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Korean J Fam Med > Volume 42(6); 2021 > Article
Korean Journal of Family Medicine 2021;42(6):453-463.
DOI: https://doi.org/10.4082/kjfm.20.0238    Published online November 20, 2021.
Metoclopramide for Milk Production in Lactating Women: A Systematic Review and Meta-Analysis
Nik Hazlina Nik Hussain1  , Norhayati Mohd Noor2  , Shaiful Bahari Ismail2  , Nur Amirah Zainuddin1  , Zaharah Sulaiman1 
1Women’s Health Development Unit, Kubang Kerian, Malaysia
2Department of Family Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Corresponding author:  Zaharah Sulaiman, Tel: +60-9-7676886, Fax: +60-9-7653370, 
Email: zaharah@usm.my
Received: 18 October 2020   • Revised: 8 December 2020   • Accepted: 17 December 2020
Abstract
Background
Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological development of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metoclopramide for enhancing milk production in lactating women.
Methods
We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized controlled trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included breastfeeding women with term or preterm infants.
Results
We retrieved 164 records from our search of the electronic databases and 20 records from other sources. Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk volume of the intervention groups compared to that of the control groups. There was a significant increase in the serum concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse events were reported.
Conclusion
Metoclopramide did not improve milk production in lactating women. Therefore, we do not recommend using metoclopramide to increase milk production in lactating women.
Key Words: Breast Feeding; Lactation; Galactagogues; Metoclopramide


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