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Journal of the Korean Academy of Family Medicine 1992;13(1):72-78.
Published online January 1, 1992.
Prevalence and clinical characteristics of the anti-HCV positive patients who had invreased transaminase levels with negative HBsAg.
Eun Joo Ahn, Tae Ho Chung, Hee Chul Kang, Chul Young Bae, Dong Hak Shin
간효소치가 증가된 B형 간염 표면항원 음성 환자의 C형 간염 항체 유병률및 임상적 특징
안은주, 정태호, 강희철, 배철영, 신동학
계명대학교의과대학 가정의학교실
Abstract
Background
: There have been a number of researches of hepatitis and parenterally infected NANB viral hepatitis where clonization was successful. Viral hepatitis C would be named by this process, and enzymatic-immunologic tests and serologic tests to diagnose viral hepatitis C were developed.

Methods : Seventy nine patients were selected from those whose HBsAg tests were negative and transaminase levels were abnormal from Jan. 1 to Sep. 30, 1991. We assessed the prevalence and clinical aspects of viral hepatitis C. We divided all patients into anti-HCV positive and negative groups and compared them with regard to symptoms of hepatitis, transaminase level and transfusion history.

Results : 22(27.8%) out of 79 patients showed positive anti-HCV, and the positive rate was highest in the group aged 60~69 years in men and 50~59 years in women. There was no sex difference. The positive rates of anti-HCV in the groups of positive and negative anti-HBc were 28.6% and 25.8%, respectively.

Conclusion : A positive rate of anti-HCV was higher(27.8%) in the patients with negative HBsAg & increased transaminase levels than in normal subjects. But, the number of case is small, so total morbidity is difficult to analyze.
초록
연구배경 : 간염 바이러스에 관한 연구가 활발하게 진전됨에 따라 경주적으로 감염되는 NANB형 바이러스의 cloning에 성공함으로써 이를 HCV라 명명하게 되었고, Anti-HCV를 검사하는 방사면역분석법 및 효소면역법도 개발되어 혈청학적 진단이 가능해졌다.

방법 : 1990년 1월부터 9월까지 HBsAg음성이면서 transaminase효소치가 증가된 79례를 대상으로하여 C형 간염 항체 유병률 및 성별, 연령군별 분포, Anti-HBc와의 관계를 조사하였으며 C형 간염 항체 양성군과 음성군간의 증상, 간기능수치, 수혈 과거력 여부 등에 관하여 비교 분석하였다.

결과 : 79례 중 C형 간염 항체 양성은 22례로 27.8%이고 연령군별로는 남자는 61~70세에서 66.7%, 여자는 50~59세에서 50.0%이었고 성에 따른 양성률의 차이는 없었다. Anti-HBc 양성인 군과 음성인 군에서의 HCV항체 양성률은 각각 28.6%, 25.9%이었다.

결론 : HBsAg 음성이면서 Transaminase 효소치가 증가한 예에서 HCV항체 양성률은 27.8%로 높았으나 조사연구 대상수가 적어 전체적인 발병률은 나타내기가 어려웠다.


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