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Original Articles

Determinants of COVID-19 Vaccination Willingness among Health Care Workers: A Quick Online Survey in India
Rajesh Kumar, Kalpana Beniwal, Yogesh Bahurupi, Ravi Kant, Mukesh Bairwa
Korean J Fam Med 2021;42(6):445-452.   Published online November 20, 2021
DOI: https://doi.org/10.4082/kjfm.21.0071
Background
The coronavirus disease 2019 (COVID-19) pandemic has caused a large number of deaths along with severe socio-economic effects. The vaccine is considered to be the last hope to control viral transmission. This study aimed to explore the determinants of health care workers’ (HCWs) willingness to take the COVID-19 vaccination.
Methods
A structured, pre-validated, and pre-tested questionnaire was administered online to 599 HCWs including physicians, residents, and nurses from different types of healthcare set-ups across India. Information was collected regarding vaccine acceptability, attitude toward vaccination, and reasons for hesitancy. The chi-square test, followed by multinomial regression analysis, was applied to determine the factors associated with HCWs’ vaccination willingness.
Results
It was found that 73 % (n=437) of HCWs were willing to accept the vaccines, while 10.85% (n=65) refused and 16.2% (n=96) needed more time to decide. Gender (P<0.001), occupation (P=0.040), working as front-line workers (P=0.008), vaccine manufacturing country preferences (P<0.001), and perceived risk of catching COVID-19 in the next 6 months (P=0.005) had a significant association with intent to receive vaccination (the response were “yes” vs. “no” and “not sure”). The reasons for vaccine hesitancy were vaccine safety and efficacy concerns, antivaccine attitude and beliefs, personal choice, and not wanting to take a vaccine before others.
Conclusion
The majority of HCWs agreed to take COVID-19 vaccines once available. Nevertheless, providing support to manage evolving vaccine environments will help change the perception of HCWs who refuse or are reluctant to take the vaccines.

Citations

Citations to this article as recorded by  
  • Willingness to take Mpox vaccine and associated factors among health professionals in Ethiopia: A cross-sectional study
    Getahun Fetensa, Tadesse Tolossa, Marga Besho, Girma Yadesa, Jilcha Gugsa, Derara Girma Tufa, Feyiso Bati, Kitesa Biresa Duftu, Bizuneh Wakuma
    Vaccine.2025; 49: 126822.     CrossRef
  • Knowledge, attitude, intentional practice and individualized determinants of COVID‐19 vaccine uptake among adults: A cross‐sectional study in Tanzania
    Amimu A. Nassoro, Walter C. Millanzi, Patricia Z. Herman
    Nursing Open.2024;[Epub]     CrossRef
  • COVID-19 Vaccine Hesitancy among Adults in India: A Systematic Review and Meta-analysis
    M. D. Sangeetha, P. K. Sreenath Menon, Bhalangki Kupar Kharmawphlang, Darshan Hoysanahalli Shivashankarappa, Sharath Burugina Nagaraja
    Indian Journal of Public Health.2024; 68(4): 534.     CrossRef
  • Determinants of vaccine acceptance, knowledge, attitude, and prevention practices against COVID‐19 among governmental healthcare workers in Addis Ababa and Adama, Ethiopia: A cross‐sectional study
    Aderajew M. Girmay, Mesaye G. Weldegebriel, Melaku G. Serte, Daniel A. Dinssa, Tsigereda A. Alemayehu, Moa A. Kenea, Abel Weldetinsae, Kirubel T. Teklu, Sisay D. Mengesha, Zinabu A. Alemu, Belaynesh Demisie, Bedasa Wagari, Martin R. Evans, Masresha Tessem
    Health Science Reports.2023;[Epub]     CrossRef
  • Evaluation of Short-Term Side Effects Following the First Dose of COVID-19 Vaccines Among Physicians and Dentists: A Cross-Sectional Study from India
    Md Anwarul Azim Majumder, Keerti Singh, WMS Johnson, Archana Rajasundaram, Subir Gupta, Uma Gaur, Santosh Kumar, Madhuri Chatterjee, Ahbab Mohammad Fazle Rabbi, Vijay Prasad Sangishetti, Sayeeda Rahman, Michael H Campbell, Heather Harewood, Ambadasu Bhara
    Journal of Multidisciplinary Healthcare.2023; Volume 16: 161.     CrossRef
  • Acceptance of COVID-19 Vaccines in India: A Systematic Review and Meta-Analysis
    Gunjan Kumar, Samikshya Jena, Niher Tabassum Snigdha, Sakeenabi Basha, Jayaraj Kodangattil Narayanan, Alexander Maniangat Luke
    Vaccines.2023; 11(5): 964.     CrossRef
  • Perception and Mental Health Status Regarding COVID-19 Vaccination Among Taiwanese Adolescents and Their Caregivers
    Jade Winjei Hwang, Shao Ju Chien, Chih-Chi Wang, Kuang-Che Kuo, Kuo-Shu Tang, Yu Lee, Yi-Chun Chen, Mao-Hung Lo, Ing-Kit Lee, Seng-Kee Chuah, Chien-Te Lee, Chia-Te Kung, Liang-Jen Wang
    Adolescent Health, Medicine and Therapeutics.2023; Volume 14: 195.     CrossRef
  • Factors Associated With Psychological Outcomes Among Vaccinated and Unvaccinated Health Care Workers Against COVID-19 Infection in Bangladesh
    Md. Dhedharul Alam, Sujan Kumer Paul, Mahmuda Momi, Li Ni, Yi Xu
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Contested bodies and delayed decisions: Attitudes to COVID-19 vaccines among Jamaicans
    Aieka Yasheva Smith
    Opera.2022; (32): 185.     CrossRef
  • COVID-19 Vaccine Hesitancy among Health Care Workers
    Seung-Won Oh
    Korean Journal of Family Medicine.2021; 42(6): 411.     CrossRef
  • 6,437 View
  • 92 Download
  • 12 Web of Science
  • 10 Crossref
Trends in Influenza Vaccination Coverage Rates among Korean Cancer Survivors: Analysis of the Korea National Health and Nutrition Examination Survey III–VI
Ye-Seul Kim, Jae-woo Lee, Hee-Taik Kang, Yonghwan Kim, Hyo-Sun You
Korean J Fam Med 2020;41(1):45-52.   Published online November 11, 2019
DOI: https://doi.org/10.4082/kjfm.18.0165
Background
Few studies have reported on the trends in influenza vaccination rates among cancer survivors in Korea. We investigated these trends over a recent 11-year period (2005–2015).
Methods
Data were obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) III– VI (2005–2015). After excluding individuals younger than 40 years of age, the participants included 2,210 cancer survivors (861 men and 1,349 women). We categorized these study participants into four groups according to age and sex.
Results
The influenza vaccination rate decreased significantly among male cancer survivors, with rates of 74.8, 64.7, 56.2, and 55.2% (β coefficient=-0.257, P for trend <0.001) in KNHANES III, VI, V, and VI, respectively. While influenza vaccination rates decreased significantly among older male cancer survivors (≥65 years) (β coefficient=-0.359, P for trend=0.017), they increased among older female cancer survivors (β coefficient=0.375, P for trend=0.011) from 2005 to 2015.
Conclusion
Influenza vaccination rates in older cancer survivors significantly decreased in men but increased in women in successive KNHANES phases. Efforts are needed to improve immunization education and awareness, especially in older male cancer survivors.

Citations

Citations to this article as recorded by  
  • Influenza vaccine effectiveness in immunocompromised patients with cancer: A Danish nationwide register‐based cohort study
    Lau Amdisen, Lars Pedersen, Niels Abildgaard, Christine Stabell Benn, Deirdre Cronin‐Fenton, Signe Sørup
    Cancer.2025;[Epub]     CrossRef
  • Disentangling behavioral determinants of seasonal influenza vaccination in post-corona era: An integrated model approach
    So-Hyun Kim, Minsoo Jung, Hani Amir Aouissi
    PLOS One.2025; 20(5): e0323184.     CrossRef
  • The coverage of influenza vaccination and predictors of influenza non-vaccination in Danish cancer patients: A nationwide register-based cohort study
    Lau Amdisen, Lars Pedersen, Niels Abildgaard, Christine Stabell Benn, Mikael Rørth, Deirdre Cronin-Fenton, Signe Sørup
    Vaccine.2024; 42(7): 1690.     CrossRef
  • Vaccination uptake among post-treatment cancer survivors: A multi-vaccine scoping review
    Kavita Renduchintala, Mariana Arevalo, Gabriella Fonseca, Mary Katherine Haver, Clement K. Gwede, Smitha Pabbathi, Shannon M. Christy
    Vaccine.2024; 42(22): 125995.     CrossRef
  • Seasonal influenza vaccination among cancer patients: A systematic review and meta-analysis of the determinants
    George N. Okoli, Otto L.T. Lam, Tiba Abdulwahid, Christine J. Neilson, Salaheddin M. Mahmud, Ahmed M. Abou-Setta
    Current Problems in Cancer.2021; 45(2): 100646.     CrossRef
  • A cross‐sectional study of factors associated with influenza vaccination in Korean cancer survivors
    Ji Eun Lee, Dong Wook Shin, Jinyoung Shin, In Young Cho, Jungkwon Lee, JiHye Hwang, BeLong Cho, Yun‐Mi Song
    European Journal of Cancer Care.2021;[Epub]     CrossRef
  • Influenza Vaccination Status and Its Affecting Factors among Stroke Survivors: Findings from the Korea National Health and Nutrition Examination Survey
    Eung-Joon Lee, Oh Deog Kwon, Seung Jae Kim
    Vaccines.2021; 9(7): 763.     CrossRef
  • 9,485 View
  • 112 Download
  • 7 Web of Science
  • 7 Crossref
The Association between Smoking Status and Influenza Vaccination Coverage Rate in Korean Adults: Analysis of the 2010–2012 Korea National Health and Nutrition Examination Survey
Jung Keun Park, Soo Lee, Ji Eun Lee, Kyung-Do Han, Ji Hyun Kim, Jin Hee Yoon, Suk Won Park, Yang-Hyun Kim, Kyung-Hwan Cho
Korean J Fam Med 2018;39(2):90-95.   Published online March 22, 2018
DOI: https://doi.org/10.4082/kjfm.2018.39.2.90
Background

Globally, smoking is one of the biggest challenges in public health and is a known cause of several important diseases. Influenza is preventable via annual vaccination, which is the most effective and cost-beneficial method of prevention. However, subjects who smoke have some unhealthy behaviours such as alcohol, low physical activity, and low vaccination rate. In this study, we analyzed the relationship between smoking status and factors potentially related to the influenza vaccination coverage rate in the South Korean adult population.

Methods

The study included 13,565 participants aged >19 years, from 2010 to 2012 from the Korea National Health and Nutrition Examination Survey data. Univariate analyses were conducted to examine the association between influenza coverage rate and related factors. Multivariate analysis was obtained after adjusting for variables that were statistically significant.

Results

The overall vaccination rate was 27.3% (n=3,703). Older individuals (P<0.0001), women (P<0.0001), non-smokers (P<0.0001), light alcohol drinkers (P<0.0001), the unemployed (P<0.0001), and subjects with diabetes mellitus (P<0.0001), hypercholesterolemia (P<0.0001), and metabolic syndrome (P<0.0001) had higher influenza vaccination coverage than the others. In multivariate analyses, current smokers and heavy smokers showed lower vaccination rates (odds ratio, 0.734; 95% confidence interval, 0.63–0.854).

Conclusion

In the current study, smokers and individuals with inadequate health-promoting behaviors had lower vaccination rates than the others did.

Citations

Citations to this article as recorded by  
  • The Impact of COVID‐19 Vaccine Myths and Conspiracy Theories on Vaccine Hesitancy and Vaccine Refusal in Turkey: Future Implications
    Ayşe Gül Parlak, Gönül Gökçay, Yasemin Karacan
    Public Health Nursing.2026; 43(1): 91.     CrossRef
  • Smoking and serological response to influenza vaccine
    Won Suk Choi, Mary Patricia Nowalk, Krissy Moehling Geffel, Michael Susick, Sean Saul, Chyongchiou Jeng Lin, Ted M. Ross, Richard K. Zimmerman
    Human Vaccines & Immunotherapeutics.2024;[Epub]     CrossRef
  • Determining the intention of receiving the influenza vaccine: a cross-sectional survey among international and domestic college students in the USA
    ChengChing Liu, Angela Chia-Chen Chen, Jiying Ling, Charles Liu, Nagwan Zahry, Ravichandran Ammigan, Loveleen Kaur
    BMJ Open.2024; 14(12): e085377.     CrossRef
  • Factors Associated With Influenza Vaccination During the COVID-19 Pandemic in Older Adults Residing in Brazil
    Bruna Moretti Luchesi, Nathalia de Oliveira Andrade, Mariana Ferreira Carrijo, Humberta Correia Silva Azambuja, Tatiana Carvalho Reis Martins, Rosimeire Aparecida Manoel Seixas
    Journal of Gerontological Nursing.2023; 49(5): 31.     CrossRef
  • Influenza Vaccination Uptake and Associated Factors Among Adults With and Without Human Immunodeficiency Virus in a Large, Integrated Healthcare System
    Brandon M Imp, Tory Levine, Derek D Satre, Jacek Skarbinski, Mitchell N Luu, Stacy A Sterling, Michael J Silverberg
    Clinical Infectious Diseases.2023; 77(1): 56.     CrossRef
  • Understanding Factors Contributing to Vaccine Hesitancy in a Large Metropolitan Area
    Paolo Montuori, Immanuela Gentile, Claudio Fiorilla, Michele Sorrentino, Benedetto Schiavone, Valerio Fattore, Fabio Coscetta, Alessandra Riccardi, Antonio Villani, Ugo Trama, Francesca Pennino, Maria Triassi, Antonio Nardone
    Vaccines.2023; 11(10): 1558.     CrossRef
  • Secular trends and determinants of influenza vaccination uptake among patients with cardiovascular disease in Korea: Analysis using a nationwide database
    Min Kim, Bumhee Yang, Seonhye Gu, Eung-Gook Kim, So Rae Kim, Kyeong Seok Oh, Woong-Su Yoon, Dae-Hwan Bae, Ju Hee Lee, Sang Min Kim, Woong Gil Choi, Jang-Whan Bae, Kyung-Kuk Hwang, Dong-Woon Kim, Myeong-Chan Cho, Hyun Lee, Dae-In Lee
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Factors Associated with Annual Influenza Vaccination Uptake in U.S. Older Adults from 2019 to 2020
    Margaret Anne Lovier, Roger Wong
    Journal of Ageing and Longevity.2022; 2(4): 340.     CrossRef
  • An Assessment on Impact of COVID-19 Infection in a Gender Specific Manner
    Himanshu Agrawal, Neeladrisingha Das, Sandip Nathani, Sarama Saha, Surendra Saini, Sham S. Kakar, Partha Roy
    Stem Cell Reviews and Reports.2021; 17(1): 94.     CrossRef
  • Smoking increases the risk of infectious diseases: A narrative review
    Chen Jiang, Qiong Chen, Mingxuan Xie
    Tobacco Induced Diseases.2020;[Epub]     CrossRef
  • Health Behavior, Health Service Use, and Health Related Quality of Life of Adult Women in One-person and Multi-person Households
    Hyun Ju Chae, MiJong Kim
    Korean Journal of Women Health Nursing.2019; 25(3): 299.     CrossRef
  • 6,551 View
  • 61 Download
  • 9 Web of Science
  • 11 Crossref
Knowledge, Current Status, and Barriers toward Healthcare Worker Vaccination among Family Medicine Resident Participants in a Web-Based Survey in Korea
Kyungjin Ko, Sungjong Kim, Sang-Hyun Kim, Ki Young Son, Jungun Lee, Dong Ryul Lee
Korean J Fam Med 2017;38(1):21-27.   Published online January 18, 2017
DOI: https://doi.org/10.4082/kjfm.2017.38.1.21
Background

We investigated the knowledge, status, and barriers toward healthcare workers receiving vaccinations among Korean family medicine residents. To date, a systematic study has not been conducted among medical practitioners examining these variables.

Methods

A web-based, anonymous, self-administered questionnaire was distributed to all 942 family medicine residents working in 123 training hospitals in Korea. A multiple logistic regression analysis was performed to investigate factors affecting vaccination completion.

Results

Korean family medicine residents (N=242, 25.7%) from 54 training hospitals (43.9%) participated in the survey. Only 24 respondents (9.9%) had correct knowledge on all the recommended vaccinations by the Korean Society of Infectious Diseases. The complete vaccination rates against hepatitis B virus and influenza were relatively high (69.4% and 83.0%, respectively), whereas they were relatively low against other infections (e.g., 16.5%– 53.1%). The most common reason for not receiving a vaccination was the belief that there was little possibility of infection from the vaccine-preventable diseases.

Conclusion

Knowledge and vaccination coverage were poor among family medicine residents in Korea. Medical schools should provide vaccination information to healthcare workers as part of their mandatory curriculum. Further research should confirm these findings among primary care physicians and other healthcare workers.

Citations

Citations to this article as recorded by  
  • Hepatitis B vaccination status, knowledge and associated factors among healthcare professionals in Dongola, Sudan, 2024: a cross-sectional study
    Mogahid Mohamed Awad, Sami Altalib, Kamil M. Shaaban
    BMC Infectious Diseases.2025;[Epub]     CrossRef
  • Hepatitis B in Healthcare Personnel: An Update on the Global Landscape
    Georgia B. Nikolopoulou, Ioannis Tzoutzas, Athanasios Tsakris, Helena C. Maltezou
    Viruses.2023; 15(12): 2454.     CrossRef
  • COVID-19 vaccine hesitancy in Sana'a, Yemen
    Redhwan Ahmed Al-Naggar, Hisham Alshaikhli, Reyadh R. Al-Rashidi, Sharon Murtagh
    International Journal of One Health.2022; : 58.     CrossRef
  • Prevalence and management of rubella susceptibility in healthcare workers in Italy: A systematic review and meta-analysis
    Francesco Paolo Bianchi, Pasquale Stefanizzi, Giusy Diella, Andrea Martinelli, Antonio Di Lorenzo, Maria Serena Gallone, Silvio Tafuri
    Vaccine: X.2022; 12: 100195.     CrossRef
  • Prevention of Hepatitis B among Homeless People: Challenges for Vaccination in Brazil
    Thaynara Lorrane Silva Martins, Marcos André de Matos, Sheila Araujo Teles, Raquel Silva Pinheiro, Paulie Marcelly Ribeiro Carvalho, Márcia Maria de Souza, Camila Canhete Ferreira, Regina Maria Bringel Martins, Karlla Antonieta Amorim Caetano
    Journal of Poverty.2021; 25(4): 347.     CrossRef
  • Promotion of healthcare personnel vaccinations among newly employed doctors and nurses: Evidence-guided strategy
    Hyo-Ju Son, Eunjung Lee, Se Yoon Park, Seungjae Lee, Hyohyun Hong, Eun Ju Choo, Tark Kim, Min Hyok Jeon, Shinae Yu, Jung Wan Park, Tae Hyong Kim
    Vaccine.2021; 39(26): 3480.     CrossRef
  • Knowledge, Vaccination Status, and Reasons for Avoiding Vaccinations against Hepatitis B in Developing Countries: A Systematic Review
    Putri Bungsu Machmud, Saskia Glasauer, Cornelia Gottschick, Rafael Mikolajczyk
    Vaccines.2021; 9(6): 625.     CrossRef
  • A Nationwide Survey on the Hospital Vaccination Policies in Korea
    Sun Hee Park, Mi Suk Lee, Sung Ran Kim, Yee Gyung Kwak
    Journal of Korean Medical Science.2020;[Epub]     CrossRef
  • PERCEPÇÕES ACERCA DA IMPORTÂNCIA DAS VACINAS E DA RECUSA VACINAL NUMA ESCOLA DE MEDICINA
    Amanda Hayashida Mizuta, Guilherme de Menezes Succi, Victor Angelo Martins Montalli, Regina Célia de Menezes Succi
    Revista Paulista de Pediatria.2019; 37(1): 34.     CrossRef
  • Immunization attitudes, opinions, and knowledge of healthcare professional students at two Midwestern universities in the United States
    Lauren L. Dybsand, Kylie J. Hall, Paul J. Carson
    BMC Medical Education.2019;[Epub]     CrossRef
  • Vaccine refusal – what we need to know
    Regina Célia de Menezes Succi
    Jornal de Pediatria.2018; 94(6): 574.     CrossRef
  • Measles vaccination status of nurses and associated factors during community measles outbreaks
    Kyung Mi Kim, Jeong Sil Choi
    Japan Journal of Nursing Science.2018; 15(3): 249.     CrossRef
  • Comparison of three immunoassays for determination of immunity to rubella virus in healthcare workers
    Su-Yeon Jo, Kyung-Hwa Shin, Sun Min Lee, Eun-Young Jeong, Hyun-Ji Lee, Chulhun L. Chang
    Journal of Immunological Methods.2018; 463: 84.     CrossRef
  • Vaccine refusal – what we need to know
    Regina Célia de Menezes Succi
    Jornal de Pediatria (Versão em Português).2018; 94(6): 574.     CrossRef
  • Seroprevalence of hepatitis B virus infection and associated factors among healthcare workers in northern Tanzania
    Elichilia R. Shao, Innocent B. Mboya, Daniel W. Gunda, Flora G. Ruhangisa, Elizabeth M. Temu, Mercy L. Nkwama, Jeremia J. Pyuza, Kajiru G. Kilonzo, Furaha S. Lyamuya, Venance P. Maro
    BMC Infectious Diseases.2018;[Epub]     CrossRef
  • 7,337 View
  • 55 Download
  • 13 Web of Science
  • 15 Crossref
Association between Living Arrangements and Influenza Vaccination Rates among Elderly South Korean People: The Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2)
Hye Min Cho, Joo-Yeon Kim, Seo Eun Hwang, Jae Chul Kim, Moo-Young Kim, Soo Hyoung Lee
Korean J Fam Med 2015;36(4):186-190.   Published online July 17, 2015
DOI: https://doi.org/10.4082/kjfm.2015.36.4.186
Background

This study aimed to investigate the association between living arrangements and influenza vaccination among elderly South Korean subjects.

Methods

We used data from the fifth Korean National Health and Nutrition Examination Survey. Participants older than 65 years were included and categorized into 4 groups according to the type of living arrangement as follows: (1) living alone group; (2) living with a spouse group; (3) living with offspring (without spouse) group; and (4) living with other family members group. A total of 1,435 participants were included in this cross-sectional analysis.

Results

A lower vaccination rate was observed in the living with offspring (without spouse) group, whereas the living with a spouse group had higher rates of both seasonal and H1N1 influenza vaccination. After adjusting for age, sex, region, education level, income level, and number of comorbidities, the living with offspring (without spouse) group had a higher H1N1 vaccination non-receipt rate than the living alone group (odds ratio, 2.03; 95% confidence interval, 1.08-3.82).

Conclusion

Influenza vaccination rates differed according to the type of living arrangement. Particularly, those living with offspring (without spouse) had the lowest H1N1 influenza vaccination rate compared to those with other living arrangements, and this difference was significant. Interventions to improve influenza vaccination coverage should target not only elderly persons who live alone, but also those living with offspring.

Citations

Citations to this article as recorded by  
  • Organizational barriers in HPV vaccination uptake: A cross-sectional study among health sciences students
    Giuseppina Palena, Irene Stilo, Michele Sorrentino, Claudio Fiorilla, Raffaele Palladino, Nicola Serra
    PLOS One.2025; 20(6): e0326694.     CrossRef
  • Factors Associated with Influenza Vaccination Among Urban Community-Dwelling Chinese Elderly: Results from a Multicity Cross-Sectional Study
    Jiayue Guo, Xitong Jiao, Shuai Yuan, Lili You
    Vaccines.2025; 13(11): 1171.     CrossRef
  • Understanding Factors Contributing to Vaccine Hesitancy in a Large Metropolitan Area
    Paolo Montuori, Immanuela Gentile, Claudio Fiorilla, Michele Sorrentino, Benedetto Schiavone, Valerio Fattore, Fabio Coscetta, Alessandra Riccardi, Antonio Villani, Ugo Trama, Francesca Pennino, Maria Triassi, Antonio Nardone
    Vaccines.2023; 11(10): 1558.     CrossRef
  • Secular trends and determinants of influenza vaccination uptake among patients with cardiovascular disease in Korea: Analysis using a nationwide database
    Min Kim, Bumhee Yang, Seonhye Gu, Eung-Gook Kim, So Rae Kim, Kyeong Seok Oh, Woong-Su Yoon, Dae-Hwan Bae, Ju Hee Lee, Sang Min Kim, Woong Gil Choi, Jang-Whan Bae, Kyung-Kuk Hwang, Dong-Woon Kim, Myeong-Chan Cho, Hyun Lee, Dae-In Lee
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • The Association between Smoking Status and Influenza Vaccination Coverage Rate in Korean Adults: Analysis of the 2010–2012 Korea National Health and Nutrition Examination Survey
    Jung Keun Park, Soo Lee, Ji Eun Lee, Kyung-Do Han, Ji Hyun Kim, Jin Hee Yoon, Suk Won Park, Yang-Hyun Kim, Kyung-Hwan Cho
    Korean Journal of Family Medicine.2018; 39(2): 90.     CrossRef
  • The coverage rates for influenza vaccination and related factors in Korean adults aged 50 and older with chronic disease: based on 2016 Community Health Survey data
    Kyeong Hyang Byeon, Jaiyong Kim, Boyoung Choi, Bo Youl Choi
    Epidemiology and Health.2018; 40: e2018034.     CrossRef
  • Influenza Vaccination Status in Korean Adult Population in Relation with Socioeconomic and Medical Factors
    Gyeong-Ran Byeon, Yang-Im Hur, Jae-Heon Kang, Hyun-Ah Park, Kyoung-Woo Kim, Young-Gyu Cho, Koh-Eun Shin, Bong-Hee Kang
    Korean Journal of Health Promotion.2016; 16(1): 20.     CrossRef
  • 6,393 View
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  • 6 Web of Science
  • 7 Crossref
Validity of Measles Immunization Certificates and Perception of General Practitioners Concerning Immunization Certificate.
Kun Sei Lee, Hee Kyung Joh, Eunyoung Shin, Sun Hwan Bae, Yoon Jeong Kim, Hyun Kyung Oh
J Korean Acad Fam Med 2006;27(12):1005-1012.   Published online December 10, 2006
Background
: In Korea, the law reguires submission of immunization certificate to elementary school on admission since 2001 in order to prevent measles outbreaks such as those that occurred in the year 2000 and 2001. As a result, the submission rate of immunization certificate has been almost 99%. To that effect it seems to have been a very successful policy. But the validity and accuracy of such certificates have not been guestioned. This study aimed to assess the validity of the measles immunization certificates and general practitioners' perception of the law to submit immunization certificate.

Methods : A postal survey was conducted from April to May 2005 among general practitioners who were pediatricians and family physicians. The main questions were the method to confirm childrens' past vaccination and the proportion of doing booster vaccination, and also their opinions on governments' policy to extend the submission of immunization certificate on school admission.

Results : The total study subjects were 840. The proportion of issued immunization certificates based on exact vaccination records or booster vaccination was 98.7%. The opinions concerning the law to submit immunization certificates were: very necessary (88.8%), and should include all children basic immunization (62.8%). On the other hand, the most common reason against the law was that they did not feel the necessity (31.4%).

Conclusion : The validity of immunization certificates was very high. The opinions concerning the law to submit immunization certificates were favorable in most subjects. And mutual understanding between the general practitioners and the government is in demand before the law to submit immunization certificates becomes effect.
  • 1,664 View
  • 14 Download
Immune Response to Hepatitis B Vaccination for Adults with Isolated Antibody to Hepatitis B Core Antigen in the Hepatitis B Endemic Area.
Hee Jeong Koh, Ji Ho Choi, Sung Ryul Kim, Hong Soo Lee, Heyn Eun Kang, Tai Woo Yoo
J Korean Acad Fam Med 2004;25(5):392-396.   Published online May 10, 2004
Background
: Korea is a highly prevalent area of isolated anti-HBc with a rate of 15%, but there is neither vaccination nor management guideline agreed. To know the management for Hepatitis B Vaccination for adults with isolated anti-HBc, we investigated immune response to hepatitis B vaccination in adults with isolated anti-HBc.

Methods : The 23 adults with persistent isolated anti-HBc, who visited a health promotion center from Dec. 1998 to Aug. 1999, were vaccinated with Hepavax±-B by the standard schedule (0, 1, 6 month) and anti-HBs titers were measured 1 month after 1st and 3rd vaccinations (1, 7 month).

Results : After the 1st vaccination, 18 (78.26%) developed anti-HBs seroconversion. Among them, 4 (17.39%) had titers of 10∼49 mIU/ml, 8 (34.78%) 50∼99 mIU/ml, and 6 (26.09%) more than 100 mIU/ml. All non-responders after the 1st vaccination remained as such even with 3 doses of complete vaccination. The majority of seroconverted group did not show more anti-HBs response with further vaccination.

Conclusion : Since none of adults with isolated anti-HBc had a primary response, which indicated few false positive results. Therefore they should be excluded on vaccination programs in Korea. To differentiate between immunity and occult infections, a single dose of vaccine with a follow-up anti-HBs test is preferable for adults with isolated anti-HBc. If the test shows a seroconversion it would indicate protective immunity, if not, then occult infection may be suspected.
  • 1,592 View
  • 13 Download

Randomized Controlled Trial

Is the Use of Physician Reminder Sticker on Medical Records Effective for Improving the Rate of Recommending Influenza Vaccination?.
Sarah Lee, Yun Mi Song, Jeong Ho Choi, Seung Heon Han
J Korean Acad Fam Med 2003;24(8):715-720.   Published online August 10, 2003
Background
: For people who have high risk diseases or who are aged 65 years or more, routine influenza vaccination is required. However, in Korea, influenza vaccination rate of such people is low. We performed a study to assess the effectiveness of physician reminder in improving the rate of recommending influenza vaccination.

Methods : Among the patients who registered to tertiary care hospital family clinic center, 305 patients with diabetes mellitus or aged 65 years or more were randomly assigned into physician reminder group and control group. After excluding the patients who were vaccinated before the medical consultation or who did not attend the clinic, remaining 253 patients were included as final study subjects. For the physician reminder group, a sticker showing that influenza vaccination was needed was placed on each medical record. Demographic and clinical characteristics, recommendation of vaccination by physician, and the receipt of vaccination were checked through self-administered questionnaires, review of medical chart and order communication system, and telephone interview.

Results : The rates of recommending vaccination in the physician reminder group and the control group were 36% and 29.7%, respectively. The difference between the two groups was not significant. Vaccination rate in patients for whom influenza vaccination was recommended by their physician was 87.0%, whereas those for whom vaccination was not recommended was only 41.2%.

Conclusion : Physician reminder for influenza vaccination was not effective in this study. However, the physician's recommendation was effective in improving the influenza vaccination rate. Effective strategies will be needed to encourage physicians to recommend influenza vaccination.
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Incidence of Influenza-like Illness after Influenza Vaccination in the Elderly.
Sang Yeoup Lee, Won Hee Choi, Sang Han Choi, Yun Jin Kim, Byeung Man Cho
J Korean Acad Fam Med 2002;23(5):652-656.   Published online May 31, 2002
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Original Articles
A case study for measles patients confirmed by clinical and serological examination.
Deok Jin Lee, Tae Beom Kim, Jong Hak Lee, Sung Jai You
J Korean Acad Fam Med 2002;23(3):374-380.   Published online March 1, 2002
Background
: An outbreak of measles was reported again in 2000 nationwide. For that reason, research was done to evaluated the necessity of relevant re-vaccination and efficacy of primary vaccination of MMR when measles was prevalent, by way of comparative study for serological test results of the patients hospitalized at SAMSUN HOSPITAL in Busan in 2000.

Methods : From Jan to Dec 2000, we reviewed 108 cases with medical history confirmed as measles by clinical and serological examination and checked whether inoculation of primary vaccination of MMR was done or not and the date of vaccination through telephone survey, separated. The study subjects were into two groups, vaccinated, and unvaccinated, and antibody of measles were checked according to sex, season and age.

Results : It was observed that a great number of people caught measles in May-June comprising 56 case (58.3%) among 108 cases analyzed and the wide range of an attack of measles was under two years of age with 37 cases(34.3%) under on year of age and 33 cases (30.6%) between 1-2 year old.

Conclusion : According to the results of serum diagnosis of the measles case study, vaccination for measle is needed at the age of 6 month to one year because all those under on year of age who had not received a vaccine contacted the disease. The importance of booster was raised for those above 3 years old because those who had prior vaccination against measles contacted the disease.
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Hepatitis B vaccination completion rate between 0, 1, 2 month and 0, 1, 6 month schedule.
Nak Jin Sung, Ki Heum Park
J Korean Acad Fam Med 2001;22(1):52-58.   Published online January 1, 2001
Background
: Hepatitis B is an important disease in South Korea because the prevalence is high. There are two officially-granted hepatitis B vaccination schedules; 0, 1, 2-month schedule (not, 0, 1, 2, 12-month schedule) and 0, 1, 6-month schedule. This study was performed to compare vaccination completion rate between the two schedules.

Methods : The study subjects were all subjects who came to the City Medical Center to receive their first hepatitis vaccination dose from March to September, 1998. On odd-numbered day, 0, 1, 2-month schedule was delivered and on even-numbered day 0, 1, 6-month schedule was deliv-ered. On the first visit, the data about general characteristics were collected via self-administered questionnaire. Whether three vaccination doses were all received or not was ascertained by vaccination registration book. The subjects whose vaccination completion could not be ascertained by the book were called by telephone. The data were analyzed by Excel and SPSS-PC.

Results : Total collected cases were 822. Among them, 99 cases were excluded from analysis due to reasonable incompletion (11), incorrect inclusion (9) and impossible confirmation (79), which left 723 cases. General characteristics between two groups were not different except the existence of intrafamilial hepatitis carrier. The hepatitis B vaccination completion rate was higher in 0, 1, 2 -month schedule (85.4%) than in 0, 1, 6-month schedule (76.1%) only in the cases without intrafamilial hepatitis B carrier member.

Conclusion : The completion rate of heatitis B vaccination was higher in 0, 1, 2-month schedule than 0, 1, 6-month schedule in the cases without intrafamilial hepatitis B carrier member.
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The effects of influenza vaccination.
Chul Soo Jun, Byung Sung Kim, Gun Soon Kim, Jong Jin Lee, Jang Ho Park, Sung Soo Joo, Hong Seo, Hoon Ki Park, Byung Uk Doh
J Korean Acad Fam Med 1999;20(7):925-932.   Published online July 1, 1999
Background
: Influenza is a respiratory infectious disease with high morbidity and relatively high mortality which occurs every winter. Therefore, influenza vaccination is recommended annually for high risk groups. However, the vaccination rate is not very high. It is well known that influenza vaccination prevents influenza, and some reports show partial preventive effects for the common cold. Therefore, the authors implemented this study to find out the preventive effects of influenza vaccination for influenza and the common cold.

Methods : The study period was six months form October 1997 to March 1998, and the subjects were chosen from those who visited seven Family Practice Clinics and two Family Practice Outpatient Departments of University Hospital. The vaccination group composed of those who received influenza vaccination during the period and the control group was those who did not receive the vaccination with age difference ±3 years and of same gender.
The study was done by a survey questionnaire. The data were analyzed using SPSS version 8.0 and chi-square test, t-test, and logistic regression was implemented.

Results : The number of vaccination group was 223, the number of control group was 214, and the total subjects were 437 persons. Influenza occurred in 4 persons(1.8%) for the vaccination group, and 12 persons(5.6%) for the control group which showed significant difference(p=0.032). The common cold occurred in 69.1% of vaccination group and in 71.0% of control group with no difference. However, the duration of the common cold was 6.0 days for the vaccination group which was slightly shorter than 7.5 days for the control group(p=0.088), and the frequency of the common cold was 1.49 times for the vaccination group and 1.84 times for the control group(p=0.033). Logistic regression analysis showed that the relative risk of influenza for the vaccination group was 0.261(p=0.032), which meant 73.9% protective effect for influenza, but not for the common cold.

Conclusion : Influenza vaccination can protect people from influenza, but did not protect them from common cold. However, it can lessen the frequency and duration of the common cold.
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Factors influencing on the seroconversion of anti-HBs in the subjects with isolated anti-HBc.
Yun Lee, Hee Jeong KO, Beom Jung, Seung Kwon Myung, Sang Yeon Suh, Belong Cho, Bong Yul Huh
J Korean Acad Fam Med 1999;20(6):831-840.   Published online June 1, 1999
Background
: Korea is an endemic area of viral hepatitis B. In spite of the HBV vaccination program since 1983, the prevalence of HBV antigen had remained high, which was 3.9% in male, 2.7% in female in 1994. But there is no approved management guideline on isolated anti-HBc and the meaning of which is not clear except the evidence of past infection. Therefore, we tried to investigate the factors which influence th seroconversion of anti-HBs during follow-up period.

Methods : Medical records of 239 subjects with isolated anti-HBc, who visited a health promotion center from 1995 to 1997 and who were retested at least once during the 1-3 years' follow-up period, were analyzed.

Results : The seroconversion rate of anti-HBs was 45.61%(109/239) on the follow-up test. The number of newly vaccinated or non-newly vaccinated subjects during the follow-up period was 156 and 72, respectively. the seroconversion rate of anti-HBs of each group were 57.69(90/156) and 22.22%(16/72) respectively(P<0.01). The subjects without previous history of HBV vaccination was 103. Among them the seroconversion rate of anti-HBs of the newly vaccinated or the non-newly vaccinated group were 59.70%(40/67) and 22.22%(8/36), respectively(P<0.01). Sex, age, BMI, smoking, previous history of HBV vaccination did not influence significantly on th seroconversion rate of anti-HBs among the subjects with isolated anti-HBc.

Conclusion : The seroconversion rate in people with isolated anti-HBc was significantly higher in the newly vaccinated than the non-newly vaccinated regardless of the previous history of HBV vaccination in this study. In spite of the nondifferentiation of anamnestic response from primary antibody response, we can expect to benefit from HBV vaccination in those with isolated anti-HBc.
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The risk factors of the nonresponders after hepatitis B vaceinatio and the immunogenecity after a double-dose revaccination in the nonresponders.
Hee Jeong Koh, Kie Jung Lee, Kyeng Won Sim, Wol Mi Park, Sang Wha Lee, Hong Soo Lee
J Korean Acad Fam Med 1998;19(8):652-661.   Published online August 1, 1998
Background
: Korea is an endemic area of viral hepatitis B with a rate of 5~10% carrier state. Therefore, hepatitis B vaccination is performed nationwide. But 5~15% of health individuals fail to respond adequately to the vaccine and an approved guideline for the nonresponders has not been developed yet. This study is designed to identify risk factors for those who lack anti-HBs after hepatitis B vaccination and to document the results of a double-dose revaccination in such nonresponders to the primary vaccination.

Methods : From Feb. 1996 to Aug. 1997, we assessed 51 healthy subjects(HBs Ag negative, anti-HBs negative, anti-HBs negative and a normal LFT). All subjects were vaccinated with Hepavax-B® 1.0ml, 24 by a rapid schedule(0, 1, and 2 months) and and 27 by a standard schedule(0, 1, and 6 months). Anti-HBs titers were evaluated 3 months after the third vaccine and assessed the nonresponders(anti-HBsTiter < 2mIU/ml) and the hyporesponders(2~10 mIU/ml). All 13 nonresponders were revaccinated with 2 ml of Hepavax-B 3 months after the primary vaccination. Anti-HBs titers were evaluated 1 month later.

Results : The difference in age(p<0.01) and smoking amount(p<0.05) between the responders andhe hypo and the nonresponders were statistically significant. There were more males and higher body mass index in the hypo and the nonresponders but not statistically significant. The seroconversion rate after the double-dose vaccination was 92.3%(12/13) with an average titer of 58.08 mIU/ml(1~132.4 mIU/ml).

Conclusion : Increase in age and smoking amount were the risk factors of the nonresponders after the primary vaccination. Most of the hypo and the nonresponders to the primary vaccination responded adequately to the double-dose revaccination.
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Epidemiological Study of Rubella Outbreak in Chungchungnam-Do in Middle and High School Students in a Local Small Town.
Yoo Seock Cheong, Young Ill Won, Sun Mi Yoo, Eal Whan Park, Chang Suk Lee
J Korean Acad Fam Med 1998;19(3):252-262.   Published online March 1, 1998
Background
: Rubella is a viral infection of childhood. Its clinical manifestations are not serious, but rubella in early pregnancy can result in congenital rubella syndrome. In Korea, there have been several rubella outbreaks in 1996. We performed an epidemiological study about a rubella outbreak in middle and high school students in an isolated small town.

Methods : This study was carried out from March 22, 1996 to April 29, 1996. The target populations were middle and high school students(middle school-1,269, high school-966 students) in Namseonri. They were given a questionnaire containing sociodemographic characteristics, past vaccination history and rubella-like symptoms. We selected 70 clinically diagnosed patients and 233 students with rubella-like symptoms from the questionnaires. Through IgM and IgG ELISA, we analyzed the serum of selected students. All of the middle and high school students except those with clinical rubella were vaccinated on March 27.

Results : 1) The number of IgM positive students was 65 among 303 selected students. 58 students among the IgM positive group were diagnosed clinically, and 7 patients had subclinical infection. 2) Male patients were more predominant than female, especially in high school(M:F, 2:1 in middle school, 7:1 in high school). 3) Positive rates of IgG gradually increased by grade from 58.3% to 92.9%(1st grade of middle school to 3rd grade of high school). 4) IgG titer of the booster vaccinees(2nd and 3rd grade female, high school) was significantly higher than younger female students(p<.05). 5) After mass vaccination, 3 more patients caught rubella in high school during 1 month follow-up.

Conclusion : Among 2335 students, IgM positive patients were 65 with incidence rate of 2.8%. Mass vaccination of the students is an effective preventive method in a rubella outbreak.
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