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Journal of the Korean Academy of Family Medicine 2002;23(3):374-380.
Published online March 1, 2002.
A case study for measles patients confirmed by clinical and serological examination.
Deok Jin Lee, Tae Beom Kim, Jong Hak Lee, Sung Jai You
Department of Family Medicine, Samsun Hospital, Korea.
임상적 혈청학적으로 확진된 홍역환자의 사례
이덕진, 김태범, 이종학, 이현택, 유성재
부산 삼선병원 가정의학과
: An outbreak of measles was reported again in 2000 nationwide. For that reason, research was done to evaluated the necessity of relevant re-vaccination and efficacy of primary vaccination of MMR when measles was prevalent, by way of comparative study for serological test results of the patients hospitalized at SAMSUN HOSPITAL in Busan in 2000.

Methods : From Jan to Dec 2000, we reviewed 108 cases with medical history confirmed as measles by clinical and serological examination and checked whether inoculation of primary vaccination of MMR was done or not and the date of vaccination through telephone survey, separated. The study subjects were into two groups, vaccinated, and unvaccinated, and antibody of measles were checked according to sex, season and age.

Results : It was observed that a great number of people caught measles in May-June comprising 56 case (58.3%) among 108 cases analyzed and the wide range of an attack of measles was under two years of age with 37 cases(34.3%) under on year of age and 33 cases (30.6%) between 1-2 year old.

Conclusion : According to the results of serum diagnosis of the measles case study, vaccination for measle is needed at the age of 6 month to one year because all those under on year of age who had not received a vaccine contacted the disease. The importance of booster was raised for those above 3 years old because those who had prior vaccination against measles contacted the disease.
연구배경 : 2000년 홍역이 다시 전국적인 유행의 발생을 보이고 있다. 따라서 저자는 2000년 본원에 홍역으로 입원한 환자를 대상으로 혈청하적 검사 결과를 비교 검토하여, 홍역 유행시 홍역예방 백신의 효과 및 적절한 추가접종의 필요성을 평가하고자 본 연구를 실시하였다.

방법 : 2000년 1월부터 12월까지 본원에서 임상적, 혈청학적 검사로 홍역으로 확진된 108예를 대상으로 의무기록을 확인하였고, 전화 설문을 통해 홍역 예방접종 여부와 접종시기를 물은 뒤, 접종군과 비접종군으로 분류, 성별 및 계절적, 연령별 분포, 홍역 항체가를 조사하였다.

결과 : 홍역 108예를 분석해 보면 5-6월에 56예(58.3%)로 가장 많이 발생하고, 호발 연령은 1세 미만이 37예(34.3%), 1-2세는 33예(30.6%)로 주로 2세 이전에 많았다. 홍역 특이 lgG항체 양성인 환자는 37예(34.4%)였고, lgG항체 음성인 환자는 57예(52.8%)였다.

결론 : 홍역 사례의 혈청진단 분류결과 1세 이하에서는 모두 비접종자에서 홍역이 발생했으므로 홍역 유행시 6개월 이후 1세 이전에 조기 접종이 필요하고, 3세 이상에서는 주로 접종자에서 발병했으므로 추가접종의 중요성이 제기된다.
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