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Original Article

Seasonal variation of blood pressure in patients with hypertension.

Jai Jn Byeon, Dong Jin Kim
Journal of the Korean Academy of Family Medicine 1999;20(12):1770-1777.
Published online: December 1, 1999
Department of Family Medicine, Samsung Seoul Hospital, Korea. 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삼성서울병원 가정의학과
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Background
: Seasonal variation of blood pressure(BP) is well documented. It means that season should be considered in diagnosis ad treatment of hypertension. This study was done to evaluate seasonal influence on blood pressure of hypertensive patients who had been taking the same antihypertensive medicine for a long time.

Methods : In medical records, we reviewed the blood pressure recordings of 328 hypertensive patients who had been taking the same medicines through the consecutive summer(June., Jul., & Sep.) and winter(Dec., Jan., & Feb.) period. We evaluated the blood pressure difference between summer and winter, and also evaluated influence of age, sex, BMI, smoking, alcohol drinking and exercise on seasonal difference of blood pressure.

Results : An average of four blood pressure readings per patient, two for summer and two for winter were recorded. Ambient temperature was over 22°C in summer and below 4°C in winter. The systolic blood pressure in summer and winter were 135.5mmHg ad 140.5mmHg, respectively, and the diastolic blood pressure in summer and winter were 85.0mmHg and 87.4mmHg, respectively. Both systolic and diastolic blood pressure increased significantly in winter. Both I systolic ad diastolic blood pressure, sex, smoking, alcohol drinking, exercise did not have an influence on seasonal difference. Age and BMI did not have an influence on seasonal difference of systolic blood pressure. But in diastolic blood pressure, age and BMI had an influence on seasonal difference and elderly patients had a greater seasonal difference in diastolic blood pressure than younger patients.

Conclusion : In hypertensive patients who had taken the same antihypertensive medicines for a long time, both systolic and diastolic blood pressure was significantly increased during the winter. Therefore season should be considered in the treatment of hypertension even though patients are stable with the same medicines.

연구배경 : 고혈압환자의 혈압은 계절에 따라 변동함이 알려져 있다. 이는 고혈압을 진단하고 치료하는 과정에서 계절을 고려해야할 필요성이 있음을 시사한다. 본 연구에서는 같은 종류와 용량의 항고혈압약제로 장기간 치료받고 있는 고혈압 환자의 혈압에 계절간 변동이 있는지 여부와 이제 영향을 미치는 요인들에 대해 알아보고자 하였다.

방법 : 고혈압으로 약물치료를 받는 환자 중, 연속적인 여름(6,7,8월)과 겨울 (12,1,2월)을 경과하면서 계속해서 항고혈압약제의 종류와 용량에 변동이 없었던 환자들의 의무기록을 검토하여, 여름 및 겨울의 혈압, 체질량지수, 흡연, 음주, 운동에 대한 자료를 얻었다. 계절에 따른 혈압의 차이와 성, 연령, 체질량지수, 흡연, 음주, 운동이 여름-겨울간 혈압차이에 영향을 미치는지 여부를 보았다.

결과 : 연구 대상자는 남자 146명, 여자 182명이었으며, 평균연령은 58.7세 이었다. 연구기간 중 여름의 평균기온은 22℃ 이상이었으며, 겨울의 평균기온은 4℃ 이하였다. 여름의 수축기 혈압은 135.5mmHg, 겨울의 수축기 혈압은 140.5mmHg로서 겨울에 5.0mmHg만큼 높았으며 이는 통계적으로 유의하였다. 이완기 혈압은 여름에는 85.0mmHg, 겨울에는 87.4mmHg로서 겨울에 2.4mmHg 만큼 높았으며, 이도 통계적으로 유의하였다. 수축기 혈압과 이완기 혈압 모두에 있어서 성, 흡연, 음주, 운동은 여름-겨울간 혈압차이에 영향을 미치지 않았다. 연령 및 체질량지수는 수축기 혈압의 여름-겨울간 혈압차이에는 영향을 미치지 않았으나, 이완기 혈압에서는 여름-겨울간 혈압차이에 영향을 미쳤으며, 연령이 감소할수록 여름-겨울간 이완기 혈압차이가 유의하게 증가하였다.

결론 : 동일한 종류와 용량의 항고혈압약제를 장기간 투약받고 있는 고혈압 환자에서 겨울철의 혈압이 여름철의 혈압보다 높았으며, 따라서 항고혈압약제를 일정하게 장기 투약하는 환자들도 계절이 변할 때는 추적관찰에 유의해야 한다.

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