1.98; P=0.020), 1.78 (95% CI, 1.25–2.55; P=0.002), 1.70 (95% CI, 1.08–2.67; P=0.022), and 0.59 (95% CI, 0.43–0.82; P=0.002) times higher risk of sleep disorder, respectively. In male survivors, living with a spouse/or partner was associated with 57% (95% CI, 0.20–0.95; P=0.036) lower risk of sleep disorder. Analyses of cancer sites showed that the factors associated with sleep disorder varied across cancer sites.
Conclusion
One-fifth of adult cancer survivors had sleep disorder. Age, menopausal status, FCR, anxiety, living with a spouse or partner, and quality of life were independently associated with sleep disorder in Korean cancer survivors.

Citations

• Social support, fear of cancer recurrence and sleep quality in breast cancer: A moderated network analysis
  Yingting Jiang, Xinyu Wu, Hongman Li, Ying Xiong, M. Tish Knobf, Zengjie Ye
  European Journal of Oncology Nursing.2025; 74: 102799.     CrossRef
• Subgroups of sleep quality and associated risk factors in patients with cancer undergoing radiotherapy: A cross-sectional study based on latent profile analysis
  Liuna Bi, Xian Zhang, Linlin Wang, Yanxiu Cai, Jing Han
  European Journal of Oncology Nursing.2024; 68: 102488.     CrossRef

Background
Cancer survivors experience decreased physical function and reduced muscle strength, which leads to lower quality of life (QOL). The hand grip strength (HGS) can be a predictor of poor health-related QOL as a parameter of sarcopenia. The purpose of this study was to investigate the relationship between low HGS and QOL in cancer survivors and healthy controls.
Methods
We analyzed 392 cancer survivors and 1,176 healthy controls from the Korea National Health and Nutrition Examination Survey, 2014–2017. We defined low HGS as 2 standard deviation values for healthy young Korean adults from a previous study. QOL was evaluated using the European Quality of Life Scale-Five Dimensions. A complex sample logistic regression model was used to assess the relationship between each dimension of low HGS and QOL.
Results
The odds ratios (ORs) for decreased QOL were significantly higher in male cancer survivors with low HGS on self-care (OR, 8.51; 95% confidence interval [CI], 1.69–42.83) and usual activities (OR, 6.63; 95% CI, 1.22–36.03). The ORs for problems in mobility (OR, 5.87; 95% CI, 2.04–16.91), usual activities (OR, 14.46; 95% CI, 3.84–54.44), pain/discomfort (OR, 4.90; 95% CI, 2.00–12.01), and anxiety/depression (OR, 6.43; 95% CI, 2.16–19.12) were significantly high in female cancer survivors with low HGS. However, healthy controls showed no significant relationship between low HGS and QOL.
Conclusion
For cancer survivors, low HGS was associated with poor QOL in some domains. Strategies to increase muscle strength must be considered to improve the QOL of cancer survivors.

Citations

• Association between handgrip strength, handgrip strength asymmetry, and anxiety in Korean older adults: The Korean National Health and Nutrition Examination Survey 2022
  Sang-Youn Choi, Su-Min Park, Eun-Cheol Park, Marina De Rui
  PLOS ONE.2025; 20(4): e0315256.     CrossRef
• The quality of life impacting factors in malnourished patients with gastric cancer
  Hong Zhao, Chenan Liu, Guotian Ruan, Xin Zheng, Yue Chen, Shiqi Lin, Xiaoyue Liu, Jinyu Shi, Xiangrui Li, Shuqun Li, Hanping Shi
  Frontiers in Oncology.2024;[Epub]     CrossRef
• Cardiovascular and metabolic determinants of quality of life in patients with cancer
  Ruben Evertz, Katharina Gödde, Christine Diehl, Miroslava Valentova, Tania Garfias‐Veitl, Friederike Braulke, Gerald G. Wulf, Tobias R. Overbeck, Annalen Bleckmann, Alexander O. König, Pia Weinländer, Sophia Potthoff, Sara Hadzibegovic, Alessia Lena, Ulri
  ESC Heart Failure.2023; 10(1): 167.     CrossRef
• Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis
  Jinho Kim, Gum-Ryeong Park
  Research on Aging.2023; 45(7-8): 586.     CrossRef
• Better Handgrip Strength Is Related to the Lower Prevalence of Pain and Anxiety in Community-Dwelling Older Adults
  Natalia Sosowska, Agnieszka Guligowska, Bartłomiej Sołtysik, Ewa Borowiak, Tomasz Kostka, Joanna Kostka
  Journal of Clinical Medicine.2023; 12(11): 3846.     CrossRef
• Predictors of lower exercise capacity in patients with cancer
  Ruben Evertz, Christine Diehl, Katharina Gödde, Miroslava Valentova, Tania Garfias-Veitl, Tobias R. Overbeck, Friederike Braulke, Alessia Lena, Sara Hadzibegovic, Annalen Bleckmann, Ulrich Keller, Ulf Landmesser, Alexander O. König, Gerd Hasenfuss, Andrea
  Scientific Reports.2023;[Epub]     CrossRef
• NEUROCANTRIAL: study protocol for a randomised controlled trial of a pain neuroscience education programme in adults with cancer pain
  Leidy Tatiana Ordoñez-Mora, Ilem D Rosero, Marco Antonio Morales-Osorio, Rocío Guil, Giancarlo Quintero Jordan, Julian Alberto Agudelo Jimenez, Katherine Gonzalez-Ruiz, Juan Carlos Avila-Valencia
  BMJ Open.2023; 13(9): e071493.     CrossRef
• Differences in Health-Related Quality of Life in Older People with and without Sarcopenia Covered by Long-Term Care Insurance
  Masahiro Kitamura, Kazuhiro P. Izawa, Kodai Ishihara, Peter H. Brubaker, Hiroaki Matsuda, Soichiro Okamura, Koji Fujioka
  European Journal of Investigation in Health, Psychology and Education.2022; 12(6): 536.     CrossRef
• Associations of Physical Activity and Handgrip Strength with Health-Related Quality of Life in Older Korean Cancer Survivors
  Jeonghyeon Kim, Seamon Kang, Donghyun Kim, Hyunsik Kang
  Cancers.2022; 14(24): 6067.     CrossRef
• Differences in the Relationships Between Muscle Strength, Muscle Mass, Balance Function, and Quality of Life for Middle-Aged and Older Breast Cancer Survivors
  Shinichiro Morishita, Ryuichi Kasahara, Yuichi Yamamoto, Ryohei Jinbo, Aya Takano, Mitsuhiko Yasuda, Atsuhiro Tsubaki, Osamu Aoki, Jack B. Fu, Tetsuya Tsuji
  Integrative Cancer Therapies.2022;[Epub]     CrossRef

Background
Although many studies have demonstrated that the first cigarette in the morning increases the prevalence of smoking-related morbidity, limited studies have examined the impact of time to first cigarette (TTFC) on the health-related quality of life (HRQoL). Thus, we assessed this relationship using nationally-representative data from the Korea National Health and Nutrition Examination Survey VII-1 (2016).
Methods
We conducted a cross-sectional study using data from 577 current male smokers aged 30–59 years, after excluding those with a certain disease. Participants were divided into four categories according to TTFC (≤5 min, 6–30 min, 31–60 min, >60 min). HRQoL was measured using self-reported EuroQol-5 (EQ-5D). The relationship between TTFC and EQ-5D index was analyzed using a multivariate-adjusted generalized linear model to assess how HRQoL varies according to TTFC. After adjusting for confounders, a multivariate-adjusted logistic regression analysis was performed to identify which of the five dimensions of the EQ-5D affected the HRQoL according to TTFC.
Results
The generalized linear analysis indicated that as TTFC decreased (6–30 min, 31–60 min vs. >60 min), the EQ-5D index score decreased significantly (P=0.037). Shorter TTFC (≤5 min vs. >60 min) was associated with higher pain/discomfort (odds ratio [OR], 3.82; 95% confidence interval [CI], 1.39–10.48) and anxiety/depression (OR, 7.58; 95% CI, 1.75–32.88).
Conclusion
Higher nicotine dependence was associated with impaired HRQoL. These results may be used to improve smoking cessation treatment outcomes.

Citations

• Current status of tobacco use, cessation and control policy in Korea
  Cheol Min Lee
  Journal of the Korean Medical Association.2022; 65(12): 789.     CrossRef

Background
Heart failure is an important chronic and progressive disease worldwide. Patients are faced with several stressors that decrease their quality of life (QoL). The present study aimed to determine the effectiveness of implementing a continuous care model on improving the QoL of patients with heart failure.
Methods
In the present randomized controlled trial, 72 patients with heart failure admitted to Shahid Chamran Hospital of Isfahan (in Central Iran) were randomly divided into 36-individual two groups: the experimental (continuous care model) and control (normal care) groups. In the experimental group, the continuous care model was implemented for 3 months. Data were collected using the standard Minnesota Living with Heart Failure Questionnaire for patients with heart failure. Subsequently, the collected data were entered into the IBM SPSS ver. 20.0 (IBM Corp., Armonk, NY, USA) and analyzed using the Mann-Whitney U-test, chi-square test, and independent and paired t-test at a significance level of α≤0.05.
Results
The results indicated that the mean scores of QoL before the implementation of continuous care model were 43.3±6.1 in the experimental group and 42.7±5.1 in the control group, indicating no statistically significant difference between the two groups. After the implementation of continuous care model, the mean score of QoL of the experimental group was significantly higher than that of the control group.
Conclusion
Considering the results obtained in the present study, model implementation could improve the overall scores of QoL in patients with chronic heart failure.

Citations

• INVESTIGATING THE EFFECT OF IMPLEMENTING THE CONTINUOUS CARE MODEL ON THE ATTITUDE RELATED TO ADHERENCE TO DIET AND FLUIDS IN PATIENTS TREATED WITH HEMODIALYSIS
  Ali Asghar Rahmanian Kushkaki, Mohsen Faseleh jahromi, Rasul Eslami Akbar
  Nursing and Midwifery Journal.2023; 21(6): 463.     CrossRef

Background
Dry sauna treatments improve the quality of life for chronic pain, congestive heart failure, and type 2 diabetes patients. This study aimed to determine whether dry sauna therapy improved the quality of life of obese people.
Methods
A total of 38 consecutive participants aged over 20 years with a body mass index of ≥25 kg/m² were recruited for the study. The participants were treated with a 90°C dry sauna for 15 minutes, twice daily for 4 consecutive days. To assess the quality of life, all participants completed the 5 level EQ-5D questionnaires and the EQ-Visual Analog Scale. Study parameters were measured on the same day prior to commencing the sauna sessions in a fasted state and 2 days after the last sauna session.
Results
The average age was 62.3±9.5 years; 84.2% of the participants were female. The mean body mass index was 28.5±2.4 kg/m². Dry sauna significantly improved the mean 5 level EQ-5D index scores from 0.83±0.12 to 0.89±0.11 and increased the mean EQ-Visual Analog Scale from 79.0±15.2 to 91.1±9.7. However, there were no significant changes in body mass index, blood pressure, heart rate, or body composition before and after the 8-session sauna therapy.
Conclusion
Dry sauna improved the health-related quality of life of obese patients without adverse events. Further clinical studies in larger study populations are needed to verify these findings and provide concrete evidence for obesity treatment.

Citations

• Clinical Implication of Korean Dry Sauna Therapy
  Teruhiko Imamura
  Korean Journal of Family Medicine.2021; 42(3): 257.     CrossRef

Background
Physicians and caregivers are conflicted over whether to inform patients that their disease is terminal. Studies examining the effect of awareness of prognosis on the survival and quality of life of terminally ill cancer patients report conflicting results. This study aimed to assess the effects of prognosis awareness on the survival time and psychological health of terminally ill cancer patients.
Methods
Patients in the hospice wards of two general hospitals were asked to complete a questionnaire. All were mentally alert and could express themselves clearly. Awareness of prognosis was defined as knowing both the diagnosis and exact prognosis. Survival time was defined as the time from hospital admission to death. Multiple psychological examinations were conducted to verify the effect of prognosis awareness on psychological health.
Results
Of the 98 subjects who met the inclusion criteria, 65 (66.3%) were aware of their terminal status. The patients’ awareness was significantly related to survival time after adjusting for clinical variables with a hazard ratio of 1.70 (95% confidence interval [CI], 1.01–2.86). Furthermore, the unaware group had a higher risk of cognitive impairment (Mini-Mental State Examination <24; adjusted odds ratio [aOR], 3.65; 95% CI, 1.26–10.59) and a poorer quality of life (physical component summary of the Short Form 36-item Health Survey <20; aOR, 3.61; 95% CI, 1.12– 11.60) than the aware group.
Conclusion
Knowledge of the exact prognosis might have a positive effect on the survival and quality of life of terminally ill cancer patients.

Citations

• Diagnostic awareness, psychosocial symptoms, and survival time in patients with advanced lung cancer
  Hulya Abali, Seda Tural Onur, Yusuf Baser, Dilara Demir, Asli Bicen
  The International Journal of Psychiatry in Medicine.2025; 60(4): 456.     CrossRef
• To be aware or not to be aware of the prognosis in the terminal stage of cancer? A systematic review of the associations between prognostic awareness with anxiety, depression, and quality of life according to cancer stage
  Federica Luciani, Giorgio Veneziani, Emanuele Giraldi, Virginia Campedelli, Federica Galli, Carlo Lai
  Clinical Psychology Review.2025; 116: 102544.     CrossRef
• What Have You Been Told? Awareness of Prognosis of Patients in an Italian Home Palliative Care Service
  Claudia Bolpagni, Federico Nicoli, Patrizia Borghetti, Matteo Rota, Giovanni Zaninetta, Michele Fortis
  Palliative Medicine Reports.2025; 6(1): 17.     CrossRef
• The association of prognostic awareness with quality of life, spiritual well-being, psychological distress, and pain severity in patients with advanced cancer: Results from the APPROACH Study in Indonesia
  Rudi Putranto, Hamzah Shatri, Cosphiadi Irawan, Soehartati Gondhowiardjo, Eric Finkelstein, Chetna Malhotra, Semra Ozdemir, Irene Teo, Grace Meijuan Yang
  Palliative and Supportive Care.2024; 22(6): 1778.     CrossRef
• Advanced statistical methods for hazard modeling in cardiothoracic surgery: a comprehensive review of techniques and approaches
  H. Shafeeq Ahmed
  Indian Journal of Thoracic and Cardiovascular Surgery.2024; 40(5): 633.     CrossRef
• Psychosocial Interventions at the End-of-Life
  Nicolle Marie Chew, Ee Lynn Ting, Lucille Kerr, David J. Brewster, Philip L. Russo
  Cancer Nursing.2023; 46(6): 432.     CrossRef
• Prognostic Awareness in Terminally Ill Cancer Patients: A Narrative Literature Review of the Processes Involved
  Mariam Chichua, Davide Mazzoni, Eleonora Brivio, Gabriella Pravettoni
  Cancer Management and Research.2023; Volume 15: 301.     CrossRef
• The associations between prognostic awareness and health-related quality of life among patients with advanced cancer: A systematic review
  Sean Ng, Semra Ozdemir
  Palliative Medicine.2023; 37(6): 808.     CrossRef
• What outcomes do studies use to measure the impact of prognostication on people with advanced cancer? Findings from a systematic review of quantitative and qualitative studies
  Caitlin Spooner, Bella Vivat, Nicola White, Andrea Bruun, Gudrun Rohde, Pei Xing Kwek, Patrick Stone
  Palliative Medicine.2023; 37(9): 1345.     CrossRef
• Quality of life of the cancer patients receiving home-based palliative care in Dhaka city of Bangladesh
  Jheelam Biswas, Mithila Faruque, Palash Chandra Banik, Nezamuddin Ahmad, Saidur Rahman Mashreky, Tai-Heng Chen
  PLOS ONE.2022; 17(7): e0268578.     CrossRef
• Prognostic disclosure and quality of life in palliative care: a systematic review
  Sanhapan Wattanapisit, Richard Wagland, Katherine Hunt
  BMJ Supportive & Palliative Care.2021; 11(4): 361.     CrossRef

Background
India is home to a large number of thalassemic children. Despite malnutrition being an essential determinant of their therapeutic goals and quality of life (QoL), it was hardly ever explored. With this background, this study aimed to estimate the proportion of β-thalassemia major (β-TM) children experiencing malnutrition, its attributes, and impact on their QoL.
Methods
This cross-sectional, hospital-based, analytical observational study was conducted among 328 β-TM children attending the thalassemia day care unit of a medical college from May 2016 to April 2017, with a structured schedule. Data were analyzed following appropriate statistical methods using SPSS statistical package ver. 16.0 (SPSS Inc., Chicago, IL, USA).
Results
Among the study participants, 48.2% were malnourished with a mean body mass index of 13.9 kg/m2 . In the multivariable logistic regression model, participants’ age (adjusted odds ratio [AOR], 1.15; 95% confidence interval [CI], 1.02–1.29), caste (AOR, 2.11; 95% CI, 1.23–3.60), mothers’ educational level (AOR, 2.05; 95% CI, 1.22– 3.44), blood transfusion frequency (AOR, 1.25; 95% CI, 1.16–1.31), and palpable spleen size (AOR, 1.22; 95% CI, 1.08–1.37) were significant predictors of malnutrition after adjusting for pre-transfusion hemoglobin level and hemolytic facies status. In multiple linear regression analysis, malnutrition negatively impacted total QoL (unstandardized beta [standard error], -4.4 [1.7]; P=0.009) and various domains of the study participants except the social and school domains adjusted for age, sex, caste, place of residence, parents’ educational level, and socioeconomic status.
Conclusion
Almost half of the study participants had malnutrition. Malnutrition had a negative impact on their QoL.

Citations

• Health‐related quality of life with standard and curative therapies in thalassemia: A narrative literature review
  Richa Shah, Sherif M. Badawy
  Annals of the New York Academy of Sciences.2024; 1532(1): 50.     CrossRef
• Comparison of Yearly Cost Related to Complications Between Deferasirox and Deferiprone Monotherapy in Thalassemia
  Teny Tjitra Sari, Pustika Amalia Wahidiyat, Ludi Dhyani Rahmartani, Stephen Diah Iskandar, Isyanaditta Agung Putri
  Journal of Pediatric Hematology/Oncology.2024; 46(6): e402.     CrossRef
• Quality of life and thalassemia in India: A scoping review
  Saravanan Chinnaiyan, Jenifer Sylvia, Sowmiya Kothandaraman, Bharathi Palanisamy
  Journal of Family Medicine and Primary Care.2024; 13(4): 1183.     CrossRef
• Association of age to nutritional status and muscle mass in children with transfusion-dependent β-thalassemia: a cross-sectional study
  Li Wang, Luyang Zhang, Yanlan Yang, Yuan Luo, Lei Wang, Sandip Patil
  Frontiers in Nutrition.2024;[Epub]     CrossRef
• Premature Atherosclerosis in Children With Transfusion-Dependent Thalassemia
  Rajesh Kulkarni, B. Rameshbabu
  Indian Pediatrics.2023; 60(3): 239.     CrossRef
• Detection of endocrine disorders in young children with multi-transfused thalassemia major
  Ramadan A. Mahmoud, Ashraf Khodeary, Marwa S. Farhan
  Italian Journal of Pediatrics.2021;[Epub]     CrossRef

Background
While hypothyroidism is associated with negative health effects in the general population, older adults with hypothyroidism have better physical function and comparable rates of depression and cognitive impairment relative to their euthyroid counterparts. The aim of this study was to investigate the association between thyroid status and health-related quality of life in Korean older adults.
Methods
In this population-based cross-sectional study, 1,060 adults aged over 60 years were classified by thyroid status into four groups based on their thyroid stimulating hormone (TSH) and free T4 values: overt hypothyroid, subclinical hypothyroid, euthyroid, and subclinical hyperthyroid. The main outcome measure was self-reported health-related quality of life based on the three-level version of the EuroQol-5 dimension (EQ-5D), with utility values of -0.171 and 1.000 corresponding to the worst and best health statuses, respectively. The adjusted means of the EQ-5D three-level version utility values according to thyroid status were determined using a linear regression analysis.
Results
In the adjusted analysis, the overt hypothyroid group showed significantly higher EQ-5D three-level version utility values than did the euthyroid group (0.998 vs. 0.908, P=0.000). In the subgroup analyses by sex, the overt hypothyroid group also showed significantly higher EQ-5D three-level version utility values for both men and women than did the euthyroid group (0.998 vs. 0.940, P=0.008; 0.983 vs. 0.882, P=0.001).
Conclusion
Asymptomatic Korean older adults aged over 60 years with TSH and free T4 values corresponding to overt hypothyroidism have better health-related quality of life than their euthyroid counterparts.

Citations

• Cost-effectiveness Analysis Comparing Conventional and Digital Software Supported Management for Hypothyroidism
  Jung Hyun Kim, Jaeyong Shin, Man S Kim, Jae Hoon Moon
  The Journal of Clinical Endocrinology & Metabolism.2025; 110(6): 1596.     CrossRef
• Correlation of gender with health related-quality of life of patients in 13 groups of disease in Poland
  Marlena Krawczyk-Suszek, Arkadiusz Gaweł, Andrzej Kleinrok
  Scientific Reports.2025;[Epub]     CrossRef
• Owners’ Experience and Satisfaction with Radioiodine Treatment in Hyperthyroid Cats—A Prospective Questionnaire Study
  Sofie Muthmann, Joana Léonie Tiefenbrunner, Fabienne Blunschi, Isabell Klemm, Natali Bettina Bauer, Katarina Hazuchova
  Veterinary Sciences.2025; 12(5): 458.     CrossRef
• Prevalence and Risk Factors of Subclinical Hypothyroidism in Young and Middle‐Aged Patients With First‐Episode Drug‐Naïve Major Depressive Disorder
  Jiacheng Liu, Liying Yang, Chuanyi Kang, Xiaohong Wang, Na Zhao, Xiangyang Zhang, Drozdstoy Stoyanov
  Depression and Anxiety.2025;[Epub]     CrossRef
• The enigma of persistent symptoms in hypothyroid patients treated with levothyroxine: A narrative review
  Petros Perros, Christina Van Der Feltz‐Cornelis, Enrico Papini, Endre V. Nagy, Anthony P. Weetman, Laszlo Hegedüs
  Clinical Endocrinology.2023; 98(4): 461.     CrossRef
• The Impact of Subclinical Hypothyroidism on the Quality of Life During Pregnancy: Mapping 5-Level Version of EQ-5D and ThyPRO-39
  Jan Tuzil, Barbora Filkova Pilnackova, Torquil Watt, Jan Jiskra, Marcela Koudelkova, Eva Novotna, Klara Tuzilova, Tomas Dolezal, Jana Bartakova
  Value in Health.2023; 26(7): 1085.     CrossRef
• The Impact of Hypothyroidism on the Quality of Life of Adults in Riyadh, Saudi Arabia
  May I AlAwaji, Rana H Alhamwy
  Cureus.2023;[Epub]     CrossRef
• Assessment of Quality of Life Among Patients With Primary Hypothyroidism: A Case-Control Study
  Ranya Ghamri, Raghad Babaker, Salwan Ezzat, Haya Alsaedi, Muruj Alkhamisi, Ragad Arbaein, Rahaf Alyahya, Shahad Fayraq, Sultan Alamri
  Cureus.2022;[Epub]     CrossRef
• Association between Subclinical Thyroidism and Health Related Quality of Life: Based on the 6th Korea National Health and Nutrition Examination Survey
  Ho Soo Nam, Yeong Sook Yoon, Yun Jun Yang, Eon Sook Lee, Jun Hyung Lee, Hyo Sang Kook, Hyuk Jin Kwon
  Korean Journal of Family Practice.2022; 12(5): 333.     CrossRef
• Cost-Effectiveness of Dronedarone and Amiodarone for the Treatment of Chinese Patients With Atrial Fibrillation
  Mengran Zhang, Yu Ren, Luying Wang, Jianhao Jia, Lei Tian
  Frontiers in Public Health.2021;[Epub]     CrossRef

Background
This study compared chronic diseases and health-related quality of life (HRQoL) in between primary care underserved areas residents and the general population.
Methods
Underserved areas were identified according to accessibility and the time relevance index for primary care. Overall, 279 participants aged ≥60 years from four counties enrolled voluntarily. A total of 1,873 individuals were assigned in the control group using the Korea National Health and Nutrition Examination Survey database. We assessed the differences in prevalence, awareness, and control of hypertension and diabetes and HRQoL using both subjective health status and the Korean version of the EuroQol-5D (EQ-5D) questionnaire using multivariate logistic regression analysis between the two groups.
Results
For hypertension, prevalence did not differ significantly between the two groups, whereas awareness and control were lower in the underserved areas than that in the general population; the adjusted odds ratios (95% confidence interval) were 0.40 (0.25–0.64) and 0.27 (0.18–0.41), respectively. For diabetes, differences in prevalence, awareness, and control were statistically insignificant. The proportion reporting poor subjective health status and problems in four EQ-5D indexes (ability to exercise, daily activities, pain/discomfort, anxiety/depression) was higher in the underserved areas, which also had a lower EQ-5D index, than that in the general population.
Conclusion
Primary care underserved area residents were underdiagnosed and under-controlled for hypertension and reported poorer subjective health and HRQoL compared to the general population. Primary care is the attributable factor to awareness and control of chronic diseases and subjective health and QoL in communities.

Citations

• Measuring the Burden of Disease in Korea Using Disability-Adjusted Life Years (2008–2020)
  Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
  Journal of Korean Medical Science.2024;[Epub]     CrossRef
• The Association with COPD Readmission Rate and Access to Medical Institutions in Elderly Patients
  Tae Wan Kim, Eun Sil Choi, Woo Jin Kim, Heui Sug Jo
  International Journal of Chronic Obstructive Pulmonary Disease.2021; Volume 16: 1599.     CrossRef
• Functional Status and Health-Related Quality of Life in Patients with Peripheral Artery Disease: A Cross-Sectional Study
  Mihui Kim, Yesol Kim, Gi Wook Ryu, Mona Choi
  International Journal of Environmental Research and Public Health.2021; 18(20): 10941.     CrossRef

Background
Studies have shown the health literacy effects on the general state of health and its related factors, as well as health outcomes, physical and mental health, and health-related quality of life. This study aimed to investigate the effect of training based on health literacy through social networking strategies to promote health-related quality of life among students of Islamic Azad University, Shahr Rey Branch, Iran.
Methods
This randomized controlled trial was conducted on 120 students with poor or average quality of life score. Participants were randomly assigned into experimental and control groups (60 participants each). Health literacy and quality of life data were collected at baseline, immediately after, and 3 months after intervention. The educational intervention was conducted online using social networking services. Data were analyzed using SPSS ver. 16.0 (SPSS Inc., Chicago, IL, USA).
Results
The results showed no significant differences between the two groups in terms of health literacy and quality of life at baseline (P=0.979 and 0.269, respectively). The mean score of health literacy and quality of life in the experimental group, compared with the control group, significantly increased immediately after and 3 months after the intervention (P<0.001).
Conclusion
The educational intervention administered by applying health literacy strategies online, through social networking services, can be effective in improving the quality of life of students.

Citations

• Intervenções em qualidade de vida com universitários
  Marina de Moraes e Prado Morabi, Sebastião Benício da Costa Neto
  Revista Internacional de Educação Superior.2024; 12: e026007.     CrossRef
• Promoting Health Literacy: Preparing for Future Health Crises
  Dalmacito A. Cordero Jr.
  Korean Journal of Family Medicine.2023; 44(2): 124.     CrossRef
• Adolescent women's perspective of pregnancy in Iran: a qualitative study
  Maryam Moridi, Farkhondeh Amin Shokravi, Farzaneh Pazandeh
  British Journal of Midwifery.2023; 31(6): 336.     CrossRef
• Community health literacy outcome measurement practices: A scoping review of recent interventions
  Luke Sawyers, Claire Anderson, Parisa Aslani, Gregory Duncan, Sobia S. Janjua, Li Shean Toh
  Health Science Reports.2022;[Epub]     CrossRef
• Application of the eHealth Literacy Model in Digital Health Interventions: Scoping Review
  Mariam El Benny, Tamar Kabakian-Khasholian, Fadi El-Jardali, Marco Bardus
  Journal of Medical Internet Research.2021; 23(6): e23473.     CrossRef
• Mental and physical health-related quality of life and their associated factors among students of a comprehensive allied health institution
  Khader A. Almhdawi, Saddam F. Kanaan, Yousef Khader, Zeid Al-Hourani, Muhammed D. Al-Jarrah, Fidaa Almomani, Mazin T. Alqhazo
  Work.2021; 70(1): 63.     CrossRef

Background
Recently, despite the high prevalence of fatigue in patients, there is a lack of research on the quality of life (QoL) in unexplained fatigue patients, indicating that they are not properly diagnosed and treated. The aim of this study was to compare fatigue severity and QoL between patients with explained and unexplained fatigue.
Methods
The study consisted of 200 Korean adults who complained of fatigue without underlying disease. Fatigue Severity Scale, Short Form Health Survey-36 version 2 (SF-36v2), and Beck Depression Inventory-II (BDI-II) selfquestionnaires were administered. Participants were dichotomized to two groups, namely, patients with unexplained or explained fatigue, sorted according to laboratory examination results. The chi-square test, t-test, and Wilcoxon rank-sum test were used, and analysis of covariance was calculated after adjusting for age, sex, body mass index, smoking status, and physical component summary (PCS) of SF-36v2 or BDI-II.
Results
PCS of SF-36v2 between the two groups showed significant difference. Compared to patients with explained fatigue, those with unexplained fatigue showed lower physical component scores of QoL.
Conclusion
QoL of patients with unexplained fatigue could largely diminish than those with explained fatigue. The primary clinician should be aware of poor QoL in patients with unexplained fatigue to identify who is in need of more attention and intervention.

Citations

• The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer
  Giuseppe Di Lorenzo, Carlo Buonerba, Raffaele Baio, Eleonora Monteleone, Francesco Passaro, Antonio Tufano, Vittorino Montanaro, Vittorio Riccio, Ilaria Gallo, Francesca Cappuccio, Federica Fortino, Anna Buonocore, Federica Monaco, Antonio Verde, Anna Rit
  Diseases.2025; 13(1): 15.     CrossRef
• Die ärztliche Wahrnehmung von ME/CFS-Erkrankten (myalgische Enzephalomyelitis/chronisches Fatigue-Syndrom) als „schwierige Patienten“
  Lotte Habermann-Horstmeier, Lukas M. Horstmeier
  Prävention und Gesundheitsförderung.2024; 19(4): 567.     CrossRef
• Psychometric evaluation of the Arabic version of the fatigue 5-item measure (FM) among physiotherapy patients in Libya
  Alhadi M. Jahan, Ali E. Rwaiha, Fatma A. Iqmeea
  Fatigue: Biomedicine, Health & Behavior.2024; 12(1): 1.     CrossRef
• Systemisches Denken, subjektive Befunde und das diagnostische „Schubladendenken“ bei ME/CFS – Eine vorwiegend qualitative Public-Health-Studie aus Patientensicht
  Lotte Habermann-Horstmeier, Lukas Maximilian Horstmeier
  DMW - Deutsche Medizinische Wochenschrift.2024; 149(04): e19.     CrossRef
• Impact of vortioxetine on psychosocial functioning moderated by symptoms of fatigue in post-COVID-19 condition: a secondary analysis
  Sebastian Badulescu, Gia Han Le, Sabrina Wong, Angela T. H. Kwan, Ziji Guo, Kayla M. Teopiz, Lee Phan, Mehala Subramaniapillai, Joshua D. Rosenblat, Rodrigo B. Mansur, Roger S. McIntyre
  Neurological Sciences.2024; 45(4): 1335.     CrossRef
• Fatigue in Prostate Cancer: A Roundtable Discussion and Thematic Literature Review
  Philip Cornford, Esther Robijn, Eamonn Rogers, Richard Wassersug, Louisa Fleure
  European Urology Open Science.2024; 63: 119.     CrossRef
• Factors associated with postpartum fatigue: an exploration of the moderating role of resilience
  Baian A. Baattaiah, Mutasim D. Alharbi, Monira I. Aldhahi, Fayaz Khan
  Frontiers in Public Health.2024;[Epub]     CrossRef
• Effectiveness of meditation for fatigue management: Insight from a comprehensive systematic review and meta-analysis
  Byung-Jin Park, Yujin Choi, Jin-Seok Lee, Yo-Chan Ahn, Eun-Jung Lee, Chang-Gue Son
  General Hospital Psychiatry.2024; 91: 33.     CrossRef
• Fatigue in der Allgemeinbevölkerung: Ergebnisse der Studie „Gesundheit in Deutschland aktuell“ (GEDA 2023)
  Christina Poethko-Müller, Angelika Schaffrath Rosario, Giselle Sarganas, Ana Ordonez Cruickshank, Christa Scheidt-Nave, Robert Schlack
  Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz.2024; 67(11): 1208.     CrossRef
• Impact of Laparoscopic Sleeve Gastrectomy on Obstructive Sleep Apnea Symptoms Based on the STOP-BANG Questionnaire: A Prospective Study
  Abdullah Musleh, Walid M. Abd El Maksoud, Abdullah Dalboh, Khaled S. Abbas, Sarah Alshehri, Mohammed A. Bawahab, Abdulrahman J. Alqahtani, Adnan Q. Al-Malki
  Bariatric Surgical Practice and Patient Care.2023; 18(2): 115.     CrossRef
• Factors Determining the Level of Acceptance of Illness and Satisfaction with Life in Patients with Cancer
  Renata Piotrkowska, Agnieszka Kruk, Aneta Krzemińska, Wioletta Mędrzycka-Dąbrowska, Katarzyna Kwiecień-Jaguś
  Healthcare.2023; 11(8): 1168.     CrossRef
• Trends in study topics related to quality of life in Industry 4.0: A bibliometric analysis
  Cristiano Couto do Amarante, David Nunes Resende, Evandro Eduardo Broday, Claudia Tania Picinin
  Work.2023; 76(4): 1357.     CrossRef
• The demographic features of fatigue in the general population worldwide: a systematic review and meta-analysis
  Ji-Hae Yoon, Na-Hyun Park, Ye-Eun Kang, Yo-Chan Ahn, Eun-Jung Lee, Chang-Gue Son
  Frontiers in Public Health.2023;[Epub]     CrossRef
• Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial
  Stephen J Smith, Adrian L Lopresti, Timothy J Fairchild
  Journal of Psychopharmacology.2023; 37(11): 1091.     CrossRef
• Megestrol Acetate in the Treatment of Post COVID-19 Fatigue in a Patient of Advanced Cancer: A Case Report and Mini Review of Literature
  Chaitanya R Patil, Nilesh A Dhamne, Prasad K Tanawade, Namrata B Mestri
  Indian Journal of Medical and Paediatric Oncology.2022; 43(02): 139.     CrossRef
• “I Just Want to Feel Safe Going to a Doctor”: Experiences of Female Patients with Chronic Conditions in Australia
  Lea Merone, Komla Tsey, Darren Russell, Cate Nagle
  Women's Health Reports.2022; 3(1): 1016.     CrossRef
• Physical and Mental Health Related Quality of Life and Their Influencing Factors on Sexual Minority Women in Korea
  Ssirai Kim, Smi Choi-Kwon
  International Journal of Environmental Research and Public Health.2021; 18(4): 2115.     CrossRef
• Is Quality of Life related to the postmenopausal women' sexual life?
  Tahereh JALALI, Zahra BOSTANI KHALESI, Fatemeh JAFARZADEH-KENARSARI
  Gazzetta Medica Italiana Archivio per le Scienze Mediche.2021;[Epub]     CrossRef
• Nationwide epidemiological characteristics of chronic fatigue syndrome in South Korea
  Eun-Jin Lim, Jin-Seok Lee, Eun-Jung Lee, Seok-Ju Jeong, Ho-Young Park, Yo-Chan Ahn, Chang-Gue Son
  Journal of Translational Medicine.2021;[Epub]     CrossRef
• Prevalence and correlates of fatigue and its association with quality of life among clinically stable older psychiatric patients during the COVID-19 outbreak: a cross-sectional study
  Siyun Zou, Zi-Han Liu, Xiaona Yan, Huan Wang, Yulong Li, Xiuying Xu, Xiangdong Du, Lan Zhang, Qinge Zhang, Todd Jackson, Gabor S. Ungvari, Yu-Tao Xiang
  Globalization and Health.2020;[Epub]     CrossRef
• A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males
  Adrian L. Lopresti, Peter D. Drummond, Stephen J. Smith
  American Journal of Men's Health.2019;[Epub]     CrossRef

Citations

• Arthrose et incidence des accidents vasculaires cérébraux et des accidents ischémiques transitoires chez 320 136 adultes suivis dans des cabinets généralistes au Royaume-Uni
  Louis Jacob, Christian Tanislav, Karel Kostev
  Revue du Rhumatisme.2022; 89(1): 72.     CrossRef
• Long-term intake of Lilium lancifolium mitigated osteoarthritic effects by suppressing inflammatory cytokines in a dog model
  Jeong-Hwi Cho, Yang-Gyu Park, Jinyoung Choi, Gareeballah Osman Adam, Eun-Myeong Ju, Ho Park, Hong-Geun Oh
  Veterinary World.2022; : 2012.     CrossRef
• Osteoarthritis and incidence of stroke and transient ischemic attack in 320,136 adults followed in general practices in the United Kingdom
  Louis Jacob, Christian Tanislav, Karel Kostev
  Joint Bone Spine.2021; 88(2): 105104.     CrossRef
• Effect of Aerobic Physical Activity on Health-Related Quality of Life in Middle Aged Women with Osteoarthritis: Korea National Health and Nutrition Examination Survey (2016–2017)
  Mikyung Ryu, Sol Lee, Ho Kim, Weon-Chil Baek, Heejin Kimm
  International Journal of Environmental Research and Public Health.2020; 17(2): 527.     CrossRef
• Quality of life of rural poor elderly in Anhui, China
  Jian Rong, Hong Ding, Guimei Chen, Yanhong Ge, Tingting Xie, Nana Meng
  Medicine.2020; 99(6): e19105.     CrossRef
• Managing the Early Risk of Posttraumatic Osteoarthritis Following Anterior Cruciate Ligament Injury
  Brian Pietrosimone
  Journal of Science in Sport and Exercise.2020; 2(3): 258.     CrossRef
• Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury
  Xinnan Bao, Xinyu Hu
  BMC Musculoskeletal Disorders.2018;[Epub]     CrossRef

Citations

• Overnutrition in the Elderly Population: Socio-Demographic and Behavioral Risk Factors in Hungary
  Battamir Ulambayar, Amr Sayed Ghanem, Attila Csaba Nagy
  Nutrients.2025; 17(12): 1954.     CrossRef
• The Role of Body Mass Index, Advanced Age, and Low Educational Attainment in Mild Cognitive Impairment among the Older Adult Population: A Study in a Rural Area in Indonesia
  Aulia Miladitiya, Achmad Zulfa Juniarto, Annta Kern Nugrohowati, Tri Indah Winarni
  Journal of Nutrition in Gerontology and Geriatrics.2023; 42(3-4): 144.     CrossRef
• Automatic Segmentation of Periapical Radiograph Using Color Histogram and Machine Learning for Osteoporosis Detection
  Rini Widyaningrum, Enny Itje Sela, Reza Pulungan, Anindita Septiarini, Mario Dioguardi
  International Journal of Dentistry.2023; 2023: 1.     CrossRef
• Quality of life profiles and their associations with depressive symptoms and cognitive impairment of community-dwelling older adults in Hong Kong
  Guozhi Luo, Weiping Li, Donghai Wu, Xinyue Wei, Yanpeng Zang, Jing-Dong Liu
  Frontiers in Public Health.2023;[Epub]     CrossRef
• Association between Body Mass Index, Physical Activity and Quality of Life amongst Older People in Malaysia during COVID-19: A Cross-Sectional Analysis
  Nor Safura Mohd Noor, Nur Kamilah Mohd Fauzy, Sakinah Harith, Wan Rohani Wan Taib, Rosliza Yahaya, Almira Sitasari, Furaida Khasanah
  Malaysian Journal of Medicine and Health Sciences.2023; 19(6): 42.     CrossRef
• The Impact of Obesity on the Health of the Older Population: A Cross-Sectional Study on the Relationship between Health-Related Quality of Life and Body Mass Index across Different Age Groups
  Patrick Reinbacher, Alexander Draschl, Maria Anna Smolle, Andrzej Hecker, Franz Gaderer, Kay-Bernd Lanner, Paul Ruckenstuhl, Patrick Sadoghi, Andreas Leithner, Stefan Nehrer, Thomas Klestil, Kevin Brunnader, Gerwin A. Bernhardt
  Nutrients.2023; 16(1): 51.     CrossRef
• Distinct biological ages of organs and systems identified from a multi-omics study
  Chao Nie, Yan Li, Rui Li, Yizhen Yan, Detao Zhang, Tao Li, Zhiming Li, Yuzhe Sun, Hefu Zhen, Jiahong Ding, Ziyun Wan, Jianping Gong, Yanfang Shi, Zhibo Huang, Yiran Wu, Kaiye Cai, Yang Zong, Zhen Wang, Rong Wang, Min Jian, Xin Jin, Jian Wang, Huanming Yan
  Cell Reports.2022; 38(10): 110459.     CrossRef
• New BMI Cut-Off Points for Obesity in Middle-Aged and Older Adults in Clinical Nutrition Settings in Italy: A Cross-Sectional Study
  Laura Di Renzo, Leila Itani, Paola Gualtieri, Massimo Pellegrini, Marwan El Ghoch, Antonino De Lorenzo
  Nutrients.2022; 14(22): 4848.     CrossRef
• Social Activities and Health-Related Quality of Life in Rural Older Adults in South Korea: A 4-Year Longitudinal Analysis
  JiYeon Choi, Kyeongra Yang, Sang Hui Chu, Yoosik Youm, Hyeon Chang Kim, Yeong-Ran Park, Youn-Jung Son
  International Journal of Environmental Research and Public Health.2020; 17(15): 5553.     CrossRef
• Association between body mass index and health-related quality of life among Chinese elderly—evidence from a community-based study
  Hua You, Xiao-lu Li, Kang-zhen Jing, Zhi-guang Li, Hong-mei Cao, Jin Wang, Lan Bai, Jing-hong Gu, Xiaoman Fan, Hai Gu
  BMC Public Health.2018;[Epub]     CrossRef

Citations

• Higher Intakes of Nutrients are Associated with Improved Health-Related Quality of Life among Individuals with Comorbidities
  Hai Duc Nguyen
  American Journal of Lifestyle Medicine.2023; : 155982762311680.     CrossRef
• Effectiveness of Maternal Vitamin D Supplementation in Preventing Respiratory Tract Infections in Children
  Soo Young Kim
  Korean Journal of Family Medicine.2022; 43(3): 155.     CrossRef
• Interactions between nutrient intake and comorbidities for quality of life in premenopausal and postmenopausal women
  Hai Duc Nguyen
  Menopause.2022; 29(11): 1285.     CrossRef
• Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway
  Laura M. Huiberts, Karin C.H.J. Smolders
  Sleep Medicine Reviews.2021; 55: 101379.     CrossRef
• Vitamin D status was not associated with anxiety, depression, or health-related quality of life in Middle Eastern and African-born immigrants in Sweden
  Lena E Granlund, Anna K Ramnemark, Christer Andersson, Marie C Lindkvist, Margareta Norberg, Eva M Fhärm
  Nutrition Research.2020; 75: 109.     CrossRef
• Role of vitamin D deficiency in type 2 diabetes mellitus and diabetic neuropathy development
  Anna P. Stepanova, Tatiana L. Karonova, Anna A. Bystrova, Vadim B. Bregovsky
  Diabetes mellitus.2018; 21(4): 301.     CrossRef
• Vitamin D Studies: Mistaking Correlation for Causation
  Seung-Won Oh
  Korean Journal of Family Medicine.2016; 37(4): 203.     CrossRef

Citations

• Assessment of Quality of Life in Lithuanian Patients with Multimorbidity Using the EQ-5D-5L Questionnaire
  Olga Vasiliauskienė, Dovydas Vasiliauskas, Aušrinė Kontrimienė, Lina Jaruševičienė, Ida Liseckienė
  Medicina.2025; 61(2): 292.     CrossRef
• Assessment of Health‐Related Quality of Life and Its Associated Factors Among Cardiovascular Disease Patients at a Teaching Hospital in Northwest Ethiopia: A Cross‐Sectional Study
  Assefa Belay Asrie, Mulugeta Dereje, Amanuel Getachew, Betelhem Genetu, Simona Saponara
  BioMed Research International.2025;[Epub]     CrossRef
• Impact of Metabolic Syndrome and Cardiovascular Risk on the Quality of Life of People Living with HIV
  Ítalo Inácio Pereira, Adrielly Katrine Tozetto Morais Muto, Regyane Ferreira Guimarães Dias, Hélio Ranes de Menezes Filho, Eduardo Vignoto Fernandes, Luiz Fernando Gouvêa-e-Silva, Ludimila Paula Vaz Cardoso
  Current HIV Research.2024; 22(3): 170.     CrossRef
• Modern psychometric evaluation of Thai WHOQOL-BREF and its shorter versions in patients undergoing warfarin in Thailand: Rasch analysis
  Krittaphas Kangwanrattanakul, Nattanichcha Kulthanachairojana
  Scientific Reports.2024;[Epub]     CrossRef
• Perspectives on Quality of Life in Women with Breast Cancer
  Edgar Fabian Manrique-Hernandez, Esther Ballesteros Goes, Kendrys Hoyos Madera, Anderson Bermon, Alexandra Hurtado-Ortiz, Maricel Licht-Ardila, Giselly Mayerly Nieves-Cuervo
  Indian Journal of Palliative Care.2024; 30: 347.     CrossRef
• A systematic review and meta-analysis of health-related quality of life among patients with cardiovascular diseases in Ethiopia
  Worku Chekol Tassew, Agerie Mengistie Zeleke, Samson Sisay Woldie, Yeshiwas Ayale Ferede
  Frontiers in Cardiovascular Medicine.2024;[Epub]     CrossRef
• The Added Value of Remote Technology in Cardiac Rehabilitation on Physical Function, Anthropometrics, and Quality of Life: Cluster Randomized Controlled Trial
  Heli Lahtio, Ari Heinonen, Teemu Paajanen, Tuulikki Sjögren
  Journal of Medical Internet Research.2023; 25: e42455.     CrossRef
• Positivity and Health Locus of Control: Key Variables to Intervene on Well-Being of Cardiovascular Disease Patients
  Bárbara Luque, Naima Z. Farhane-Medina, Marta Villalba, Rosario Castillo-Mayén, Esther Cuadrado, Carmen Tabernero
  Journal of Personalized Medicine.2023; 13(5): 873.     CrossRef
• The Effect of Inhalation Aromatherapy on Patients with Cardiovascular Disease Seeking Pain Relief: A Systematic Review and Meta-analysis
  Razieh Mohammadi-Dashtaki, Saeid Heidari-Soureshjani, Catherine Mary Turner Sherwin
  Current Drug Therapy.2023; 18(3): 262.     CrossRef
• Modelling population-level and targeted interventions of weight loss on chronic disease prevention in the Canadian population
  Emilie Pianarosa, Meghan O'Neill, Kathy Kornas, Lori M. Diemert, Christopher Tait, Laura C. Rosella
  Preventive Medicine.2023; 175: 107673.     CrossRef
• A score appraising Paleolithic diet and the risk of cardiovascular disease in a Mediterranean prospective cohort
  Víctor de la O, Itziar Zazpe, Leticia Goni, Susana Santiago, Nerea Martín-Calvo, Maira Bes-Rastrollo, J. Alfredo Martínez, Miguel Á. Martínez-González, Miguel Ruiz-Canela
  European Journal of Nutrition.2022; 61(2): 957.     CrossRef
• The Impact of Risk Factor Control on Health-Related Quality of Life in Individuals with High Cardiovascular Disease Risk: A Cross-sectional Study Based on EQ-5D Utility Scores in Inner Mongolia, China
  Ning Cao, Zhihui Hao, Liwei Niu, Nan Zhang, Hao Zhu, Han Bao, Tao Yan, Xin Fang, Xiaoqian Xu, Lehui Li, Yan Liu, Yuan Xia, Xiong Su, Xingguang Zhang
  Journal of Epidemiology and Global Health.2022; 12(1): 133.     CrossRef
• The Association between Health-Enhancing Physical Activity and Quality of Life in Patients with Chronic Kidney Disease: Propensity Score Matching Analysis
  Tae Ryom Oh, Hong Sang Choi, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Suah Sung, Seung Hyeok Han, Kook Hwan Oh, Seong Kwon Ma, Soo Wan Kim
  International Journal of Environmental Research and Public Health.2022; 19(3): 1318.     CrossRef
• Health-related quality of life and treatment satisfaction of patients with cardiovascular disease in Ethiopia
  Kebron Tito, Girma Tekle Gebremariam, Kebede Beyene, Beate Sander, Gebremedhin Beedemariam Gebretekle
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  Yeunhee Kwak, Yoonjung Kim, Soo Jin Kwon, Haekyung Chung
  International Journal of Environmental Research and Public Health.2021; 18(2): 514.     CrossRef
• Depressive Symptoms and Health-Related Quality of Life in Patients with Cardiovascular Diseases Attending a Tertiary Care Hospital, Puducherry—A Cross-Sectional Study
  Arokiasamy Senthilkumar, Lakshminarayanan Subitha, Essakky Saravanan, Dinesh Kumar Giriyappa, Santhosh Satheesh, Vikas Menon
  Journal of Neurosciences in Rural Practice.2021; 12: 376.     CrossRef
• Quantitative Determination of Epa and Dha in Fish Oil Capsules for Cardiovascular Disease Therapy in Indonesia by Gc-Ms
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  Journal of Public Health Research.2021;[Epub]     CrossRef
• Oral health-related quality of life (OHRQoL) in cardiovascular patients referring to Fatima Zahra Hospital in Sari, Iran
  Tahereh Molania, Ali Malekzadeh Shafaroudi, Mehdi Taghavi, Hodis Ehsani, Mahmood Moosazadeh, Azam Haddadi, Negar Gholizadeh, Maede Salehi
  BMC Oral Health.2021;[Epub]     CrossRef
• Periodontitis stage and grade are associated with poor oral‐health‐related quality of life: Findings from the Porto Alegre cohort study
  Joseane Goergen, Jasim M. Albandar, Rui Vicente Oppermann, Cassiano Kuchenbecker Rösing, Cristiano Susin, Alex Nogueira Haas
  Journal of Clinical Periodontology.2021; 48(10): 1333.     CrossRef
• Effect of depression and anxiety on quality of life among cardiovascular patients visiting Tertiary Care hospital Lahore
  Andleeb Shakoor, Hafsa Kamran, Maryam Shakoor, Sidra Khalid, Sughra Shakoor, Maria Aslam, Hina Shakoor
  Pakistan BioMedical Journal.2021;[Epub]     CrossRef
• Diagnostic Precision of Anthropometric Variables for the Detection of Hypertension in Children and Adolescents
  Manuel Vaquero-Álvarez, Rafael Molina-Luque, Francisco Javier Fonseca-Pozo, Guillermo Molina-Recio, José López-Miranda, Manuel Romero-Saldaña
  International Journal of Environmental Research and Public Health.2020; 17(12): 4415.     CrossRef
• Associations of Knowledge, Attitude and Practices of Food Label on Cardiovascular Diseases (CVD) Risk amongst University Students in Selangor, Malaysia
  Ho EVELYN, Ainor Farahin AZIZ, Sarina SARIMAN
  Journal of Nutritional Science and Vitaminology.2020; 66(Supplement): S275.     CrossRef
• Effectiveness of mindfulness-based stress reduction program on quality of life in cardiovascular disease patients
  Darioush Jalali, Mohammad Abdolazimi, Zahra Alaei, Kamal Solati
  IJC Heart & Vasculature.2019; 23: 100356.     CrossRef
• Association between physical inactivity and health-related quality of life in adults with coronary heart disease
  Reginald Wardoku, Cindy Blair, Ryan Demmer, Anna Prizment
  Maturitas.2019; 128: 36.     CrossRef
• Cardiac self-efficacy and quality of life in patients with coronary heart disease: a cross-sectional study from Palestine
  Aya Barham, Reem Ibraheem, Sa’ed H. Zyoud
  BMC Cardiovascular Disorders.2019;[Epub]     CrossRef
• Factors related to the Identification of Middle-Aged Women Who are Disadvantaged by Cardio-cerebrovascular Disease
  Moon Jung Kang, Jee Seon Yi, Chang Seung Park
  Korean Journal of Women Health Nursing.2018; 24(2): 185.     CrossRef
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Citations

• Comparative Study on Health-Related Quality of Life of Farmers and Workers
  Xiaofang Liu, Shuyan Gu, Shengnan Duan, Yuan Wu, Chiyu Ye, Jing Wang, Hengjin Dong
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• Impact of caring for patients with severe and complex disabilities on health care workers’ quality of life: determinants and specificities
  Marie‐Christine Rousseau, Karine Baumstarck, Tanguy Leroy, Cherazad Khaldi‐Cherif, Catherine Brisse, Laurent Boyer, Noémie Resseguier, Claire Morando, Thierry Billette De Villemeur, Pascal Auquier
  Developmental Medicine & Child Neurology.2017; 59(7): 732.     CrossRef
• Relación entre la calidad de vida de los pacientes, mediante el cuestionario EuroQol-5D, y la clasificación de morbilidad Clinical Risk Groups
  Daniel Ríos García, Meritxell Calderó Solé, Manuel Pena Arnaiz, Virginia Sánchez Fernández, Jordi Real Gatius, Rosa Llovet Font, Gemma Pascual Sol
  Medicina General y de Familia.2015; 4(2): 47.     CrossRef

Background
Obesity is known to influence on physical, mental, functional health problems but there have been no study of relationship between body mass index (BMI) and quality of life (QOL) in Korean elderly. Methods: A total of 216 elderly who had been attending two geriatric welfare facilities in Seoul answered the Korean version of obesity-related quality of life (KOQOL) questionnaire. Height, weight, waist circumference were measured. Body fat (%) was measured with HTM20 by impedance technique. Sociodemographic and medical factors were interviewed. QOL was assessed using KOQOL (ver.1) after excluding two sexual life related questions and one work related question. The total score is 48 points. The higher is the score, the poorer is the QOL. Results: In multivariable analysis, BMI, age, history of diabetes mellitus, history of osteoarthritis were associated with KOQOL score. Especially, BMI was significantly associated with KOQOL score after adjusting for waist circumference, body fat (%) (P = 0.002). Conclusion: The more BMI increases, the worse the obesity related QOL is in Korean ambulatory elderly.

Citations

• Affecting Factors for Dietary, Exercise and Behavioral Modification of Women on Diet Improvement through Mediating Effects of Improve the Quality of Life
  Yoojin Oh
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• Factors Affecting the Deterioration of the Physical Health Status of Taxi Drivers by Age Group
  Jongsun Ok, Kyonghwa Kang, Hyeongsu Kim
  International Journal of Environmental Research and Public Health.2022; 19(6): 3429.     CrossRef
• Efficacy and safety of Euiiyin-tang in Korean women with obesity: A randomized, double-blind, placebo-controlled, multicenter trial
  Chunhoo Cheon, Yun-Kyung Song, Seong-Gyu Ko
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• The associations between body mass index (BMI) and life satisfaction among older adults: Focusing on mediating effects of depressive symptoms
  Hae Sook Jeon
  Korean Journal of Health Education and Promotion.2019; 36(3): 83.     CrossRef
• Association between body mass index and health-related quality of life among Chinese elderly—evidence from a community-based study
  Hua You, Xiao-lu Li, Kang-zhen Jing, Zhi-guang Li, Hong-mei Cao, Jin Wang, Lan Bai, Jing-hong Gu, Xiaoman Fan, Hai Gu
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• Euiiyin-tang in the treatment of obesity: study protocol for a randomised controlled trial
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• Association between Body Mass Index and Quality of Life in Elderly People over 60 Years of Age
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• Body Mass Index (BMI)-Related Factors of Community-Dwelling Elders: Comparison between Early and Late Elderly People
  Hye Sun Hyun, In Sook Lee
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Background
Constipation is one of the most common digestive complaints. Although, there are increased interest on the socioeconomic effect of constipation and studies associated with quality of life on constipation, there is no study about the infl uence of constipation onto quality of life (QOL) in Korea. We studied the impact of functional constipation on QOL. Methods: Between March to June 2008, person to person survey with 844 elderly aged over 60 years was performed at two senior care centers, a public health center, and secondary hospital in Seoul metrocity and Chung-ju city. The diagnosis of functional constipation was based on the Rome III criteria and QOL was measured by the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36). Results: The average age was 73.6 years and the prevalence rate of constipation was 20.3%. The average SF-36 score was 63.5 in total population, 57.9 in constipation group, and 64.9 in normal group. Conclusion: These results suggest that the constipation lowers QOL in adults aged over 60 years old. Further study will be necessary to explore if QOL changes according to the severity of constipation and its treatment and to assess QOL using a disease-specifi c measurement tool that can be used for Korean environment.

Citations

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  Yu Hyun Lim, Dong Hyun Kim, Moon Young Lee, Min Cheol Joo
  Annals of Rehabilitation Medicine.2012; 36(3): 371.     CrossRef
• Correlation among Dietary Habits Score, Life Stress Score and Health-Related Quality of Life (HRQL) Score for Female College Students with Functional Constipation
  Jeong Soon You, Ji Yeon Park, Kyung Ja Chang
  The Korean Journal of Nutrition.2010; 43(6): 620.     CrossRef

Background
Overactive bladder syndrome (OAB) is a common disorder in primary care that affects negatively on the quality of life of outpatients. However, little information is available on related factors and the quality of life in adults with overactive bladder. The purpose of this study was to fi nd related factors of overactive bladder and to measure the quality of life in adults with overactive bladder. Methods: Among the people who visited a hospital in Seoul and Chung-ju for a health xamination or primary care between October 1 and December 31, 2008, we selected 327 participants over 20 years old. We measured their Overactive Bladder Questionnaire (OAB-q), took medical history and reviewed their demographic data. The relationship between OAB, other independent variables and health related quality of life (HRQL) were analyzed. Results: Of 327 respondents, the prevalence of OAB in adults was 38 (11.6%). The factors related to OAB were age (P = 0.007), history of prescription for congestive heart failure (P = 0.023), benign prostatic hyperplasia (BPH) (P = 0.002), and depression (P = 0.008). OAB was signifi cantly associated with BPH medication (P = 0.042; OR = 8.757) and depression medication (P = 0.005; OR = 9.977) in multivariable logistic regression analysis. In each T-test analysis, OAB decreased in HRQL. Conclusion: OAB is a common disorder in adults, history of BPH medication and depression medication is more common in OAB. The symptoms that were suggestive of OAB were affected negatively on the quality of life in adults. Effective health care polices and prompt management of OAB should be implemented.

Citations

• The Effect of Korean Medical Treatment on the Overactive Bladder Syndrome with Coughing: Case Report
  Ju-hyun Oh, Yu-ra Lee, Jin-young Song, Geon-sik Kong, Jin-hun Park, So-won Kim, Man-ho Kang, Hyung-chul Lee, Guk-hyeon Eom, Woo-sub Song
  The Journal of Internal Korean Medicine.2020; 41(5): 724.     CrossRef
• Sex Difference in Associations between Severity Level of Overactive Bladder and Perceived Stress, Depression in Korean Patients
  Ji-Young Ji-Young, So-Yeon Ryu, Jong Park, Seong-Woo Choi
  Journal of Health Informatics and Statistics.2019; 44(1): 14.     CrossRef
• Factors Influencing Overactive Bladder Symptom Severity in Community Residents
  Eun Hui Choi, Eun Nam Lee, Jeong Lim Cho, Moon Jung Jang
  Journal of muscle and joint health.2016; 23(1): 39.     CrossRef

Health conomics refers to the scientific discipline that compares the value of one healthcare program to another. It is a sub-discipline of Micro-economics. A health economic study evaluates the cost (expressed in monetary terms) and effects (expressed in terms of monetary value, effi cacy or enhanced quality of life) of a healthcare program or product. We can distinguish several types of health economic evaluation: cost-minimization analysis, cost-benefi t analysis, cost-effectiveness analysis and cost-utility analysis. Health economics studies serve to guide optimal healthcare resource allocation, in a standardized and scientifi cally grounded manner. Health economics research facilitates the translation of health technology assessment into useful information for healthcare decision-makers to ensure that society allocates scarce health care resources wisely, fairly and effi ciently. Health economics usually evaluate the outcomes like clinical, economics and humanistic outcomes per costs. Health economics research include pharmacoeconomics, clinical epidemiology, decision analysis, modeling, risk assessment, patient-reported outcomes (quality of life), database analyses, observational studies, and patients registries.

Citations

• Cost-Benefit Analysis of Occupational Therapy in Center for Dementia Based on Public Data
  Seung-Hyun Cho, Kyung-Yoon Kam, Sung-Yoon Bae, Nam-Hoon Cho, Hye-Won Oh, Young-Ae Yang
  Journal of Korean Society of Occupational Therapy.2018; 26(2): 99.     CrossRef
• A Review of Economic Evaluations in Acupuncture for Allergic Rhinitis
  Dong-Hyo Lee
  The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology.2016; 29(2): 1.     CrossRef
• Association between research topics and disease burden in health technology assessment
  Hee Sun Kim, Jisu Lee, Bit-Na Yoo
  Journal of the Korean Medical Association.2016; 59(7): 536.     CrossRef
• Economic Impact of Atopic Dermatitis in Korean Patients
  Chulmin Kim, Kui Young Park, Seohee Ahn, Dong Ha Kim, Kapsok Li, Do Won Kim, Moon-Beom Kim, Sun-Jin Jo, Hyeon Woo Yim, Seong Jun Seo
  Annals of Dermatology.2015; 27(3): 298.     CrossRef
• Cost-effectiveness analysis of low density lipoprotein cholesterol-lowering therapy in hypertensive patients with type 2 diabetes in Korea: single-pill regimen (amlodipine/atorvastatin) versus double-pill regimen (amlodipine+atorvastatin)
  Ji-Hyun Park, Yong-Ho Lee, Su-Kyoung Ko, Bong-Soo Cha
  Epidemiology and Health.2015; 37: e2015010.     CrossRef
• Value-based medicine: concepts and application
  Jong-Myon Bae
  Epidemiology and Health.2015; 37: e2015014.     CrossRef

Background
Menstruation is often regarded as a privilege for women allowing reproductive activity. However, abrupt hormonal fluctuations in menstrual cycle may cause distressing physical and psychological symptoms such as premenstrual syndrome (PMS). PMS is known to have a great impact on daily life activities and social functions, and might result in significantly decreased quality of life (QOL). In this study, we aimed to evaluate a relation between PMS and QOL in young adult Korean women. Methods: Self-administered questionnaires were distributed to a total of 514 women who were aged 16∼35 years and who were employed in an industrial complex located in Gyeonggi-do, Korea. PMS was assessed using diagnostic criteria recommended by the American Psychiatric Association. QOL was assessed using Korean health related Quality of Life Scale. The association between PMS and QOL was examined in 440 women using the two-sample t-test after excluding 74 women who were missing for variables essential for the assessment of PMS and QOL. Results: The prevalence of PMS was 7.3% (32 out of 440 women). Women with PMS had the worse QOL score in almost all domains of QOL except for spiritual health (physical function, psychological health, social function, pain, vitality, role limitation, health status perception, and health status change). Conclusion: There was a significant relation between PMS and QOL. The finding of significantly lower QOL in women with PMS suggests that PMS should be evaluated and treated actively in primary care. (J Korean Acad Fam Med 2008;29:108-113)

Background
Numerous studies have identified that physical activity influences decrements of both mortality and morbidity. Besides these objective indices, positive influences of physical activity on individuals' lives are being studied upon various populations. The purpose of this study was to evaluate the association of physical activity on health-related quality of life (HRQOL) in relatively healthy adults of Korea. Methods: Questionnaires were sent by mail to one thousand examinees who were scheduled for health check-up. We analyzed data from 214 men and 195 women. The physical activities were measured using the International Physical Activity Questionnaraire (IPAQ)-short form and the HRQOL was assessed by the CMCHS ver 1.0. The subjects were separated by gender and into either a recommended level of physical activity group or a lower physical activity group according to the physical activity scale. Results: The group with physical activity beyond the recommended level had better HRQOL measures than those who did not. After revising the factors that affected the HRQOL, cognition of present heath status, satisfaction for health status, bodily pain, physical function, emotional function, social function and general health measure scores were significantly higher in the female group with physical activity beyond recommended quantity than those who did not. However, there were no statical significance in the male group. Conclusion: Physical activity was associated with health related quality of life in middle aged women.

Background
: Recently, several health risk appraisal programs have been developed to suit Korean character which is currently implemented. This study was conducted to find out the correlation with health age and health- related quality of life through health risk appraisal.

Methods : From March 1, 2004 to July 30, 2004, 107 male patients aged 30 to 59 who visited the family medicine clinic in a university hospital and had agreed to participate in the study have been assessed to determine the correlation between health age and health-related quality of life by measuring tools of health risk appraisal, CMCHS V1.0 questionnaire and Yangseng measurement questionnaire.

Results : Among the total 107 subjects, 3 were excluded because of incomplete questionnaire. There were 28 people aged in their thirties, 36 in forties, and 40 in fifties. The health age and health-related quality of life showed a negative correlation. The correlation in men in their life showed the strongest. Indexes between the health age and health perception, changes in health, vitality, morality Yangseng, diet Yangseng, sleep Yangseng and active and rest Yangseng have shown a strong negative correlation (P＜0.05).

Conclusion : The lower the health age is, the better health- related quality of life in several domains of CMCHS V1.0 and Yangseng in middle aged Korean men.