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"mental disorders"

Review Article

Association between depression and medication adherence in noncommunicable diseases: a narrative review
Urfa Khairatun Hisan, Bagoes Widjanarko, Ayun Sriatmi, Zahroh Shaluhiyah
Korean J Fam Med 2025;46(4):231-239.   Published online July 20, 2025
DOI: https://doi.org/10.4082/kjfm.25.0018
Noncommunicable diseases (NCDs), including cancer, diabetes, hypertension, cardiovascular diseases, and chronic respiratory conditions, are the leading global causes of morbidity and mortality. Depression frequently co-occurs with these conditions, and may significantly reduce medication adherence, thereby worsening health outcomes. This narrative review examines the relationship between depression and medication adherence in patients with NCDs. It also highlights the current challenges in managing this comorbidity and explores potential strategies for improving adherence outcomes. Most studies have reported a significant negative association between depression and medication adherence in diverse NCD populations. Depressive symptoms impair motivation, memory, and executive functioning, which are essential for the maintenance of treatment regimens. However, inconsistencies across studies have been observed due to variability in the measurement of depression and adherence, study design, and control of confounding factors. Despite evidence from high-income countries supporting integrated care models such as collaborative care and cognitive behavioral therapy, implementation of these models in low- and middle-income countries remains limited. Emerging strategies, including task shifting, digital health tools (e.g., mobile health apps and telemedicine), and community-based support systems, offer promising avenues for intervention. Addressing this issue requires integrated and scalable interventions tailored to local contexts. Future research should focus on longitudinal and interventional studies, particularly in resource-limited settings, to inform policies and practices.

Citations

Citations to this article as recorded by  
  • Health behaviors, lifestyle factors, and healthcare challenges in family medicine: a comprehensive review of recent evidence from Asian populations
    Joung Sik Son
    Korean Journal of Family Medicine.2025; 46(4): 215.     CrossRef
  • 2,392 View
  • 65 Download
  • 1 Web of Science
  • 1 Crossref
Original Articles
Validity of Alcohol Use Disorder Identification Test-Korean Revised Version for Screening Alcohol Use Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Criteria
Jung Wei Chang, Jong Sung Kim, Jin Gyu Jung, Sung Soo Kim, Seok Joon Yoon, Hak Sun Jang
Korean J Fam Med 2016;37(6):323-328.   Published online November 18, 2016
DOI: https://doi.org/10.4082/kjfm.2016.37.6.323
Background

The Alcohol Use Disorder Identification Test (AUDIT) has been widely used to identify alcohol use disorder (AUD). This study evaluated the validity of the AUDIT-Korean revised version (AUDIT-KR) for screening AUD according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria.

Methods

This research was conducted with 443 subjects who visited the Chungnam National University Hospital for a comprehensive medical examination. All subjects completed the demographic questionnaire and AUDIT-KR without assistance. Subjects were divided into two groups according to DSM-5 criteria: an AUD group, which included patients that fit the criteria for AUD (120 males and 21 females), and a non-AUD group, which included 146 males and 156 females that did not meet AUD criteria. The appropriate cut-off values, sensitivity, specificity, and positive and negative predictive values of the AUDIT-KR were evaluated.

Results

The mean±standard deviation AUDIT-KR scores were 10.32±7.48 points in males and 3.23±4.42 points in females. The area under the receiver operating characteristic curve (95% confidence interval, CI) of the AUDIT-KR for identifying AUD was 0.884 (0.840–0.920) in males and 0.962 (0.923–0.985) in females. The optimal cut-off value of the AUDIT-KR was 10 points for males (sensitivity, 81.90%; specificity, 81.33%; positive predictive value, 77.2%; negative predictive value, 85.3%) and 5 points for females (sensitivity, 100.00%; specificity, 88.54%; positive predictive value, 52.6%; negative predictive value, 100.0%).

Conclusion

The AUDIT-KR has high reliability and validity for identifying AUD according to DSM-5 criteria.

Citations

Citations to this article as recorded by  
  • Intimate partner domestic violence exposure and the onset of hazardous alcohol use: A population-based longitudinal study of married adults in South Korea (2009–2024)
    Seong-Uk Baek, Jin-Ha Yoon
    Journal of Affective Disorders.2026; 393: 120254.     CrossRef
  • Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective Sleep Measures: Observational Cohort Study
    Ji Won Yeom, Hyungju Kim, Seung Pil Pack, Heon-Jeong Lee, Taesu Cheong, Chul-Hyun Cho
    JMIR Mental Health.2025; 12: e67478.     CrossRef
  • Development and validation of short-term, medium-term, and long-term suicide attempt prediction models based on a prospective cohort in Korea
    Jeong Hun Yang, Ri-Ra Kang, Dae Hun Kang, Yong-gyom Kim, Jieun Yoo, C. Hyung Keun Park, Sang Jin Rhee, Min Ji Kim, Sang Yeol Lee, Chan-Mo Yang, Se-Hoon Shim, Jung-Joon Moon, Seong-Jin Cho, Shin Gyeom Kim, Min-Hyuk Kim, Jinhee Lee, Won Sub Kang, Weon-Young
    Asian Journal of Psychiatry.2025; 106: 104407.     CrossRef
  • The impact of minimum wage policy on alcohol use disorder: a quasi-experimental study in South Korea
    Yihong Bai, Chungah Kim, Antony Chum
    American Journal of Epidemiology.2025; 194(5): 1230.     CrossRef
  • Developing a machine learning algorithm to predict psychotropic drugs-induced weight gain and the effectiveness of anti-obesity drugs in patients with severe mental illness: Protocol for a prospective cohort study
    Hye Jun Lee, Na Yeon Kim, Da Seul Kim, Youngbin Kim, Jung-Ha Kim, Doug Hyun Han, Sun Mi Kim, Marwan Al-Nimer
    PLOS One.2025; 20(5): e0324000.     CrossRef
  • Portuguese Validated Versions of the Alcohol Use Disorders Identification Test: A Systematic Review of Academic and Grey Literature
    Diogo Phalempin Cardoso, Daniela Oliveira, Beatriz Antunes, Rosa Saraiva, Kathryn Angus, Eugenia Gallardo, Frederico Rosário
    Drug and Alcohol Review.2025; 44(5): 1581.     CrossRef
  • Effect of Theracurmin Products for Alleviating Alcohol Hangovers in Healthy Adults
    Yeongtaek Hwang, Paul Kim, Minji Kwon, Sung-Vin Yim, Bo-Hyung Kim, Hyunjung Lim
    Journal of Clinical Medicine.2025; 14(19): 6996.     CrossRef
  • Does This Patient Have Alcohol Use Disorder?
    Evan Wood, Jeffrey Pan, Zishan Cui, Paxton Bach, Brittany Dennis, Seonaid Nolan, M. Eugenia Socias
    JAMA.2024; 331(14): 1215.     CrossRef
  • Development and external validation of a logistic and a penalized logistic model using machine-learning techniques to predict suicide attempts: A multicenter prospective cohort study in Korea
    Jeong Hun Yang, Yuree Chung, Sang Jin Rhee, Kyungtaek Park, Min Ji Kim, Hyunju Lee, Yoojin Song, Sang Yeol Lee, Se-Hoon Shim, Jung-Joon Moon, Seong-Jin Cho, Shin Gyeom Kim, Min-Hyuk Kim, Jinhee Lee, Won Sub Kang, C. Hyung Keun Park, Sungho Won, Yong Min A
    Journal of Psychiatric Research.2024; 176: 442.     CrossRef
  • Characteristics of High-Risk Groups for Suicide in Korea Before and After the COVID-19 Pandemic: K-COMPASS Cohort Study
    Jeong Hun Yang, Dae Hun Kang, C. Hyung Keun Park, Min Ji Kim, Sang Jin Rhee, Min-Hyuk Kim, Jinhee Lee, Sang Yeol Lee, Won Sub Kang, Seong-Jin Cho, Shin Gyeom Kim, Se-Hoon Shim, Jung-Joon Moon, Jieun Yoo, Weon-Young Lee, Yong Min Ahn
    Journal of Korean Neuropsychiatric Association.2024; 63(4): 246.     CrossRef
  • Impact of Evolutionary Changes in Nonalcoholic Fatty Liver Disease on Lung Function Decline
    Hyun Woo Lee, Goh Eun Chung, Bo Kyung Koo, Hyungtai Sim, Murim Choi, Dong Hyeon Lee, Seung Ho Choi, Soo Heon Kwak, Deog Kyeom Kim, Won Kim
    Gut and Liver.2023; 17(1): 139.     CrossRef
  • Association of habitual alcohol use on risk-taking behaviors while using a car: The Korean National Health and Nutrition Examination Survey 2009–2013
    Doo Woong Lee, Kwanghyun Kim, Jongmin Baek, Sarah Soyeon Oh, Sung-In Jang, Eun-Cheol Park
    Accident Analysis & Prevention.2020; 144: 105651.     CrossRef
  • The Korean Cohort for the Model Predicting a Suicide and Suicide-related Behavior: Study rationale, methodology, and baseline sample characteristics of a long-term, large-scale, multi-center, prospective, naturalistic, observational cohort study
    C. Hyung Keun Park, Jae Won Lee, Sang Yeol Lee, Jung-Joon Moon, Dong-Wook Jeon, Se-Hoon Shim, Seong-Jin Cho, Shin Gyeom Kim, Jeewon Lee, Jong-Woo Paik, Min-Hyuk Kim, Seokho Kim, Jae-Hyun Park, Sungeun You, Hong Jin Jeon, Sang Jin Rhee, Yong Min Ahn
    Comprehensive Psychiatry.2019; 88: 29.     CrossRef
  • Gender Differences in Harmful Use of Alcohol Among Korean Adults
    Eunok Park, Yeon Sook Kim
    Osong Public Health and Research Perspectives.2019; 10(4): 205.     CrossRef
  • Concurrent validity of the Alcohol Use Disorders Identification Test (AUDIT) in relation to Alcohol Use Disorder (AUD) severity levels according to the brief DSM-5 AUD diagnostic assessment screener
    Håkan Källmén, Tobias H. Elgán, Peter Wennberg, Anne H. Berman
    Nordic Journal of Psychiatry.2019; 73(7): 397.     CrossRef
  • Implications of Increased Trait Impulsivity on Psychopathology and Experienced Stress in the Victims of Early Trauma With Suicidality
    C. Hyung Keun Park, Jae Won Lee, Sang Yeol Lee, Se-Hoon Shim, Jung-Joon Moon, Jong-Woo Paik, Seong-Jin Cho, Shin Gyeom Kim, Min-Hyuk Kim, Seokho Kim, Jae-Hyun Park, Sungeun You, Hong Jin Jeon, Yong Min Ahn
    Journal of Nervous & Mental Disease.2018; 206(11): 840.     CrossRef
  • Validity of Alcohol Use Disorder Identification Test: Methodological Issues
    Siamak Sabour
    Korean Journal of Family Medicine.2017; 38(2): 106.     CrossRef
  • Comparison of Baseline Characteristics between Community-based and Hospital-based Suicidal Ideators and Its Implications for Tailoring Strategies for Suicide Prevention: Korean Cohort for the Model Predicting a Suicide and Suicide-related Behavior
    C. Hyung Keun Park, Jae Won Lee, Sang Yeol Lee, Jungjoon Moon, Se-Hoon Shim, Jong-Woo Paik, Shin Gyeom Kim, Seong-Jin Cho, Min-Hyuk Kim, Seokho Kim, Jae-Hyun Park, Sungeun You, Hong Jin Jeon, Yong Min Ahn
    Journal of Korean Medical Science.2017; 32(9): 1522.     CrossRef
  • 5,897 View
  • 64 Download
  • 16 Web of Science
  • 18 Crossref
Prevalence of Mental Disorders in Family Practice Centers in Korea and the Utility of a Diagnostic Tool.
Young Sik Kim, Yeong Sook Yoon, Jeong Yeol Oh, Hee Tak Ryu, Dae Hyun Kim, Young Sung Suh, Byung Sung Kim, Yun Jin Kim, Sang Wook Song, Jungkwon Lee
J Korean Acad Fam Med 2005;26(11):699-705.   Published online November 10, 2005
Background
: A considerable portion of patients in primary care are thought to have mental disorders in Korea. But they are not easily noticed and are thus underdiagnosed and approached improperly. This study was done to assess the prevalence of common mental disorders in a hospital-based family practice and to evaluate the utility of a diagnostic tool, the Patient Health Questionnaire (PHQ).

Methods : Ten or more patients each day were systematically selected in family practice clinics for two weeks in a university and a community hospital-based family practice clinics in Seoul, Korea. Routine care was delivered as a control during the first week and the PHQ was administered to patients during the second week and the physicians were allowed to review the PHQ just before making clinical decisions. Physicians were asked to answer whether they recognized patients' with mental disorders before reviewing the PHQ.

Results : The prevalence of mental disorders was higher in the test group than the control except for eating disorders and other anxiety disorders (P<0.05)(test vs. control group): major depressive disorders 1.75% vs. 3.8%, other depressive disorders 6.8% vs. 11.4%, panic disorders 0.6% vs. 2.3, somatoform disorders 3% vs. 5%, alcohol abuse 2.2% vs. 8.7%, and any mental disorders 20.9% vs. 29.4%. In the test group, the percentage (95% confidence interval in parenthesis) of newly diagnosed mental disorders after physicians' review of the PHQ were 66% (49∼82) in major depressive disorders, 70% (50∼90) in panic disorders, 70% (56∼83) in somatoform disorders, 84% (75∼92) in alcohol abuse, and 68% (62∼74) in any mental disorders. Patients' response to the PHQ was overall very receptive.

Conclusion : One-week prevalence of common mental disorders in the hospital-based family practice was 29.4% and the PHQ tool was efficient to help the family physicians recognize hidden mental disorders.
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