Background
Polypharmacy poses a growing challenge to healthcare systems because of its association with adverse effects and the misuse of medication. This study aimed to identify the sociodemographic factors and comorbidities associated with polypharmacy.
Methods
We selected patients aged ≥30 years registered in the National Health Information Database in 2018 who were prescribed at least one medication for ≥180 days. Multivariate logistic regression analyses were performed to evaluate the associations between polypharmacy, sociodemographic characteristics, and comorbidities.
Results
Polypharmacy was significantly associated with increasing age, with the strongest association observed in adults aged ≥65 years. Compared with medical aid recipients, higher-income groups had a weaker association with polypharmacy. After adjusting for covariates, significant associations with polypharmacy were found for specific comorbidities, such as Parkinson disease (odds ratio [OR], 3.804; 95% confidence interval [CI], 3.733–3.876; P<0.001) and chronic ischemic heart disease (OR, 3.199; 95% CI, 3.178–3.221; P<0.001).
Conclusion
These findings may help reduce the burden of polypharmacy by facilitating the development of targeted strategies tailored to patients.

Background
This study examined the impact of the COVID-19 pandemic on adult vaccination uptake, specifically recombinant zoster vaccine (RZV), influenza (FLU), and pneumococcal vaccines (PnV), and explored factors influencing COVID-19 vaccine receipt in US adults.
Methods
We conducted a retrospective analysis of nationally representative cross-sectional data from the 2019 and 2022 Behavioral Risk Factor Surveillance Systems (n=777,807). Multivariable regression models assessed vaccination status for COVID-19, RZV, FLU, and PnV, adjusting for sociodemographic factors, geography, and healthcare coverage.
Results
Among insured adults, RZV vaccination increased from 31.9% in 2019 to 41.5% in 2022, and FLU vaccination increased from 42.7% to 45.0%. Among uninsured individuals, FLU vaccination rates declined 3.2%, while RZV remained unchanged. PnV rates remained stable among the insured but decreased by 15.4% among the uninsured. Individuals with healthcare coverage were 2.9 times more likely (95% confidence interval, 2.6–3.2) to have received ≥1 dose of the COVID- 19 vaccine. Minorities reported higher uptake for 1 to 2 doses of the COVID-19 vaccine but lower uptake for FLU, RZV, and PnV than non-Hispanic Whites, who had higher rates of >4 doses of COVID-19 vaccine.
Conclusion
Despite free access to the COVID-19 vaccine, healthcare coverage significantly influenced its uptake. Increases in RZV and FLU vaccination among the insured, in contrast to minimal changes or decreases among the uninsured, highlight the critical role of healthcare access. While RZV and FLU uptake improved post-pandemic, PnV uptake remained stable. We found no evidence that COVID-19 vaccine safety affected RZV, FLU, and PnV vaccination rates.

Background
This study examined disparities in 1-year mortality rates between infants born to married and unmarried single-parent families, emphasizing the need for targeted health policies.
Methods
Data from 3,298,263 cases, obtained from the South Korea National Statistical Office (2010–2017), were analyzed. T-tests and chi-square tests were used to assess the demographic characteristics of the study group. The number of deaths per 1,000 live births was calculated, and logistic and multivariable logistic regressions were employed to compare infant mortality rates between family types. Additional stratified analyses, based on gestational age and birth weight, further elucidated the relationship between parental marital status and infant mortality.
Results
Infants from unmarried families exhibited a 3.34-fold higher crude odds ratio (OR) for 1-year mortality (95% confidence interval [CI], 2.56–4.36; P<0.001) than that from married families. After adjusting for confounders, the adjusted OR was 1.40 (95% CI, 1.03–1.92). Stratification by gestational age and birth weight revealed crude ORs of 4.62 (95% CI, 3.34– 6.39) in non-preterm infants (≥37 weeks) and 4.76 (95% CI, 3.46–6.56) in non-low-birth-weight infants (≥2.5 kg), highlighting a more pronounced disparity in infants born at or above normal weight and full term. No significant difference (P>0.05) was found in the crude OR for 1-year mortality rates among low-birth-weight (<2.5 kg) or preterm (<37 weeks) infants between the two-family types.
Conclusion
This study highlights the significant disparity in infant mortality rates based on parental marital status, underscoring the need for enhanced social support and tailored policies for unmarried single-parent families.

Metabolism-associated steatotic liver disease (MASLD) is the most prevalent chronic liver condition worldwide and affects nearly 30% of the global population. While traditionally associated with metabolic risk factors, such as obesity and insulin resistance, increasing attention is being directed toward socioeconomic and environmental determinants that contribute to disparities in MASLD prevalence and outcomes. Low-income populations often experience higher rates of MASLD owing to limited access to healthcare, poor diet quality, and reduced opportunities for physical activity. Conversely, high-income countries are witnessing a paradoxical rise in MASLD cases, driven by sedentary lifestyles and excessive consumption of ultra-processed foods. This review examined the effects of socioeconomic status, education, healthcare access, and environmental exposure on the epidemiology of MASLD. The findings revealed that individuals from lower socioeconomic backgrounds and migrant populations experience a disproportionately higher burden of MASLD due to systemic healthcare barriers, dietary transitions, and occupational exposure. Children and adolescents face increasing susceptibility owing to rising obesity rates, and geographic disparities highlight Europe as the most affected region, followed by Asia and North America. Given the growing public health impact of MASLD, addressing both socioeconomic and environmental determinants is essential. Future efforts should prioritize policy-driven interventions, including equitable healthcare access, lifestyle modifications, and research into novel therapeutic approaches to mitigate the disease burden and improve patient outcomes.

Citations

• Barriers and facilitators to non-pharmacological management of metabolic dysfunction-associated steatotic liver disease: a qualitative evidence synthesis
  Yusuf Yilmaz
  Frontiers in Pharmacology.2025;[Epub]     CrossRef
• A review of multidisciplinary care in metabolic dysfunction‐associated steatohepatitis and cardiometabolic disease, with a focus on Canada
  James Kim, Paolo Raggi, Anne‐Marie Carreau, Sean Wharton, Alice Y. Y. Cheng, Mark G. Swain
  Diabetes, Obesity and Metabolism.2025; 27(12): 6831.     CrossRef
• The association between neighborhood context, allostatic load, and metabolic dysfunction-associated steatosis liver disease in Mexican-origin farmworkers along the Southern Arizona US/Mexico border
  A. Maldonado, E. Torres, M. Flores, M. Rodriguez, E.A. Villavicencio, R. Torres, I. Castro, F. Torres, J.C. Loya, N. Alkhouri, S. Carvajal, Garcia
  SSM - Population Health.2025; 32: 101862.     CrossRef
• Sex Hormones and Metabolic Dysfunction-Associated Steatotic Liver Disease
  Ralf Weiskirchen, Amedeo Lonardo
  International Journal of Molecular Sciences.2025; 26(19): 9594.     CrossRef
• Rising burden of steatotic liver disease in women of childbearing age and projections till 2035
  Youxin Wang, Ruiqiu Chen, Shi Yan Lee, Eunice X.X. Tan, Mark Muthiah, Zhou Yu, Margaret L.P. Teng, Jazleen Leo, Cheng Han Ng, Ashok Choudhury, Daniel Q. Huang
  JHEP Reports.2025; : 101646.     CrossRef
• Enhancing MAFLD Care: Efficacy of a Multidisciplinary Community Intervention on Self-Management and Hepatic Outcomes
  Huan-Jing Cai, Hai-Lun Liang, Lei-Yu Shi, Yi-Hui Rong, Jing Li, Yan Zhang, Rui-Fang Ma
  INQUIRY: The Journal of Health Care Organization, Provision, and Financing.2025;[Epub]     CrossRef
• From steatosis to cirrhosis: the role of obesity in the progression of liver disease
  Klaudia Nowak, Maria Paluch, Maja Cudzik, Klaudia Syska, Wiktoria Gawlikowska, Jakub Janczura
  Journal of Diabetes & Metabolic Disorders.2025;[Epub]     CrossRef

Primary care services improve healthcare outcomes and limit unnecessary specialty care. Thus, it is essential to monitor primary care physician demand and supply projections to suggest evidence-based healthcare reforms and promote better healthcare delivery. This study evaluates 28 demand variables, 50 supply variables, and 26 additional variables associated with the demand and supply projections of physicians by reviewing scenarios from other countries, including Taiwan, Singapore, Japan, and the United States of America. The results indicate that Korea uses less diverse demand and supply indicators and suggest the need to implement variables used in the other four countries to improve projection modeling.

Citations

• What is the optimal number of physicians for a sustainable healthcare system?
  Seung-Won Oh
  Korean Journal of Family Medicine.2025; 46(1): 1.     CrossRef

Background
The influx of immigrants into Korea has increased in recent years, affecting Korean society and the healthcare system. This study analyzed the frequency of anxiety and depression in immigrants, which negatively affects their quality of life.
Methods
We analyzed data from a 2020 survey on the Health Rights of Migrants and the Improvement of the Medical Security System. Bivariate analyses and a multiple logistic regression model were used to identify the risk factors associated with the presence of anxiety or depression among immigrants.
Results
We included 746 immigrants, 55.9% of whom were female. The overall rate of anxiety or depression was 31.77%, with 38.3% in females, which was significantly higher than the 26.62% in males. The frequency of anxiety and depression was also strongly associated with certain immigrant groups, including immigrants of African or Western Asian origin (over 64%); those with student visas (60.53%); those who self-reported poor health (52%), physical or mental disabilities (69.23%), or chronic diseases (58.43%); and those facing difficulties accessing medical services (59.47%).
Conclusion
This study showed the frequency of feelings of anxiety or depression and associated risk factors among immigrants. These findings may have implications for policymakers in reducing the likelihood of developing anxiety or depression in the future and improving the quality of life of immigrants in Korea.

Background
Circadian misalignment is associated with metabolic syndrome. This study aimed to examine the association between circadian rhythm-disturbing factors and metabolic syndrome.
Methods
We used data from the 7th and 8th Korea National Health and Nutrition Examination Survey conducted between 2016 and 2020, which surveyed 16,253 individuals. Circadian rhythm-disturbing factors were defined as follows: sleep duration outside the reference group (6–8 hours), irregular breakfast, shift work, and physical inactivity. The adjusted odds ratio (aOR) for metabolic syndrome was calculated based on the number of circadian rhythm-disturbing factors present in adults over the age of 19 years.
Results
Among a total of 16,253 participants (mean age 48.2±15 years), metabolic syndrome was found in 5,237 participants (29.3%). The participants were classified into three categories based on the number of circadian rhythm-disturbing factors as follows: 2,627 (15.6%) did not have any factors, 6,406 (38.13%) had one factor, and 7,220 (46.3%) had two or more factors. Participants with a single circadian rhythm-disturbing factor were 21% more likely to have metabolic syndrome (aOR, 1.21; 95% confidence interval [CI], 1.08–1.36), and participants with two or more factors were 27% more likely to have metabolic syndrome (aOR, 1.27; 95% CI, 1.12–1.43).
Conclusion
Circadian rhythm-disturbing factors were significantly associated with the prevalence of metabolic syndrome in Korean adults. This finding has potential clinical implications for maintaining circadian rhythms by avoiding certain factors to prevent metabolic syndrome. Further studies are required to confirm these findings.

Citations

• Cumulative circadian disruption factors and metabolic syndrome
  Jungun Lee
  Korean Journal of Family Medicine.2025; 46(3): 125.     CrossRef

Background
Prevention and management of metabolic syndrome (MetS) during childhood are crucial. Recently, obesity among children and adolescents has increased with an increase in mothers’ working hours. The present study was conducted to determine the relationship between mothers’ working hours and MetS in their children.
Methods
Data from the 2016–2020 National Health and Nutrition Examination Survey were used, and 2,598 children and adolescents aged 10–18 years were included. Logistic regression analysis was conducted to confirm the association between MetS and mothers’ working hours for each risk factor. Linear regression analysis was conducted to confirm the association between mothers’ working hours and the number of risk factors for MetS.
Results
Abdominal obesity in children was higher when the mothers’ working hours were 53 hours or more (odds ratio [OR], 2.267; 95% confidence interval [CI], 1.21–4.25). In the trend analysis, the OR of children’s abdominal obesity increased significantly as mothers’ working hours increased (P-value <0.05). Additionally, sex-stratified analysis revealed a significant trend between maternal work hours and the presence of MetS in female children (P=0.016). The adjusted OR of the presence of MetS in female children with mothers working 53 hours or more weekly was 6.065 (95% CI, 1.954–18.822).
Conclusion
Mothers’ working hours were highly correlated with the risk of abdominal obesity in their children. The OR of the presence of MetS significantly increased in female children with mothers having longer working hours compared with those with stay-at-home mothers.

Citations

• No, either or both parents with metabolic syndrome: comparative study of its impact on sons and daughters
  Jun-Hong Park, Min Hyung Cho, Hae Sang Lee, Young Suk Shim
  Frontiers in Endocrinology.2025;[Epub]     CrossRef

Background
Sickness presenteeism (SP) refers to the phenomenon where employees attend work while sick, a decision that impacts both their physical and mental well-being and can lead to burnout. This study aimed to determine the prevalence of and factors influencing SP among Thai and foreign teachers following the end of the coronavirus disease 2019 public health emergency of international concern (PHEIC).
Methods
A sample of 400 individuals was analyzed using chi-square tests and logistic regression to obtain odds ratios (ORs) and 95% confidence intervals (CI).
Results
Post-PHEIC, a significant proportion of teachers (51.9%) perceived an increase in their workload, and 62.1% reported having taken health-related leave of absence. The prevalence of SP was high (35.0%). Factors significantly associated with SP (P<0.05) included being younger than 37 years (OR, 1.825; 95% CI, 1.108–3.006), facing monthly financial challenges (OR, 1.627; 95% CI, 1.028–2.575), doing school-related work on holidays (OR, 1.920; 95% CI, 1.180–3.122), and experiencing sleep disturbances owing to work-related stress (OR, 1.910; 95% CI, 1.203– 3.033). No discernible difference existed in SP rates between Thai and foreign teachers.
Conclusion
As a course of action, we recommend the provision of appropriate financial planning resources for teachers. Policywise, school events and activities should be scheduled on working days to ensure that teachers maintain a work-life balance. Additionally, task allocation that caters to individual strengths and limitations can mitigate the effects of SP.

Citations

• Reflecting on progress and challenges: the Korean Journal of Family Medicine in 2024
  Seung-Won Oh
  Korean Journal of Family Medicine.2025; 46(2): 55.     CrossRef
• Influence of low back pain on absenteeism and presenteeism among academics in public universities
  Noordiyana Izyanti Mohamad Saufi, Eva Nabiha Zamri, Hazwani Ahmad Yusof, Nurul Izzah Shari
  WORK: A Journal of Prevention, Assessment & Rehabilitation.2025;[Epub]     CrossRef
• Comprehensive Health Strategies for the Post-pandemic Era: Integrating Physical Health, Psychological Resilience, Lifestyle Choices, and Occupational Well-being
  Su Hwan Cho
  Korean Journal of Family Medicine.2024; 45(6): 303.     CrossRef

Background
This study aimed to examine the effects of different types of skipped meals on cardiometabolic risk factors (CMRF) in Korean adults.
Methods
We analyzed 14,062 adults from the Korea National Health and Nutrition Examination Survey conducted between 2016 and 2018. The irregularity of breakfast, lunch, and dinner consumption was assessed using 24-hour recall data, and we categorized the habit of skipping regular meals into eight types. Multiple linear regression was used to estimate the association between each type of meal skipping and the CMRF. We also presented the estimated effects of individual types of meal skipping on the CMRF based on their predicted values and mean differences.
Results
Korean adults tended to have irregular meal consumption habits when they had one or more of the following characteristics: female sex, under the age of 50 years, middle-high to high household income, high school or college or higher education levels, alcohol consumption, and current smoking. Compared to regular eaters, we have observed significantly higher total cholesterol in the following types of meal skipping: irregular breakfast (IB) (P<0.001), irregular lunch (P=0.005), irregular breakfast and lunch (IBL) (P=0.001), irregular breakfast and dinner (P=0.001); higher low-density lipoprotein-cholesterol in IB (P=0.009); higher triglyceride in IB (P=0.005) and IBL (P=0.034); and higher fasting glucose in IB (P=0.046).
Conclusion
Different types of meal skipping were associated with CMRF. Regular breakfast and lunch consumption should be emphasized to prevent and manage cardiometabolic disorders. However, skipping dinner showed no significant association with CMRF.

Citations

• A Biochemical View on Intermittent Fasting’s Effects on Human Physiology—Not Always a Beneficial Strategy
  Willian F. Zambuzzi, Marcel Rodrigues Ferreira, Zifan Wang, Maikel P. Peppelenbosch
  Biology.2025; 14(6): 669.     CrossRef
• Past Meal-Skipping Habits Associate With Physical Frailty in Later Life: A Retrospective Cohort Study
  Chiharu Nishijima, Kenji Harada, Satoshi Kurita, Masanori Morikawa, Kazuya Fujii, Daisuke Kakita, Hiroyuki Shimada
  Journal of the American Medical Directors Association.2025; 26(12): 105893.     CrossRef
• Primary Care Physicians’ Important Role: Lifestyle Modification for Chronic Disease Management
  Su-Min Jeong
  Korean Journal of Family Medicine.2024; 45(5): 237.     CrossRef

Background
Physical activity (PA) is associated with a favorable metabolic risk profile in adults. However, its role in adolescents remains unclear. In this study, using data (2019–2021) from the 8th Korea National Health and Nutrition Examination Survey, we investigated the optimal exercise type for preventing metabolic complications in adolescents.
Methods
A total of 1,222 eligible adolescent participants (12–18-year-old) were divided into four groups as follows: aerobic exercise (AE), resistance exercise (RE), combined aerobic and resistance exercise (CE), and no exercise (NE). Daily PA was assessed using the international PA questionnaire. Blood samples were collected to measure lipid, glucose, and insulin levels. Additionally, the homeostasis model assessment for insulin resistance (HOMA-IR) and triglyceride-glucose (TyG) indices were measured. Multivariate regression analysis was used to compare the metabolic risk factors across the PA groups before and after propensity score matching (PSM) adjustment for confounding variables.
Results
The CE group exhibited improved fasting glucose levels, lower TyG index, reduced white blood cell count, and higher high-density lipoprotein (HDL) cholesterol levels than the NE group. The RE group exhibited lower mean blood pressure, triglyceride, fasting insulin, HOMA-IR, TyG index and a reduced risk of metabolic syndrome than the NE group. The AE group had higher total and HDL cholesterol levels. In detailed comparison of the AE and RE groups, the RE group consistently exhibited favorable metabolic parameters, including lower blood pressure and total and low-density cholesterol levels, which persisted after PSM.
Conclusion
These findings highlight the positive effects of PA on cardiovascular risk factors in adolescents. Thus, RE may have a more favorable metabolic effect than AE. Further studies are needed to validate the benefits of exercise according to the exercise type.

Citations

• Reflecting on progress and challenges: the Korean Journal of Family Medicine in 2024
  Seung-Won Oh
  Korean Journal of Family Medicine.2025; 46(2): 55.     CrossRef
• Lifestyle interventions for hypertension management in primary care: a narrative review
  Byoungduck Han, Gyu Bae Lee, Jihyun Yoon, Yang-Hyun Kim
  Ewha Medical Journal.2025; 48(4): e56.     CrossRef

Background
Sedentary behavior is associated with several adverse health outcomes. Data on factors that influence sedentary behavior are lacking in Bhutan. This study examined factors associated with increased sedentary behavior in Bhutan, with a focus on exploring sex differences.
Methods
Data of 2,796 adults from the nationally representative 2014 Bhutan STEP-wise surveillance (STEPS) survey were analyzed. Factors associated with sedentary behavior were identified using backward elimination multiple logistic regression analysis, disaggregated by sex. The analysis accounted for the complex survey design used in the primary survey.
Results
The overall prevalence of sedentary behavior was 8.2%, with a higher proportion among women than men (10.3% vs. 4.9%). In the full sample, female sex, being single, high education and income, urban residence, inadequate physical activity, and high blood sugar were associated with increased odds of sedentary behavior. Among females, those who had high education and income, were single, physically less active, and urban residents were more likely to be sedentary. Self-employment was related to reduced odds of sedentary behavior among women and in the overall sample population. In males, being single, higher education level, and urban residence were associated with sedentariness.
Conclusion
The findings suggest that interventions targeting females, especially those who are physically less active and from higher socioeconomic groups, urban residents, and those with hyperglycemia can potentially help reduce sedentary behavior and avert the associated detrimental impacts.

Citations

• High sedentary behavior and low physical activity among adults in Afghanistan: results from a national cross-sectional survey
  Supa Pengpid, Ahmad Siyar Noormal, Karl Peltzer
  Frontiers in Public Health.2023;[Epub]     CrossRef
• Status of Sedentary Time and Physical Activity of Rural Residents: A Cross-Sectional Population-Based Study in Eastern China
  Jiayuan Wang, Ya Wang, Mallikarjuna Korivi, Xi Chen, Rong Zhu
  Frontiers in Public Health.2022;[Epub]     CrossRef
• Trends in sedentary behaviour and associated factors among adults in Mongolia: results from national cross-sectional surveys in 2009, 2013 and 2019
  Supa Pengpid, Karl Peltzer
  BMJ Open.2022; 12(6): e058330.     CrossRef
• Current status of health promotion in Korea
  Soo Young Kim
  Journal of the Korean Medical Association.2022; 65(12): 776.     CrossRef

Avascular necrosis, or osteonecrosis of the femoral head, is a debilitating condition which leads to the destruction of the hip joint due to an interruption in the blood supply to the bony region and is most commonly due to trauma. The case discussed here has been highlighted as it presented as non-traumatic osteonecrosis of the femoral head with an absence of risk factors in a healthy adult male. A 37-year-old male presented with a 4-month history of recurrent left hip pain, which worsened with initiation of movement and weightbearing on the affected side. The patient was overweight but normotensive with a full range of movement of the hips bilaterally. There were no abnormalities detected on initial X-ray images of the left hip. However, due to the persistent pain and sclerotic changes in a subsequent X-ray, a magnetic resonance image of the bilateral hips was obtained, leading to the diagnosis of osteonecrosis of the bilateral femoral heads. Due to the lack of improvement with physiotherapy and analgesia, the patient was subjected to conservative surgery of the symptomatic left hip with concurring evidence of avascular necrosis based on intraoperative anatomical biopsy. This case emphasizes the importance of identifying underlying issues during history taking and physical examination in adults without risk factors. The early diagnosis of osteonecrosis assists in preventing joint collapse and can delay the requirement of joint replacements. High levels of suspicion are necessary to instigate investigation in persistent cases without the presence of risk factors.

Olfactory impairment occurs in patients with Alzheimer’s disease, and olfactory function tests are performed for the diagnosis of Alzheimer’s disease. However, the diagnosis and patient status are not currently outlined for vascular dementia, and many physicians do not consider concurrent vascular dementia in patients complaining of olfactory dysfunction. Here, we report a case of vascular dementia with no symptoms of dementia other than olfactory dysfunction. This case suggested that the olfactory function test is helpful not only for the diagnosis of Alzheimer’s disease but also for the early diagnosis of vascular dementia.

Citations

• Odor-Based Molecular Communications: State-of-the-Art, Vision, Challenges, and Frontier Directions
  Dilara Aktas, Beyza E. Ortlek, Meltem Civas, Elham Baradari, Ahmet B. Kilic, Fatih E. Bilgen, Ayse S. Okcu, Melanie Whitfield, Oktay Cetinkaya, Ozgur B. Akan
  IEEE Communications Surveys & Tutorials.2025; 27(4): 2658.     CrossRef
• Odor Intensity Shift Keying (OISK) and Channel Capacity of Odor-Based Molecular Communications in Internet of Everything
  Aditya Powari, Ozgur B. Akan
  IEEE Transactions on Molecular, Biological, and Multi-Scale Communications.2024; 10(3): 396.     CrossRef
• Inflammation and olfactory loss are associated with at least 139 medical conditions
  Michael Leon, Emily T. Troscianko, Cynthia C. Woo
  Frontiers in Molecular Neuroscience.2024;[Epub]     CrossRef
• Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression
  Michael Leon, Cynthia C. Woo
  Frontiers in Neuroscience.2022;[Epub]     CrossRef

Background
Few studies have been conducted in Korea on concordance regarding chronic diseases and lifestyle factors among couples. We, therefore, evaluated spousal concordance regarding lifestyle factors and chronic diseases among Korean couples.
Methods
A total 1,040 participants (520 couples) who visited family physicians were recruited from 22 hospitals. All participants were aged ≥40 years. Participants completed questionnaires on smoking, drinking, physical activity, and irregular eating habits, including skipping breakfast. We estimated the spousal concordance regarding lifestyle factors and chronic diseases using McNemar tests and logistic regression analysis.
Results
The concordance rate was high among couples who shared unhealthy behaviors, such as low physical activity, irregular diet, and skipping breakfast (P<0.05). When cardiovascular risk factors such as overweight (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.14–2.63), hypertension (OR, 1.88; 95% CI, 1.23–2.86), or hyperlipidemia (OR, 2.41; 95% CI, 1.60–3.64) were prevalent among husbands, the odds that their wives also had the same risk factors at the same time was significantly high. The odds of being depressed when the spouse was depressed were also significantly high in both men (OR, 5.54; 95% CI, 2.19–13.96) and women (OR, 4.52; 95% CI, 1.77–11.53).
Conclusion
There was a high level of concordance regarding lifestyle factors among couples, which could lead to an increase in the prevalence of chronic diseases among couples. In addition, if a spouse has depression, the odds of their partner also having depression was high.

Citations

• Mortality After Partner’s Cancer Diagnosis or Death: A Population-based Prospective Cohort Study in Japan
  Takeshi Makiuchi, Masako Kakizaki, Tomotaka Sobue, Tetsuhisa Kitamura, Hiroshi Yatsuya, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada
  Journal of Epidemiology.2025; 35(3): 118.     CrossRef
• Type D personality as a risk factor for 3-year cardiovascular events in patients with coronary artery disease and their spouse: a prospective cohort study
  Yini Wang, Bingji Huang, Mengru Sun, Bo Yu, Ping Lin
  European Journal of Preventive Cardiology.2025; 32(6): 430.     CrossRef
• Partnership and marriage and risk of type 2 diabetes: a narrative review
  Bernd Kowall, Wolfgang Rathmann
  Diabetologia.2025; 68(4): 704.     CrossRef
• Mechanisms creating homogamy in depressiveness in couples: A longitudinal study from Czechia
  Zsófia Csajbók, Jakub Fořt, Peter K. Jonason, Jan Havlíček, Jakub Binter, Zuzana Štěrbová
  Scientific Reports.2025;[Epub]     CrossRef
• Transgenerational transmission of eating disorders: the role of eating disorder symptoms and socio-cultural attitudes
  Bar Zissu, Helene Sher, Ortal Slobodin
  Journal of Eating Disorders.2025;[Epub]     CrossRef
• Aggregation of type-2 diabetes, prediabetes, and metabolic syndrome in German couples
  Lara Brieger, Sara Schramm, Börge Schmidt, Ulla Roggenbuck, Raimund Erbel, Andreas Stang, Bernd Kowall
  Scientific Reports.2024;[Epub]     CrossRef
• In sickness and health? Examining the co-occurrence and concordance of healthy lifestyle behaviours among spouses in Namibia
  A. Dunn, E.O. Olamijuwon, N. McGrath
  Public Health.2024; 235: 111.     CrossRef
• Concordance of Non-Alcoholic Fatty Liver Disease and Associated Factors among Older Married Couples in China
  Xueli Yuan, Wei Liu, Wenqing Ni, Yuanying Sun, Hongmin Zhang, Yan Zhang, Peng Yin, Jian Xu
  International Journal of Environmental Research and Public Health.2023; 20(2): 1426.     CrossRef
• Spousal Similarities in Cardiovascular Risk Factors in Northern China: A Community-Based Cross-Sectional Study
  Binbin Lin, Li Pan, Huijing He, Yaoda Hu, Ji Tu, Ling Zhang, Ze Cui, Xiaolan Ren, Xianghua Wang, Jing Nai, Guangliang Shan
  International Journal of Public Health.2023;[Epub]     CrossRef
• Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits
  Tanya B. Horwitz, Jared V. Balbona, Katie N. Paulich, Matthew C. Keller
  Nature Human Behaviour.2023; 7(9): 1568.     CrossRef
• Association between behavioral patterns and depression symptoms: dyadic interaction between couples
  Qianhui Yang, Xin Gao, Ying Tang, Hong Gan, Baoling Wang, Mengdie Li, Guixia Pan, Shuangshuang Bao, Peng Zhu, Shanshan Shao, Fangbiao Tao
  Frontiers in Psychiatry.2023;[Epub]     CrossRef
• Association between Ultra-Processed Food Consumption and Excess of Weight in Women with Endometrial Cancer
  Caroline Laranjeira da Silva, Amine Farias Costa, Alex Oliveira da Camara, Lidiane Araújo Cezário, Ana Luisa Kremer Faller, Gabriela Villaça Chaves
  Nutrition and Cancer.2022; 74(3): 927.     CrossRef
• Pregnancy loss and subsequent risk of prediabetes, diabetes and metabolic syndrome in couples: Tehran lipid and glucose study
  Maryam Rahmati, Marzieh Saei Ghare Naz, Fereidoun Azizi, Fahimeh Ramezani Tehrani
  Journal of Translational Medicine.2022;[Epub]     CrossRef
• Spousal concordance of ideal cardiovascular health metrics: findings from the 2014–2019 Korea National Health and Nutrition Examination Survey
  Manh Thang Hoang, Hokyou Lee, Hyeon Chang Kim
  Clinical Hypertension.2022;[Epub]     CrossRef
• Gender differences in the longitudinal association between husbands' and wives' depressive symptoms among Korean older adults: the moderating effects of the spousal relationship
  Jiwon Baek, Yoosik Youm, Hyeon Chang Kim
  Quality of Life Research.2021; 30(12): 3535.     CrossRef
• Spousal Concordance in Dietary Behaviors and Metabolic Components, and Their Association: A Cross-Sectional Study
  Dann-Pyng Shih, Chu-Ting Wen, Hsien-Wen Kuo, Wen-Miin Liang, Li-Fan Liu, Chien-Tien Su, Jong-Yi Wang
  Nutrients.2020; 12(11): 3332.     CrossRef

Background
We evaluated the effects of socioeconomic factors and psychosocial factors, both individually and combined, on all-cause mortality risk (mortality risk).
Methods
We conducted an 8-year (2006–2014) longitudinal analysis of 10,247 individuals who took part in the Korean Longitudinal Study of Aging, a nationwide survey of people aged 45–79 years. Socioeconomic vulnerability (SEV) was assessed with factors such as education, household income, commercial health insurance, and residential area. Mental health (MH) was assessed with factors such as depression, social engagement, and life satisfaction. The covariates were age, gender, marital status, cohabiting, number of chronic diseases, and health behaviors such as regular exercise, smoking, and alcohol intake. We used a Cox proportional hazard analysis to investigate the effects of SEV and MH on mortality risk and also to analyze the superimposed effects of SEV-MH on mortality risk.
Results
After the controlling for the covariates, high SEV and negative MH were found to be strong predictors of all-cause mortality. The highest quartile of SEV (vs. lowest) had a 1.70 times greater mortality risk (hazard ratio [HR], 1.70; 95% confidence interval [CI], 1.24–2.33) and the highest quartile of MH (vs. lowest) had a 2.13 times greater mortality risk (HR, 2.13; 95% CI, 1.72–2.64). Being in the highest quartile for both SEV and MH (vs. lowest) increased mortality risk more than 3 times (HR, 3.11; 95% CI, 2.20–4.40).
Conclusion
High SEV and negative MH were independently associated with increased mortality risk, and their superimposed effects were associated with an increased risk of mortality.

Citations

• Sustained Low Income, Income Changes, and Risk of All-Cause Mortality in Individuals With Type 2 Diabetes: A Nationwide Population-Based Cohort Study
  Hong Seok Lee, Jimin Clara Park, Inkwan Chung, Junxiu Liu, Seong-Su Lee, Kyungdo Han
  Diabetes Care.2023; 46(1): 92.     CrossRef
• The role of social factors in the successful ageing – Systematic review
  J. Takács, C. Nyakas
  Developments in Health Sciences.2022; 4(1): 11.     CrossRef
• Combined Effects of Depression and Chronic Disease on the Risk of Mortality: The Korean Longitudinal Study of Aging (2006-2016)
  Hyunji Kim, Sung Hi Kim, Yoon Jeong Cho
  Journal of Korean Medical Science.2021;[Epub]     CrossRef
• KLoSA—Korean Longitudinal Study of Aging
  Jungun Lee
  Korean Journal of Family Medicine.2020; 41(1): 1.     CrossRef

Background
Peripheral arterial disease (PAD) can progress silently without any clinical symptoms. Ankle-brachial index (ABI) is the recommended method used in primary care. We aimed to determine the prevalence of PAD and its related risk factors in primary care.
Methods
In this cross-sectional study, 250 participants aged ≥45 years were recruited randomly from the registered patients of family health center in a district of Izmir, Turkey. Patients’ demographic data, PAD symptoms, and PAD risk factors were obtained. The PAD group consisted of patients with ABI levels <0.9; the non-compressible artery (NCA) group consisted of patients with ABI levels >1.3.
Results
The prevalence of PAD was 17.6% (22.5% in women and 11.1% in men), while that of NCA was 15.2% (12.7% in women and 25.0% in men). About 27.3% and 54.5% of patients with PAD did not have claudication and problems with walking distance, respectively. Of the NCA patients, 15.8% had problems with walking distance and 39.5% had claudication. Regression analysis revealed two predictors of PAD (age ≥65 years: odds ratio [OR], 3.51; 95% confidence interval [CI], 1.65–7.47; claudication: OR, 3.41; 95% CI, 1.58–7.39) and three predictors of NCA (age <65 years: OR, 2.55; 95% CI, 1.01–6.45; male sex: OR, 2.40; 95% CI, 1.10–5.25; triglyceride [TG] >200 mg/dL: OR, 4.11; 95% CI, 1.58–10.67).
Conclusion
PAD had a prevalence of 17.6% and was associated with age ≥65 years and claudication. NCA had a prevalence of 15.2% and was associated with age <65 years, TG >200 mg/dL, and male sex.

Citations

• Orem’s Self-Care Deficit Nursing Theory with Persons with Peripheral Artery Disease: A Mixed Method Study
  Nevra Kalkan, Mevlude Karadağ
  Nursing Science Quarterly.2025; 38(1): 55.     CrossRef
• Predictive Factors of Peripheral Arterial Disease in Home Care Patients
  Halis Yılmaz, Seda Arslan Özkul, Kübra Temel Aslan, Pemra Cöbek Ünalan, Çiğdem Apaydın Kaya
  Konuralp Tıp Dergisi.2024; 16(3): 225.     CrossRef
• Differences in Symptom Presentation in Women and Men with Confirmed Lower Limb Peripheral Artery Disease: A Systematic Review and Meta-Analysis
  Cindy P. Porras, Michiel L. Bots, Martin Teraa, Sander van Doorn, Robin W.M. Vernooij
  European Journal of Vascular and Endovascular Surgery.2022; 63(4): 602.     CrossRef
• The Frequency of Primary Healthcare Contacts Preceding the Diagnosis of Lower-Extremity Arterial Disease: Do Women Consult General Practice Differently?
  Cindy P. Porras, Martin Teraa, Michiel L. Bots, Annemarijn R. de Boer, Sanne A. E. Peters, Sander van Doorn, Robin W. M. Vernooij
  Journal of Clinical Medicine.2022; 11(13): 3666.     CrossRef
• Ankle-brachial Index and associated factors in individuals with coronary artery disease
  Saulo Henrique Salgueiro de Aquino, Isabelle Tenório Melo, Carlos Dornels Freire de Souza, Francisco de Assis Costa
  Revista da Associação Médica Brasileira.2020; 66(4): 407.     CrossRef

Background
Fertility and childbearing are the most important determinants of population variation around the world. This study was conducted with the aim of determining the psychological and sociodemographic factors predicting fertility intention among women referred to comprehensive health centers in Hamadan based on the beliefs, attitudes, subjective norms, and enabling factors (BASNEF) model.
Methods
This descriptive analytical study was performed in comprehensive health centers in Hamadan in 2016. Through a multi-stage sampling method, 484 women were enrolled in the study. The data collection tool was a selfreport questionnaire based on the constructs of the BASNEF model. Data were analyzed using linear regression, independent t-test, and a one-way analysis of variance using IBM SPSS software ver. 22.0 (IBM Corp., Armonk, NY, USA).
Results
The mean±standard deviation of the women’s age was 31.85±6.13 years. The variables of motivation to comply (β=0.228), enabling factors (β=0.162), subjective norms (β=0.134), and attitude (β=0.122) were the predictors of fertility intention in women. This model was able to explain 16.8% of variance in behavioral intention. Also, lower age, higher education, shorter duration of marriage, and having a daughter resulted in a greater fertility intention.
Conclusion
It seems that designing and implementing educational programs to improve attitudes, promoting positive subjective norms, and enhancing enabling factors can play a major role in increasing fertility intention in women.

Citations

• The effect of motivational interviewing on attitude and intention for childbearing in healthcare provider women
  Akram Rahimi, Moslem Taheri, Maryam Dafei, Fatemeh ZareMobini
  BMC Psychology.2025;[Epub]     CrossRef
• Examining the Relationship between Parents' Spiritual Health and the Desire to Have Children: A Systematic Review
  Rasoul Raesi, Hossein Shamsi Gooshki, Seyed Saeed Tabatabaee, Abolfazl Khoshi, Seyed Hassan Saadat, Salman Daneshi, Saied Bokaie, Kiavash Hushmandi
  The Open Public Health Journal.2025;[Epub]     CrossRef
• The Relationship Between Social Determinants of Health and Attitudes Towards Childbearing with the Mediation of Social Support Among Women of Reproductive Age: A Path Analysis
  Fereshte Ghahremani, Mahbobeh Ahmadi Doulabi, Zohreh Mahmoodi, Malihe Nasiri
  Iranian Journal of Psychiatry and Behavioral Sciences.2025;[Epub]     CrossRef
• “May we not orchestrate our own misfortune”: a qualitative study on perception about causes and prevention of occupational injuries among bricklayers and carpenters in Osun State, Nigeria
  Temitope Olumuyiwa Ojo, Nisha Naicker, Funmilayo Juliana Afolabi, Adedeji Ayodeji Onayade
  Frontiers in Public Health.2025;[Epub]     CrossRef
• Examining the impact of an educational intervention on enhancing different aspects of health-promoting behaviors: using the BAZNEF model
  Sahar Mohammad Nabizadeh
  Health Education.2025; 125(5): 553.     CrossRef
• Factors affecting subsequent dose of COVID-19 vaccine uptake based on BASNEF model among older adults
  Majid Barati, Hanieh Jormand, Salman Khazaei, Saeed Bashirian, Mohadeseh Sadri, Maryam Afshari
  BMC Infectious Diseases.2024;[Epub]     CrossRef
• Immediate Antecedents of Intentions for Having Children in Southeast Iranian Women
  Javad Ghasemi, Mansoureh Safizadeh, Zahra Khajeh, Nouzar Nakhaee
  Korean Journal of Family Medicine.2023; 44(5): 289.     CrossRef
• Attitude of childless married women towards childbearing in Zanjan, Iran
  Fereshteh Naderipour, Jamileh Abolghasemi, Tahereh Dehdari, Roghayeh Nouri
  Payesh (Health Monitor) Journal.2023; 22(3): 335.     CrossRef
• Factors affecting childbearing intention in women employees in Birjand: Application of the theory of planned behavior
  Toktam Alizadeh, Mitra Moodi, Fatemeh Salmani, Asieh Moudi
  Journal of Education and Health Promotion.2023;[Epub]     CrossRef
• Spatial Variations in Fertility Desire in West Africa
  Ezra Gayawan, Fidelia Dake, Justin Dansou, Olusegun Sunday Ewemooje
  Spatial Demography.2022; 10(2): 359.     CrossRef
• Factors Affecting Fertility Intention Among People Living with HIV in Kunming, China
  Yingwu Guo, Yingrong Du, Sanguan Lerkiatbundit, Jun Liu, Jingsong Bai, Yongrui Yang, Yin Yang, Aihui Wu, Virasakdi Chongsuvivatwong
  HIV/AIDS - Research and Palliative Care.2022; Volume 14: 265.     CrossRef
• Understanding the rationales behind childbearing
  Babak Moeini, Amir Erfani, Majid Barati, Amin Doosti-Irani, Hatam Hosseini, Mokhtar Soheylizad
  Journal of Education and Health Promotion.2022; 11(1): 119.     CrossRef
• Effect of Training Program on Snack Consumption in Elementary School Girls: Application of the BASNEF Model
  Zahra Jalili, Zahra Saboohi, Reza Tavakoli
  Journal of Education and Community Health.2021; 8(1): 3.     CrossRef
• The association of psychological well-being and fertility intention in parents of children with intellectual disability: A foundation for reproductive education
  Sepideh Sheidanik, Mitra Savabi-Esfahani, Amir Ghamarani, Amir Erfani
  Journal of Education and Health Promotion.2021;[Epub]     CrossRef
• Determinants of fertility intentions among women of reproductive age in South Africa: evidence from the 2016 demographic and health survey
  Olusegun Sunday Ewemooje, Elizabeth Biney, Acheampong Yaw Amoateng
  Journal of Population Research.2020; 37(3): 265.     CrossRef
• The Effect of Home Base Physical Activity Program based on the BASNEF Model on Motor Recovery in Patients with Stroke
  Fatemeh Esteki-Ghashghaei, Mohammad Saadatnia, Fariborz Khorvash, Hossein Shahnazi
  Home Health Care Services Quarterly.2020; 39(3): 154.     CrossRef

Background
Knee osteoarthritis is highly prevalent, especially among the elderly. However, its risk factors have not been well identified, especially in the Korean population. This study aimed to assess the epidemiologic characteristics and risk factors of knee osteoarthritis in the Korean population.
Methods
Data of 2,280 (1,295 women) participants of the 2013 Korea National Health and Nutrition Examination Survey aged ≥50 years who underwent knee radiography were analyzed. According to the American College of Rheumatology clinical/radiographic classification criteria, knee osteoarthritis was defined as knee pain and radiographic knee osteoarthritis. The association between risk factors and knee osteoarthritis was analyzed using the chi-square test and binominal logistic regression.
Results
The participants had an average age of 62.6 years; 56.8% of them were women. The average body mass index was 24.2 kg/m2 , and 296 (13%) participants were diagnosed with knee osteoarthritis. After adjustment for multiple risk factors, age of ≥65 years (adjusted odds ratio [OR], 2.552; 95% confidence interval [CI], 1.868–3.486), female sex (OR, 2.050; 95% CI, 1.275–3.295), obesity (body mass index, ≥25.0 kg/m2 ; OR, 1.563; 95% CI, 1.191–2.051), hypertension (OR, 1.394; 95% CI, 1.052–1.846), low educational level (lower than or equal to elementary school: OR, 4.761; 95% CI, 2.131–10.635; middle school: OR, 3.184; 95% CI, 1.375–7.369), and low strength exercise frequency (<2 times/wk; OR, 1.829; 95% CI, 1.202–2.784) increased the risk of knee osteoarthritis.
Conclusion
Old age, sex, obesity, hypertension, low educational level, and low strength exercise frequency were found to be risk factors for knee osteoarthritis.

Citations

• Effect of knee pain on muscles imbalance and physical limitation in individuals with bilateral knee osteoarthritis: A comparative cross-sectional study
  Shabana Khan, Huma Waseem, Uzair Ahmad
  Journal of Musculoskeletal Surgery and Research.2024; 8: 119.     CrossRef
• Prevalence and Risk Factors of Osteoarthritis in Korea: A Cross-Sectional Study
  Do-Youn Lee
  Medicina.2024; 60(4): 665.     CrossRef
• The association between ADAMTS14/rs4747096 gene polymorphism and some risk factors and knee osteoarthritis
  Ghada A. Elshaarawy, Iman I. Salama, Somaia I. Salama, Amany H. Abdelrahman, Mirhane Hassan, Eman Eissa, Sherif Ismail, Sherif E. Eldeeb, Doaa E. Ahmed, Hazem Elhariri, Rasmia Elgohary, Aida M. Abdelmohsen, Walaa A. Fouad, Hala M. Raslan
  BMC Musculoskeletal Disorders.2024;[Epub]     CrossRef
• The relationship between experience of knee pain and physical activity participation: A scoping review of quantitative studies
  Lu Yang, Peipei Wang, Bronwyn McGill
  International Journal of Nursing Sciences.2023; 10(2): 258.     CrossRef
• Assessment of the quality of life in patients with knee osteoarthritis
  Natasa Milenovic, Marijana Hornjak, Sonja Lukac, Ana Simundja, Milan Veselinovic, Gordan Bajic
  Medicinski pregled.2022; 75(3-4): 103.     CrossRef
• Metabolic syndrome, hypertension, and hyperglycemia were positively associated with knee osteoarthritis, while dyslipidemia showed no association with knee osteoarthritis
  Yinhao Xie, Wei Zhou, Zhihong Zhong, Ziping Zhao, Haotao Yu, Yaxiang Huang, Ping Zhang
  Clinical Rheumatology.2021; 40(2): 711.     CrossRef
• Association of the Risk of Osteoarthritis and Hypertension in the Korean Adult Population Aged 40–59 in Pre- and Postmenopausal Women: Using Korea National Health and Nutrition Examination Survey 2012–2016 Data
  Mikyung Ryu, Ji Sun Ha, Sol Lee, Weon-Chil Baek, Heejin Kimm, Ho Gym, Massimo Salvetti
  International Journal of Hypertension.2021; 2021: 1.     CrossRef
• Healthcare Utilization and Knee Osteoarthritis Symptoms among Urban Older Malaysian
  Siti Salwana Kamsan, Devinder Kaur Ajit Singh, Maw Pin Tan, Saravana Kumar
  International Journal of Environmental Research and Public Health.2021; 18(7): 3777.     CrossRef
• The multimorbidity of hypertension and osteoarthritis and relation with sleep quality and hyperlipemia/hyperglycemia in China’s rural population
  Li Ran, Qi Chen, Jingyi Zhang, Xinlong Tu, Xiaodong Tan, Yuting Zhang
  Scientific Reports.2021;[Epub]     CrossRef
• A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
  Ka-Won Kang, Ji Eun Song, Byung-Hyun Lee, Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Yong Park, Byung Soo Kim
  Scientific Reports.2021;[Epub]     CrossRef
• Barriers to and Facilitators of Physical Activity among Korean Female Adults with Knee Osteoarthritis and Comorbidity: A Qualitative Study
  Eunyoung Park, Hyung-Ran Park, Eui-Sung Choi
  Healthcare.2020; 8(3): 226.     CrossRef
• Prevalence of sarcopenia in community-dwelling older adults using the definition of the European Working Group on Sarcopenia in Older People 2: findings from the Korean Frailty and Aging Cohort Study
  Miji Kim, Chang Won Won
  Age and Ageing.2019; 48(6): 910.     CrossRef
• Multimodal neural block analgesia versus morphine analgesia after elective knee surgery
  Dragana Lončar-Stojiljković
  Scripta Medica.2019; 50(3): 122.     CrossRef
• Comparison of Knee Muscle Strength and Endurance of Affected Legs of Korean Women Diagnosed with Kellgren-Lawrence grade (K-L II) by Age
  Soung-Kyun Hong, Dong-Geon Lee, Sun-Hae Song, Seung-Hoo Lee, Doo-Chul Shin
  Journal of The Korean Society of Physical Medicine.2019; 14(4): 1.     CrossRef
• Proximal fibular osteotomy in the treatment of medial osteoarthritis of the knee – A narrative review of literature
  Saseendar Shanmugasundaram, Srinivas B. S. Kambhampati, Samundeeswari Saseendar
  Knee Surgery & Related Research.2019;[Epub]     CrossRef

Background
Hypertension is a major contributor to the global disease burden of cardiovascular and cerebrovascular disease. The aim of this study was to determine demographic and clinical factors associated with adherence to antihypertensive medication.
Methods
From August 2012 to February 2015, we recruited 1,523 Korean patients with hypertension who visited family physicians. The study was conducted in 24 facilities located in urban and metropolitan areas. Of these facilities, two were primary care clinics and 22 were level 2 or 3 hospitals. Adherence was assessed using the pill count method; a cut-off value of 80% was used as the criterion for good adherence. Sociodemographic and lifestyle factors were compared between the adherent and nonadherent groups using the chi-square test for categorical variables and t-test for continuous variables. Binary logistic regression analysis was performed with medication adherence as the outcome variable.
Results
Of the 1,523 patients, 1,245 (81.7%) showed good adherence to antihypertensive medication. In the multivariate logistic analysis, age ≥65 years, exercise, treatment in a metropolitan-located hospital, being on ≥2 classes of antihypertensive medication and concomitant medication for diabetes, and a family history of hypertension or cardiovascular diseases were associated with good adherence. Patients who had a habit of high salt intake were less adherent to medication.
Conclusion
Multiple classes of antihypertensive medications, concomitant medication, and exercise were associated with good adherence to antihypertensive medication, and high salt intake was associated with poor adherence to antihypertensive medication. These factors should be considered to improve hypertension control.

Citations

• Prevalence of antihypertensive medication adherence and associated factors in India: A systematic review and meta-analysis
  B. Pal, A. Dutta, V. Chaudhary, S. Kumari, S. Meenakshi, K. Murti
  Hipertensión y Riesgo Vascular.2025; 42(3): 156.     CrossRef
• Analysis of Adherence Status and Influencing Factors Among Middle‐Aged and Elderly Hypertension Patients in Rural Areas of Northeast China
  Xinyuan Lu, Jiwei Wang, Sikun Chen, Lin Lv, Jinming Yu, Peng Geng
  International Journal of Hypertension.2025;[Epub]     CrossRef
• Adherence to hypertension management at a rural hospital in Limpopo: A cross-sectional study
  Murendeni F. Sikhau, Mbuyisa J. Makhubu, Gert J.O. Marincowitz, Clara Marincowitz
  South African Family Practice.2025;[Epub]     CrossRef
• Development and Validation of Predictive Models for Non-Adherence to Antihypertensive Medication
  Cristian Daniel Marineci, Andrei Valeanu, Cornel Chiriță, Simona Negreș, Claudiu Stoicescu, Valentin Chioncel
  Medicina.2025; 61(7): 1313.     CrossRef
• Self-care practice and associated factors among hypertensive patients in Ethiopia: Umbrella review of systematic review and meta-analysis studies
  Sefineh Fenta Feleke, Anteneh Mengist Dessie, Atitegeb Abera Kidie, Muluemebet Kassa, Tesfaye Engdaw Habtie, Natnael Amare Tesfa, Zenebe Daniel Getachew, Tadele Emagneneh, Wagaw Abebe
  International Journal of Nursing Studies Advances.2025; 9: 100433.     CrossRef
• Frequency of missed doses and its effects on the regulation of glucose levels in patients with type 2 diabetes: A retrospective analysis
  Megumi Shiomi, Tesshu Takada, Katsuya Otori, Kiyoshi Shibuya
  Medicine.2024; 103(15): e37711.     CrossRef
• Non-adherence to appointment follow-up and its associated factors among hypertensive patients in follow-up clinics in South Gondar hospitals
  Gebrie kassaw Yirga, Getu Sisay Mekonen, Endalk Getasew Hiruy, Kirubel Shiferaw, Berihun Bantie
  Scientific Reports.2024;[Epub]     CrossRef
• Factors associated with suboptimal adherence to antihypertensive medication: Cross-sectional study using nationally representative databases
  Sangyong Jo, Taegyu Um, Jihye Shin, Dongchan Lee, Kyungil Park, Minkook Son
  Heliyon.2024; 10(19): e38531.     CrossRef
• ОСОБЛИВОСТІ ПАЦІЄНТ-ОРІЄНТОВАНОГО СПІЛКУВАННЯ ІЗ ПАЦІЄНТОМ З АРТЕРІАЛЬНОЮ ГІПЕРТЕНЗІЄЮ
  Д. О. Лагода
  Здобутки клінічної і експериментальної медицини.2024; (4): 39.     CrossRef
• Blood Pressure Profile and Factors Affecting Medication Adherence in Older Persons with Hypertension in Two Care Centers
  Chinonyerem O. Iheanacho, Agbaje Akeem Babatunde, Uchenna I. H. Eze
  Ageing International.2023; 48(3): 729.     CrossRef
• Opportunities of Amlodipine as a Potential Candidate in the Evaluation of Drug Compliance during Antihypertensive Therapy
  Dmitrijs Kustovs, Inga Urtāne, Eduards Sevostjanovs, Eva Moreino, Kārlis Trušinskis
  Medicina.2023; 59(2): 340.     CrossRef
• Impact of health literacy and social support on medication adherence in patients with hypertension: a cross-sectional community-based study
  Aizhen Guo, Hua Jin, Jianbo Mao, Weihong Zhu, Ye Zhou, Xuhua Ge, Dehua Yu
  BMC Cardiovascular Disorders.2023;[Epub]     CrossRef
• Effectiveness of the Combination of Enalapril and Nifedipine for the Treatment of Hypertension versus Empirical Treatment in Primary Care Patients
  Humberto Badillo-Alonso, Marisol Martínez-Alanis, Ramiro Sánchez-Huesca, Abel Lerma, Claudia Lerma
  Journal of Cardiovascular Development and Disease.2023; 10(6): 243.     CrossRef
• Factors Influencing Medication Adherence in Elderly Patients with Hypertension: A Single Center Study in Western China
  Qiuyu Pan, Cheng Zhang, Lansicheng Yao, Chenyao Mai, Jinpeng Zhang, Zhitong Zhang, Jun Hu
  Patient Preference and Adherence.2023; Volume 17: 1679.     CrossRef
• The Development and Validation of the “Hippocratic Hypertension Self-Care Scale”
  Hero Brokalaki, Anastasia A. Chatziefstratiou, Nikolaos V. Fotos, Konstantinos Giakoumidakis, Evaggelos Chatzistamatiou
  Healthcare.2023; 11(18): 2579.     CrossRef
• Adherence Behaviors and Related Factors Among Elderly Hypertensive Patients in China: Evidence from the China Health and Retirement Longitudinal Study
  Fengyu Liu, Huajing Chang, Xiaojun Liu
  Patient Preference and Adherence.2023; Volume 17: 3539.     CrossRef
• Predictors of non-adherence to antihypertensive medications: A cross-sectional study from a regional hospital in Afghanistan
  Muhammad Haroon Stanikzai, Mohammad Hashim Wafa, Essa Tawfiq, Massoma Jafari, Cua Ngoc Le, Abdul Wahed Wasiq, Bilal Ahmad Rahimi, Ahmad Haroon Baray, Temesgen Anjulo Ageru, Charuai Suwanbamrung, Kahsu Gebrekidan
  PLOS ONE.2023; 18(12): e0295246.     CrossRef
• The Indian REgistry on Current Patient PrOfiles and TReatment TrenDs in Hypertension (RECORD): Final Outcomes of the Real-world Observational Study
  Girish C Rajadhyaksha, Himanshu Reddy, Amresh K Singh, Abraham Oomman, Srilakshmi M Adhyapak, Mayur Jadhav, Sachin Suryawanshi, Rujuta Gadkari, Sumit Bhushan, Prashant Mishra, Hanmant Barkate
  Journal of the Association of Physicians of India.2023; 71(11): 43.     CrossRef
• Burden of hypertension in Ghana – Analysis of awareness and screening campaign in the Ashanti Region of Ghana
  Elliot Koranteng Tannor, Obed Ofori Nyarko, Yaw Adu-Boakye, Saabea Owusu Konadu, Gilda Opoku, Frank Ankobea-Kokroe, Mercy Opare Addo, Evans Xorse Amuzu, Gilgal Justice Ansah, Kate Appiah-Boateng, Daniel Ansong
  JRSM Cardiovascular Disease.2022;[Epub]     CrossRef
• Antihypertensive medications adherence and associated uncontrolled blood pressure among hypertensive patients in Ethiopia: Systematic review and meta-analysis
  Melaku Desta, Desalegn Yibeltal, Peter Memiah, Temesgen Ayenew, Henok Mulugeta, Mihretie Gedefaw, Bekalu Bewket Kidanie, Molla Yigzaw Birhanu, Zenaw Tessema, Belayneh Mengist, Muluneh Alene, Muluye Molla Simieneh, Atsede Alle Ewunetie, Wondimeneh Shibabaw
  International Journal of Africa Nursing Sciences.2022; 16: 100404.     CrossRef
• Association of adherence measured by self-reported pill count with achieved blood pressure level in hypertension patients: a cross-sectional study
  Iin Ernawati, Eziah Ika Lubada, Ria Lusiyani, Rahmad Aji Prasetya
  Clinical Hypertension.2022;[Epub]     CrossRef
• Urban-Rural Difference in Treatment Adherence of Chinese Hypertensive Patients
  Jingjing Pan, Haizhen Yu, Bin Hu, Qiongge Li
  Patient Preference and Adherence.2022; Volume 16: 2125.     CrossRef
• Prevalence of Hypertension in Ghana: Analysis of an Awareness and Screening Campaign in 2019
  Elliot Koranteng Tannor, Obed Ofori Nyarko, Yaw Adu-Boakye, Saabea Owusu Konadu, Gilda Opoku, Frank Ankobea-Kokroe, Mercy Opare-Addo, Lambert Tetteh Appiah, Evans Xorse Amuzu, Gilgal Justice Ansah, Kate Appiah-Boateng, Emmanuel Ofori, Daniel Ansong
  Clinical Medicine Insights: Cardiology.2022;[Epub]     CrossRef
• Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta‐Analysis Involving 27 Million Patients
  Eric K. P. Lee, Paul Poon, Benjamin H. K. Yip, Yacong Bo, Meng‐Ting Zhu, Chun‐Pong Yu, Alfonse C. H. Ngai, Martin C. S. Wong, Samuel Y. S. Wong
  Journal of the American Heart Association.2022;[Epub]     CrossRef
• Assessment of Patients’ Views on Drug Benefits and Risks: An Interview Study with Cardiovascular Patients
  Ines Wakob, Ina Wintsche, Annett Frisch, Yvonne Remane, Ulrich Laufs, Thilo Bertsche, Susanne Schiek, Yigit Canga
  International Journal of Clinical Practice.2022;[Epub]     CrossRef
• Determinants of Adherence to Antihypertensives Among Elderly: A Multifactorial Concern
  Melita Sheilini, H Manjunatha Hande, Elsa Sanatombi Devi, Asha Kamath, Baby S Nayak, Donald E Morisky, Anice George
  Patient Preference and Adherence.2022; Volume 16: 3185.     CrossRef
• Factors related to treatment adherence among hypertensive patients: A cross-sectional study in primary healthcare centers in Taif city
  Mohammed A. Alsofyani, Adel O. Aloufi, Nada S. Al-Qhtani, Sarah O. Bamansour, Raghad S. Almathkori
  Journal of Family and Community Medicine.2022; 29(3): 181.     CrossRef
• Determining the Prevalence of and the Factors Associated with Antihypertensive Medication Non-Adherence in the Gaza Strip
  Khalid Khadoura, Elham Shakibazadeh, Mohammad Ali Mansournia, Yousef Aljeesh, Akbar Fotouhi
  Korean Journal of Family Medicine.2021; 42(2): 150.     CrossRef
• Prevalence of non-adherence to antihypertensive medication in Asia: a systematic review and meta-analysis
  Sajid Mahmood, Zahraa Jalal, Muhammad Abdul Hadi, Tahir Mehmood Khan, M. Sayeed Haque, Kifayat Ullah Shah
  International Journal of Clinical Pharmacy.2021; 43(3): 486.     CrossRef
• Adherence to Antihypertensive Medication and Incident Cardiovascular Events in Young Adults With Hypertension
  Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Ji Eun Heo, Dong-Wook Kim, Sungha Park, Donald M. Lloyd-Jones, Hyeon Chang Kim
  Hypertension.2021; 77(4): 1341.     CrossRef
• Medication Adherence and Effective Management of Hypertension
  Seung-Won Oh
  Korean Journal of Family Medicine.2021; 42(2): 89.     CrossRef
• Self-Care Practice and Associated Factors among Hypertensive Patients in Ethiopia: A Systematic Review and Meta-Analysis
  Adam Wondmieneh, Getnet Gedefaw, Addisu Getie, Asmamaw Demis, Kai Hu
  International Journal of Hypertension.2021; 2021: 1.     CrossRef
• Effects of morbidity on smoking cessation: a national smoking cessation program
  Young-Gyun Seo, Min-Woo Jo, Yu-Jin Paek, Jaekyung Choi
  Addiction Science & Clinical Practice.2021;[Epub]     CrossRef
• Behavioral Factors Associated with Medication Nonadherence in Patients with Hypertension
  Shu-Mei Chang, I-Cheng Lu, Yi-Chun Chen, Chin-Feng Hsuan, Yin-Jin Lin, Hung-Yi Chuang
  International Journal of Environmental Research and Public Health.2021; 18(18): 9614.     CrossRef
• Patient adherence to antihypertensive medications in upper Egypt: a cross-sectional study
  Ahmed Hussein, Mohammad Shafiq Awad, Hossam Eldin M. Mahmoud
  The Egyptian Heart Journal.2020;[Epub]     CrossRef
• Factors associated with nonadherence to antihypertensive medication among middle-aged adults with hypertension: findings from the Taiwan National Health Interview Survey
  Chia-Pei Chou, Chun-Yu Chen, Kun-Siang Huang, Shih-Chun Lin, Chih-Fang Huang, Malcolm Koo
  Journal of International Medical Research.2020;[Epub]     CrossRef
• Impact of satisfaction with physician–patient communication on self-care and adherence in patients with hypertension: cross-sectional study
  Natalia Świątoniowska-Lonc, Jacek Polański, Wojciech Tański, Beata Jankowska-Polańska
  BMC Health Services Research.2020;[Epub]     CrossRef
• Mediating Effect of Self-Efficacy on the Relationship Between Medication Literacy and Medication Adherence Among Patients With Hypertension
  Zhiying Shen, Shuangjiao Shi, Siqing Ding, Zhuqing Zhong
  Frontiers in Pharmacology.2020;[Epub]     CrossRef
• Influence of socio-demographic factors and length of disease on adherence of patients with arterial hypertension
  Marijana Jandrić-Kočič, Snežana Knežević
  Timocki medicinski glasnik.2020; 45(4): 140.     CrossRef
• Baixo Letramento em Saúde: uma realidade brasileira
  Josué Da Silva Brito, Christiano Tadeu Sanches Mattos Kilesse, Priscilla Itatianny De Oliveira Silva
  HU Revista.2020; 46: 1.     CrossRef
• Association of Total Medication Burden With Intensive and Standard Blood Pressure Control and Clinical Outcomes: A Secondary Analysis of SPRINT
  Catherine G. Derington, Tyler H. Gums, Adam P. Bress, Jennifer S. Herrick, Tom H. Greene, Andrew E. Moran, William S. Weintraub, Ian M. Kronish, Donald E. Morisky, Katy E. Trinkley, Joseph J. Saseen, Kristi Reynolds, Jeffrey T. Bates, Dan R. Berlowitz, Ta
  Hypertension.2019; 74(2): 267.     CrossRef
• Association Between Medication Literacy and Medication Adherence Among Patients With Hypertension
  Shuangjiao Shi, Zhiying Shen, Yinglong Duan, Siqing Ding, Zhuqing Zhong
  Frontiers in Pharmacology.2019;[Epub]     CrossRef
• Assessment of adherence to drug treatment and affecting factors among hypertensive patients
  Burkay YAKAR, Asli AZAKOGLU KARACA, Erhan ONALAN
  Family Practice and Palliative Care.2019; 4(3): 89.     CrossRef
• Medication Adherence in Korean Hypertensive Patients
  Young Gyu Cho
  Korean Journal of Family Medicine.2018; 39(6): 323.     CrossRef

Background
Few studies have evaluated risk factors for behavioral and psychological symptoms of dementia at the initial assessment for Alzheimer disease in large patient samples. In this study, the factors influencing Alzheimer disease were examined using the Clinical Research of Dementia of South Korea data.
Methods
This cross-sectional study was conducted using data of 1,128 patients with Alzheimer disease. The behavioral and psychological symptoms of dementia were examined using the Korean version of the Neuropsychiatric Inventory. Demographic characteristics, health-related behavior, neuropsychological tests, comorbidities, blood test results, and caregiver characteristics were assessed. Median logistic regression analysis with adjustment for covariates was conducted.
Results
The behavioral and psychological symptoms of dementia were negatively associated with memory (P=0.022) and frontal/executive (P<0.001) function in the Seoul Neuropsychological Screening Battery-dementia, Barthel Index for Activities of Daily Living (P<0.001), Korean version of the Mini-Mental State Examination score (P=0.003), and caregiver age (P=0.005) after adjustment for confounding factors, and positively associated with the Seoul-Instrumental Activities of Daily Living score (P<0.001), Clinical Dementia Rating Sum of Box (P<0.001), Global Deterioration Scale score (P<0.001), abnormality of free T4 level (P<0.001), anemia (P<0.001), and family history of stroke (P=0.001). Patients with female caregivers exhibited more severe behavioral and psychological symptoms of dementia than those with male caregivers.
Conclusion
Behavioral and psychological symptoms of dementia in Alzheimer disease patients were associated with various risk factors including the inability to live independently and Alzheimer disease severity. These findings suggest that prevention and treatment strategies for the behavioral and psychological symptoms of dementia should be comprehensive.

Citations

• A retrospective study on blood microbiota as a marker for cognitive decline: implications for detecting Alzheimer’s disease and amnestic mild cognitive impairment in Republic of Korea
  Youngchan Park, Jong-Young Lee, Eek-Sung Lee
  Osong Public Health and Research Perspectives.2025; 16(2): 141.     CrossRef
• The impact of lifetime excessive alcohol use on behavioural and psychological symptoms of dementia
  Emytis Tavakoli, Elaina Niciforos, Parmida Amid, Ari B Cuperfain, Amer M Burhan, Sarah Colman, Li Chu, Simon J C Davies, Peter Derkach, Philip Gerretsen, Ariel Graff-Guerrero, Maria Hussain, Zahinoor Ismail, Donna Kim, Linda Krisman, Benoit H Mulsant, Bru
  Alcohol and Alcoholism.2025;[Epub]     CrossRef
• The Associations Between Neuropsychiatric Symptoms and Cognition in People with Dementia: A Systematic Review and Meta-Analysis
  Julieta Sabates, Wei-Hsuan Chiu, Samantha Loi, Amit Lampit, Hanna M. Gavelin, Terence Chong, Nathalie Launder, Anita M. Y. Goh, Amy Brodtmann, Nicola Lautenschlager, Alex Bahar-Fuchs
  Neuropsychology Review.2024; 34(2): 581.     CrossRef
• Development of the Dardashna Checklist for Identifying Triggers of Behavioral Change in Individuals With Dementia: A Qualitative Study
  Parastoo Amiri, Mehdi Samadani, Parviz Rashidi Khazaee, Kambiz Bahaadinbeigy
  Journal of Gerontological Nursing.2024; 50(1): 37.     CrossRef
• Prevalence of behavioral risk factors and their association with dementia in the urban population of North India
  Ram B Singh, Agnieszka Wilczynska, Jan Fedacko, Rie Horiuchi, Toru Takahashi, Ghizal Fatima, MA Manal Ismail, Aminat Magomedova
  MOJ Public Health.2023; 12(1): 46.     CrossRef
• Case Management-based Collaborative Care Model Associated with improvement in neuropsychiatric outcomes in community-dwelling people living with dementia
  Yu-Hsuan Hung, Wen-Fu Wang, Ming-Che Chang, Kai-Ming Jhang
  BMC Geriatrics.2023;[Epub]     CrossRef
• Risk, Resilience, and the Two-Track Model of Dementia Grief Among Spouses of People Living With Cognitive Decline
  Alexander Manevich, Simon Shimshon Rubin, Michael Katz, Rachel Ben-Hayun, Judith Aharon-Peretz
  Gerontology and Geriatric Medicine.2023;[Epub]     CrossRef
• The effects of caregiver characteristics on behavioral and psychological symptoms of dementia of patients with dementia
  Pei-Chao Lin, Hui-Tzu Lin, Yu-Hsiang Yang, Yuan-Han Yang
  Aging & Mental Health.2022; 26(2): 263.     CrossRef
• Red Cell Distribution Width, Anemia, and Brain Volumetric Outcomes Among Middle-Aged Adults
  May A. Beydoun, Sharmin Hossain, Peter H. MacIver, Dhivya Srinivasan, Hind A. Beydoun, Ana I. Maldonado, Leslie I. Katzel, Christos Davatzikos, Rao P. Gullapalli, Stephen L. Seliger, Guray Erus, Michele K. Evans, Alan B. Zonderman, Shari R. Waldstein
  Journal of Alzheimer's Disease.2021; 81(2): 711.     CrossRef
• Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults
  May A. Beydoun, Danielle Shaked, Sharmin Hossain, Jordan Weiss, Hind A. Beydoun, Ana I. Maldonado, Leslie I. Katzel, Christos Davatzikos, Rao P. Gullapalli, Stephen L. Seliger, Guray Erus, Michele K. Evans, Alan B. Zonderman, Shari R. Waldstein
  Neurobiology of Aging.2021; 105: 229.     CrossRef
• The complex conundrum of geriatric depression and dementias
  Sanchari Mukhopadhyay, Debanjan Banerjee
  Journal of Geriatric Mental Health.2021; 8(2): 93.     CrossRef
• Influence of the Mediterranean and Ketogenic Diets on Cognitive Status and Decline: A Narrative Review
  Federica Vinciguerra, Marco Graziano, Maria Hagnäs, Lucia Frittitta, Andrea Tumminia
  Nutrients.2020; 12(4): 1019.     CrossRef
• Relationship between Performance on the Mini-Mental State Examination Sub-Items and Activities of Daily Living in Patients with Alzheimer’s Disease
  Gwanghee Han, Michio Maruta, Yuriko Ikeda, Tomohisa Ishikawa, Hibiki Tanaka, Asuka Koyama, Ryuji Fukuhara, Shuken Boku, Minoru Takebayashi, Takayuki Tabira
  Journal of Clinical Medicine.2020; 9(5): 1537.     CrossRef
• Association of Antioxidant Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort Study of Middle-Aged Adults
  May A. Beydoun, Jose A. Canas, Marie T. Fanelli-Kuczmarski, Ana I. Maldonado, Danielle Shaked, Mika Kivimaki, Michele K. Evans, Alan B. Zonderman
  Nutrients.2020; 12(11): 3558.     CrossRef

Background
Dry eye disease is an aging-related ophthalmic disease that not only affects the daily activities but also causes deterioration in the quality of life. This study aimed to evaluate the factors associated with dry eye symptoms in elderly Koreans.
Methods
We investigated 4,185 subjects (men=1,787 and women=2,398) aged ≥65 years from the fifth Korea National Health and Nutrition Examination Survey 2010−2012. Data were analyzed using multiple logistic regressions to identify the relationships between dry eye symptoms and other factors.
Results
The prevalence of dry eye symptoms was 17.9%. After adjustment for confounding factors, dry eye symptoms were significantly associated with female sex (adjusted odds ratio [aOR], 1.806; 95% confidence interval [CI], 1.410−2.313), a history of cataract (aOR, 1.683; 95% CI, 1.255−2.255), suicidal ideation (aOR, 1.414; 95% CI, 1.070−1.870), hypercholesterolemia (aOR, 1.289; 95% CI, 1.025−1.621), age ≥80 years (aOR, 0.538; 95% CI, 0.337−0.859), and sleep duration ≥9 h/d (aOR, 0.524; 95% CI, 0.330−0.834).
Conclusion
Among elderly Koreans, female sex, a history of cataract, suicidal ideation, and hypercholesterolemia may be the risk factors for dry eye symptoms, whereas sleep duration ≥9 h/d can be a protective factor against dry eye symptoms.

Citations

• Mass spectrometry (MS)-based metabolomics of plasma and urine in dry eye disease (DED)-induced rat model
  Hyang Yeon Kim, Jung Dae Lee, HongYoon Kim, YuJin Kim, Jin Ju Park, Soo Bean Oh, Hyeyoon Goo, Kyong Jin Cho, Kyu-Bong Kim
  Journal of Toxicology and Environmental Health, Part A.2025; 88(3): 122.     CrossRef
• Clinical validation of the Dry Eye Severity nursing outcome from the Nursing Outcomes Classification
  Mércio Gabriel de Araújo, Jéssica Naiara de Medeiros Araújo, Ana Clara Dantas, Amanda Barbosa da Silva, Ana Paula Nunes de Lima Fernandes, Fabiane Rocha Botarelli, Allyne Fortes Vitor
  Heliyon.2025; 11(10): e43165.     CrossRef
• TFOS DEWS III: Digest
  Fiona Stapleton, Pablo Argüeso, Penny Asbell, Dimitri Azar, Charles Bosworth, Wei Chen, Joseph B. Ciolino, Jennifer P. Craig, Juana Gallar, Anat Galor, José A.P. Gomes, Isabelle Jalbert, Ying Jie, Lyndon Jones, Kenji Konomi, Yang Liu, Jesus Merayo-Lloves,
  American Journal of Ophthalmology.2025; 279: 451.     CrossRef
• Associations of Sleep Duration and Social Jetlag with Dry Eye Disease in Chinese School-Aged Children and Adolescents
  Yuzhu Luo, Yuting Gao, Zhong Guan, Heting Liu, Shuman Tao
  Nature and Science of Sleep.2025; Volume 17: 2041.     CrossRef
• Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development
  Hao Zeng, Xue Yang, Kai Liao, Xin Zuo, Lihong Liang, Dalian He, Rong Ju, Bowen Wang, Jin Yuan
  Experimental & Molecular Medicine.2024; 56(7): 1655.     CrossRef
• Association between potential factors and dry eye disease: A systematic review and meta-analysis
  Kuiliang Yang, Shangcao Wu, Lan Ke, Han Zhang, Shanshan Wan, Mingzhi Lu, Jiewen Mao, Yuelan Gao, Yanning Yang, Yiqiao Xing, Wanju Yang
  Medicine.2024; 103(52): e41019.     CrossRef
• The Association Between Sleep Disorders and Incidence of Dry Eye Disease in Ningbo: Data From an Integrated Health Care Network
  Qinxiang Zheng, Saiqing Li, Feng Wen, Zhong Lin, Kemi Feng, Yexiang Sun, Jie Bao, Hongfei Weng, Peng Shen, Hongbo Lin, Wei Chen
  Frontiers in Medicine.2022;[Epub]     CrossRef
• Association of dry eye disease with smoking: A systematic review and meta-analysis
  Muhammad Ali Tariq, Hamza Amin, Bilal Ahmed, Uzair Ali, Ashar Mohiuddin
  Indian Journal of Ophthalmology.2022; 70(6): 1892.     CrossRef
• Association of Dry Eye Diseases and Auditory Sensitivity
  Kyung Wook Kim, Jin Sun Hwang, Jiwon Chang, Young Joo Shin
  Journal of Clinical Medicine.2022; 11(14): 4171.     CrossRef
• Factors Influencing Self-Recognition of Dry Mouth and Dry Eye
  Hyungoo Kang, Yuyeon Jung
  Journal of Korean Ophthalmic Optics Society.2022; 27(4): 327.     CrossRef
• The global prevalence of dry eye disease: A Bayesian view
  Eric B Papas
  Ophthalmic and Physiological Optics.2021; 41(6): 1254.     CrossRef
• Improved accuracy of intraocular lens power calculation by preoperative management of dry eye disease
  Jinsoo Kim, Mee Kum Kim, Yuseung Ha, Hae Jung Paik, Dong Hyun Kim
  BMC Ophthalmology.2021;[Epub]     CrossRef
• Ocular conditions and dry eye due to traditional and new forms of smoking: A review
  Dimitra Makrynioti, Zoi Zagoriti, Constantinos Koutsojannis, Philip B. Morgan, George Lagoumintzis
  Contact Lens and Anterior Eye.2020; 43(3): 277.     CrossRef

Acquired hemophilia is a rare, potentially life-threatening disease that usually remains under-recognized especially in a primary setting; thus, diagnosing this disease is very challenging. Given its prevalence in elderly patients, awareness and diagnosis of this condition in the aging population (particularly those with unexplained bleeding or prolonged activated partial thromboplastin time) should be improved and better managed by the clinicians. Early diagnosis and prompt treatment are usually effective in preventing the adverse outcomes of this disease. In this report, we discuss a case of an elderly patient with acquired hemophilia who initially presented with swelling of his lower left limb. The diagnosis of acquired hemophilia was made a month after the appearance of symptoms. Early diagnosis with proper treatment could have been provided to this patient, if the initial assessment had been thoroughly conducted.

Citations

• Assessment of Lebanese healthcare professionals’ awareness on acquired haemophilia: a cross-sectional study
  Ali Taher, Layal Al Mahmasani, Abdallah Aadra, Patricia Yazbeck, Georges Abi Saad, Fadi Nasr, Rita Habib, Amal Chalfoun, Fadi Haddad
  Hematology.2021; 26(1): 83.     CrossRef

Background
The eating habits of Jeju Island natives are quite different from those of the mainland people because of geographic isolation. Diet is a main factor affecting gallstone disease. We investigated the prevalence of gallstone disease in both Jeju Island natives and migrants and studied the risk factors affecting gallstone disease in the Jeju Island people.
Methods
A total of 20,763 subjects who underwent medical checkups at the Health Promotion Center of Jeju National University Hospital in Korea from January 2003 to December 2015 were enrolled in the study. Ultrasonography was used to determine the presence of gallbladder stones. Body mass index and biochemical parameters, including liver function test results, lipid profiles, and fasting blood glucose levels, were verified, and data on age, birthplace, and sex were collected from medical records. Univariate and multivariate analyses were performed to identify risk factors affecting gallstone disease.
Results
The prevalence of gallstone disease in the Jeju Island people was 4.0%: Jeju Island natives, 3.8% and migrants, 4.4% (P=0.047). After multivariate logistic regression analysis, the independent risk factors were older age, Jeju migrants, higher fasting blood glucose and alanine aminotransferase levels, and lower high-density lipoprotein cholesterol levels.
Conclusion
The prevalence of gallstone disease was significantly lower in natives than in migrants from Jeju Island. Older age, Jeju migrants, higher fasting blood glucose and alanine aminotransferase levels, and lower highdensity lipoprotein cholesterol levels contributed to gallstone disease prevalence in the Jeju Island people.

Citations

• Retrospective Study of the Prevalence and Associated Factors of Gallbladder Polyps among Residents of Two Korean Cities
  Oh-Sung Kwon, Young-Kyu Kim, Hyeon Ju Kim
  Journal of Clinical Medicine.2024; 13(8): 2290.     CrossRef
• Liver Function‐Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta‐Analysis
  Shiyi Li, Pei Zhu, Fangyuan Chen, Wenqian Yu, Linjun Xie, Jing Xia, Peng Jiao, Ping Cui, Chi Zhang, Ye Bai, Guoheng Jiang, Hongyu Li, Yanmei Lou, Guangcan Li, Xuefeng Shan, Xin Wang, Fariborz Mansour-Ghanaei
  Gastroenterology Research and Practice.2024;[Epub]     CrossRef
• Cholecystectomy reduces the risk of myocardial and cerebral infarction in patients with gallstone-related infection
  Seon Mee Park, Hyun Jung Kim, Tae Uk Kang, Heather Swan, Hyeong Sik Ahn
  Scientific Reports.2022;[Epub]     CrossRef
• Epidemiological survey to determine the prevalence of cholecystolithiasis in Uyghur, Kazakh, and Han Ethnic Groups in the Xinjiang Uyghur Autonomous Region of China: cross-sectional studies
  Fujun Lv, Guangjun Wang, Dandan Ding, Caifu Shen, Jiangwei Liu, Feng Ji, Yan Kang
  BMC Gastroenterology.2021;[Epub]     CrossRef
• Prevalence and risk factors for gallstone disease: A population‐based cross‐sectional study
  Sen Tao Song, Jian Shi, Xiao Hang Wang, Yi Bin Guo, Ping Fang Hu, Feng Zhu, Xin Zeng, Wei Fen Xie
  Journal of Digestive Diseases.2020; 21(4): 237.     CrossRef
• Physical activity can reduce the prevalence of gallstone disease among males
  Oh-Sung Kwon, Young-Kyu Kim, Kyu Hee Her, Hyeon Ju Kim, Seung Duk Lee
  Medicine.2020; 99(26): e20763.     CrossRef
• The grade of nonalcoholic fatty liver disease is an independent risk factor for gallstone disease
  Young-Kyu Kim, Oh-Sung Kwon, Kyu Hee Her
  Medicine.2019; 98(27): e16018.     CrossRef

Citations

• Deliberating Effects of Sedentary Lifestyle on Young Adults: A Review of Literature
  Hira Iqrar, Maham Mohsin, Vaneeza Ahmad, Misbah Qayum, Wajida Perveen
  Pakistan BioMedical Journal.2025; : 02.     CrossRef
• Correlation of Working Style to Stress, Coping Mechanism and Metabolic Syndrome Risk in Sedentary Workers
  Dominikus Raditya Atmaka, Shintia Yunita Arini, Bian Shabri Putri Irwanto, Asri Meidyah Agustin, Aliffah Nurria Nastiti, Muh. Agus Prianto, Andi Suci Rahman
  The Indonesian Journal of Occupational Safety and Health.2025; 14(1): 15.     CrossRef
• Physical activity time and lifestyle correlates of cardiovascular disease status in older adults in Accra
  Nestor Asiamah, Kyriakos Kouveliotis, Carl Petersen, Richard Eduafo, Richard Borkey
  Journal of Public Health.2023; 31(9): 1453.     CrossRef
• Associations between objectively measured patterns of sedentary behaviour and arterial stiffness in Chinese community-dwelling older women
  Litao Du, Guangkai Li, Pengfei Ren, Qiang He, Yang Pan, Si Chen, Xianliang Zhang
  European Journal of Cardiovascular Nursing.2023; 22(4): 374.     CrossRef
• Detrimental Impact of Sedentary Behaviour on Health
  Suriya Kumareswaran
  European Journal of Medical and Health Sciences.2023; 5(1): 18.     CrossRef
• Does the built environment influence location- and trip-based sedentary behaviors? Evidence from a GPS-based activity space approach of neighborhood effects on older adults
  C. Perchoux, R. Brondeel, S. Klein, O. Klein, B. Thierry, Y. Kestens, B. Chaix, P. Gerber
  Environment International.2023; 180: 108184.     CrossRef
• Is Sedentary Behavior a Novel Risk Factor for Cardiovascular Disease?
  Andrea T. Duran, Emily Romero, Keith M. Diaz
  Current Cardiology Reports.2022; 24(4): 393.     CrossRef
• Heart Rate Recovery as an Assessment of Cardiorespiratory Fitness in Young Adults
  J. Matthew Thomas, W. Scott Black, Philip A. Kern, Julie S. Pendergast, Jody L. Clasey
  Journal of Clinical Exercise Physiology.2022; 11(2): 44.     CrossRef
• TV time, physical activity, sedentary behaviour and cardiometabolic biomarkers in pregnancy—NHANES 2003–2006
  Brittany A. Matenchuk, Valerie Carson, Laurel A. Riske, Allison Carnio, Margie H. Davenport
  Canadian Journal of Public Health.2022; 113(5): 726.     CrossRef
• Improved self‐esteem and activity levels following a 12‐week community activity and healthy lifestyle programme in those with serious mental illness: A feasibility study
  Peter Gallagher, Cailín Boland, Aisling McClenaghan, Felicity Fanning, Elizabeth Lawlor, Mary Clarke
  Early Intervention in Psychiatry.2021; 15(2): 367.     CrossRef
• The Built Environment and Socio-Demographic Correlates of Partial and Absolute Sedentary Behaviours in Community-Dwelling Older Adults in Accra, Ghana
  Nestor Asiamah, Carl Petersen, Kyriakos Kouveliotis, Richard Eduafo
  Journal of Cross-Cultural Gerontology.2021; 36(1): 21.     CrossRef
• Nuances between sedentary behavior and physical inactivity: cardiometabolic effects and cardiovascular risk
  Erika Andressa Simões de Melo, Laryssa Elza de Santana Ferreira, Rodolfo José Ferreira Cavalcanti, Carlos Alberto de Lima Botelho Filho, Matheus Rodrigues Lopes, Romero Henrique de Almeida Barbosa
  Revista da Associação Médica Brasileira.2021; 67(2): 335.     CrossRef
• Effects of Living Alone and Sedentary Behavior on Quality of Life in Patients With Multimorbidities: A Secondary Analysis of Cross-Sectional Survey Data Obtained From the National Community Database
  Young Eun AHN, Chin Kang KOH
  Journal of Nursing Research.2021; 29(5): e173.     CrossRef
• Run, lift, or both? Associations between concurrent aerobic–muscle strengthening exercise with adverse cardiometabolic biomarkers among Korean adults
  Jason A Bennie, Ding Ding, Asaduzzaman Khan, Emmanuel Stamatakis, Stuart JH Biddle, Junghoon Kim
  European Journal of Preventive Cardiology.2020; 27(7): 738.     CrossRef
• Effect of Sedentary Time on the Risk of Orthopaedic Problems in People Aged 50 Years and Older
  S.H. Kang, J.H. Joo, E.C. Park, Sung-In Jang
  The Journal of nutrition, health and aging.2020; 24(8): 839.     CrossRef
• Objectively Measured Sedentary Behavior and Cardiovascular Disease Risk Factors
  Hoyong Sung, Jungjun Lim, Junbae Mun, Yeonsoo Kim
  The Korean Journal of Sports Medicine.2020; 38(3): 143.     CrossRef
• Sedentary Lifestyle and Cardiovascular Health
  Soo Young Kim
  Korean Journal of Family Medicine.2018; 39(1): 1.     CrossRef
• The effects of high-intensity interval training on reverse cholesterol transport elements: A way of cardiovascular protection against atherosclerosis
  Saleh Rahmati-Ahmadabad, Hossein Shirvani, Abbass Ghanbari-Niaki, Fatemeh Rostamkhani
  Life Sciences.2018; 209: 377.     CrossRef

Citations

• Socioeconomic disparities in suicide: Causation or confounding?
  Vincent Lorant, Dharmi Kapadia, Julian Perelman, Astrid M. Kamperman
  PLOS ONE.2021; 16(1): e0243895.     CrossRef
• Income-related inequities of adult obesity and central obesity in China: evidence from the China Health and Nutrition Survey 1997–2011
  Ling Zhou, Dan Cao, Yafei Si, Xuexue Zhu, Liang Du, Yu Zhang, Zhongliang Zhou
  BMJ Open.2020; 10(10): e034288.     CrossRef
• Trends of Suicide Attempts and Completed Suicide in Ilam Province of Iran; A Demographic Analysis Study
  Yousef Veisani, Ali Delpisheh, Fathola Mohamadian, Reza Valizadeh
  Bulletin of Emergency and Trauma.2018; 6(3): 245.     CrossRef
• Suicidal ideation among Chinese methadone-maintained patients: prevalence and correlates
  Yan-Min Xu, Bao-Liang Zhong, Wen-Cai Chen, Jun-Hong Zhu, Jin Lu
  Oncotarget.2017; 8(49): 86181.     CrossRef

Citations

• Association between waist circumference or weight change after smoking cessation and incidence of cardiovascular disease or all-cause death in Korean adults with type 2 diabetes
  Heajung Lee, Jaeyong Shin, Jae Woo Choi
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Lifelong smoking status, weight gain, and subsequent risk of major adverse cardiovascular events: Long‐term follow‐up of a middle‐aged Chinese population
  Lirong Liang, Changwei Li, Xiaoqing Liu, Long Zhou, Shuilian Chu, Ruiyuan Zhang, Jinzhuang Mai, Adrianna Westbrook, Jiachen Li, Di Zhang, Liancheng Zhao, Yangfeng Wu
  Obesity.2022; 30(3): 762.     CrossRef
• Smoking Cessation May Reduce Risk of Visual Field Progression in Heavy Smokers
  Golnoush Mahmoudinezhad, Takashi Nishida, Robert N. Weinreb, Sally L. Baxter, Evan Walker, Medi Eslani, Jeffrey M. Liebmann, Christopher A. Girkin, Sasan Moghimi
  Journal of Glaucoma.2022; 31(10): 796.     CrossRef
• Thirty-six Year Trends in Mortality from Diseases of Circulatory System in Korea
  Jongmin Baek, Hokyou Lee, Hyeok-Hee Lee, Ji Eun Heo, So Mi Jemma Cho, Hyeon Chang Kim
  Korean Circulation Journal.2021; 51(4): 320.     CrossRef
• Weight Gain After Smoking Cessation and Risk of Major Chronic Diseases and Mortality
  Berhe W. Sahle, Wen Chen, Lal B. Rawal, Andre M. N. Renzaho
  JAMA Network Open.2021; 4(4): e217044.     CrossRef
• Smoking Cessation, Weight Gain, Cardiovascular Risk, and All-Cause Mortality: A Meta-analysis
  Xiaowen Wang, Li-Qiang Qin, Ahmed Arafa, Ehab S Eshak, Yonghua Hu, Jia-Yi Dong
  Nicotine & Tobacco Research.2021; 23(12): 1987.     CrossRef
• Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea
  Se Eun Park, Mi Hae Seo, Jung-Hwan Cho, Hyemi Kwon, Yang-Hyun Kim, Kyung-Do Han, Jin-Hyung Jung, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee
  Diabetes & Metabolism Journal.2021; 45(4): 539.     CrossRef
• Cancer risk among young men with weight gain after smoking cessation: A population-based cohort study
  Kyuwoong Kim, Seulggie Choi, Gyeongsil Lee, Su-Min Jeong, Sung Min Kim, Joung Sik Son, Jae-Moon Yun, Yeon-Yong Kim, Seong Yong Park, Sang Min Park
  Cancer Epidemiology.2019; 60: 86.     CrossRef
• Changes in carotid artery structure with smoking cessation
  Carol Mitchell, Megan E Piper, Stevens S Smith, Claudia E Korcarz, Michael C Fiore, Timothy B Baker, James H Stein
  Vascular Medicine.2019; 24(6): 493.     CrossRef
• Weight gain after smoking cessation: more data to refute concerns
  Nancy A Rigotti, Carole Clair
  European Heart Journal.2018; 39(17): 1532.     CrossRef

Citations

• Translation and investigation of the psychometric properties of the revised female sexual distress scale among Iranian couples
  Roghieh Bayrami, Hamid Sharif-Nia, Roksana Janghorban, Daniz Montakhabi Oskuii, Esmaeil Hoseinzadeh
  Scientific Reports.2025;[Epub]     CrossRef
• Machine learning driven biomarker selection for medical diagnosis
  Divyagna Bavikadi, Ayushi Agarwal, Shashank Ganta, Yunro Chung, Lusheng Song, Ji Qiu, Paulo Shakarian, John Adeoye
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