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Korean J Fam Med > Volume 31(1); 2010 > Article
Korean Journal of Family Medicine 2010;31(1):16-23.
DOI: https://doi.org/10.4082/kjfm.2010.31.1.16    Published online January 20, 2010.
Effect of Cis-9-Cetylmyristoleate Containing Fatty Acids Complex Extracted from Vegetable Oils on Knee Pain in Patients with Osteoarthritis.
Tae Guk Ha, Joo Hyoung Kang, In Bum Lee, Cheol Soo Ahn, Chi Hoon Lee, Sang Chul Lee, Seung Wan Kang
1Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
2Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea. drdemian@snu.ac.kr
3Institute of Complementary and Integrative Medicine, Seoul National University Medical Research Center, Seoul, Korea.
Cetyl Myristoleate를 주성분으로 하는 식물성 복합 지방산의 퇴행성 슬관절염 환자에 대한 통증 감소 효과
하태국, 강주형, 이인범, 안철수, 이치훈, 이상철, 강승완
Previous study suggested that beef tallow extract including cis-9-cetylmyristoleate was a safe and effective treatment for patients with osteoarthritis. We used extract of vegetable oils containing cetyl myristoleate. This study assessed the effect of this supplementation on knee pain and function in patients with osteoarthritis. Methods: The 70 patients who manifested the symptoms and signs of osteoarthritis of knee were randomly assigned to placebo (36) and plant-fatty acids complex (FAC) group (34). Two capsules of placebo (corn starch 350 mg) and plant-FAC (12% cetyl myristoleate in 350 mg) were orally administered to placebo and plant-FAC group three times a day for 60 day, respectively. Visual analogue scale (VAS) and Korean version of Western Ontario and McMaster' Universities Osteoarthritis Index (KWOMAC) were assessed before and after the intervention and we monitored any adverse effects. Results: The 6 of 36 patients (16.7%) in the placebo and the 5 of 34 patients (14.7%) in the plant-FAC group were missed due to low compliance. In the plant-FAC group, the VAS score was improved by mean 0.76 (P = 0.03) but the improvement was lower than that of placebo group. The KWOMAC was improved by mean 8.90 and 8.13 in the plant-FAC and placebo group, respectively. But the independent t-test showed no statistical signifi cance (P = 0.47). Conclusion: We failed to show the superiority of plant-FAC to placebo on the pain and function of patients with osteoarthritis of the knee.
Key Words: Cis-9-Cetylmyristoleate; Osteoarthritis; Fatty Acids Complex; Infl ammatory Cytokines
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