Korean Journal of Family Medicine

"Selective Serotonin Reuptake Inhibitors"

Review Article

Review of hormonal replacement therapy options for the treatments of menopausal symptoms: Melissa Edelweishia, Andreas Christoper, Evelyne Theresia, Veronica Angelia; Korean J Fam Med 2025;46(5):299-306. Published online September 20, 2025; DOI: https://doi.org/10.4082/kjfm.25.0039

Abstract
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Menopause is a natural part of the aging process that every woman experiences at some point in life. Menopausal symptoms have a negative impact on the quality of life. Common menopausal symptoms include vasomotor symptoms, mood swings, concentration issues, vaginal dryness, atrophy of secondary sexual traits, libido loss, musculoskeletal discomfort, osteopenia, and osteoporosis. The most effective treatment for the relief of menopausal symptoms is estrogen, with or without. Hormone replacement therapy (HRT) is most beneficial before 60 years of age or within 10 years of menopause. Other menopause-related symptoms including mood swings, sleep disturbance, sexual dysfunction, and myalgia may improve with HRT. HRT is also effective in preventing bone loss associated with menopause and in reducing the incidence of all osteoporosis-related fractures, including those of the vertebrae and hip.

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Case Report

Escitalopram-Induced Amenorrhea and False Positive Urine Pregnancy Test: Vithyalakshmi Selvaraj, Siv Hour, Palanikumar Gunasekar, Caron Gray, James F. Smith; Korean J Fam Med 2017;38(1):40-42. Published online January 18, 2017; DOI: https://doi.org/10.4082/kjfm.2017.38.1.40

Abstract
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Escitalopram is a selective serotonin reuptake inhibitor antidepressant approved by the Food and Drug Administration for the treatment of major depressive disorder and generalized anxiety disorder. A 34-year-old female patient with major depressive disorder developed amenorrhea and had a false-positive urine pregnancy test after initiation of escitalopram treatment. To our knowledge, no published case report of amenorrhea and false-positive urine pregnancy tests in women taking escitalopram exists. This case report suggests that women of child-bearing age should be carefully monitored for amenorrhea while they are on an antidepressant treatment regimen.

Citations

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