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Korean J Fam Med > Volume 31(4); 2010 > Article
Korean Journal of Family Medicine 2010;31(4):267-274.
DOI: https://doi.org/10.4082/kjfm.2010.31.4.267    Published online April 20, 2010.
Relationship between Metabolic Syndrome and QTc Interval Prolongation.
Kwang Shik Park, Min Seok Seo, Wan Je Cho, Jung Hyun Lee, Hye Ree Lee, Jae Yong Shim
Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. hope@yuhs.ac
대사증후군과 QTc 간격 연장과의 관계
박광식, 서민석, 조완제, 이정현, 이혜리, 심재용
연세대학교 의과대학 강남세브란스병원 가정의학과
Abstract
Background
The prevalence of the metabolic syndrome in Korea is about 20%. The metabolic syndrome is known to increase the risk of cardiovascular disease. However, the relationship of this syndrome with electrocardiographic subclinical risk factors such as corrected QT (QTc) interval prolongation has not been evaluated extensively in Korea. In this perspective, we studied the relationship between metabolic syndrome and QTc interval prolongation among Korean adults. Methods: We analysed 1,560 Korean subjects (men, 873; women, 687; age, 30 to 75 years) at a health promotion center of a university hospital from November, 2006 to Jun, 2007. Subjects were evaluated for metabolic syndrome using a questionnaire, physical examination, blood pressure and blood test. QTc interval was measured from the standard 12-lead electrocardiogram. Results: In women, the odds ratios of QTc interval prolongation according the number 1, 2, 3 ≥ of diagnostic criteria of metabolic syndrome were 1.62 (1.07 to 2.45), 2.70 (1.59 to 4.59), 3.24 (1.65 to 6.32) compared to the number 0 (P for trend < 0.001). In men, the odds ratios according the number 2, 3 ≥ of them were 2.53 (1.56 to 4.11), 3.49 (2.05 to 5.93) (P for trend < 0.001). Conclusion: In Korean Adult, metabolic syndrome is significantly associated with QTc prolongation. As the number of diagnostic criteria of this syndrome increased, the ratio of QTc prolongation tends to be increased. This study suggest that the measurement of QTc interval of subjects with the diagnostic components of this syndrome can help predict cardiovascular risk of prolonged QTc.
Key Words: Metabolic Syndrome; Corrected QT; Electrocardiogram


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