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Korean J Fam Med > Volume 35(1); 2014 > Article
Wiwanitkit: Oxidative Stress and Metabolic Syndrome
Dear Editor,
Sir, the recent report on oxidative stress and metabolic syndrome is very interesting.1) Chung et al.1) concluded that 'high hs-CRP, the presence of metabolic syndrome, and female gender were associated with high oxidative stress.' The correlation may be due to several factors. Recently, Limberg et al.2) noted that 'oxidative stress influences vascular responsiveness.' Nevertheless, it should be noted that there are many disorders that can lead to high oxidative stress and those disorders might not directly relate to metabolic syndrome. For example, a cancerous patient can have high oxidative stress,3) but such patients are usually thin, not obese. Another example is patients with underlying hemoglobinopathy, who can also present with high oxidative stress.4) The patient might simply be anemic, without metabolic syndrome.
Yours Sincerely


No potential conflict of interest relevant to this article was reported.


1. Chung SW, Kang SG, Rho JS, Kim HN, Song IS, Lee YA, et al. The association between oxidative stress and metabolic syndrome in adults. Korean J Fam Med 2013;34:420-428. PMID: 24340164.
crossref pmid pmc
2. Limberg JK, Harrell JW, Johansson RE, Eldridge MW, Proctor LT, Sebranek JJ, et al. Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress. Am J Physiol Heart Circ Physiol 2013;305:H1230-H1237. PMID: 23934859.
crossref pmid pmc
3. Athar M. Oxidative stress and experimental carcinogenesis. Indian J Exp Biol 2002;40:656-667. PMID: 12587714.
4. Palasuwan A, Kittisakulrat T, Amornrit W, Soogarun S, Wiwanitkit V, Pradniwat P. Antioxidant in plasma of hemoglobin-E trait. Southeast Asian J Trop Med Public Health 2005;36(Suppl 4):271-273. PMID: 16438222.


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