Journal of the Korean Academy of Family Medicine 1990;11(10):18-28.
Published online October 1, 1990.

한국인 관상동맥질환에서 위험인자 및 생화학적지표에 관한 연구 - 혈청지질 , 혈청지단백을 중심으로 - (The Study of Risk Fator Variables and Biochemical Markers in Angiographically Dfined Coronary Artery Disease in Korean Adults)

김현철(Kim Hyun Chul),조홍준(Cho Hong Jun),김영식(Kim Young Sik),박혜순(Park Hye Soon),문태식(Moon Tae Sik)

울산대학교의과대학 서울중앙병원 가정의학교실

Abstract

The importance of risk factor variables and serum lipid, serum lipoprotein disturbance as an etiologic factor in the development and potentiation of coronary artery disease is supported by a considerable eviednce amassed from epidemiological studies.
To investigate the discriminative, predictive parameter of biochemical markers in the presence and degree of coronary artery disease, serum lipid and serum lipoprotein were measured in 226 patients who underwent coronary angiographic evaluation of chest pain suggestive of coronary artery disease. who were admitted at Asan Medical center from Apr 1989 to Aug 1990.
The results were summarized as follows ;
1. In male patients, there were no significant differences in age, hypertension, diabetes mellitus, obesity, family history, number of risk factor to compare with control groups, however, significant differences in smoking(P<0.01), pack year(P<0.01). In female patients, there were no differences in risk factor variables.
2. In female patients, no significant differences were showed in TG, HDL-C VLDL-C to compare with control group, however, there were significant differences in TC(P<0.05), LDL-C(P<0.01), HDL-C / TC(P<0.001), HDL-C / LDL-C(P<0.01). In male patients, significant differences were showed in all biochemical markers(P<0.001-P<0.01. relatively).
3. There were no significant differences between male and female in the degree of coronary artery disease which underwent coronary angiography(P>0.05). However, there were significant differences between the degree of coronary artery disease and risk factors, biochemical markers ; smoking(P<0.05), pack year(P<0.01), HDL-C/TC(P<0.05). HDL-C/LDL-C(P<0.05). etc.
4. In male patients, significant correlation were observed between coronary artery disease and age, pack year, number of risk factor, TC, TG, LDL-C, VLDL-C, HDL-C/ TC, HDL-C, HDL-C/TC, HDL-C/LDL-C(R=0.2168-0.3919:P<0.001-P<0.01. reatively). In female patients, age, number of risk factor, TC, LDL-C HDL-C / were significantly correlated with coronary artery disease(R=0.2678-0.4202 ; P<0.001-P<0.01 relatively) however, TG, HDL-C , VLDL-C were not correlated with coronary artery disease.
5. The most sensitive predictive parameter in all patient which underwent coronary angiography was HDL-C/TC(P<0.001). Further studise of risk factor variables, serum lipid and serum lipoproteins with large population are needed.