Effectiveness of Maternal Vitamin D Supplementation in Preventing Respiratory Tract Infections in Children
- Soo Young Kim*
See the article "Maternal Vitamin D Supplementation for the Prevention of Respiratory Tract Infections in Offspring: A Meta-Analysis" in volume 43 on page 174.
Vitamin D exhibits a hormone-like action in our body and the deficiency or insufficiency of vitamin D is known to be related to the occurrence or prognosis of various diseases. In the Korean Journal of Family Medicine, papers on the relationship between vitamin D levels and colon polyps [1], autoimmune thyroid disease [2], lung function [3], dry eyes [4], cardiovascular disease risk [5], and quality of life [6] were published. Among these effects, vitamin D is known to play an important role in bone growth and immune function. Although it is known that the administration of vitamin D reduces respiratory infections, there has been an interest in whether vitamin D administration during pregnancy reduces respiratory tract infections (RTIs) in newborns.
In the present issue, Sulaiman et al. [7] investigated the effect of maternal vitamin D supplementation in preventing RTIs in children. This systematic review selected three randomized controlled trials with a total of 3,224 participants (mother–infant pairs). It was found that maternal vitamin D supplements had no effects on RTIs among children (n=1,486 offspring; risk ratio, 0.95; 95% confidence interval, 0.82–1.11; random effects; I2 statistics, 0%).
A systematic review on a topic similar to this study was published twice, but the conclusions of the two reviews were different. The systematic review by Christensen et al. [8] showed results supporting a preventive role of vitamin D during pregnancy on the risk of RTIs in offspring, whereas the systematic review by Tareke et al. [9] showed that there is no significant evidence to promote vitamin D supplementation. However, based on these results, it can be said that maternal vitamin D supplementation had no effect on RTIs in children.
Moreover, these results do not mean that pregnant women have no need for vitamin D supplementation. A study found that 4,000 IU of vitamin D daily had the greatest benefits in preventing preterm labor/births and infections [10], and most institutions recommend vitamin D supplementation during pregnancy. Therefore, vitamin D supplementation should be continued. However, supplementation is not necessary to reduce RTIs in children since its effect is insignificant.
- CONFLICTS OF INTEREST
CONFLICT OF INTEREST No potential conflict of interest relevant to this article was reported.
- REFERENCES
- 1. Yoo MY, Lee J, Chung JI, Yeo Y, Cho IY. The association between serum vitamin D concentration and colon polyp: a cross-sectional study using health care screening database in a tertiary hospital in Korea. Korean J Fam Med 2021; 42: 303–9.
[Article] [PubMed] [PMC]2. Kim CY, Lee YJ, Choi JH, Lee SY, Lee HY, Jeong DH, et al. The association between low vitamin D status and autoimmune thyroid disease in Korean premenopausal women: the 6th Korea National Health and Nutrition Examination Survey, 2013-2014. Korean J Fam Med 2019; 40: 323–8.
[Article] [PubMed] [PMC]3. Kim MS, Choi CJ, Kwon KM, Kim KS, Choi WS, Oh YJ. Association of lung function with serum 25-hydroxyvitamin D level according to the presence of past pulmonary tuberculosis in Korean adults. Korean J Fam Med 2019; 40: 93–9.
[Article] [PubMed] [PMC]4. Kim MH, Kim YS, Oh HJ, Kwon YR, Kim HW. The association between 10-year atherosclerotic cardiovascular diseases risk score calculated using 2013 American College of Cardiology/American Heart Association guidelines and serum 25-hydroxyvitamin D level among aged 40-79 years in Korea: the sixth Korea National Health and Nutrition Examination Surveys. Korean J Fam Med 2018; 39: 174–9.
[Article] [PubMed] [PMC]5. Kim MJ, Hwang HR, Kim YJ, Lee SY, Lee JG, Jeong DW, et al. Association between serum 25-hydroxyvitamin D levels and dry eye in Korean adults: a study based on Korean National Health and Nutrition Examination Survey, 2010-2011. Korean J Fam Med 2017; 38: 81–5.
[Article] [PubMed] [PMC]6. Kim JS, Choi YE, Baek JK, Cho HJ, Kim YS. The association between vitamin D and health-related quality of life in Korean adults. Korean J Fam Med 2016; 37: 221–7.
[Article] [PubMed] [PMC]7. Sulaiman Z, Noor NM, Ismail SB, Lukman AS, Irfan M, Hussain NH. Maternal vitamin D supplementation for the prevention of respiratory tract infections in offspring: a meta-analysis. Korean J Fam Med 2022; 43: 174–82.
[Article] [PubMed] [PMC]8. Christensen N, Sondergaard J, Fisker N, Christesen HT. Infant respiratory tract infections or wheeze and maternal vitamin D in pregnancy: a systematic review. Pediatr Infect Dis J 2017; 36: 384–91.
[PubMed]