Background
: Bone mass changes in men is related to age, BMI, sex hormones and other factors. In prior studies, bone markers were negatively correlated with bone mineral density, free testosterone, and estrogen and was positively correlated with SHBG. In a study of sex hormones and bone markers in Korean men estradiol was negatively correlated with deoxypyridinoline. In this study, the relationship of testosterone, estradiol, calculated free testosterone, FEI and SHBG to bone turnover markers in adult men were investigated.

Methods : This was a cross-sectional study of 184 men who had undertaken a health screening program in one general hospital in Bundang from November, 2001 to February, 2003. We surveyed information concerning the past medical history, current medication, alcohol consumption amount per week and smoking amount by means of self questionnaire records. Serum total testosterone, estradiol, SHBG and osteocalcin, alkaline phosphatase were measured at a fasting state. Urine was tested for deoxypyridinoline. Free testosterone was calculated using albumin, SHBG, and total testosterone level.

Results : Deoxypyridinoline adjusted by age, BMI was negatively correlated with FEI (r=-0.17, P=0.020) and was positively correlated with smoking amount (r=0.20 P= 0.007). Osteocalcin was negatively correlated with calculated free testosterone and ethanol consumption amount (r=-0.186, P=.0.12, r=-0.186, P=0.012). Multiple regression analysis showed that the most powerful factor influencing deoxypyridinoline was smoking amount (R²= 0.046), followed by FEI, BMI, and the one influencing osteocalcin was BMI (R²=0.050), ethanol amount and calculated free testosterone. After adjusting for age, BMI, drinking amount and smoking amount FEI shown to be a predictor of deoxypyridinoline (β=-0.08, p＜0.01, R²=0.101). After adjusting for age, BMI, and drinking amount calculated free testosterone was shown to be a predictor of osteocalcin (β=-0.570, P＜0.01, R²=0.130) in multiple regression model.

Conclusion : In adult men, FEI shown to be a predictor of deoxypyridinoline and calculated free testosterone to be a predictor of osteocalcin as an independent variable.

Background
: Biochemical markers have been proposed as sensitive indicators of high bone turnover and for monitoring response to osteoporosis treatment. We conducted a retrospective study to investigate the pattern of biochemical markers of bone metabolism (urinary deoxypryridinoline (D-PYD), serum osteocalcin) across menopausal transition in women.

Methods : We measured the urinary excretion of D-PYD, serum osteocalcin and BMD in 44 premenopausal and age-matched 44 postmenopausal women who visited a tertiary hospital from May 1, 1997 to July 31, 1997. Each values between premenopausal and postmenopausal women were anaysed with paired t-tests. Pearson's correlation coefficients were performed to assess the relationships between the three values.

Results : Urinary excretion of D-PYD in postmenopausal women (12.103±2.27 nM/mM creatinine) was higher than in premenopausal women (9.322±.53 nM/mM creatinine) (P<0.05). Serum osteocalcin in postmenopausal women (12.8698±3.1 ng/ml) was higher than in premenopausal women (9.0949±2.7 ng/ml) (P<0.01). BMD in postmenopausal women (0.9979±0.1863 g/cm2) was lower than in postmenopausal women (1.1845±0.1591 g/cm2)(P<0.01). The serum osteocalcin level was positively correlated with D-PYD (r=0.547, p<0.01). Urine excretion of D-PYD was negatively correlated with BMD (r=-0.36, p<0.01). Serum osteocalcin was negatively correlated with BMD (r=-0.427, P<0.01).

Conclusion : Urinary D-PYD excretion and serum osteocalcin were increased, by BMD was decreased significantly in postmenopausal women. Urinary D-PYD, serum osteocalcin, and BMD were significantly correlated with each other in women.