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"Thalassemia"

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"Thalassemia"

Original Articles
Malnutrition, Its Attributes, and Impact on Quality of Life: An Epidemiological Study among β-Thalassemia Major Children
Bijit Biswas, Narendra Nath Naskar, Keya Basu, Aparajita Dasgupta, Rivu Basu, Bobby Paul
Korean J Fam Med 2021;42(1):66-72.   Published online January 20, 2020
DOI: https://doi.org/10.4082/kjfm.19.0066
Background
India is home to a large number of thalassemic children. Despite malnutrition being an essential determinant of their therapeutic goals and quality of life (QoL), it was hardly ever explored. With this background, this study aimed to estimate the proportion of β-thalassemia major (β-TM) children experiencing malnutrition, its attributes, and impact on their QoL.
Methods
This cross-sectional, hospital-based, analytical observational study was conducted among 328 β-TM children attending the thalassemia day care unit of a medical college from May 2016 to April 2017, with a structured schedule. Data were analyzed following appropriate statistical methods using SPSS statistical package ver. 16.0 (SPSS Inc., Chicago, IL, USA).
Results
Among the study participants, 48.2% were malnourished with a mean body mass index of 13.9 kg/m2 . In the multivariable logistic regression model, participants’ age (adjusted odds ratio [AOR], 1.15; 95% confidence interval [CI], 1.02–1.29), caste (AOR, 2.11; 95% CI, 1.23–3.60), mothers’ educational level (AOR, 2.05; 95% CI, 1.22– 3.44), blood transfusion frequency (AOR, 1.25; 95% CI, 1.16–1.31), and palpable spleen size (AOR, 1.22; 95% CI, 1.08–1.37) were significant predictors of malnutrition after adjusting for pre-transfusion hemoglobin level and hemolytic facies status. In multiple linear regression analysis, malnutrition negatively impacted total QoL (unstandardized beta [standard error], -4.4 [1.7]; P=0.009) and various domains of the study participants except the social and school domains adjusted for age, sex, caste, place of residence, parents’ educational level, and socioeconomic status.
Conclusion
Almost half of the study participants had malnutrition. Malnutrition had a negative impact on their QoL.

Citations

Citations to this article as recorded by  
  • Health-related quality of life and associated factors in Chinese pediatric patients with β-thalassemia major receiving transfusion and iron chelation therapy: a cross-sectional study
    Haiyan Liang, Yang Yang, Lin Pan, Yanni Xie, Yongrong Lai
    Expert Review of Hematology.2026; : 1.     CrossRef
  • Dietary Patterns Among Patients With Beta‐Thalassemia Major in Vietnam
    Thi Ngoc Anh Hoang, Ha‐Linh Quach
    Journal of Human Nutrition and Dietetics.2025;[Epub]     CrossRef
  • Health‐related quality of life with standard and curative therapies in thalassemia: A narrative literature review
    Richa Shah, Sherif M. Badawy
    Annals of the New York Academy of Sciences.2024; 1532(1): 50.     CrossRef
  • Comparison of Yearly Cost Related to Complications Between Deferasirox and Deferiprone Monotherapy in Thalassemia
    Teny Tjitra Sari, Pustika Amalia Wahidiyat, Ludi Dhyani Rahmartani, Stephen Diah Iskandar, Isyanaditta Agung Putri
    Journal of Pediatric Hematology/Oncology.2024; 46(6): e402.     CrossRef
  • Quality of life and thalassemia in India: A scoping review
    Saravanan Chinnaiyan, Jenifer Sylvia, Sowmiya Kothandaraman, Bharathi Palanisamy
    Journal of Family Medicine and Primary Care.2024; 13(4): 1183.     CrossRef
  • Association of age to nutritional status and muscle mass in children with transfusion-dependent β-thalassemia: a cross-sectional study
    Li Wang, Luyang Zhang, Yanlan Yang, Yuan Luo, Lei Wang, Sandip Patil
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Premature Atherosclerosis in Children With Transfusion-Dependent Thalassemia
    Rajesh Kulkarni, B. Rameshbabu
    Indian Pediatrics.2023; 60(3): 239.     CrossRef
  • Detection of endocrine disorders in young children with multi-transfused thalassemia major
    Ramadan A. Mahmoud, Ashraf Khodeary, Marwa S. Farhan
    Italian Journal of Pediatrics.2021;[Epub]     CrossRef
  • 8,254 View
  • 186 Download
  • 10 Web of Science
  • 8 Crossref
Depression, Anxiety, and Perceived Social Support among Adults with Beta-Thalassemia Major: Cross-Sectional Study
Aghbabak Maheri, Roya Sadeghi, Davoud Shojaeizadeh, Azar Tol, Mehdi Yaseri, Alireza Rohban
Korean J Fam Med 2018;39(2):101-107.   Published online March 22, 2018
DOI: https://doi.org/10.4082/kjfm.2018.39.2.101
Background

Considering the high prevalence of depression and anxiety among thalassemia patients and the role of social support in preventing mental disorders, this study aimed to determine prevalence of depression, anxiety, and perceived social support (PSS) among adults with beta-thalassemia major.

Methods

This cross-sectional study was performed with 389 adults with beta-thalassemia major. Data were collected via a questionnaire consisting of three parts: demographic and medical information, the Persian version of the hospital anxiety and depression scale, and the Persian version of the Multidimensional Scale of Perceived Social Support. Data were analyzed using IBM SPSS ver. 23.0 (IBM Corp., Armonk, NY, USA) through analytical statistics (independent-samples t-test, one-way analysis of variance, Pearson correlation coefficient, and multilevel linear regression), and the results less than 0.05 were considered to be significant.

Results

The mean scores of depression, anxiety, and PSS of patients were 7.42±3.17, 7.47±4.35, and 41.8±8.64, respectively. Of 389 patients, 19.8% had depression and 23.7% had an anxiety disorder. Relationships of depression and anxiety with age, the level of education, job, and family income were statistically significant, as were those of PSS with age, thalassemia center, family income, job, and the level of education. PSS from family, friends, and significant others were the significant predictive factors of depression and anxiety among adult patients with beta-thalassemia major.

Conclusion

Considering the PSS as a factor influencing the reduction in depression and anxiety in thalassemia patients, social support from the social networks (spouse, family members, friends, and healthcare workers) should be integrated with interventions that are designed to improve the mental and physical health of thalassemia patients.

Citations

Citations to this article as recorded by  
  • Investigating the Relationship between Perceived Social Support, Sleep Quality, and Corona Anxiety in Medical Staff
    Roya Dokoohaki, Sajjad Ranjbar Kouchaksaraei, Mohsen Atefat Doost, Shahrzad Yektatalab, Fatemeh Vizeshfar
    Social Medicine.2026; 19(2): 249.     CrossRef
  • The effect of mobile application based genetic counseling on the psychosocial well-being of thalassemia patients and caregivers: A randomized controlled trial
    Henri Setiawan, Wenkui Xu, Chunfeng Wang, Chengyang Li, Heri Ariyanto, Fidya Anisa Firdaus, Acep Hidayatul Mustopa, Nur Hidayat, Rong Hu
    Patient Education and Counseling.2025; 130: 108457.     CrossRef
  • Assessment of health-related quality of life in transfusion dependent beta thalassemia
    Sokiyna Ababneh, Ali A. Abu Siyam, Majdi M. Alzoubi, Nour A. Al-Sawalha, Farah F. Al Sukhni, Tahani Al Rahbeni, Khalid Al-Mugheed, Sally Mohammed Farghaly Abdelaliem
    Scientific Reports.2025;[Epub]     CrossRef
  • Temporal Changes in Quality of Life and Psychological Burden of Patients with Thalassemia: A Comparative Data Analysis from 2018 to 2025
    Nikos Rikos, Marilena Tzagkaraki, Antigoni Linardaki, Maria Moloudaki, Manolis Linardakis
    Thalassemia Reports.2025; 15(4): 11.     CrossRef
  • Quality of life, mood disorders, and cognitive impairment in adults with β-thalassemia
    Maya Bizri, Rawan Koleilat, Nathalie Akiki, Reem Dergham, Alexandra Monica Mihailescu, Rayan Bou-Fakhredin, Khaled M. Musallam, Ali T. Taher
    Blood Reviews.2024; 65: 101181.     CrossRef
  • Gender Disparities in Psychological Disturbances and Quality of Life Among Adolescent and Adult Patients with Thalassemia: A Review
    Pandji Fianza, Anita Rahmawati, Indra Wijaya, Amaylia Oehadian, Dimmy Prasetya, Putri Vidyaniati, Gusti Harti, Trinugroho Fadjari, Ramdan Panigoro
    Journal of Multidisciplinary Healthcare.2024; Volume 17: 1663.     CrossRef
  • Assessing Psychological Disorders in Turkish Adolescents with Transfusion-Dependent Thalassemia
    Aylin Yetim Şahin, Ibrahim Kandemir, Hüseyin Dağ, Emine Türkkan, Melike Tuğrul Aksakal, Memduh Sahin, Firdevs Baş, Zeynep Karakaş
    Children.2024; 11(7): 837.     CrossRef
  • Exploring the perceptions and experiences of female’s with ß-thalassemia major in a Tertiary Care Private Hospital in Pakistan
    Rawshan Jabeen, Iqra Ansari, Butool Durrani, Mubarak Jabeen Salman, Laraib Mazhar, Muhammad Usman Hussain Ansari, Ali Hussain Ansari, Saba Kabani, Saqib Husain Ansari
    Transfusion Clinique et Biologique.2024; 31(4): 244.     CrossRef
  • Systematic literature review of the indirect costs and humanistic burden of β-thalassemia
    Yesim Aydinok, Sneha Purushotham, Aylin Yucel, Mrudula Glassberg, Sohan Deshpande, Barbara Potrata, Myrto Trapali, Farrukh Shah
    Therapeutic Advances in Hematology.2024;[Epub]     CrossRef
  • RETRACTED: A systematic review of social support and related factors among burns patients
    Ramyar Farzan, Pooyan Ghorbani Vajargah, Amirabbas Mollaei, Samad Karkhah, Pirouz Samidoust, Poorya Takasi, Atefeh Falakdami, Mahbobeh Firooz, Seyed Javad Hosseini, Arman Parvizi, Soudabeh Haddadi
    International Wound Journal.2023; 20(8): 3349.     CrossRef
  • PSYCHOSOCIAL ILLNESS IN CHILDREN WITH THALASSEMIA: A CASE-CONTROL STUDY
    Erum Afzal, Muhammad Aslam Sheikh, Sajjad Hussain Bhaba, Tanveer Ahmed, Imran Iqbal, Muhammad Khalid Iqbal
    Journal of Rawalpindi Medical College.2023;[Epub]     CrossRef
  • Depression symptoms and associated factors among thalassemia patients in the Palestinian Territories: a cross-sectional study
    Adnan Lutfi Sarhan, Shahenaz Modallal, Fayez Azez Mahamid, Denise Ziya Berte
    Middle East Current Psychiatry.2022;[Epub]     CrossRef
  • The association between sleep quality and psychological distress among older Chinese adults: a moderated mediation model
    Chichen Zhang, Shujuan Xiao, Huang Lin, Lei Shi, Xiao Zheng, Yaqing Xue, Fang Dong, Jiachi Zhang, Benli Xue
    BMC Geriatrics.2022;[Epub]     CrossRef
  • Promoting Adherence to Iron Chelation Treatment in Beta-Thalassemia Patients
    Chinea Eziefula, Farrukh T Shah, Kofi A Anie
    Patient Preference and Adherence.2022; Volume 16: 1423.     CrossRef
  • The survey on the relationship between frustration and social relationships among patients with Thalassemia major in Tehran, Iran
    Shiva Nazari, Fatemeh Malek, Atefe Marzo, Atefe Bidokhti
    International Journal of Africa Nursing Sciences.2022; 17: 100441.     CrossRef
  • Concomitant Pre- and Post-splenectomy Physiotherapy Rehabilitation in a 17-Year-Old Patient With Beta Thalassemia Major: A Case Report
    Chitrakshi A Choubisa, Moli Jain, Vishnu Vardhan, Yukta J Budhwani, Akanksha R Hege
    Cureus.2022;[Epub]     CrossRef
  • Common Mental Disorders and its Associated Factors among Thalassemic Patients
    Mubashir Zafar
    Annals of Indian Psychiatry.2022; 6(4): 328.     CrossRef
  • Health status, anxiety, depression, and quality of life of patients with thalassemia
    Nikos Rikos, Georgia-Konstantina Giannadaki, Andromachi Spontidaki, Marilena Tzagkaraki, Manolis Linardakis
    Journal of Public Health.2021; 29(6): 1313.     CrossRef
  • Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.
    Hussein Kadhem Al-Hakeim, Asawer Hassan Najm, Shatha Rouf Moustafa, Michael Maes
    Journal of Affective Disorders.2021; 282: 644.     CrossRef
  • Concerns of Thalassemia Patients, Carriers, and their Caregivers in Malaysia: Text Mining Information Shared on Social Media
    Yuen Chi Phang, Azleena Mohd Kassim, Ernest Mangantig
    Healthcare Informatics Research.2021; 27(3): 200.     CrossRef
  • Quality of Life and Related Factors in β-Thalassemia Patients
    Koorosh Etemad, Parisa Mohseni, Mohammad Aghighi, Ayad Bahadorimonfared, Razieh Hantooshzadeh, Niloufar Taherpour, Negar Piri, Sahar Sotoodeh Ghorbani, Fatemeh Malek, Fatemeh Kheiry, Azimeh Khodami, Tannaz Valadbeigi, Mahmoud Hajipour
    Hemoglobin.2021; 45(4): 245.     CrossRef
  • The Effect of Peer Education on the Anxiety of Patients with Thalassemia Major: A Quasi-experimental Study
    MS Sargolzaei, A Khachian, M Seyedoshohadaee, H Haghani
    Iran Journal of Nursing.2021; 34(129): 39.     CrossRef
  • Beta Thalassemia Minor: Patients Are Not Tired but Depressed and Anxious
    Rafet Eren, Abdülkadir Karışmaz, Ceyda Aslan, Mehmet Hilmi Doğu, Şermin Altındal, Osman Yokuş, Elif Suyanı
    Medical Principles and Practice.2021; 30(1): 69.     CrossRef
  • Development of Android-based Mobile Application “Cyber Gen” for Genetic Counselling Implementation among Thalassemia Patients
    Henri Setiawan, Doni Setiawan, Suhanda, Acep Hidayatul Mustopa
    Journal of Physics: Conference Series.2021; 2111(1): 012037.     CrossRef
  • The effect of sociodemographic factors on anxiety, depression, and perceived social support in patients with internal medicine and surgical problems
    Arzu Yüksel, Emel Bahadir‐Yilmaz
    Perspectives in Psychiatric Care.2020; 56(4): 837.     CrossRef
  • The role of social support and emotional exhaustion in the association between work-family conflict and anxiety symptoms among female medical staff: a moderated mediation model
    Hui Zhang, Leiwen Tang, ZhiHong Ye, Ping Zou, Jing Shao, Man Wu, Qi Zhang, Guojin Qiao, Shaoyu Mu
    BMC Psychiatry.2020;[Epub]     CrossRef
  • Depression, Anxiety, and Stress Symptoms in Patients With Beta Thalassemia Major in Almadinah Almunawwarah, Saudi Arabia
    Mohammed A Zolaly, Farah M Zolaly, Lama Al Belowi , Raafat Shuqdar, Mohammed A Al Belowi, Turki A Alwasaidi, Muayad Albadrani
    Cureus.2020;[Epub]     CrossRef
  • The burden of psychiatric illnesses in adult patients with beta-thalassemia: a 5-year nationwide inpatient evaluation in the United States
    Krupa Patel, Siddhi Bhivandkar, Rupak Desai, Todd Antin
    Annals of Hematology.2019; 98(4): 851.     CrossRef
  • Brain functional impairment in beta‐thalassaemia: the cognitive profile in Italian neurologically asymptomatic adult patients in comparison to the reported literature
    Immacolata Tartaglione, Renzo Manara, Martina Caiazza, Pasquale Alessandro Carafa, Violetta Caserta, Teresa Ferrantino, Ilaria Granato, Noemi Ippolito, Caterina Maietta, Tiziana Oliveto, Maddalena Casale, Rosanna Di Concilio, Angela Ciancio, Elisa De Mich
    British Journal of Haematology.2019; 186(4): 592.     CrossRef
  • The Effects of Cognitive Behavioral Therapy on Depression and Anxiety among Patients with Thalassemia: a Randomized Controlled Trial
    Fateme Mohamadian, Maryam Bagheri, Maryam Sadat Hashemi, Hossein Komeili Sani
    Journal of Caring Sciences.2018; 7(4): 219.     CrossRef
  • 9,825 View
  • 122 Download
  • 30 Web of Science
  • 30 Crossref
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