Korean Journal of Family Medicine

Concurrence of Helicobacter pylori Infection and Its Associated Factors in Korean Couples: Jiwoong Choi, Jihun Kang; Korean J Fam Med 2022;43(1):77-82. Published online November 5, 2021; DOI: https://doi.org/10.4082/kjfm.21.0115

Abstract
PDF

Background
This study evaluated the prevalence of Helicobacter pylori infection and the risk factors associated with H. pylori transmission among spouses.
Methods
We assessed the spousal concurrence of H. pylori infection using the Campylobacter-like organism (CLO) test under gastro-endoscopy in 132 couples. Based on the CLO test results, participants were categorized into H. pylori concurrent and independent groups. The chi-square test and Student t-test were performed for demographic comparisons between the concurrent and independent H. pylori groups. In addition, multivariate logistic regression analysis was performed to identify factors associated with concurrent H. pylori infection.
Results
The study revealed that the concurrence rate of H. pylori infection was 42.4% in married Korean couples. The odds ratio (OR) derived from the concurrence of H. pylori infection tended to decrease in older couples (OR, 0.975; 95% confidence interval [CI], 0.949–1.002; P=0.072). Gastric erosion was also associated with a decreased OR for concurrent infection (OR, 0.488; 95% CI, 0.295–0.808; P=0.005). Conversely, active duodenal ulcers were associated with an increased OR for concurrent infections (OR, 6.501; 95% CI, 1.267–33.346; P=0.025). Duodenal ulcer scars tended to increase the OR of concurrent infections (OR, 1.392; 95% CI, 0.815–2.380; P=0.226).
Conclusion
Spousal transmission and concurrence of H. pylori infection were negatively associated with gastric erosion; however, they were positively associated with active duodenal ulcers. Further studies are warranted to elucidate the mechanisms underlying these findings.

Citations

Citations to this article as recorded by

Examining of Predictive Factors for Developing Gastroduodenal Ulcer among Patients Attending Gastrointestinal Teaching Hospitals in Baghdad
Ali Hussein Alek Al-Ganmi, Haider Mohammed Majeed, Ahmed Fleih Hassan
Journal of Nature and Science of Medicine.2025; 8(2): 146. CrossRef
Hookah Smoking and Risk of Helicobacter pylori Infection: Insights From a Case‐Control Study in Iran
Hadi Eshaghi Sani Kakhaki, Nahid Shahabi, Nooshin Ebrahimi, Ehsan Ramezanian Nik, Farshid Soleimani, Shokrollah Mohseni, Moslem Gholamnezhad, Hanieh Sedeghi, Sara Dadipoor
Health Science Reports.2025;[Epub] CrossRef

7,268 View
131 Download
1 Web of Science
2 Crossref

Lucio Phenomenon: Sequelae of Neglected Leprosy: Siti Nuryati Che Ya, Rosediani Muhamad, Rosnani Zakaria, Azlina Ishak, Wan Noor Hasbee Wan Abdullah; Korean J Fam Med 2021;42(3):245-249. Published online January 23, 2020; DOI: https://doi.org/10.4082/kjfm.19.0068

Abstract
PDF

Lucio phenomenon is a potentially fatal leprosy reaction seen in pure, primitive, and diffuse form of lepromatous leprosy. It is a globally restricted phenomenon that occurs in Mexico and Costa Rica; however, sporadic cases have been reported elsewhere. We report a rare case of a 50-year-old Indonesian, who resided in Malaysia for the past 33 years, which presented with extensive ulcers on all four limbs for 3 weeks, as well as a 16-year history of skin changes and alopecia. Full evaluation established the diagnosis of lepromatous leprosy with Lucio phenomenon. Delay in diagnosis leads to significant disabilities and disease transmission within the community. Therefore, primary care practitioners, even in non-endemic countries, should be wary of this atypical feature of leprosy to prevent complications since it is a highly curable disease.

Citations

Citations to this article as recorded by

Lucio’s Phenomenon in Hansen’s Disease: A Case Report of a Condition Not to Be Forgotten
Kelly A Arenas Sanchez, Pedro G Caicedo Vásquez, Lina M Sandoval Calle, José F Huertas, Jaime M Vinueza
Cureus.2025;[Epub] CrossRef
Rare Variant of Leprosy Reaction (Lucio Phenomenon): A Case Series
Luh Made Mas Rusyati, Herman Saputra, Made Sanitca Indah, Ni Kadek Setyawati
The International Journal of Mycobacteriology.2024; 13(1): 105. CrossRef
Leprosy reactions: Unraveling immunological mechanisms underlying tissue damage in leprosy patients
Héctor Serrano-Coll, Eric L Wan, Lina Restrepo-Rivera, Nora Cardona-Castro
Pathogens and Disease.2024;[Epub] CrossRef
The economic burden of leprosy treatment to households in Ghana: A cross-sectional study in the Volta Region of Ghana
Maxwell Ayindenaba Dalaba, Alfred Kwesi Manyeh, Mustapha Immurana, Martin Amogre Ayanore, Isaiah Agorinya, James Akazili, Patricia Akweongo, Benedict Okoe Quao
SAGE Open Medicine.2024;[Epub] CrossRef
Lucio phenomenon: A case report
Priyanka Dilipbhai Bodar, Jalpa Kailashbhai Patel, Devna Subramonia Pillai, Rita Vipul Vora
Indian Journal of Dermatology, Venereology and Leprology.2023; 91: 91. CrossRef
Lucio Phenomenon and APLA in Hansen's Disease: A Rare Phenomenon
Jayanta Sharma, Sudipto Chakroborty, Kisholoy Karan, Parthajit Das
Bengal Physician Journal.2022; 9(2): 44. CrossRef
Dermatopatología de la oclusión intraluminal vascular: parte I (trombos)
M.J. Beato Merino, A. Diago, Á. Fernández-Flores, J. Fraga, A. García Herrera, M. Garrido, M.Á. Idoate Gastearena, M. Llamas-Velasco, C. Monteagudo, J. Onrubia, Y.C. Pérez-González, N. Pérez Muñoz, J.J. Ríos-Martín, E. Ríos-Viñuela, J.L. Rodríguez Peralto
Actas Dermo-Sifiliográficas.2021; 112(1): 1. CrossRef
Clinical and Histopathologic Characteristics of the Main Causes of Vascular Occusion — Part I: Thrombi
M.J. Beato Merino, A. Diago, A. Fernandez-Flores, J. Fraga, A. García Herrera, M. Garrido, M.A. Idoate Gastearena, M. Llamas-Velasco, C. Monteagudo, J. Onrubia, Y.C. Pérez-González, N. Pérez Muñoz, J.J. Ríos-Martín, E. Ríos-Viñuela, J.L. Rodríguez Peralto
Actas Dermo-Sifiliográficas (English Edition).2021; 112(1): 1. CrossRef
Lucio’s phenomenon in untreated advanced leprosy
Nurwahyuna Rosli
Human Pathology: Case Reports.2020; 21: 200413. CrossRef

8,500 View
250 Download
6 Web of Science
9 Crossref

A Diabetic Elderly Man with Finger Ulcer: Noraini Mohamad, Salziyan Badrin, Wan Noor Hasbee Wan Abdullah; Korean J Fam Med 2018;39(2):126-129. Published online March 22, 2018; DOI: https://doi.org/10.4082/kjfm.2018.39.2.126

Abstract
PDF

Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. He experienced a cat bite over his left middle finger 1 month prior to the appearance of the lesion. A skin biopsy revealed the presence of Sporothrix schenckii. Oral itraconazole 200 mg twice daily was started empirically and the patient showed marked improvement in the skin lesion after 2 months of therapy.

Citations

Citations to this article as recorded by

Sporotrichosis: an overview of the neglected disease reported worldwide in the last five years
João Victor Moura Rosa, Juarez Antônio Simões Quaresma
Revista da Sociedade Brasileira de Medicina Tropical.2025;[Epub] CrossRef
Disseminated Cutaneous, Osteoarticular, and Tubulointerstitial Sporotrichosis in an Immunosenescent and Diabetic Host: A Case Report
Juan Esteban Velez-Hernandez, Natalia Giraldo, Erika Andrea Sánchez-Cifuentes, María del Pilar Jiménez-Alzate, Fernando Lopez-Urbano, Sergio A. Cuevas Covarrubias
Case Reports in Dermatological Medicine.2025;[Epub] CrossRef
Cutaneous disseminated sporotrichosis associated with diabetes: A case report and literature review
Xiujiao Xia, Huilin Zhi, Zehu Liu, Joshua Nosanchuk
PLOS Neglected Tropical Diseases.2023; 17(9): e0011647. CrossRef
Nonhealing ulcer on the fingertip
Vishal Gupta, Ananya Sharma, Neena Khanna, Swati Mahajan, Asit Ranjan Mridha
Indian Journal of Dermatology, Venereology and Leprology.2021; 88: 207. CrossRef
Facial Cutaneous Sporotrichosis in a Boy
Leonardo Lora Barraza, Jéssica Bissoli Tolomelli, Caroline Graça Cunha, Fred Bernardes Filho, Loan Towersey, Roderick Hay, Regina Casz Schechtman, José Augusto da Costa Nery
The Journal of Emergency Medicine.2019; 56(2): 222. CrossRef
Sporotrichosis In Immunocompromised Hosts
Flavio Queiroz-Telles, Renata Buccheri, Gil Benard
Journal of Fungi.2019; 5(1): 8. CrossRef

6,179 View
55 Download
4 Web of Science
6 Crossref

The Association between Esophagogastroduodenoscopic Findings and the Related Risk Factors of Obesity.: Yoojin Jang, Keunmi Lee, Seungpil Jung; Korean J Fam Med 2010;31(1):44-50. Published online January 20, 2010; DOI: https://doi.org/10.4082/kjfm.2010.31.1.44

Abstract
PDF

Background
The reports that obesity could be associated with upper gastrointestinal disorders such as gastritis, gastric ulcer, duodenal ulcer, reflux esophagitis have not been consistent. Therefore, we studied the association between esophagogastroduodenoscopic (EGD) fi ndings and the related risk factors of obesity. Methods: The study subjects include 2,210 adults who visited the Health Promotion Center of one university hospital from January 2006 to December 2006. All subjects had standard physical measurements as well as resting blood pressure, fasting blood glucose, HbA1c, serum lipids, and gastroendoscopic examination. BMI was classifi ed into two groups (BMI ≥ 23 kg/m2, normal; BMI < 23 kg/m2, overweight or obese). The study subjects were classifi ed into four groups according to the EGD fi ndings; normal, gastritis, gastric or duodenal ulcer, refl ux esophagitis. Results: Mean BMI of gastritis, gastric or duodenal ulcer, and refl ux esophagitis groups were higher than normal group after adjusting age, sex, alcohol and smoking (P < 0.001). Gastritis risk (OR, 2.098; 95% CI, 1.195 to 3.682; P = 0.01), gastric or duodenal ulcer risk (OR, 2.562; 95% CI, 1.282 to 5.117; P = 0.008), and refl ux esophagitis risk (OR, 2.856; 95% CI, 1.522 to 5.360; P = 0.001) were signifi cantly higher in overweight and obesity group compare with normal weight group after adjusting age, sex, alcohol and smoking. Conclusion: We suggest that overweight or obesity is the risk factor of gastritis, gastric or duodenal ulcer, and reflux esophagitis.

2,568 View
21 Download

An Aspect of Upper Gastrointestinal Disease among Young Policemen.: Gwan Hyeok Ahn, Sung Mo Baek, Suk Chun Byun, Ju Yub Shin, Ah Ryung Shin; J Korean Acad Fam Med 2005;26(5):263-268. Published online May 10, 2005

Abstract
PDF

Background
: Upper gastrointestinal diseases are relatively important in Korea. There are various studies on upper gastrointestinal diseases, especially relationships with Helicobacter pylori, but studies on young adults are relatively fewer. Therefore, we conducted this study in order to know the prevalence of various upper gastrointestinal diseases and the association with Helicobacter pylori among young policemen.

Methods : Diagnosis and classification of upper gastrointestinal diseases were made in 260 policemen, who visited the outpatient department of family medicine at one general hospital in Seoul from March 2, 2001 to December 31, 2002.

Results : The frequencies of upper gastrointestinal diseases were gastritis (62.2%), duodenal ulcer (14.4%), gastric ulcer (7.5%), duodenitis (6.9%), and no active lesion (9.0%). The frequency of multiple upper gastrointestinal disease was chronic superficial gastritis and duodenal ulcer (37%), chronic superficial gastritis and duodenitis (21.9%), and acute gastritis and duodenal ulcer (16.4%), and these groups comprised the most with 75.3%. The location of the lesion was found at antrum (62.2%) and duodenum (21.6%). Ulcer stages in gastric and duodenal ulcer were mostly in active stage. Helicobacter pylori infection in gastric and duodenal ulcer were 36% and 85.4%, respectively.

Conclusion : Most symptomatic patients had lesions which were found at antrum and duodenum as in other studies. Ulcer diseases in duodenum were much more frequent than those in stomach, which probably be associated with Helicobacter pylori. Therefore, suitable examination and treatment are necessary.

1,803 View
16 Download

Asymptomatic Duodenal Ulcer Patient with Candidiasis due to Medical Treatment.: Dong Uk Lee, Nak Jin Sung, Ki Heum Park, Jung Il Seo; J Korean Acad Fam Med 2004;25(2):146-149. Published online February 10, 2004

Abstract
PDF

Candida was found in the oral cavity, jejunum, and ileum of the healthy population.
In case of alimentary tract, the factors of favorable to candida colonization include old age,
malnutrition, diabetes, burns, trauma, surgical operations, parenteral nutrition, intravascular or
bladder catheterization, H2-blocker therapy, steroid therapy, immunosuppresive treatment and
the use of wide spectrum antibiotics: however, gastrointestinal candida colonization is rarely
found in the healthy adult. No case of duodenal ulcer with candidiasis has been reported in
healthy people. Recently we experienced a case of asymptomatic duodenal ulcer with
candidiasis in a healthy male, who had taken H2-blocker and proton pump inhibitor for 3
months after primary closure of duodenal ulcer perforation. Therefore we report this case with
review of several literatures.

1,557 View
17 Download

Alexithymia and non ulcer dyspepsia.: Su Min Ko, Jae Joon Byeon, Kyeong Hyeon Lee; J Korean Acad Fam Med 2001;22(8):1204-1213. Published online August 1, 2001

Abstract
PDF

Background
: The pathophysiology of non-ulcer dyspepsia remains unknown. But Several related factors have been investigated and psychologic factor is one of the possible mechanism. Alexithymia was introduced to explain the psychopathology of psychosomatic disorder. Until now alexithymia has been variously shown to be associated with many psychosomatic disorder, psychiatric disorder, even medical patients. This study is designed to investigate whether non-ulcer dyspepsia has more relationship with alexthymia than other illness.

Methods : To compare alexthymia tendency between non-ulcer dyspepsia and general medical patients, we collected sample from January to September 1999. Each group of 72 patients were tested using Toronto alexthymia Scale.

Results : A rate of 37.5%of alexthymia was found in the non-ulcer dyspepsia group compared with significant lower rate of 19.4% in the general medical patients group.

Conclusion : Non-ulcer dyspepsia patients had more alexthymia compare to general medical patients. This finding shows the alexthymia could be part of the pathophysiology of non-ulcer dyspepsia.

1,400 View
11 Download

Related factors of peptic ulcer in H. pylori positive patients confirmed by endoscopic biopsy of stomach.: Soon Young Oh, Suk Gu Lee; J Korean Acad Fam Med 2000;21(5):635-644. Published online May 1, 2000

Abstract
PDF

Background
: This study was conducted to investigate the reason why H.pylori infected people develop different patterns of gastric diseases and in some infected patients have peptic ulcers, but the others have not.

Methods : We analyzed 177 cases of H. pylori positive patients who were confirmed by histologic evaluation of gastric endoscopic biopsy specimens from January 1998 to July 1998 in Health Promotion Center of one medical college hospital. Among these 177 cases, 63 cases(35.6%) were peptic ulcer patients and 114 cases(64.4%) were non ulcer patients. We anlayzed the difference of sociodemographic finding, alcohol and smoking habit, past history, family history, drug history, emotional factors, body mass index and serum biochemical profiles between ulcer and non ulcer patients.

Results : 1. There were no differences of age, sex and occupation between peptic ulcer and non ulcer patients. 2.Heavy smoking(p<0.001), heavy drink(p=0.011), past history of upper gastrointestinal disease(p<0.001), fatigue(p<0.001) and depressive mood(p=0.001) were significantly more frequent in H.pylori positive peptic ulcer patients than non ulcer patients. 3.We found several related factors that might affect peptic ulcer development in H. pylori infected patients through logistic regression analysis of variables. These factors were heavy smoking(odds ratio 5.91, 95% CI 2.54-13.78), past history (odds ratio=4.24, 95% CI 1.72-10.42), depressed mood(odds ratio 2.76, 95% CI 1.15-6.63), and fatigue(odds ratio 2.42, 95% CI 1.03-5.69).

Conclusion : We conclude that past history, heavy smoking, depressed mood, and fatigue are related factors of peptic ulcer disease in H.pylori positive patients.

1,330 View
9 Download

Prevalence of Helicobacter pylori infection in patients of peptic ulcer among Korean people.: Jung Jin Cho; J Korean Acad Fam Med 1999;20(9):1084-1090. Published online September 1, 1999

Abstract
PDF

Background
: Helicobacter pylori infection is thought to be an important factor the pathogenesis of gastric and duodenal ulcer. But in Korea, there are new studies on the prevalence of Helicobacter pylori infection in peptic ulcer patients and their relationship between the location of ulcers and Helicobacter pylori infection. The aim of this study was to investigate the prevalence of Helicobacter pylori infection of gastric and duodenal ulcer patients in Korea and the relationship between the location of ulcers and Helicobacter pylori infection.

Methods : We studied 476 consecutive patients with duodenal ulcers or benign gastric ulcer which were diagnosed by gastrofiberscopy in Family Medicine of Hanil Hospital from January 1995 to December 1998l Helicobacter pylori infection was evaluated with rapid urease test(CLO test) in 72.7% patients.

Results : The test rate of CLO test was not significantly different by sex, age and site of gastric ulcer lesions, but test rate in the gastric ulcer was significantly lower than in the duodenal ulcer. The prevalence of Helicobacter pylori infection diagnosed with CLO test was 90.1%. The prevalence of Helicobacter pylori infection was not significantly different between males and females. Also it was also not significantly different according to age. 90.8% of those with gastric ulcer patients and 88.9% of the duodenal ulcer had Helicobacter pylori infection, but the difference was not significant. significantly. 94.6% of gastric ulcers located in only one area had Helicobacter pylori infection, compared to 83.6% of gastric ulcers which was located in multiple areas. The prevalence of Helicobacter pylori infection was significantly lower in patients who had lesions located in multiple areas.

Conclusion : We conclude that the majority of peptic ulcer patients in Korea have Helicobacter pylori infection. Gastric ulcer located in multiple areas had significantly lower prevalence of Helicobacter pylori infection, which may suggest that gastric ulcers in multiple areas have other etiologic factors.

1,801 View
13 Download

Comparison of stressful life events among peptic ulcer, not ulcer dyspepsia and control groups.: Je In Moon, Eun Hwa Go, Soo Young Kim, In Hong Hwang; J Korean Acad Fam Med 1999;20(6):804-811. Published online June 1, 1999

Abstract
PDF

Background
: Stress has long been recognized as a risk factor to various disorders including peptic ulcer disease. Life events are universal which everybody experiences. This study was done to find out whether stressful life events have a role in the development and exacerbation of peptic ulcer disease(PUD) and non-ulcer dyspepsia(NUD) comparing Lee's life stress scale between patients with gastroscopically proven PUD and NUD and those of control.

Methods : On hundred twenty two patients with PUD were studied at our institution from February 1, 1997 to June 30, 1997. Patients who experienced abdominal discomfort and found to have normal or chronic superficial gastritis by gastroscopic exam during the same period were selected for NUD group. Controls were selected from asymptomatic individuals who underwent upper gastrointestinal series procedure for a health screening. Stressful life events investigated were total, positive, and negative stresses measured by Lee's life stress scale(98 items), marital status, level of education, income, occupation, religion, history of cigarette smoking, and the amount of alcoholic consumption and were compared between the three groups. The data were analyzed by one was ANOVA and chi-square test.

Results : No statistically significant difference was found in total, positive, and negative stress scores between PUD group and NUD group, although they were significantly higher in PUD and NUD groups than those of the control group(p<0.05). Also statistically significant difference in income and occupa-tion, tests and school, problems associated children and familial conflict were found between PUD group and the control group)p<0.05), as weel as between NUD group and the control group(p<0.05).

Conclusion : Stressful life events were associated with development of PUD and NUD.

1,866 View
10 Download

Irregular, quick meal is associated with non-ulcer dyspepsia.: Dong Jin Kim; J Korean Acad Fam Med 1999;20(2):176-185. Published online February 1, 1999

Abstract
PDF

Background
: Many etiologies of Non-Ulcer Dyspepsia (NUD) have been suggested. Among them, gastrointestinal(GI) motility disorder seems to bean important cause. It is said that many Koreans have dyspepsia, due to rapid eating habit. Therefore, we investigated on specific eating habits that may influence GI motility resulting in NUD symptoms.

Methods : At the Health Promotion Center in a university hospital we screened 8,648 adults from May 1995 to April 1997. The patients were given a questionnaire on their eating habits, followed by history taking, physical examination, laboratory tests, UGIS (or gastrofiberoscopy), and abdominal sonography. And then the family physician evaluated the patients. Those with NUD and control who didn't have any diagnosis related to GI tract were analyzed.

Results : 1,329 persons(15.4%) were diagnosed as having NUD, and the number of control group were 4,747. NUD was more common in females(Odds Ratio=1.64). NUD group reported less regular eating(OR=0.77), and drinking(OR=0.60). NUD had significantly shorter meal duration, and lower BMI.(p<0.00). But there was no difference in the reported exercise, smoking, stress amount, frequ-ency of eating salty food, breakfast, dinner, instant food, hat food, and the amount of each meal.

Conclusion : NUD was associated with irregular, and quick eating behavior. Behavioral modification such as regular and slow eating to prevent NUD is advised.