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"Stroke"

Original Articles

Correlation between Serum Erythropoietin and Cerebral Collateral Flow in Acute Ischemic Stroke Patient
Sung Won Yun, Won Yong Kim, Jun Beom Lee
Korean J Fam Med 2023;44(1):53-57.   Published online January 19, 2023
DOI: https://doi.org/10.4082/kjfm.22.0117
Background
Erythropoietin (EPO), which is associated with anemia, exerts neuroprotective effects in ischemic stroke. In cases of stenosis or narrowing of the main cerebral blood vessel, the prognosis is favorable if collateral blood circulation is well developed in acute stroke. Several studies have investigated the relationship between EPO administration and stroke outcomes. The present study investigated the correlation between serum EPO level and cerebral collateral circulation, which could result in favorable clinical outcomes.
Methods
The study subjects were patients diagnosed with acute ischemic stroke who underwent initial brain magnetic resonance imaging between January 2020 and March 2022. Following brain computed tomography perfusion for collateral flow, serum EPO levels were measured. Collaterals were assessed according to the Mass system and divided into good collateral (GC) or poor collateral (PC) groups. Serum EPO levels were determined using a chemiluminescence immunoassay method. A correlation coefficient analysis was conducted to determine the correlation between serum EPO levels and GC. A receiver operating characteristic curve analysis determined the cutoff value of EPO for GC.
Results
Serum EPO levels were significantly higher in the GC than that in the PC group (P<0.05). The cut-off level of serum EPO for a good outcome was 9.1 mIU/mL.
Conclusion
A high serum EPO (>9.1 mIU/mL) could be a marker of GC in patients with acute ischemic stroke that predicts good clinical outcomes.

Citations

Citations to this article as recorded by  
  • Reinforcement of Transdural Angiogenesis: A Novel Approach to Treating Ischemic Stroke With Cerebral Perfusion Impairment
    Ji Man Hong, Hee Sun Shin
    Journal of Stroke.2025; 27(1): 30.     CrossRef
  • Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway
    Zhenxing Tao, Pengpeng Li, Yushi Tang, Wenhui Yang, Yilu Li, Jieqiong Yang, Jiajia Tian, Yating Zhang, Yan Zou, Bai Xu, Xudong Zhao
    Neurochemical Research.2025;[Epub]     CrossRef
  • Albumin levels and cerebral collateral circulation in patients with acute ischemic stroke due to intracranial arteriosclerotic: A propensity score-matched analysis
    Le Wang, Qiang Shi, Yi-dong Xue, Chan Cao, Ying-Ying Zheng
    Medicine.2024; 103(21): e38254.     CrossRef
  • 3,105 View
  • 64 Download
  • 3 Web of Science
  • 3 Crossref
BCL11A rs1427407 Genotypes in Sickle Cell Anemia Patients Undergo to Stroke Problems in Sudan
Fathelrahman Mahdi Hassan, Faisal Mousa Al-zahrani
Korean J Fam Med 2019;40(1):53-57.   Published online December 19, 2018
DOI: https://doi.org/10.4082/kjfm.17.0144
Background
Sickle cell disease is an autosomal recessive condition that results from the presence of a mutated form of hemoglobin. Some genetic variants of BCL11A are amenable to therapeutic manipulation. The present study investigated the relationship of a BCL11A variant (rs1427407) and its plasma levels with vaso-occlusive crises and stroke complications among patients in Sudan with sickle cell disease.
Methods
This cross-sectional study was performed between June 2014 and October 2016. The subjects included 166 patients who were diagnosed with sickle cell disease and 35 healthy control subjects, who were grouped according to sex and age (<15 years, 15–25 years, and >25 years). All patients and/or their guardians provided informed consent. Blood samples were collected from the patients and controls under aseptic conditions.
Results
Plasma BCL11A levels were elevated in cases with vaso-occlusive crises that lasted for >3 years. In addition, plasma BCL11A levels were high in cases with the GG genotype (vs. GT and TT) at rs1427407. Furthermore, the BCL11A rs1427407 GG/GT genotypes increased the risk of vaso-occlusive crisis and stroke in the patients with sickle cell disease.
Conclusion
The BCL11A variant (rs1427407) and its plasma levels were associated with vaso-occlusive crisis and stroke in patients with sickle cell disease.

Citations

Citations to this article as recorded by  
  • Genetic Variants Associated with the Risk of Stroke in Sickle Cell Anemia: Systematic Review and Meta-Analysis
    Aradhana Kumari, Ganesh Chauhan, Partha Kumar Chaudhuri, Sushma Kumari, Anupa Prasad
    Hemoglobin.2024; 48(2): 101.     CrossRef
  • Genetic Modifiers of Stroke in Patients with Sickle Cell Disease—A Scoping Review
    Morohuntodun O. Oni, Miguel Brito, Chloe Rotman, Natasha M. Archer
    International Journal of Molecular Sciences.2024; 25(12): 6317.     CrossRef
  • Genetic Variation and Sickle Cell Disease Severity
    Justin K. Kirkham, Jeremie H. Estepp, Mitch J. Weiss, Sara R. Rashkin
    JAMA Network Open.2023; 6(10): e2337484.     CrossRef
  • 5,424 View
  • 92 Download
  • 3 Web of Science
  • 3 Crossref

Case Report

A Brief Psychotic Episode with Depressive Symptoms in Silent Right Frontal Lobe Infarct
Salziyan Badrin, Noraini Mohamad, Nor Akma Yunus, Maryam Mohd Zulkifli
Korean J Fam Med 2017;38(6):380-382.   Published online November 14, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.6.380

Psychiatric symptoms may be related to a silent cerebral infarct, a phenomenon that has been described previously in literature. Acute psychosis or other neuropsychiatric symptoms including depression may present in stroke patients and patients with lesions either within the prefrontal or occipital cortices, or in subcortical areas such as the basal ganglia, thalamus, mid-brain, and brainstem. Psychosis in clinical stroke or in silent cerebral infarction is uncommon and not well documented in the literature. Neurological deficits are the most common presentation in stroke, and nearly a third of patients that suffer a stroke may experience psychological disorders such as depression and anxiety, related to physical disability. The present case report describes an elderly female patient who presented with hallucinations and depressive symptoms, and was discovered to have a recent right frontal brain infarction, without other significant neurological deficits.

Citations

Citations to this article as recorded by  
  • Influence of Evidence-Based Nursing on Psychological Status, Neurological Function, and Life Quality of Patients with Acute Poststroke Depression
    Yan Song, Fei Wang, Yakun Yang, Xing Liu, Chenghong Zhu, Zhongjie Shi
    Disease Markers.2022; 2022: 1.     CrossRef
  • Predicting hallucination proneness based on mindfulness in university students: the mediating role of mental distress
    Seyed Ruhollah Hosseini, Nikzad Ghanbari Pirkashani, Mahshid Zarnousheh Farahani, Sheyda Zarnousheh Farahani, Roghieh Nooripour
    Community Mental Health Journal.2021; 57(2): 203.     CrossRef
  • Cranial Magnetic Resonance Imaging as a Screening Tool for Evaluation of Silent Brain Ischemia in Severe Coronary Artery Disease: A Clinical Based Study
    Tuğba İlkem KURTOĞLU ÖZÇAĞLAYAN, Demet ÖZKARAMANLI GÜR, Ömer ÖZÇAĞLAYAN, Birol TOPCU, Aysun ÜNAL
    Düzce Tıp Fakültesi Dergisi.2020; 22(3): 201.     CrossRef
  • Auditory Hallucinations as a Rare Presentation of Occipital Infarcts
    Firas Ido, Reina Badran, Brandon Dmytruk, Zain Kulairi
    Case Reports in Neurological Medicine.2018; 2018: 1.     CrossRef
  • 5,271 View
  • 49 Download
  • 5 Web of Science
  • 4 Crossref
Original Articles
Predictors of Successful Smoking Cessation after Inpatient Intervention for Stroke Patients
Eugene Ha, Jun-Yong Jo, Ah-Leum Ahn, Eun-Jung Oh, Jae-Kyung Choi, Dong-Yung Cho, Hyuk-Jung Kweon
Korean J Fam Med 2016;37(2):85-90.   Published online March 25, 2016
DOI: https://doi.org/10.4082/kjfm.2016.37.2.85
Background

Smoking is a well-known risk factor of cancer, chronic disease, and cerebrovascular disease. Hospital admission is a good time to quit smoking but patients have little opportunity to take part in an intensive smoking cessation intervention. The purpose of this study was to identify the factors of successful smoking cessation among stroke patients who undergo an intensive cessation intervention during the hospitalization period.

Methods

Thirty-nine male smokers who were admitted with stroke were enrolled in the study. They participated in a smoking cessation intervention during hospitalization. Smoking status was followed up by telephone 3 months later. Nicotine dependence, sociodemographic factors, and other clinical characteristics were assessed.

Results

After 3 months post-intervention, the number of patients who stopped smoking was 27 (69.2%). In addition, there was no significant difference in nicotine dependence, sociodemographic factors, and clinical characteristics. Only the stages of readiness for smoking cessation were a significant predictor (odds ratio, 18.86; 95% confidence interval, 1.59–223.22).

Conclusion

This study shows that a patient's willingness to quit is the most significant predictor of stopping smoking after Inpatient cessation Intervention for stroke Patients.

Citations

Citations to this article as recorded by  
  • Association between post-stroke smoking and stroke recurrence in first-ever ischemic stroke survivors: based on a 10-year prospective cohort
    Qiang Yao, Bai-Yang Zhang, Yi-Die Lin, Mei-Jing Hu, Min Jiang, Mu-Ke Zhou, Cai-Rong Zhu
    Neurological Sciences.2023; 44(10): 3595.     CrossRef
  • Rates, Predictors, and Impact of Smoking Cessation after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis
    Jean Jacques Noubiap, John L. Fitzgerald, Celine Gallagher, Gijo Thomas, Melissa E. Middeldorp, Prashanthan Sanders
    Journal of Stroke and Cerebrovascular Diseases.2021; 30(10): 106012.     CrossRef
  • Analysis of Factors Affecting the Intention to Quit Smoking in Stroke Patients
    Junghee Youn, Mee Kyung Shin
    The Korean Journal of Rehabilitation Nursing.2021; 24(1): 78.     CrossRef
  • Public Health Intervention for Smoking Cessation
    Soo Young Kim
    Korean Journal of Family Medicine.2021; 42(5): 343.     CrossRef
  • Intervenção para cessação do tabagismo em pacientes internados por AVC
    Daniella Porfírio Nunes, Marcos Christiano Lange, Luiza Moschetta Zimmermann, Élcio Juliato Piovesan, Isabel Cristina Scarinci
    Revista Psicologia e Saúde.2021; : 33.     CrossRef
  • Assessing motivation to smoking cessation in hospitalized patients
    Juana María Sepúlveda-Sánchez, José Carlos Canca-Sánchez, Francisco Rivas-Ruiz, Mónica Martín-García, Celia Lorente Márquez, Eva María Timonet-Andreu
    Enfermería Clínica (English Edition).2018; 28(1): 13.     CrossRef
  • Evaluación de la motivación para la cesación tabáquica en pacientes hospitalizados
    Juana María Sepúlveda-Sánchez, José Carlos Canca-Sánchez, Francisco Rivas-Ruiz, Mónica Martín-García, Celia Lorente Márquez, Eva María Timonet-Andreu
    Enfermería Clínica.2018; 28(1): 13.     CrossRef
  • Determinants of smoking cessation and abstinence in a Russian smoking-cessation center
    Vladimir Levshin, Nina Slepchenko
    Tobacco Prevention & Cessation.2017;[Epub]     CrossRef
  • 4,572 View
  • 46 Download
  • 6 Web of Science
  • 8 Crossref
Coffee Consumption and Stroke Risk: A Meta-analysis of Epidemiologic Studies
Byungsung Kim, Yunjung Nam, Junga Kim, Hyunrim Choi, Changwon Won
Korean J Fam Med 2012;33(6):356-365.   Published online November 27, 2012
DOI: https://doi.org/10.4082/kjfm.2012.33.6.356
Background

Coffee is one of the most widely consumed beverages in the world, and contains caffeine and phenolic compounds. Many studies on the association between coffee consumption and risk of stroke have been reported, however, more research is needed to further explore many studies' inconsistent results. Therefore, we conducted a meta-analysis to verify the relationship between coffee consumption and stroke.

Methods

We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library, using the keywords "coffee" or "caffeine" for the exposure factors, and "transient ischemic attack" or "stroke" or "acute cerebral infarction" or "cardiovascular events" for the outcome factors. We included prospective cohort and case-control studies published between 2001 and July 2011 in this review. The search was limited to English language.

Results

Among 27 articles identified for this review, only 9 studies met the inclusion criteria, all of which were cohort studies. When using all cohort studies, the pooled relative risk (RR) of stroke for the highest vs. lowest category of coffee consumption was 0.83 (95% confidence interval [CI], 0.76 to 0.91). When subgroup analysis was performed, for Europeans, increased coffee drinking showed a preventive effect on stroke occurrence with RR 0.82 (95% CI, 0.74 to 0.92); RR for women 0.81 (95% CI, 0.70 to 0.93); for ischemic stroke 0.80 (95% CI, 0.71 to 0.90); and for those drinking 4 cups or more per day 0.83 (95% CI, 0.75 to 0.91).

Conclusion

We found that coffee consumption of 4 cups or more per day showed a preventive effect on stroke in this meta-analysis.

Citations

Citations to this article as recorded by  
  • Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an in vitro study
    Haizhen Jia, Huajun Fan, Jiarui Liang, Runqing He
    Neurological Research.2025; 47(4): 242.     CrossRef
  • An umbrella review of meta-analysis to understand the effect of coffee consumption and the relationship between stroke, cardiovascular heart disease, and dementia among its global users
    Harmeet Gill, Neel Patel, Nishthaben Naik, Lovekumar Vala, Rishabh K. Rana, Sakshi Jain, Vaishnavi Sirekulam, Shika M. Jain, Tanzina Khan, Sudharani Kinthada, Rashi B. Patel, Athmananda Nanjundappa, Chandu Siripuram, Urvish Patel
    Journal of Family Medicine and Primary Care.2024; 13(11): 4783.     CrossRef
  • Caffeine and Its Neuroprotective Role in Ischemic Events: A Mechanism Dependent on Adenosine Receptors
    D. Pereira-Figueiredo, A. A. Nascimento, M. C. Cunha-Rodrigues, R. Brito, K. C. Calaza
    Cellular and Molecular Neurobiology.2022; 42(6): 1693.     CrossRef
  • Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
    Na Guo, Ying Zhu, Dandan Tian, Yating Zhao, Chenguang Zhang, Changqing Mu, Chen Han, Ruixia Zhu, Xu Liu
    BMC Medicine.2022;[Epub]     CrossRef
  • The Cardiovascular Benefits of Caffeinated Beverages: Real or Surreal? “Metron Ariston - All in Moderation”
    Antonis A. Manolis, Theodora A. Manolis, Evdoxia J. Apostolopoulos, Helen Melita, Antonis S. Manolis
    Current Medicinal Chemistry.2022; 29(13): 2235.     CrossRef
  • Effect of Roasting Degree on Major Coffee Compounds: A Comparative Study between Coffee Beans with and without Supercritical CO2 Decaffeination Treatment
    Masaki Honda, Daishi Takezaki, Masahiro Tanaka, Masashi Fukaya, Motonobu Goto
    Journal of Oleo Science.2022; 71(10): 1541.     CrossRef
  • Components of a healthy diet and different types of physical activity and risk of atherothrombotic ischemic stroke: A prospective cohort study
    Anna Johansson, Stefan Acosta, Pascal M. Mutie, Emily Sonestedt, Gunnar Engström, Isabel Drake
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Coffee Consumption and Stroke Risk: Evidence from a Systematic Review and Meta-Analysis of more than 2.4 Million Men and Women
    Chuan Shao, Hui Tang, Xiaoya Wang, Jiaquan He
    Journal of Stroke and Cerebrovascular Diseases.2021; 30(1): 105452.     CrossRef
  • Polyphenols and Human Health: The Role of Bioavailability
    Chiara Di Lorenzo, Francesca Colombo, Simone Biella, Creina Stockley, Patrizia Restani
    Nutrients.2021; 13(1): 273.     CrossRef
  • Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study
    Yu Qian, Ding Ye, Huijun Huang, David J. H. Wu, Yaxuan Zhuang, Xia Jiang, Yingying Mao
    Annals of Neurology.2020; 87(4): 525.     CrossRef
  • Intake of Caffeine and Its Association with Physical and Mental Health Status among University Students in Bahrain
    Haitham Jahrami, Mana Al-Mutarid, Peter E. Penson, Mo’ez Al-Islam Faris, Zahra Saif, Layla Hammad
    Foods.2020; 9(4): 473.     CrossRef
  • PREVALENCE AND SIDE EFFECTS OF CAFFEINE CONSUMPTION AMONGST MEDICAL STUDENTS.
    Kabir Bansal, Anika Chhabra
    GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2020; : 1.     CrossRef
  • The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation
    Astrid Nehlig, Rodrigo Cunha
    Nutrients.2020; 12(10): 3141.     CrossRef
  • Neuroprotective Effects of Coffee Bioactive Compounds: A Review
    Katarzyna Socała, Aleksandra Szopa, Anna Serefko, Ewa Poleszak, Piotr Wlaź
    International Journal of Molecular Sciences.2020; 22(1): 107.     CrossRef
  • Consumers’ Perceptions of Coffee Health Benefits and Motives for Coffee Consumption and Purchasing
    Antonella Samoggia, Bettina Riedel
    Nutrients.2019; 11(3): 653.     CrossRef
  • Caffeine Consumption through Coffee: Content in the Beverage, Metabolism, Health Benefits and Risks
    Juliana dePaula, Adriana Farah
    Beverages.2019; 5(2): 37.     CrossRef
  • Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
    Charlotte E. Mills, Andreas Flury, Cynthia Marmet, Laura Poquet, Stefano F. Rimoldi, Claudio Sartori, Emrush Rexhaj, Roman Brenner, Yves Allemann, Diane Zimmermann, Glenn R. Gibson, Don S. Mottram, Maria-Jose Oruna-Concha, Lucas Actis-Goretta, Jeremy P.E.
    Clinical Nutrition.2017; 36(6): 1520.     CrossRef
  • Relationship between coffee consumption and stroke risk in Korean population: the Health Examinees (HEXA) Study
    Jeeyoo Lee, Ji-Eun Lee, Yuri Kim
    Nutrition Journal.2017;[Epub]     CrossRef
  • Coffee, Caffeine, and Health Outcomes: An Umbrella Review
    Giuseppe Grosso, Justyna Godos, Fabio Galvano, Edward L. Giovannucci
    Annual Review of Nutrition.2017; 37(1): 131.     CrossRef
  • Caffeine may enhance orthodontic tooth movement through increasing osteoclastogenesis induced by periodontal ligament cells under compression
    Jianru Yi, Boxi Yan, Meile Li, Yu Wang, Wei Zheng, Yu Li, Zhihe Zhao
    Archives of Oral Biology.2016; 64: 51.     CrossRef
  • Diterpenes: Advances in Neurobiological Drug Research
    Md. Torequl Islam, Claucenira Bandeira da Silva, Marcus Vinícius Oliveira Barros de Alencar, Márcia Fernanda Correia Jardim Paz, Fernanda Regina de Castro Almeida, Ana Amélia de Carvalho Melo-Cavalcante
    Phytotherapy Research.2016; 30(6): 915.     CrossRef
  • Scientific Opinion on the safety of caffeine

    EFSA Journal.2015;[Epub]     CrossRef
  • Gene-Coffee Interactions and Health
    Marilyn C. Cornelis
    Current Nutrition Reports.2014; 3(3): 178.     CrossRef
  • The impact of coffee on health
    A. Cano-Marquina, J.J. Tarín, A. Cano
    Maturitas.2013; 75(1): 7.     CrossRef
  • Coffee and tea
    Salman K. Bhatti, James H. O’Keefe, Carl J. Lavie
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 688.     CrossRef
  • 6,589 View
  • 58 Download
  • 25 Crossref
Reasons of delay of hospital presentation in patients with acute stroke.
So Yeon Kim, Tai Hyeong Ryeom, Young Eun Choi, Hang Suk Cho, Jae Yong Shim, Hye Ree Lee
J Korean Acad Fam Med 2001;22(10):1511-1519.   Published online October 1, 2001
Background
: Recent advances have been made in the treatment of acute stroke, but the effectiveness of the new therapies is highly time dependent. Patients with acute stroke often arrive at the hospital too late to receive the maximum benefit from these new stroke therapies. Efforts to reduce delay time of therapy for acute stroke may be more effective if the factors that delay hospital arrival are identified and targeted for specific intervention. So we studied about reason of delay of hospital presentation in patients with acute stroke.

Methods : The 85 acute stroke patients group who admitted to the Young-dong severance hospital from April to August 1999 were enrolled in this study. We collected clinical data from the medical record, including demographic characteristics, date and time of symptom onset, date and time of presentation to the hospital, medical history, and symptoms at stroke onset. And informants about stroke, method of transportation, the patient's interpretation of the symptoms were interviewed. We defined early arrival as within 3 hours of awareness of symptoms.

Results : The 85 patients were interviewed, early arrival were more likely to arrive by ambulance (P<0.001), admit via emergency department(p=0.001), interpret their symptoms as a stroke(P=0.005) and use readings as a informants about stroke(P=0.027) than late arrivals. Also they were younger than late arrivals(P=0.027). Main reason of delay of hospital presentation was because they expect spontaneous improvement(43%), mistake as other disease(23.3%), arrive via other medical institute(20%).

Conclusion : Late arrivals expected spontaneous improvement, misinterpreted their symptoms as those of other disease and didn't choose proper medical institute for acute management. Considerable education is needed to increase the knowledge about stroke and proper acute management.
  • 1,238 View
  • 13 Download
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