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Journal of the Korean Academy of Family Medicine 2003;24(5):456-460.
Published online May 10, 2003.
The Association between C-Reactive Protein and Features of the Metabolic Syndrome.
Yun Jeong Kim, Soon Bok Hwang, Soo Young Kim, In Hong Hwang
Department of Family Medicine, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea. pclove@hallym.or.kr
C-반응성단백과 대사증후군과의 관계
김윤정,황순복,김수영,황인홍
한림의대 강동성심병원 가정의학교실
Abstract
Background
: The Metabolic Syndrome is highly associated with an increased risk of coronary heart disease. C-reactive protein (CRP), a sensitive systemic marker of inflammation, is considered to show an association with risk of coronary heart disease. This study was done to assess the association of circulating levels of CRP with different components of the Metabolic Syndrome.

Methods : Total cholesterol (TC), triglycerides (TG), HDL cholesterol, body mass index (BMI), waist circumference, fasting glucose, hemoglobin A1c (HbA1c), blood pressure (BP), and CRP were measured in 1,203 men and women who have visited the Health Promotion Center in Kangdong Sacred Heart Hospital. The relationship of CRP and variables of the metabolic syndrome using t-test and regression analysis as assessed.

Results : CRP was associated with BMI (P<0.001), waist circumference (P<0.0001), diastolic blood pressure (P= 0.004), HDL cholesterol (P=0.015), and TG (P<0.0001). Subjects with the Metabolic Syndrome had a significantly higher CRP concentration (0.89 mg/L) than individuals without the metabolic syndrome (0.33 mg/L, P<0.0001).

Conclusion : CRP seems to be related to variables of the metabolic syndrome. The data suggest that a variety of features of the metabolic syndrome are associated with systemic inflammation.
Key Words: metabolic syndrome, C-reactive protein, inflammation
초록
연구배경 : 대사증후군은 관상동맥질환의 발생을 증가시키는 것으로 알려져 있다. 최근에는 염증 반응의 지표인 C-반응성단백이 관상동맥질환과 관련되어 증가한다는 보고가 있다. 이에 저자들은 대사증후군과 C-반응성단백의 관계를 알아보았다.

방법 : 2001년 1월부터 12월까지 강동성심병원 건강증진센터를 방문한 1,203명을 대상으로 설문조사, 신체계측 및 혈액검사를 시행하여 총콜레스테롤, 중성지방, 고밀도지단백, 체질량지수, 허리둘레, 공복 혈당, hemoglobin A1c, 그리고 C-반응성단백을 측정하여 대사증후군의 각 인자와 C-반응성 단백과의 관계를 분석하였다.

결과 : 대사증후군의 인자 중 허리둘레(P<0.0001), 이완기 혈압(P=0.004), 고밀도지단백(P=0.015), 그리고 중성지방(P<0.0001)이 C-반응성단백과 관련이 있었다. 대사증후군에서 C-반응성단백 농도의 기하평균은 0.89 mg/L로 대사증후군이 아닌 군의 평균(0.33 mg/L)에 비해 높았다(P<0.0001).

결론 : 대사증후군의 각 인자와 C-반응성단백과는 관련이 있었고 이는 대사증후군이 염증성 반응과 연관이 있을 것이라는 사실을 시사한다.
중심 단어: 대사증후군, C-반응성단백, 염증


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