Background
The concern about growth hormone, used for treatment of growth hormone deficiency, wasting diseases, is increasing recently. There is much to be desired about the study for the reference range of insulin-like growth factor-1 (IGF-1) of Korean healthy adults, because there was the lack for the studies of their IGF-1 level. The authors investigated the concentration of IGF-1 according to age groups, and the correlation factor with IGF-1 level in healthy adult in Korea. Methods: The subjects were 10,681 Korean healthy adults (5,263 female, 5,418 male) aged over 20 years, who visited a Department of Family Practice and Community Health in a university hospital from March 1998 to December 2003. We excluded the persons with DM, liver disease, renal disease, thyroid disease, cancer etc. We measured the serum IGF-1, fasting glucose, lipid profile, serum albumin, protein, waist circumference, hip circumference, and body mass index. Results: IGF-1 level showed the sexual difference (184.6 ± 86.3 ng/mL for men, 178.6± 91.8 ng/mL for women) and decreased with aging significantly. Age is the most reliable correlation factor with IGF-1 (R: -0.325 for men, R:-0.463 for women). After adjusting ageand weight, IGF-1 showed the correlation with total protein, albumin, creatinin, triglyceride, HDL cholesterol for men and height, waist circumference, body mass index, waist-hip ratio, systolic blood pressure, total protein, albumin, creatinin, triglyceride, HDL cholesterol for women. Conclusion: IGF-1 concentration decreases with aging over 20 years old. It shows the strongest correlation with age in both sexes.

Citations

• Correlation between Serum IGF-1, IGFBP-3 Levels, and Hand-Wrist Radiographs in Determining Skeletal Maturity
  Misun Kwak, Yon-joo Mah
  THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2023; 50(3): 334.     CrossRef
• High Prevalence of Nonalcoholic Fatty Liver Disease Among Adolescents and Young Adults With Hypopituitarism due to Growth Hormone Deficiency
  Seok Jin Kang, Ahreum Kwon, Mo Kyung Jung, Hyun Wook Chae, Seung Kim, Hong Koh, Hyun Joo Shin, Ho-Seong Kim
  Endocrine Practice.2021; 27(11): 1149.     CrossRef
• Establishment of Reference Intervals for Serum Insulin-Like Growth Factor I in Korean Adult Population
  Boyeon Kim, Yonggeun Cho, Cheol Ryong Ku, Sang-Guk Lee, Kyung-A Lee, Jeong-Ho Kim
  Endocrinology and Metabolism.2020; 35(4): 960.     CrossRef
• Long-term Changes in Serum IGF-1 Levels After Successful Surgical Treatment of Growth Hormone–Secreting Pituitary Adenoma
  Mi-Seon Shin, Ji Hee Yu, Jong Han Choi, Chang Hee Jung, Jenie Yoonoo Hwang, Young Hyun Cho, Chang Jin Kim, Min-Seon Kim
  Neurosurgery.2013; 73(3): 473.     CrossRef

Background
: Pulse pressure, a clinical marker of arterial stiffness, is an independent and strong predictor of cardiovascular disease, and reflects aging of arterial system. It is a well known fact that serum IGF-1 level is a parameter of growth hormone (GH) secretion and decreased GH secretion is related to aging. The aim of this study was to find out if there was any correlation between pulse pressure and IGF-1 concentration.

Methods : By reviewing the medical records of a hospital in Korea, healthy 194 men and 180 women were studied. We measured serum IGF-1, triglyceride, total cholesterol, HDL cholesterol concentrations and fasting blood sugar (FBS). Also, anthropometric and blood pressure measurements were performed.

Results : In men, the pulse pressure was positively correlated with age (r=0.29, P＜0.001), systolic blood pressure (SBP) (r=0.70, P＜0.001), diastolic blood pressure (DBP) (r=0.22, P=0.003), and body mass index (BMI) (r= 0.28, P＜0.001) and inversely with IGF-1 levels (r=-0.27, P＜0.001). In women, pulse pressure was positively levels with SBP (r=0.28, P＜0.001), BMI (r=0.27, P＜0.001), triglyceride (r=0.19, p=0.011), total cholesterol (r=0.15, P=0.049) levels, and FBS (r=0.17, P=0.027) and was not correlated with age, DBP, and serum IGF-1 levels. After adjustment for age, BMI, triglyceride, total cholesterol, and FBS, the pulse pressure was independently negatively correlated with serum IGF-1 levels (β=-6.052, P=0.007) in men. The multiple regression analysis showed that serum IGF-1 levels (R²=0.04) was the third most powerful factor influencing the pulse pressure.

Conclusion : There was as independent negative correlation between the pulse pressure and serum IGF-1 levels in healthy men.