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Korean J Fam Med > Volume 30(6); 2009 > Article
Korean Journal of Family Medicine 2009;30(6):449-456.
DOI: https://doi.org/10.4082/kjfm.2009.30.6.449    Published online June 20, 2009.
The Role of C-reactive Protein as a Inflammation-related Factor in Metabolic Syndrome.
Jeon Su Park, Yun Jin Kim, Jeong Gyu Lee, Young Joo Kim, Sangyeoup Lee, Hong Gi Min, Byung Mann Cho
1Department of Family Medicine, Pusan National University Hospital, Pusan, Korea. yujkim@pusan.ac.kr
2Medical Education Unit, Pusan National University School of Medicine, Pusan, Korea.
3Department of Preventive Medicine, Pusan National University School of Medicine, Pusan, Korea.
대사증후군과 염증관련인자로서 C-반응단백의 역할
박전수, 김윤진, 이정규, 김영주, 이상엽, 민홍기, 조병만
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2
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Abstract
Background
The metabolic syndrome has been known as the cluster of insulin resistance, dyslipidemia, hypertension, and abdominal obesity. There have been many studies about the infl ammatory role in atherosclerosis and cardiovascular diseases, also. We aimed to elucidate the role of high sensitivity C-reactive protein (hs-CRP) as a infl ammation-related factor in metabolic syndrome in Korean adults by correlation and factor analysis. Methods: A cross sectional study was carried out in 1,512 men and 1,836 women (over 20 years old) who had an examination at a center for health promotion of an university hospital from May 2004 through March 2005. The NCEP-ATP III definition and Asian-Pacific adjusted criteria were used to obtain the metabolic syndrome group. And we evaluated the role and gender difference of hs-CRP in metabolic syndrome by correlation and factor analysis.Results: In women, hs-CRP was statistically correlated with most metabolic variables, especially insulin resistance. In factor analysis, 3 factors (obesity, blood pressure, and insulin resistance) were obtained in men and 4 factors (obesity, blood pressure, insulin resistance, and dyslipidemia) in women, respectively. In women, hs-CRP was a part of dyslipidemia factor.Conclusion: In factor anaylsis of metabolic syndrome factors with hs-CRP, hs-CRP was not a signifi cant factor in men, but was included as a part of dyslipidemia factor in women.
Key Words: Metabolic Syndrome; hs-CRP; Infl ammation; Correlation Analysis; Factor Analysis; Gender Difference; Korean Adults


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