Korean Journal of Family Medicine

Association between Dyslipidemia and the Prevalence of Colon Polyps Based on a Health Evaluation of Subjects at a Hospital: Yeong-Ju Kim, Kyung-Jin Lee, Si-Young Park, Jee-Hae Han, Kil-Young Kwon, Jung-Hwan Kim; Korean J Fam Med 2014;35(3):143-151. Published online May 22, 2014; DOI: https://doi.org/10.4082/kjfm.2014.35.3.143

Abstract
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Background

Colonic neoplasm is associated with western diet intake and physical inactivity. These life styles are also risk factors for dyslipidemia and metabolic syndrome. The aim of this study was to evaluate the association between dyslipidemia and the prevalence of colon polyps including colon adenoma as a precancerous lesion of colonic neoplasms.

Methods

We selected subjects undergoing a colonoscopy for health screening at the Health Promotion Center of Eulji General Hospital from January 2006 to June 2010. Subjects with histories of cancers, dyslipidemia treatment, and other intestinal diseases like Crohn's disease and ulcerative colitis were excluded. The total numbers of subjects included in the study was 605. Chi-square test and t-test and were used for the analysis. Additionally we used multivariate logistic regression to adjust for sex, age, smoking, drinking, and other risk factors.

Results

The prevalence of colon polyps was 48.70% and 28.05% in males and females, respectively. When adjusting for variables that included age, body mass index, hypertension, diabetes mellitus, smoking, drinking, and exercise, dyslipidemia was not significantly associated with the prevalence of colon polyps. However upon analyzing adenomatous colon polyps in men, dyslipidemias due to triglycerides and high density lipoproteins were significant factors (odds ratio [OR], 2.13; confidence interval [CI], 1.14 to 3.98; OR, 2.24; CI, 1.15 to 4.34, respectively).

Conclusion

Dyslipidemia was not a significant factor in the prevalence of colon polyps. However it had a significant association with the prevalence of adenomatous colon polyps in men.

Citations

Citations to this article as recorded by

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Children and Parental Factors Affecting Cholesterol Levels of First-grade Students in Elementary School in Gwacheon.: Seol Whee Roh, Sun Young Lee, Kyu Nam Kim, Hyeon Keun Kim, Sun Mi Yoo, Jae Heon Kang, Ji Hyun Song, Myeong Ho Jung; J Korean Acad Fam Med 2007;28(10):754-761. Published online October 10, 2007

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The relationship between low serum cholesterol and depression.: Dong Hyun Lim, Hwan Seok Lee, Nan Yeong Kim, Hyung Don Joo, Chang ho Youn, Jung Bum Lee; J Korean Acad Fam Med 2000;21(9):1157-1163. Published online September 1, 2000

Abstract
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Background
: Although elevated serum cholesterol level has been considered as a significant health problem because it is associated with coronary artery disease, the relation with various health problem (esp. depression) from low serum cholesterol is not well known in Korean people. The authors tried to observe the degree of depression in low serum cholesterol group for its better management.

Methods : The study population was selected among adults who visited the National University Hospital Health Screening Center between May and July 1998. They had no history of cancer and liver disease and no significant medical illnesses which may affect blood cholesterol level. Using the Korean standard BDI, we evaluated the degree of depression scale.

Results : The number of subjects with low serum cholesterol was 77 (males 42, females 35) and that of the control group was 82 (males 47, females 34). The low serum cholesterol group had a statistically significantly higher BDI score(12.2±8.2) than the control group(7.6±6.3) (P<0.05). In males the mean BDI score of 11.9±7.4 in the low serum cholesterol group was significantly higher than the mean score of 5.0±3.8 in the control group(P<0.5), In females, there was no significant difference in depression scale between both groups.

Conclusion : Since the male low serum cholestrerol group had a high depression scale, the multi disciplinary approaches which include psychological supports may be required to manage and treat them. And persistent, significant association between low serum total cholesterol level and psychological problems suggests that further long-term study on the association of low choleserol with depression is necessary.