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Journal of the Korean Academy of Family Medicine 2002;23(7):925-933.
Published online July 10, 2002.
Relationship between Carcinoembryonic Antigen (CEA) and Pulmonary Function in Middle-aged Male Smokers.
Byoung Joon Moon, Dong Jin Lee, Kyeong Duk Ko, Sun Woo Yang, Kyeong Su Chun, Mi Kyeong Oh
Department of Family Medicine, Kang-Nung Medical Center, College of Medicine, Ulsan University, Korea. ilovechss@freechal.com
중년 남성 흡연자에서 혈청 Carcinoembryonic Antigen (CEA)과 폐기능과의 연관성
울산대학교 의과대학 강릉병원 가정의학과

Department of Family Medicine, Kang-Nung Medical Center, College of Medicine, Ulsan University



Carcinoembryonic antigen (CEA) is a glycoprotein on cellular surface, which is highly condensed in embryonic tissue and tumor of various kinds. Previous study found out that CEA may grow with various cancer or other diseases other than cancer as well. Besides, it is widely known that smoking also influences the rise in CEA. Among the same smokers, some of them show high CEA figures in serum when others remain in normal range. There are those whose pulmonary function is not influenced by smoking when that of others are susceptible to it. Therefore, this study was undertaken with an aim to study the relationship between serum CEA and pulmonary function by investigating how the change in pulmonary function caused by smoking influences serum CEA.

From Nov, 1997 to Feb, 2001, this study carried out tests on adult male smokers ages 35 to 64 who visited a hospital located in Kang Nung city. The subjects were divided into two groups: one group of 29 subjects with high CEA with over 6.0 ng/ml with normal colon study; the other group, which is the CEA normal group, consisted of 58 subjects selected through age adjusted random sampling. Data on personal information, smoking and clinical history was collected from a questionnaire. CEA was tested using radioimmunoassay of Abott. Pulmonary function was examined using Analyzer assembly Vmax 20C from Sensormedics Company. These examinations was limited to those who have been screened not to have cancer by chest X-ray, abdominal ultrasonography, and duodenofibroscopy.

Smoking per day for the group with high serum CEA was 1.3 pack (±0.4 pack), which was found to be significantly higher compared to that of normal group (P<0.01). Pack-years with high serum CEA group was 32.6±13.5 which was also comparatively higher than that of the normal group with 22.4±10.9 (P<0.01). Pulmonary function test indicated that FEV1 for the group with high serum CEA was 3.0±0.5 L, which marked lower than that of the normal group with 3.4±0.5 L (P<0.05). After compensating for age and pack years, FEV1 decreased in proportion to the rise in CEA.

This study has established a link between serum CEA and daily smoking, pack years, and pulmonary function and found that FEV1 was inversely proportionate to the rise in CEA regardless of corrected pack years and daily smoking. Consequently, serum CEA alone is thought to be related to the pulmonary function. Therefore, it is advised that smokers with high serum CEA need to take heed of the influence on pulmonary function.

중심 단어: 흡연, Carcinoembryonic antigen (CEA), 폐기능, smoking, carcinoembryonic antigen (CEA), pulmonary function


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