Background
The metabolic syndrome has been known as the cluster of insulin resistance, dyslipidemia, hypertension, and abdominal obesity. There have been many studies about the infl ammatory role in atherosclerosis and cardiovascular diseases, also. We aimed to elucidate the role of high sensitivity C-reactive protein (hs-CRP) as a infl ammation-related factor in metabolic syndrome in Korean adults by correlation and factor analysis. Methods: A cross sectional study was carried out in 1,512 men and 1,836 women (over 20 years old) who had an examination at a center for health promotion of an university hospital from May 2004 through March 2005. The NCEP-ATP III definition and Asian-Pacific adjusted criteria were used to obtain the metabolic syndrome group. And we evaluated the role and gender difference of hs-CRP in metabolic syndrome by correlation and factor analysis.Results: In women, hs-CRP was statistically correlated with most metabolic variables, especially insulin resistance. In factor analysis, 3 factors (obesity, blood pressure, and insulin resistance) were obtained in men and 4 factors (obesity, blood pressure, insulin resistance, and dyslipidemia) in women, respectively. In women, hs-CRP was a part of dyslipidemia factor.Conclusion: In factor anaylsis of metabolic syndrome factors with hs-CRP, hs-CRP was not a signifi cant factor in men, but was included as a part of dyslipidemia factor in women.

Citations

• The Relationship between Metabolic Syndrome Risk Factors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women
  Kyung-A Shin
  The Korean Journal of Clinical Laboratory Science.2017; 49(2): 121.     CrossRef
• Clinical Outcomes after Modified Fasting Therapy Supplied with Gamrosu: A Retrospective Observational Study
  Seung-Uoo Shin, Dong-Hwan Kim, Hyun-Taeg Shin, Dal-Seok Oh
  Journal of Korean Medicine for Obesity Research.2016; 16(1): 36.     CrossRef

Background
: C-reactive protein is a substance that elevates when there is an abnormal metabolic reaction or inflammatory condition. Some researchers in Korea reported different results about the association between smoking and CRP. In this study, the relationship between CRP and various smoking characteristics among Korean men was investigated.

Methods : Data were analyzed in healthy men, who had visited a health promotion center in a university hospital from September, 2003 to December, 2003. CRP was quantitatively analyzed by high sensitivity-CRP. Elevated CRP (≥2.2 mg/L) level in relation to various smoking characteristics were studied and multiple logistic regression analysis for elevated CRP (≥2.2 mg/L) level was conducted.

Results : The number of current smokers was 893, past smokers 550, and non-smokers 413. The association between smoking status, daily smoking amount, duration of smoking (P=0.031, P=0.003, P=0.034) and elevated CRP level was shown by chi-square test. After multiple logistic regression analysis for risk factors, elevated CRP level was shwon to be associated with daily smoking amount in the current smokers, body fat percentage, WBC count and HDL-cholesterol. The odds ratios for elevated CRP level by smoking amount were 2.32 (95% confidence interval 1.11∼4.85) in those who smoked 10∼19 cigarettes per day, 3.54 (95% confidence interval 1.64∼7.63) in those who smoked more than 20 cigarettes per day compared to those who smoked less than 10 cigarettes per day.

Conclusion : Among current smokers, elevated CRP level was associated with daily smoking amount in the current smokers, This is the first study to report the relationship between CRP level and smoking behaviors among Korean men.