| Metabolic Syndrome and the Risk for Chronic Kidney Disease among Korean Women. |
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Sun Kyung Chae, Jee Soo Lee, Jee Hyun Chun, Hye Soon Park |
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Department of Family Medicine, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. hyesoon@amc.seoul.kr |
| 성인 여자에서 대사증후군과 만성 신질환과의 관계 |
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채선경, 이지수, 천지현, 박혜순 |
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울산대학교 의과대학 서울아산병원 가정의학교실 |
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| Abstract |
Background
Metabolic syndrome (MetS), characterized by abdominal obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, high blood pressure, and high fasting glucose level, is a common risk factor for cardiovascular disease and associated complication. We examined the relationshipbetween the metabolic syndrome and risk of chronic kidney disease (CKD) in Korean women. Methods: We used data from 10,170 women, aged 30-89 years, who had visited the health examination center at a tertiary care hospital in 2006. The data were studied cross-sectionally. MetS was identified using the modified criteria of the National Cholesterol Education Program Adult Treatment Panel Ⅲ (NCEP-ATPⅢ). CKD was defined as an estimated GFR< 60 ml/min per 1.73 m2. The multivariable-adjusted(adjustment for age, a high school education, body mass index (BMI),alcohol drinking, current and former smoking, previous coronary heart disease, menopause and physical inactivity) odds ratio of CKD (95% CI) associated with each component of the metabolic syndrome, was calculated using logistic regression models. Result: 1,039 participants developed MetS. The multivariable-adjusted odds ratios (OR) of CKD in participants with MetS, hypertriglyceridemia and high blood pressure compared with participants without those factors were 2.68 (95% CI, 1.77-4.06), 1.96 (95% CI, 1.34-2.88), 2.00(95% CI, 1.38-2.89). Compared with participants with no MetS traits, those with one, two, equal to or more than three traits of MetShad OR of CKD of 1.24 (95% CI, 0.75-2.06), 1.56 (95% CI, 0.89-2.75), 2.18 (95% CI, 1.21-3.93), respectively. Conclusion: We found that Korean women with MetS had an increased risk for developing CKD. Finally, earlier identification and management of MetS might improve patient health and prevent the progression of CKD. |
| Key Words:
Metabolic Syndrome Chronic Kidney Disease Glomerular Filtration Rate |
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